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Aboubakr Elnashar
Benha University Hospital, EGYPT
Vaginismus
When a Woman's Body says
No to Sex
ABOUBAKR ELNASHAR
FEMALE SEXUAL RESPONSE
 Master & Johonson (1966):
 Excitement,
 Plateau
 Orgasm &
 Resolution.
 Completely mechanistic
 ignores feelings
 Distinction between Excitement & Plateau is
imprecise
 Kaplan (1979):
 Desire
 Excitement (Plateau is a part of Excitement).
 Orgasm &
 Resolution.
This fits better with FSD
FSD
1. Sexual desire disorders:
Hypoactive sexual desire & sexual aversion
2. Sexual arousal disorders
3. Orgasmic disorders
4. Penetration disorders:
Dysparunia
Vaginismus
5. Other sexual disorders:
Sexual phobias,
Anesthesia with arousal & orgasm,
Genital pain during non-coital activities.
1. DEFINITION
1862
Dr. Marion Sims
Introduced the term “vaginismus”
Reflex-like contraction of the circumvaginal
musculature, resulting in non-consummation of
marriage.
ABOUBAKR ELNASHAR
Old:
Recurrent or persistent involuntary contraction of
the outer 1/3 of the vagina interfering with sexual
intercourse
Vaginal spasm has been considered the
defining diagnostic characteristic of vaginismus
for150 y.
This remarkable consensus, based primarily on expert
clinical opinion, is preserved in the DSMIVTR.
ABOUBAKR ELNASHAR
Studies:
1. Vaginal muscle spasm
 has never been validated
 EMG: 28% of the vaginismus
(Reissing et al, 1999)
2. Vaginismus cannot be reliably dd from superficial
dyspareunia
(Basson, 1996; Har-Toov et al., 2001; Kaneko, 2001; de Kruiff et al., 2000; van
Lankveld et al., 1996; Wijma et al., 2000 ; Ng, 2001; Okawa, 2001; Pukall et al.,
2000; Reissing et al., 1999, 2004; Lahaie et al, 2015)
ABOUBAKR ELNASHAR
Recent:
International Definitions Committee”, 2005
Persistent or recurrent difficulties of the women to
allow vaginal entry (penis, finger, and/or object…).
despite her expressed wish to do so..
ABOUBAKR ELNASHAR
3. TYPES
1. Primary
lifelong, never able to have
intercourse
Secondary
acquired, past history of vaginal
penetration without problems.
2.Global
unable to place any thing in the
vagina
situational
able to use a tampon, tolerate a
pelvic examination but cannot
have intercourse
1. Spasmodic
[Leiblum, 2000]
spasm of the vagina
2. Non spasmodic.
ABOUBAKR ELNASHAR
4. CAUSES
Most often, never delineated.
Multidimensional condition
Physical and a psychological condition
[Rosenbaum, 2013].
ABOUBAKR ELNASHAR
Precipitating
factors
Painful SI
Painful Pelvic EX
Sexual assault
Childhood abuse
PID
Gyn surgery
Urogenital atrophy
Predisposing
factors:
Anxiety disorders
Maintaining
factors
When a couple
continue trying to have
intercourse despite the
pain: reinforce spasm
of the musculature.
ABOUBAKR ELNASHAR
5. DIAGNOSIS
A. History
• Medical
• Psychosocial
• Sexual history, including any episodes of traumatic
sexual experience
(Crowley et al, 2009).
A clear description of the pain, fear, and avoidance
responses.
The woman’s ability to tolerate genital exploration by
herself or another.
History of
severe pain during intercourse or
intercourse being impossible.
ABOUBAKR ELNASHAR
 Sexual history
(Crowley, 2009)
1. Is penetration possible?
2. If so, is it painful?
3. Is it painful only at penetration?
4. How anxious does she feel at the thought of
penetration?
5. Can she insert tampons or fingers?
ABOUBAKR ELNASHAR
B. Genital examination
To exclude organic pathology:
herpes virus, lichen sclerosis, and others
[Crowley, 2009)
Several consultations may be needed before the
woman is ready to be examined
ABOUBAKR ELNASHAR
6. CLASSIFICATION
Lamont and Pacik
Stratifying the severity of vaginismus
{success in tt is related to the severity}
depends on:
1. Degree of vaginal spasm
2. Degree of fear and anxiety
ABOUBAKR ELNASHAR
ABOUBAKR ELNASHAR
7. TREATMENT
Aim:
•Exercise her mind:
•Make the women feels that she owns her vagina and can
share it for sexual activity should she wish. : sexual
counseling
•Exercise her body:
•prove that something can go into the vaginal without pain:
Dilator.
