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1Copyright © 2014 Well Woman Clinic. All rights reserved.
Impact of Vitamin D Deficiency on
Women’s Health
Dr Nupur Gupta, Director Obstetrics & Gynecology
2Copyright © 2014 Well Woman Clinic. All rights reserved.
Sunshine Vitamin: Everyone Needs
 One of the most controversial nutrients
Strong bones, body,
coordination of nerve &
muscles
Healthy teeth &
Robust immune system
3Copyright © 2014 Well Woman Clinic. All rights reserved.
Synthesis (25 hydroxy Vitamin D)
 Skin epidermis
(sunlight UVB Rays &
dehydrocholesterol)
 Types: D2
(ergocalciferol) & D3
(cholecalciferol)
4Copyright © 2014 Well Woman Clinic. All rights reserved.
Why is Bioavailability low?
 GI liquids – chemical instability, poor solubility,
slow absorption & first pass metabolism
 Less exposure – lack of time & lack of open
spaces
5Copyright © 2014 Well Woman Clinic. All rights reserved.
What is the daily requirement?
Recommended Daily Allowance
Infants – 200-400 IU
Adult - 600 IU
Elderly - 800 IU
Normal: 30-100 ng/ml
6Copyright © 2014 Well Woman Clinic. All rights reserved.
How can we fulfill our daily requirements?
 Best time 11am – 3pm
 Minimum 40 min daily exposure
 20% body parts
7Copyright © 2014 Well Woman Clinic. All rights reserved.
Are there any Risk Factors
for deficiency?
 LIFESTYLE – use of sunscreen, time sent outdoors
 GEOGRAPHICAL LOCATION
Less – higher altitude, North India (Himalayas)
More – equator, South India
 AGE – less in elderly
 OBESITY – lower levels
8Copyright © 2014 Well Woman Clinic. All rights reserved.
Who is Deficient?
 Almost everyone
 Fat malabsorption, anticonvulsant use, chronic
kidney disease, & obesity
 Dark-skinned people, women using sunscreen
lotions, & those areas with thick layer of ozone
 People from urban & polluted areas
9Copyright © 2014 Well Woman Clinic. All rights reserved.
Who is more Deficient?
 Children (growing age)
 Women (pregnancy & menstruation)
 Elderly (less cholesterol in the skin)
10Copyright © 2014 Well Woman Clinic. All rights reserved.
How do we suspect deficiency?
 Tiredness, laziness
 Joint pains, constant pain in body
 Weakness of joints & muscles
 Poor immunity
 Hair loss
 Mood swings
 Infertility
 Irregularity of bones (frequent fractures)
11Copyright © 2014 Well Woman Clinic. All rights reserved.
You might be at risk
 Milk allergy or poor
intake
 Shun the sun
 Vegan diet
12Copyright © 2014 Well Woman Clinic. All rights reserved.
Five Common Signs & Symptoms
of Vitamin D deficiency
13Copyright © 2014 Well Woman Clinic. All rights reserved.
FIRST……………….
 Bone pain & muscle
weakness
14Copyright © 2014 Well Woman Clinic. All rights reserved.
SECOND………….
Constant Fatigue &
Tiredness
15Copyright © 2014 Well Woman Clinic. All rights reserved.
THIRD………….
 Mood swings,
feeling of sadness &
Depression
16Copyright © 2014 Well Woman Clinic. All rights reserved.
FOURTH………….
 Rickets &
osteomalacia
 Osteoporosis
17Copyright © 2014 Well Woman Clinic. All rights reserved.
How do you get Vitamin D?
 Sun
 Food
 Supplements
18Copyright © 2014 Well Woman Clinic. All rights reserved.
What are the Rich Sources?
 Cod liver oil
 Fish – Salmon, sardines
 Fortified milk, egg yolk
 Fortified yogurt, mushrooms
 Fortified soy products,
 Oysters & fortified cereals
19Copyright © 2014 Well Woman Clinic. All rights reserved.
20Copyright © 2014 Well Woman Clinic. All rights reserved.
Vitamin D3 & Calcium
 Ca & bone mineral metabolism
 Works with PTH
 Calcium & phosphorous homeostasis
21Copyright © 2014 Well Woman Clinic. All rights reserved.
CALCIUM
22Copyright © 2014 Well Woman Clinic. All rights reserved.
Vitamin D in Gynaecology
 Endometriosis (improves dysmenorrhoea)
 Assisted reproduction (improves conception rate)
 Ovarian & breast cancer (protective effect)
23Copyright © 2014 Well Woman Clinic. All rights reserved.
Vitamin D & Pregnancy
 Prevents Gestational Diabetes Mellitus (dec IR & inc
Insulin production)
 Prevents preeclampsia (helps is placental invasion,
implantation & angiogenesis)
 Prevents low birthweight & risk of severe PPH
 Increases risk of preterm birth
24Copyright © 2014 Well Woman Clinic. All rights reserved.
