This document summarizes vascular development from the arterial and venous systems. It describes how the arterial system develops from aortic arches which give rise to major arteries. It also describes how the venous system initially develops from vitelline, umbilical and cardinal veins. Defects that can occur in vascular development are also discussed such as patent ductus arteriosus, coarctation of the aorta and interrupted aortic arch.

1. Vascular Development
Dr. Rezaul Hayat
Resident (Phase A)
Pediatric Cardiology

2. Vascular development occurs by two
mechanisms
Vasculogenesis
In which vessels arise by
coalescence of angioblast.
The major vessels,
including the dorsal aorta
and cardinal veins, are
formed by vasculogenesis.
Angiogenesis
whereby vessels sprout
from existing vessels.
The remainder of the
vascular system is formed
by angiogenesis.

3. Vascular Development
Arterial System
Venous System
Circulation Before and after birth
Lymphatic System

4. ARTERIAL SYSTEM

5. Pharyngeal Arches
When pharyngeal arches
form during the fourth
and fifth weeks of
development, each arch
receives its own cranial
nerve and its own artery.
These arteries are the
aortic arches which
arises from the aortic
sac (most distal part of
truncus arteriosus)

6. Aortic Arches
Aortic arches are embedded in
mesenchyme of the
pharyngeal arches and gives
rise to total 5 pair of arteries.
The fifth arch either never
forms or forms incompletely
and then regresses.
They terminate in the right and
left dorsal aortae. (In the
region of the arches, the dorsal
aortae remain paired, but
caudal to this region they fuse
to form a single vessel.)
End of 4th Week

7. Aortic Arches
Aortic arches are embedded in
mesenchyme of the
pharyngeal arches and gives
rise to total 5 pair of arteries.
The fifth arch either never
forms or forms incompletely
and then regresses.
They terminate in the right and
left dorsal aortae. (In the
region of the arches, the dorsal
aortae remain paired, but
caudal to this region they fuse
to form a single vessel.)
Aortic arches at the end of the fourth week.
The first arch is obliterated before the sixth
is formed.
End of 4th week

8. Aortic Arches
Division of the truncus
arteriosus by the
aorticopulmonary septum
divides the outflow
channel of the heart into
the ventral aorta and the
pulmonary trunk. The
aortic sac then forms
right and left horns.
aorticopulmonary septum and
the large pulmonary arteries.
At the beginning of 6th week

9. Aortic Arches

10. Aortic Arches
The aortic sac then forms
right and left horns
Aortic arches and dorsal aorta before
transformation into the definitive vascular
pattern

11. Aortic Arches
1st aortic arch
By the day 27 most of the
right aortic arch has
disappeared (small
portion persists to form
the maxillary artery)
2nd aortic arch
Soon disappears.
Remaining portion of this
arch are hyoid and
stapedial arteries.
Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

12. Aortic Arches
3rd aortic arch
Distal parts of the third pair
of aortic arches join with
the dorsal aortas to form
the internal carotid arteries
Proximal parts of these
arteries form the common
carotid arteries
The external carotid artery
is a sprout of the third aortic
arch. Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

13. Aortic Arches
4th aortic arch
persists on both sides.
On the left, it forms part of the
arch of the aorta, between the
left common carotid and the
left subclavian arteries.
On the right, it forms the most
proximal segment of the right
subclavian artery, the distal
part of which is formed by a
portion of the right dorsal
aorta and the seventh
intersegmental artery
Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

14. Intersegmental Arteries
The dorsal aortae gives off a
series of lateral inter-segmental
branches to the body wall
One of these, the 7th
intersegmental artery supplies
the upper limb bud. It comes to
be attached to the dorsal aorta
near the attachment of the 4th
arch artery

15. Aortic Arches
Aortic arches and dorsal aortae after the transformation
Broken line- obliterated components.

16. Aortic Arches
6th aortic arch
Right side
The proximal part of the artery
persists as the proximal part of
the right pulmonary artery. The
distal part of the artery
degenerates
Left side
The proximal part of the artery
persists as the proximal part of
the left pulmonary artery
The distal part of the artery
passes from the left pulmonary
artery to the dorsal aorta and
forms a prenatal shunt, the
ductus arteriosus (DA).
Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

17. Aortic Arches
Ascending aorta is formed
by aortic sac.
The Right horn of the
aortic sac forms the
brachiocephalic artery
The proximal portion of
the aortic arch is derived
from the left horn of the
aortic sac
C. The great arteries in the adult

18. Other changes
(a) The dorsal aorta
between the entrance of
the third and fourth
arches, known as the
carotid duct, is
obliterated
(b) The right dorsal aorta
disappears between the
origin of the seventh
intersegmental artery and
the junction with the left
dorsal aorta
Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