•Break the vicious cycle (Fear – ms spams – pain):
•Botox
ABOUBAKR ELNASHAR
•Requirements:
Warm, sympathetic attitude
Great patience
ABOUBAKR ELNASHAR
 Lines of treatment: PS MD BO
1. Phobia: Exploration
History
False beliefs
2. Sex: Education
Anatomy
Physiology
3. Muscle: Control
Adductors: Relaxation exercise
P coccygeus: Kegel s exerciseABOUBAKR ELNASHAR
4. Desensitization: Systematic vaginal
Step 1:Insertion of a trainers under controlled
relaxation
Step 2: Sharing of control with husband
Step 3: Insertion of penis with the woman in
control
Step 4: Transfer control of insertion of penis to
husband
5. BOTOX= Botulinum toxin
6. Other modalities
ABOUBAKR ELNASHAR
1. PHOBIA: EXPLORATION
Difficult
1. History of psychological causes should be
addressed.
History of childhood traumatic experience:
recalled & the emotions which accompanied it relived
in order to help the woman to come to terms with them
ABOUBAKR ELNASHAR
2. Dealing with false beliefs: (common myths):
1. Vagina is too small to allow penetration
In fact:
vagina is a “potential space”.
At rest, the walls of the vagina lie touching each other, but
separates to make room for something entering it
Baby is able to travel through the vaginal canal during
childbirth
Vagina lengthens by 50% during sexual arousal:
accommodating almost any penis size.
ABOUBAKR ELNASHAR
2. Fear of tearing of the hymen: pain, bleeding.
In fact
most women:
 minor and temporary discomfort
± happen without her awareness
ABOUBAKR ELNASHAR
2. SEX EDUCATION
Woman and her husband
More effective than
condescending remarks in
decreasing patient anxiety
[Huber et al,2009].
1. Genital anatomy
PC (pubococcygeus)
muscles, that tightens
involuntarily when
vaginismus is experienced.
ABOUBAKR ELNASHAR
Self exploration of sexual anatomy (guided tour)
Semi-sitting position
legs apart
mirror placed in front of her vulva, she explores her
genitalia (with the doctor) explaining the anatomy &
physiology.
ABOUBAKR ELNASHAR
2. Sexual physiology & behavior
How their genital organs are put together
how they both function.
The vagina muscles
do not contract on their own,
the reasons of their contraction are the negative
thoughts and beliefs about sexuality and sexual
intercourse.
Brain
responsible of vaginismus,not vagina:
name of this sexual dysfunction must be
brainismus, not vaginismus.
ABOUBAKR ELNASHAR
3. MUSCLES CONTROL
a. Relaxation exercises
 to the adductor muscles
To help her to relax when anticipates vaginal
penetration.
The doctor hold the woman ‘s knees together
firmly while she attempts to separate them,
then slowly she is allowed to succeed.
ABOUBAKR ELNASHAR
b. Contraction /relaxation exercise
(Kegel ‘s exercise)
To gain control over the muscles surrounding her
introits .
1. The patient must learn first how to identify the
muscle for herself.
2. She is advised to sit on the toilet with her legs
spread as far apart as possible.
3. If she then starts & stops the flow of urine, she
becomes aware of the pubococcygeus action.
ABOUBAKR ELNASHAR
4. Once the muscle is identified, the woman can
practice contracting it repeatedly whenever she has
time or 10-15 times a day
ABOUBAKR ELNASHAR
Recommended for every woman especially
• To strengthen or restore pelvic floor muscle tone.
• To increase sexual health and sexual confidence with her partner.
• To avoid incontinence or are currently experiencing urinary stress/urge
incontinence.
•Giving or has given birth.
• Going through menopause. ABOUBAKR ELNASHAR
ABOUBAKR ELNASHAR
4. DESENSITIZATION:
SYSTEMATIC VAGINAL DESENSITIZATION OF THE
FEAR OF VAGINAL PENETRATION
Vaginal dilatation exercises are a misnomer
{vagina is not physically stretched}
Behavioural therapy to treat phobias and other
behavioural problems that involve anxiety.
ABOUBAKR ELNASHAR
Trainers:
Fingers
commercial dilators
Tampons
specifically designed specula
Simms, Amiell, Stanley.
•The choice depend on the patient preference &
comfort level.
•Fingers are preferred
{allow to feel the muscles contracting.
easy to remove if she starts to feel any discomfort}.
