Women in Zimbabwe are disproportionately affected by HIV, with infection rates of 21.1% among women compared to 14.5% among men. Condom use within marriage is low, and most infections occur when people get married. Advocacy and training of leaders to promote gender equality, as well as interpersonal communication sessions and programs promoting responsible behavior can help address gender-based vulnerabilities to HIV in Zimbabwe. Focusing on changing social norms and directly involving men and people living with HIV are also important.