Emerging Role
 Immunity & immune disorders (rheumatoid
arthritis, multiple sclerosis)
 Diabetes (regulates insulin levels),
metabolic syndrome, skin disease
(psoriasis), hair loss
25Copyright © 2014 Well Woman Clinic. All rights reserved.
Emerging Role
 Prevention of cancer, osteoporosis
 Lung function, Hypertension
 Cardiovascular health & disease,
 Management of obesity,
 Psychiatric diseases
26Copyright © 2014 Well Woman Clinic. All rights reserved.
Vitamin D & Weight Loss
Weight Loss Plateau
Decreases serotonin levels
Increases Cortisol levels
Alters storage & formation of fat cells
27Copyright © 2014 Well Woman Clinic. All rights reserved.
MYTHS
28Copyright © 2014 Well Woman Clinic. All rights reserved.
Myth 1
 I can get enough Vitamin D from
Sunlight
29Copyright © 2014 Well Woman Clinic. All rights reserved.
Myth 2
I eat plenty of Vitamin D rich foods
30Copyright © 2014 Well Woman Clinic. All rights reserved.
Myth 3
 Only “at risk” groups need a supplement
31Copyright © 2014 Well Woman Clinic. All rights reserved.
Myth 4
 I take a multivitamin containing vitamin D so
I already get all I need
32Copyright © 2014 Well Woman Clinic. All rights reserved.
SUPPLEMENTS
Soft gelatin Capsule, Sachet, Drops
33Copyright © 2014 Well Woman Clinic. All rights reserved.
What is a healthy level of Vitamin D?
 Less than 30: DEFICIENT
 30-50: INADEQUATE
 More than 50: ADEQUATE
 More than 125: HIGH
34Copyright © 2014 Well Woman Clinic. All rights reserved.
Who should get Vitamin D levels
checked?
 Gastrointestinal disorder (IBD)
 Weight loss surgery, osteoporosis
 On anti-convulsant medications;
 Children who are immobilized, not outside & active.
 If you’re over 70
 People whose cultural or religious beliefs require
them to be fully clothed,
 If dietary habits include little or no dairy
35Copyright © 2014 Well Woman Clinic. All rights reserved.
HOME REMEDIES
 Fenugreek seeds (methi dana soak 1 tsp overnight)
 Turmeric (haldi)
 Almond in milk
 Exercise
36Copyright © 2014 Well Woman Clinic. All rights reserved.
TOXICITY: HYPERVITAMINOSIS/
Hypercalcemia
Mild – Nausea, vomiting, weakness, frequent
urination
Severe - brittle bones - bone pain and kidney
problems (formation of calcium stones), irregular
heart beat & heart attack
37Copyright © 2014 Well Woman Clinic. All rights reserved.
SUN RAYS can be harmful too…….
 Damages skin cellular DNA
 Creates genetic mutations
Skin cancers (90% nonmelanomas, 80%
melanomas)
 Premature aging
38Copyright © 2014 Well Woman Clinic. All rights reserved.
RECOMMENDATIONS
 Kids should play in sun daily (20% body
uncovered)
 Adults > 30 years, need monthly sachet
 Pregnancy & breastfeeding
 Elderly
39Copyright © 2014 Well Woman Clinic. All rights reserved.