ABOUBAKR ELNASHAR
Approaches
1. Gradual
using vaginal self-dilatation Starting with the
smallest one she inserts larger vaginal trainers
over time until one the size of a penis can be
inserted comfortably.
Rapid using vaginal mould insertion.
Duration: 2-6 weeks (2-15 sessions)
Rapid desensitization is preferred
(Biswas & Ratnam,1995)
ABOUBAKR ELNASHAR
2. In-vitro: The dilator is introduced by the doctor or
In-vivo: the dilator is introduced by the patient
No differences between the 2 forms of systematic
desensitization
(Cochrane SR, 2002)
ABOUBAKR ELNASHAR
Success rate:
72-100% success in uncontrolled trials and case
series.
limited evidence to recommend the use of systematic
desensitisation
(Cochrane SR, 2001)
ABOUBAKR ELNASHAR
 Program
Step 1: Insertion of a trainers under controlled
relaxation:
In private, in a relaxed & nonsexual setting at
home. do the exercises with a finger inside the
vagina.
clip your fingernails and use a lubricating jelly. Or
do the exercises in a bathtub, where water can be a natural lubricant.
Your finger needs to be inserted 5-6 cm. That's up
to about the first knuckle joint.
Start with one finger and work your way up to 3
The insertion of digits is a slow and graduated
process and can take weeks of nightly exercises.
ABOUBAKR ELNASHAR
ABOUBAKR ELNASHAR
Step 2: Sharing of control with husband.
When she has become comfortable with this
process, her partner’s fingers are introduced.
while she maintains control how quickly the
fingers are placed.
The husband becomes active in the vaginal dilatation
exercises only when the patient is emotionally &
physically ready & after anxiety of being touched is
extinguished.
When she is comfortable inserting the larger dilators, she can instruct her husband how to place the dilator in her vagina
ABOUBAKR ELNASHAR
Step 3: Insertion of penis with the woman
in control.
Sitting or
kneeling over her husband,
female superior position
& inserting his penis herself.
ABOUBAKR ELNASHAR
Step 4: Transfer control of insertion of
penis to husband
ABOUBAKR ELNASHAR
5. BOTULINUM NEUROTOXIN A (BOTOX)
Produced by:
Clostridium botulinum,
Mechanism:
Prevention of acetylcholine release: prevents
neuromuscular transmission: muscle weakness
Temporary muscle paralysis
Onset:
3-7 d after injection
Duration:
3-4 months.
ABOUBAKR ELNASHAR
First described by
Brin and Vapnek
[Brin, Vapnek, 1997]
although it is not licensed for this condition
(Eccleston , Woolley, 2008)
Other indications:
Treating a number of clinical conditions
associated with neuromuscular dysfunction, such as focal dystonias, upper
motor neuron syndromes, and muscle hyperactivity.
ABOUBAKR ELNASHAR
Technique:
150-400 mIU injected into the
puborectalis muscles in 3 sites on
each side of the vagina
1. A vial of 500 U botulinum toxin type A
(Dysport; Ipsen Ltd, UK) is diluted with 1.5 mL
of normal saline solution.
2. A total dose of 150–400 U equally injected in
puborectalis muscles. 3 points on each side
with a 23-gauge needle.
3. Light sedation of 1–5 mg midazolam and 50–
150 mg fentanyl. Oxygen (6–8 L/min) given
via face mask. Monitoring of SpO2 via pulse
oximetry. The sedation was not deep; some
extent of muscular contraction was required to
be visible to find the exact location of muscles
for injection.
4. Patients were discharged on the same day.
They were followed up after 1 w to check the
vaginal muscle resistance, and were thenABOUBAKR ELNASHAR
it covers the vestibular bulb it is innervated by the
deep/muscular branch of the perineal nerve, which is a branch
of the pudendal nerve
ABOUBAKR ELNASHAR
Indications
Severe or refractory cases.
?Mild and severe cases of vaginismus
Contraindications
Hypersensitivity to albumin, botulinum toxin, or any
component of the formulation
Infection at the proposed injection site(s)
Pregnancy
Diseases of neuromuscular transmission
Coagulopathy or therapeutic anticoagulation.
ABOUBAKR ELNASHAR
Side effects:
No major
1. Fecal and urinary incontinence lasting 3 to 4
months
2. Unusual pressure pain in the vagina separate
from the vaginismus pain.
ABOUBAKR ELNASHAR
Results:
No RCT
More rapid effect
Most of the success after 1 tt, but occasionally
repeat tts were required.