19. Derivatives of Aortic arches
Arch Derivatives
I Maxillary arteries
II Hyoid and stepedial arteries
III Common carotid and 1st part of the internal carotid arteries*
IV Left side Arch of aorta from the left common carotid to the left
subclavian arteries**
Right side Right subclavian artery (proximal portion)***
VI Left side Left pulmonary artery and ductus arteriosus
Right side Right pulmonary artery
*Remainder o f the internal carotid arteries are derived from the dorsal aorta; the
external carotid arteries sprout from the third aortic arch.
**The proximal portion of the aortic arch is derived from the left horn of the aortic sac;
the right horn of this sac forms the brachiocephalic artery.
***The distal portion o f the right subclavian artery as well as the left subclavian artery
form from the seventh intersegmental arteries on their respective sides

20. Vitelline arteries
Initially a number of paired
vessels supplying the yolk
sac, gradually fuse and form
the arteries in the dorsal
mesentery of the gut.
In the adult they are
represented by the celiac,
superior mesenteric, and
inferior mesenteric arteries.
These vessels supply
derivatives of the foregut,
midgut, and hindgut,
respectively.
Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

21. Umbilical arteries
initially paired ventral branches
of the dorsal aorta, course to
the placenta in close
association with the allantois.
During the fourth week, each
artery acquires a secondary
connection with the dorsal
branch of the aorta, the
common iliac artery, and loses
its earliest origin.
After birth, the proximal
portions of the umbilical
arteries persist as the internal
iliac and superior vesical
arteries, and the distal parts
are obliterated to form the
medial umbilical ligaments. Aortic arches and dorsal aortae after the
transformation. Broken lines, obliterated
components.

22. CLINICAL CORELATES
Arterial system defects

23. Patent ductus arteriosus
Under normal conditions,
the ductus arteriosus is
functionally closed
through contraction of its
muscular wall shortly
after birth to form the
ligamentuin arteriosum.
Anatomical closure by
means of intima
proliferation takes 1 to 3
months.

24. Coarctation of Aorta
the aortic lumen below
the origin of the left
subclavian artery is
significantly narrowed.
The cause of aortic
narrowing is primarily an
abnormality in the media
of the aorta, followed by
intima proliferations.
In the preductal type, the
ductus arteriosus persists.
Preaductal Type

25. Coarctation of Aorta
in the postductal type,
which is more common,
this channel is usually
obliterated.
Postductal Type

26. Abnormal origin right subclavian artery
Obliteration of the right
fourth aortic arch and the
proximal portion of the
right dorsal aorta.
persistence of the distal
portion of right dorsal
aorta.

27. Abnormal origin right subclavian artery
The origin of the
abnormal right
subclavian artery finally
settles just below that of
the left subclavian artery
The abnormal right
subclavian artery crosses
the midline behind the
esophagus and may
compress it
Postductal Type

28. Double aortic arch
Persistance of the distal portion of the right dorsal aorta
The double aortic arch forms a vascular ring around the trachea and
esophagus

29. Right aortic arch
the left fourth arch and
left dorsal aorta are
obliterated and
persistance of the distal
portion of right dorsal
aorta

30. Interrupted aortic arch
very rare defect (3/1,000,000 live births) caused by
abnormal regression patterns in the right and left
fourth aortic arches. The result is an interruption
between the aortic arch and descending aorta.
three types depending on where the break occurs:
Although rare, the defect occurs in 50% of children with
DiGeorge syndrome, part of the 22q11 deletion
syndrome complex

31. Interrupted aortic arch
type A (3% to 40%),
between the left subclavian
artery and descending
aorta
type B [50% to 60%]
between the left common
carotid and left subclavian
arteries
type C [4%], between the
right and left common
carotid arteries.
patent ductus arteriosus is present to allow blood to reach the descending aorta to
the lower parts of the body, A ventricuiar septal defect is also present because the
conotruncai septum responsible for septating the outflow tract fails to extend and
fuse with the ventral endocardial cushion in the atrioventricular canal

32. VENOUS SYSTEM

33. Venous system
In the fifth week, three pairs of major veins can be
distinguished:
(a) vitelline veins, or omphalomesenteric veins, carrying
blood from the yolk sac to the sinus venosus
(b) umbilical veins, originating in the chorionic villi and
carrying oxygenated blood to the embryo
(c) Cardinal veins, draining the body of the embryo
proper.