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Vitamin D and Women's Health [autosaved]

  • 1. 1Copyright © 2014 Well Woman Clinic. All rights reserved. Impact of Vitamin D Deficiency on Women’s Health Dr Nupur Gupta, Director Obstetrics & Gynecology
  • 2. 2Copyright © 2014 Well Woman Clinic. All rights reserved. Sunshine Vitamin: Everyone Needs  One of the most controversial nutrients Strong bones, body, coordination of nerve & muscles Healthy teeth & Robust immune system
  • 3. 3Copyright © 2014 Well Woman Clinic. All rights reserved. Synthesis (25 hydroxy Vitamin D)  Skin epidermis (sunlight UVB Rays & dehydrocholesterol)  Types: D2 (ergocalciferol) & D3 (cholecalciferol)
  • 4. 4Copyright © 2014 Well Woman Clinic. All rights reserved. Why is Bioavailability low?  GI liquids – chemical instability, poor solubility, slow absorption & first pass metabolism  Less exposure – lack of time & lack of open spaces
  • 5. 5Copyright © 2014 Well Woman Clinic. All rights reserved. What is the daily requirement? Recommended Daily Allowance Infants – 200-400 IU Adult - 600 IU Elderly - 800 IU Normal: 30-100 ng/ml
  • 6. 6Copyright © 2014 Well Woman Clinic. All rights reserved. How can we fulfill our daily requirements?  Best time 11am – 3pm  Minimum 40 min daily exposure  20% body parts
  • 7. 7Copyright © 2014 Well Woman Clinic. All rights reserved. Are there any Risk Factors for deficiency?  LIFESTYLE – use of sunscreen, time sent outdoors  GEOGRAPHICAL LOCATION Less – higher altitude, North India (Himalayas) More – equator, South India  AGE – less in elderly  OBESITY – lower levels
  • 8. 8Copyright © 2014 Well Woman Clinic. All rights reserved. Who is Deficient?  Almost everyone  Fat malabsorption, anticonvulsant use, chronic kidney disease, & obesity  Dark-skinned people, women using sunscreen lotions, & those areas with thick layer of ozone  People from urban & polluted areas
  • 9. 9Copyright © 2014 Well Woman Clinic. All rights reserved. Who is more Deficient?  Children (growing age)  Women (pregnancy & menstruation)  Elderly (less cholesterol in the skin)
  • 10. 10Copyright © 2014 Well Woman Clinic. All rights reserved. How do we suspect deficiency?  Tiredness, laziness  Joint pains, constant pain in body  Weakness of joints & muscles  Poor immunity  Hair loss  Mood swings  Infertility  Irregularity of bones (frequent fractures)
  • 11. 11Copyright © 2014 Well Woman Clinic. All rights reserved. You might be at risk  Milk allergy or poor intake  Shun the sun  Vegan diet
  • 12. 12Copyright © 2014 Well Woman Clinic. All rights reserved. Five Common Signs & Symptoms of Vitamin D deficiency
  • 13. 13Copyright © 2014 Well Woman Clinic. All rights reserved. FIRST……………….  Bone pain & muscle weakness
  • 14. 14Copyright © 2014 Well Woman Clinic. All rights reserved. SECOND…………. Constant Fatigue & Tiredness
  • 15. 15Copyright © 2014 Well Woman Clinic. All rights reserved. THIRD………….  Mood swings, feeling of sadness & Depression
  • 16. 16Copyright © 2014 Well Woman Clinic. All rights reserved. FOURTH………….  Rickets & osteomalacia  Osteoporosis
  • 17. 17Copyright © 2014 Well Woman Clinic. All rights reserved. How do you get Vitamin D?  Sun  Food  Supplements
  • 18. 18Copyright © 2014 Well Woman Clinic. All rights reserved. What are the Rich Sources?  Cod liver oil  Fish – Salmon, sardines  Fortified milk, egg yolk  Fortified yogurt, mushrooms  Fortified soy products,  Oysters & fortified cereals
  • 19. 19Copyright © 2014 Well Woman Clinic. All rights reserved.
  • 20. 20Copyright © 2014 Well Woman Clinic. All rights reserved. Vitamin D3 & Calcium  Ca & bone mineral metabolism  Works with PTH  Calcium & phosphorous homeostasis
  • 21. 21Copyright © 2014 Well Woman Clinic. All rights reserved. CALCIUM
  • 22. 22Copyright © 2014 Well Woman Clinic. All rights reserved. Vitamin D in Gynaecology  Endometriosis (improves dysmenorrhoea)  Assisted reproduction (improves conception rate)  Ovarian & breast cancer (protective effect)
  • 23. 23Copyright © 2014 Well Woman Clinic. All rights reserved. Vitamin D & Pregnancy  Prevents Gestational Diabetes Mellitus (dec IR & inc Insulin production)  Prevents preeclampsia (helps is placental invasion, implantation & angiogenesis)  Prevents low birthweight & risk of severe PPH  Increases risk of preterm birth
  • 24. 24Copyright © 2014 Well Woman Clinic. All rights reserved. Emerging Role  Immunity & immune disorders (rheumatoid arthritis, multiple sclerosis)  Diabetes (regulates insulin levels), metabolic syndrome, skin disease (psoriasis), hair loss
  • 25. 25Copyright © 2014 Well Woman Clinic. All rights reserved. Emerging Role  Prevention of cancer, osteoporosis  Lung function, Hypertension  Cardiovascular health & disease,  Management of obesity,  Psychiatric diseases
  • 26. 26Copyright © 2014 Well Woman Clinic. All rights reserved. Vitamin D & Weight Loss Weight Loss Plateau Decreases serotonin levels Increases Cortisol levels Alters storage & formation of fat cells
