The document summarizes the Wellcome Trust's experience with an author-pays open access model. It finds that around 50% of Wellcome Trust-funded papers comply with its open access policy, with 33% being immediately open access. A study of 460 open access papers published in the last quarter of 2010 found an average author-pays fee of $2,367, with a total estimated cost to the Trust of $1.04 million. Extrapolating to the Trust's total annual research output, open access fees were estimated to represent around 1.25% of total research spending. The document concludes there is growing momentum and funding support for open access publishing.