34. Venous system

35. Vitelline veins
Before entering the sinus venosus, the vitelline veins form a plexus
around the duodenum and pass through the septum transversum.
The liver cords growing into the septum interrupt the course of the
veins, and an extensive vascular network the hepatic sinusoids forms
4th week 5th week

36. Vitelline veins
With reduction of the left sinus horn, blood from the left side of the
liver is rechanneled toward the right, resulting in an enlargement of
the right vitelline vein (right hepatocardiac channel). Ultimately the
right hepatocardiac channel forms the hepatocardiac portion of the
inferior vena cava.
4th week 5th week
2nd Month 3rd month

37. Vitelline veins
The proximal & distal parts of the left vitelline vein disappears .
The anastomotic network around the duodenum develops into a
single vessel, the portal vein. The superior mesenteric vein, which
drains the primary intestinal loop, derives from the right vitelline
vein.
4th week 5th week
2nd Month 3rd month

38. Umbilical Vein
Initially, the umbilical veins pass on each side of the liver, but some
connect to the hepatic sinusoids.
4th week 5th week

39. Umbilical Vein
The proximal part of both umbilical veins and the remainder of the right
umbilical vein disappear, so that the left vein is the only one to carry blood
from the placenta to the liver. With the increase of the placental
circulation, a direct communication forms between the left umbilical vein
and the right hepatocardiac channel, the ductus venosus .This vessel
bypasses the sinusoidal plexus of the liver.
4th week 5th week
2nd Month 3rd month

40. Umbilical Vein
After birth, the left umbilical vein and ductus
venosus are obliterated and form the
ligamentum teres hepatis and ligamentum
venosum, respectively.

41. Cardinal vein
Initially the cardinal veins form the
main venous drainage system of
the embryo. This system consists
of:
1. the anterior cardinal veins,
which drain the cephalic part
of the embryo
2. the posterior cardinal veins,
which drain the rest of the
embryo
The anterior and posterior veins
join before entering the sinus horn
and form the short common
cardinal veins 7th week

42. Cardinal vein
During the fifth to the seventh
week, a number of additional
veins are formed:
(a) the subcardinal veins, which
mainly drain the kidneys
(b) the sacrocardinal veins, which
drain the lower extremities
(c) the supracardinal veins, which
drain the body wall by way of
the intercostal veins taking
over the functions of the
posterior cardinal veins 7th week

43. Superior Venacava
is characterized by the
appearance of anastomoses
between left and right in such a
manner that the blood from
the left is channeled to the
right side.

44. Superior Venacava
The anastomosis between the
anterior cardinal veins develops
into the left brachiocephalic
vein.

45. Superior Venacava
The superior vena cava is
formed by the right common
cardinal vein and the proximal
portion of the right anterior
cardinal vein.
The anterior cardinal veins
ultimately form the internal
jugular veins.

46. Inferior Venacava
The anastomosis between the subcardinal veins forms the left renal
vein. The left subcardinal vein disappears except at its distal portion
which remains as the left gonadal vein. The right subcardinal vein
becomes the main drainage channel and develops into the renal
segment of the inferior vena cava.

47. Inferior Venacava
The anastomosis between the sacrocardinal veins forms the left common iliac
vein .The right sacrocardinal vein becomes the sacrocardinal segment of the
inferior vena cava.

48. Azygos Vein
The 4th to 11th right intercostal veins empty into the right supracardinal vein,
which together with a portion of the posterior cardinal vein forms the azygos
vein.

49. Hemiazygos Vein
On the left the 4th to 7th intercostal veins enter into the left supra-cardinal
vein, and the left supracardinal vein, then known as the hemiazygos vein,
empties into the azygos vein.

50. CLINICAL CORELATES
Venous system defects

51. Double Inferior Venacava
at the lumbar level arising
from the persistence of
the left sacrocardinal
vein
The left common iliac vein
may or may not be
present, but the left
gonadal vein remains as
in normal conditions.
Persiste
nt left
sacrocar
dinal
vein

52. Absence of Inferior Venacava
The lower half of the body is drained by the azygos vein, which enters
the superior vena cava.
The hepatic vein enters the heart at the site of the inferior vena cava.
This
abnormality is
associated
with other
heart
malformation

53. Left Superior Venacava
is caused by persistence of the left anterior cardinal vein and obliteration of
the common cardinal and proximal part of the anterior cardinal veins on the
right. The left superior vena cava drains into the right atrium by coronary sinus.

54. Double Superior Venacava
is characterized by the persistence of the left anterior cardinal vein and failure
of the left brachiocephalic vein to form .
The persistent left anterior cardinal vein, the left superior vena cava, drains
into the right atrium by way of the coronary sinus.