  • 27. 27Copyright © 2014 Well Woman Clinic. All rights reserved. MYTHS
  • 28. 28Copyright © 2014 Well Woman Clinic. All rights reserved. Myth 1  I can get enough Vitamin D from Sunlight
  • 29. 29Copyright © 2014 Well Woman Clinic. All rights reserved. Myth 2 I eat plenty of Vitamin D rich foods
  • 30. 30Copyright © 2014 Well Woman Clinic. All rights reserved. Myth 3  Only “at risk” groups need a supplement
  • 31. 31Copyright © 2014 Well Woman Clinic. All rights reserved. Myth 4  I take a multivitamin containing vitamin D so I already get all I need
  • 32. 32Copyright © 2014 Well Woman Clinic. All rights reserved. SUPPLEMENTS Soft gelatin Capsule, Sachet, Drops
  • 33. 33Copyright © 2014 Well Woman Clinic. All rights reserved. What is a healthy level of Vitamin D?  Less than 30: DEFICIENT  30-50: INADEQUATE  More than 50: ADEQUATE  More than 125: HIGH
  • 34. 34Copyright © 2014 Well Woman Clinic. All rights reserved. Who should get Vitamin D levels checked?  Gastrointestinal disorder (IBD)  Weight loss surgery, osteoporosis  On anti-convulsant medications;  Children who are immobilized, not outside & active.  If you’re over 70  People whose cultural or religious beliefs require them to be fully clothed,  If dietary habits include little or no dairy
  • 35. 35Copyright © 2014 Well Woman Clinic. All rights reserved. HOME REMEDIES  Fenugreek seeds (methi dana soak 1 tsp overnight)  Turmeric (haldi)  Almond in milk  Exercise
  • 36. 36Copyright © 2014 Well Woman Clinic. All rights reserved. TOXICITY: HYPERVITAMINOSIS/ Hypercalcemia Mild – Nausea, vomiting, weakness, frequent urination Severe - brittle bones - bone pain and kidney problems (formation of calcium stones), irregular heart beat & heart attack
  • 37. 37Copyright © 2014 Well Woman Clinic. All rights reserved. SUN RAYS can be harmful too…….  Damages skin cellular DNA  Creates genetic mutations Skin cancers (90% nonmelanomas, 80% melanomas)  Premature aging
  • 38. 38Copyright © 2014 Well Woman Clinic. All rights reserved. RECOMMENDATIONS  Kids should play in sun daily (20% body uncovered)  Adults > 30 years, need monthly sachet  Pregnancy & breastfeeding  Elderly
  • 39. 39Copyright © 2014 Well Woman Clinic. All rights reserved.

Editor's Notes

  1. When your shadow is smaller than your height
  2. Vitamin D deficiency is linked to the deficiency of Calcium. This is mainly due to the fact that the body needs the vitamin to absorb Calcium. Without enough of it, one can’t form enough of the hormone calcitriol. This, in turn, leads to insufficient calcium absorption from the diet. In situations like this, the body is forced to turn to the skeleton for its supply of the mineral. Eventually, this causes existing bones to get weakened and prevents the formation of a strong, new bone in children.
  3. Your body needs vitamin D. Its main job is to help the body absorb calcium from the intestines. This calcium is necessary to help “mineralize the skeleton” over the course of your lifetime and is a critical mineral for forming the hardened bone that keeps you strong and healthy. On the other hand, “not getting enough Vitamin D can have serious consequences, including increased rates of bone loss or even osteomalacia ('soft bones') in adults and rickets (a deforming bone disorder) in children
  4. PTB is controversial (Cochrane 2019)
  5. A less commonly known fact is the connection between Vitamin D and weight loss. A shortage of the vitamin decreases serotonin levels in the body. Serotonin is a neurotransmitter that affects everything in the body from one’s mood to sleep regulation. Thus, we see increased levels of cortisol production. Eventually, this slows down one’s weight loss or even causes the person to hit a weight loss plateau. The right amount of Vitamin D in one’s body helps aid weight loss by altering the storage and formation of fat cells and increasing the serotonin and testosterone levels in the body. It helps keep hormone levels in check, which also may help enhance weight loss and decrease body fat.
  6. Oct-Apr (sun is not strong enough), Mar-Sep (apply sunscreen to protect from UVA rays, SPF 15 & above block UVB rays) Dark skin people require more exposure to sunlight than fairer ones Our lifestyle – spent indoors in office 5-10 min bare skin 2-3 times per week should be enough but breaks down too quickly leading to low storage
  7. Fish is the best source of Vit D. Not everyone eats. mackerel, salmon and tuna. Even healthy diet is not enough to fulfill daily requirements Fortified foods can help
  8. Infants & children under 5 years of age, Pregnant and breastfeeding mothers People over the age of 65, People who have little or no exposure to the sun People with darker skin pigmentation
  9. Daily req upto 70yrs & in pregnancy– 600 IU, so take adequately
  10. Soft gelatin capsule is nonveg, sachet to be taken with milk for better absorption, drops (nanoshots) for better absorption & bioavailability. Good for patients of malabsorption syndrome (IBD, celiac disease, bariatric surgery, EFA deficiency)