Vitamin B12 deficiency anemia (B12-DA) is a disease caused by a lack of vitamin B12 in the body. It can be caused by dietary deficiency, hereditary disorders that impair B12 absorption or transport, or acquired defects affecting the stomach or intestines. Symptoms include megaloblastic anemia, glossitis, neurological issues, and fatigue. Laboratory tests show large red blood cells, low vitamin B12 and folate levels, and increased methylmalonic acid. Treatment involves addressing the underlying cause, dietary changes, vitamin B12 injections or supplements, and rest.