subscribe the channel :Work&Life Hobbies watch video:https://www.youtube.com/watch?v=v3rI1lf2TZ8&t=403s This slide describes the Important Synthesis of Antiviral Drugs

1. IMPORTANT SYNTHESIS OF
ANTI-VIRAL DRUGS
Presented By:-Dr. Anjali
Bhardwaj

3. Synthesis of Acyclovir

5. Uses:-
-Acyclovir is used to treat infections caused by
certain types of viruses.
-It treats cold sores around the mouth (caused by
herpes simplex), shingles (caused by herpes zoster),
and chickenpox.
-This medication is also used to treat outbreaks of
genital herpes.
Brand Name-Zovirax, ACLOVIR DT, ALOVIR 200

6. Synthesis of Ganciclovir

8. Ganciclovir is an anti-viral drug. It is used to
prevent disease caused by a virus called
cytomegalovirus (CMV) in people who have
received organ or bone marrow transplants.
Adverse Effect
CMV disease can lead to serious infections in
the body, including an infection in the eye,
called CMV retinitis, that can cause blindness.
Brand Name-Cytovene, Cytovene IV

9. Synthesis of Idoxuridine

10. Mechanism of action of Idoxuridine
-Idoxuridine is phosphorylated by thymidine kinase in host cell
to convert into active triphosphate form which is closely
resembles thymidine.
It inhibits thymidylic phosphorylase and specific DNA
polymerases, which are necessary for the incorporation of
thymidine into viral DNA. Idoxuridine is incorporated in place of
thymidine into viral DNA, resulting in faulty DNA and the

11. Idoxuridine ophthalmic is an
antiviral medication.
It prevents the replication (reproduction)
of the herpes simplex virus.
Thus, it reduces the amount of active
virus in your system. Idoxuridine
ophthalmic is used to treat
eye infections caused by

12. Synthesis of Methisazone

13. Mechanism of Action-
Methisazone interfere with the
translation mRNA messages into protein
synthesis on the cell ribosomes,
resulting defect in protein inclusion into
the virus.
Brand Name:-Marboran

14. Synthesis of Amantadine
Brand Name:-Symmetrel, Gocovri,
Osmolex ER
Use-It is used to treat and prevent respiratory infections
caused by the influenza A virus.
It can also treat symptoms of Parkinson's disease

15. The mechanism of
Amantadine's antiviral activity
involves interference with a
viral protein M2 (an ion
channel), which is required for
the viral particle to become
"uncoated" once taken inside a
cell by endocytosis.Influenza B does not possess M2 channels, and thus the
drug is ineffective towards all Influenza B strains. •
Amantadine has been associated with several central
nervous system side effects. CNS side effects include
nervousness, anxiety, agitation, insomnia and difficulty in

16. Synthesis of
Rimantadine

17. Mechanism of Action of Rimantadine
It produce antiviral effect against influenza A virus
by interfering with the function of the
transmembrane domain of the viral M2 protein,
thereby preventing the uncoating of the virus and
subsequent release of infectious viral nucleic acids
into the cytoplasm of infected cells.
Use: Rimantadine is used to prevent or treat a
certain type of flu virus (influenza A)
Brand Name:-Flumadine

19. Synthesis of Ribavirin

20. It is a guanosine (ribonucleic) analog used to stop
viral RNA synthesis and viral mRNA capping, thus,
it is a nucleoside inhibitor. Ribavirin is a prodrug,
which when metabolized resembles purine RNA
nucleotides. In this form, it interferes with RNA
metabolism required for viral replication.Ribavirin is used in combination with other
antiviral medications (such as interferon,
sofosbuvir) to treat chronic (long-lasting) hepatitis
C, a viral infection of the liver.
Brand Name:-Rebetol, Ribasphere, RibaPak,

21. Presented By Dr. Anjali Bhardwaj
Upcoming Topics are
-Mechanism of
Action of Other Anti-
Viral
-Anti-Hiv Drugs