55. FETAL CIRCULATION

56. Fetal Circulation
Before birth
Before birth, blood from the
placenta, about 80% saturated
with oxygen, returns to the
fetus by way of the umbilical
vein.
On approaching the liver, most
of this blood flows through the
ductus venosus directly into
the inferior vena cava. A
smaller amount enters the
liver sinusoids and mixes with
blood from the portal
circulation (I).

57. Fetal Circulation
Before birth
After a short course in the inferior vena
cava (II) it enters the right atrium (III).
Here it is guided toward the oval
foramen by the valve of the inferior
vena cava, and most of the blood passes
directly into the left atrium (IV).
A small amount is prevented from doing
so by the lower edge of the septum
secundum, the crista dividens, and
remains in the right atrium.
From the left atrium, blood enters the
left ventricle and ascending aorta. Since
the coronary and carotid arteries are
the first branches of the ascending
aorta, the heart musculature and the
brain are supplied with well-oxygenated
blood.

58. Fetal Circulation
Before birth
Desaturated blood from the
superior vena cava flows by way of
the right ventricle into the
pulmonary trunk. During fetal life,
resistance in the pulmonary vessels
is high, such that most of this blood
passes directly through the ductus
arteriosus into the descending
aorta, where it mixes with blood
from the proximal aorta.
After coursing through the
descending aorta, blood flows
toward the placenta by way of the
two umbilical arteries. The oxygen
saturation in the umbilical arteries is
approximately 58%.

59. Fetal Circulation
Before birth
Blood in the umbilical vein gradually loses
its high oxygen content as it mixes with
desaturated blood
(I) In the liver by mixture with a small
amount of blood returning from the portal
system
(2)in the inferior vena cava (II) which carries
deoxygenated blood returning from the
lower extremities, pelvis, and kidneys
(3) in the right atrium (III), by mixture with
blood returning from the head and limbs;
(4)in the left atrium (IV), by mixture with
blood returning from the lungs; and
(5) at the entrance of the ductus arteriosus
into the descending aorta (V).

60. Circulatrory changes after birth
are caused by
 cessation of placental
blood flow and
 the beginning of
respiration
Ductus
arteriosus
constrict and
become solid
ligamentum
arteriosusm
IVC
Umbilical
vein
becomes
ligamentu
m teres
Umbilical
arteries
constrict
Proximal portion of UA persists
Foramen ovale
closes and
become fossa
ovalis
Ductus arteriosus
constricts and becomes
solid ligamentum
venosusm
liver

61. Circulatrory changes after birth
Closure of the umbilical arteries
Functionally the arteries close a
few minutes after birth. Distal
parts of the umbilical arteries
form the medial umbilical
ligaments, and the proximal
portions remain open as the
superior vesical arteries
Closure of the umbilical vein
and ductus venosus
occur shortly after that of the
umbilical arteries. After
obliteration, the umbilical vein
forms the ligamentum teres
hepatis. The ductus venosus,
also obliterated and forms the
ligamentum venosum.
Ductus
arteriosus
constrict and
become solid
ligamentum
arteriosusm
IVC
Umbilical
vein
becomes
ligamentu
m teres
Umbilical
arteries
constrict
Proximal portion of UA persists
Foramen ovale
closes and
become fossa
ovalis
Ductus arteriosus
constricts and becomes
solid ligamentum
venosusm
liver

62. Circulatrory changes after birth
Closure of the ductus arteriosus
by contraction of its muscular
wall occurs almost immediately
after birth. Complete anatomical
obliteration by proliferation of
the intima is thought to take 1 to
3 months. In the adult, the
obliterated ductus arteriosus
forms the ligamentum
arteriosum.
Closure of the oval foramen
is caused by an increased
pressure in the left atrium,
combined with a decrease in
pressure on the right side.
Ductus
arteriosus
constrict and
become solid
ligamentum
arteriosusm
IVC
Umbilical
vein
becomes
ligamentu
m teres
Umbilical
arteries
constrict
Proximal portion of UA persists
Foramen ovale
closes and
become fossa
ovalis
Ductus arteriosus
constricts and becomes
solid ligamentum
venosusm
liver

63. LYMPHATIC SYSTEM

64. Lymphatic System
The lymphatic system
begins its development later than the cardiovascular system, not appearing until the
fifth week of gestation.
Lymphatic vessels arise as sac-like outgrowths from the endothelium of veins .
Six primary lymph sacs are formed
 two jugular,
 two iliac,
 one retroperitoneal,
 one cisterna chyli.
Two main channels, the right and left thoracic ducts
the thoracic duct forms from anastomosis of the right and left thoracic ducts, the distal
part of the right thoracic duct, and the cranial part of the left thoracic duct.
The right lymphatic duct develops from the cranial part of the right thoracic duct

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