Recommended
More Related Content
Similar to Mitotic spindle agents
Similar to Mitotic spindle agents (20)
More from Mohammed Fathy
More from Mohammed Fathy (20)
Recently uploaded
Recently uploaded (20)
Mitotic spindle agents
- 1. Mitotic Spindle Agents Dr. Mohammed Fathy, MD Lecturer of Clinical Oncology Zagazig University
- 3. Mechanism of action Introduction (Cont.,) Vinca Alkaloids Inhibit polymerization Bind to microtubule protein Taxanes Inhibit depolymerization
- 5. Indications Vinblastine ABVD Lymphoma Toxicity Thrombocytopenia Administration Rapid infusion through tubing of running intravenous line é extravasation precautions Testicular carcinoma VeIP Anemia
- 6. Vinblastine (Cont.,) Velban (Lilly) Trade name Velbastine (EUP) Supplied as Vials 10 mg Storage 2-8oC Reconstitute NS + benzyl alcohol (1 mg/mL) Dilute NS Reconstituted solution Inspected for particulate matter & discoloration before administration Powder
- 7. Indications Vincristine CHOP NHL Toxicity Peripheral Neuropathy Administration Rapid infusion through tubing of running intravenous line é extravasation precautions HL Tissue necrosis if extravasated Acute leukemia Chronic leukemia Multiple myeloma Neuroblastoma Rhabdomyosarcoma Ewing's sarcoma Wilms' tumor Bulk laxatives routinely
- 8. Vincristine (Cont.,) Oncovin (Lilly) Trade name Vinracine (EUP) Supplied as Vials 1 mg Storage 2-8oC Dilute NS or D5% Reconstituted solution Inspected for particulate matter & discoloration before administration 2 mg 5 mg
- 9. Indications Vinorelbine Cisplatin + Vinorelbine NSCLC Toxicity Myelosuppression Administration Rapid infusion through tubing of running intravenous line é extravasation precautions Peripheral neuropathy Breast Cancer Vinorelbine Ovarian Cancer Dose Limiting
- 10. Vinorelbine (Cont.,) Navelbine (Pierre)Trade name Supplied as Vials 10 mg Storage 2-8oC Dilute NS or D5% (1.5-3mg/mL) Reconstituted solution stable for 24 hours upon refrigeration. 50 mg Capsule Solution 20 mg 30 mg
- 11. Indications Paclitaxel NSCLC Toxicity Neutropenia Peripheral neuropathy Breast Cancer AC-P Ovarian Cancer Dose Limiting Paclitaxel Paclitaxel +Carboplatin Paclitaxel +Gemcitabine Paclitaxel +Carboplatin Esophagus cancer Hypersensitivity Alopecia Thrombocytopenia Arthralgias & Myalgias Necrosis if extravasated
- 12. Paclitaxel (Cont.,) Administration Given before cisplatin in combination regimens Cardiac monitoring for patients é history of cardiac disease Extravasation precautions Premedications - Dexamethasone: 20 mg PO or IV given 12, 6, & 0.5 hours - Diphenhydramine: 50 mg IV, given 30 min before - Ranitidine: 50 mg IV, given 30 min before
- 13. Paclitaxel (Cont.,) Taxol (Bristol-Myers Squibb)Trade name Supplied as Vials 30 mg Storage 2-8oC Dilute NS or D5% in glass or polyolefin containers Reconstituted solution Should be inspected for particulate matter & discoloration before administration, stable for up to 27 hours at room temperature 100 mg Solution300 mg Unitaxel (EUP) Precautions NOT use polyvinylchloride (PVC) containers or tubing
- 14. Indications Docetaxel NSCLC Toxicity MyelosuppressionBreast Cancer Ovarian Cancer Dose Limiting FEC-D Head & Neck cancer Severe fluid retention Alopecia Stomatitis Severe hypersensitivity reactions Docetaxel Docetaxel +Capecitabine Fluid retention Elevated liver function tests Administration Premedications Dexamethasone: 4 mg PO bid onn day before, day of & day after
- 15. Docetaxel (Cont.,) Taxotere (Aventis)Trade name Supplied as Vials 20 mg Storage 2-8oC Dilute NS or D5% in glass or polyolefin containers Reconstituted solution Should be inspected for particulate matter & discoloration before administration, stable for up to 8 hours at room temperature or refrigerated. 80 mg powder Precautions NOT use polyvinylchloride (PVC) containers or tubing Protect from light Reconstitute Accompanying diluent (10 mg/mL)
- 16. Indications Albumin-bound Paclitaxel Toxicity NeutropeniaBreast Cancer Dose Limiting Hematosuppression Sensory neuropathy Arthralgias & Myalgias Abnormal liver function tests Alopecia Fluid retention Administration No premedication Nab-paclitaxel
- 17. Abraxane (Abraxis/Celgen)Trade name Supplied as Vials 100 mg Dilute NS Reconstituted solution Stable for up to 8 hours upon refrigeration or for up to 8 hours at room temperature in infusion bag Powder Albumin-bound Paclitaxel (Cont.,) Reconstitute NS (20 mL) Allow vial to sit for at least 5 min & gently swirl &/or invert vial slowly for at least 2 min until complete dissolution of any cake/powder, avoid generation of foam