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When multiple strains of the same bacterial species are sequenced, what are the features of their
genome that are typically observed?
Solution
Multiple strains of the same bacterial species features:
The sequencing of multiple strains from the same bacterial species has clearly demonstrated that
horizontal gene transfer accounts for the majority of intraspecies genome differences.
Comparative analysis of these bacterial sequences has revealed the movement of phage DNA by
lateral transfer as having significant impact on the evolution of the host genome.
Escherichia coli is an important component of the biosphere and is an ideal model for studies of
processes involved in bacterial genome evolution. The diversity within the species E. coli, and
the overlap in gene content between this and related species, suggests a continuum rather than
sharp species borders in this group of Enterobacteriaceae.

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