This document discusses the opportunities and ethical issues researchers face when using cloud computing technologies. It begins by defining cloud computing and describing the three layers of cloud services - applications, platforms, and infrastructure. It then explores how each of these layers can provide opportunities for research uses, such as online surveys, data storage, and leveraging large computing resources. However, it also outlines several ethical dimensions researchers and IRBs must consider, like subject confidentiality, data privacy, ownership and security issues. It concludes by suggesting steps researchers and IRBs can take when using cloud services and additional resources that could help navigate these new complex issues.