Success: 75%
(Pacik, 2011)
ABOUBAKR ELNASHAR
Ineffective treatments
Hymenectomy
doesn’t solve the problem but makes it worse:
avoidance of sex completely
Kegel exercises alone
ABOUBAKR ELNASHAR
Drugs:
Lubricants, topical anesthetics, anti-depressants,
sedatives, excess alcohol, hallucinogenic drugs,
muscle relaxants, antispasmodics
The only indication:
when vaginismus is a part of a more generalized
syndrome of sexual phobia.
imipramine 30-75 mg daily
Benzodiazepines to aid both relaxation & interviews
ABOUBAKR ELNASHAR
What can be done to prevent Vaginismus
 Sexual education
 Pre-marital sexual counseling and guidance
ABOUBAKR ELNASHAR
 Vaginismus, and superficial dyspareunia overlap
 Vaginal muscle spasm is not a valid or reliable
diagnostic criterion for vaginismus.
 Clinical syndrome that consists of overlapping
elements of
hypertonic pelvic floor muscles
Pain
Anxiety, and
Difficulty in penetration.
ABOUBAKR ELNASHAR
 Lines of treatment of vaginismus:
1. Phobia Exploration
2. Sex education
3. Muscle Control
4. Desensitization: Systematic vaginal desensitization
5. Botox Injection
ABOUBAKR ELNASHAR
ABOUBAKR ELNASHAR
‫من‬ ‫المحاضره‬ ‫علي‬ ‫الحصول‬ ‫يمكن‬
1.My scientific page on Face
book: Aboubakr Elnashar Lectures.
https://www.facebook.com/group
s/227744884091351/
2.Slide share web site
3.elnashar53@hotmail.com

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Vaginismus

  • 1. Aboubakr Elnashar Benha University Hospital, EGYPT Vaginismus When a Woman's Body says No to Sex ABOUBAKR ELNASHAR
  • 2. FEMALE SEXUAL RESPONSE  Master & Johonson (1966):  Excitement,  Plateau  Orgasm &  Resolution.  Completely mechanistic  ignores feelings  Distinction between Excitement & Plateau is imprecise
  • 3.  Kaplan (1979):  Desire  Excitement (Plateau is a part of Excitement).  Orgasm &  Resolution. This fits better with FSD
  • 4. FSD 1. Sexual desire disorders: Hypoactive sexual desire & sexual aversion 2. Sexual arousal disorders 3. Orgasmic disorders 4. Penetration disorders: Dysparunia Vaginismus 5. Other sexual disorders: Sexual phobias, Anesthesia with arousal & orgasm, Genital pain during non-coital activities.
  • 5. 1. DEFINITION 1862 Dr. Marion Sims Introduced the term “vaginismus” Reflex-like contraction of the circumvaginal musculature, resulting in non-consummation of marriage. ABOUBAKR ELNASHAR
  • 6. Old: Recurrent or persistent involuntary contraction of the outer 1/3 of the vagina interfering with sexual intercourse Vaginal spasm has been considered the defining diagnostic characteristic of vaginismus for150 y. This remarkable consensus, based primarily on expert clinical opinion, is preserved in the DSMIVTR. ABOUBAKR ELNASHAR
  • 7. Studies: 1. Vaginal muscle spasm  has never been validated  EMG: 28% of the vaginismus (Reissing et al, 1999) 2. Vaginismus cannot be reliably dd from superficial dyspareunia (Basson, 1996; Har-Toov et al., 2001; Kaneko, 2001; de Kruiff et al., 2000; van Lankveld et al., 1996; Wijma et al., 2000 ; Ng, 2001; Okawa, 2001; Pukall et al., 2000; Reissing et al., 1999, 2004; Lahaie et al, 2015) ABOUBAKR ELNASHAR
  • 8. Recent: International Definitions Committee”, 2005 Persistent or recurrent difficulties of the women to allow vaginal entry (penis, finger, and/or object…). despite her expressed wish to do so.. ABOUBAKR ELNASHAR
  • 9. 3. TYPES 1. Primary lifelong, never able to have intercourse Secondary acquired, past history of vaginal penetration without problems. 2.Global unable to place any thing in the vagina situational able to use a tampon, tolerate a pelvic examination but cannot have intercourse 1. Spasmodic [Leiblum, 2000] spasm of the vagina 2. Non spasmodic. ABOUBAKR ELNASHAR
  • 10. 4. CAUSES Most often, never delineated. Multidimensional condition Physical and a psychological condition [Rosenbaum, 2013]. ABOUBAKR ELNASHAR
  • 11. Precipitating factors Painful SI Painful Pelvic EX Sexual assault Childhood abuse PID Gyn surgery Urogenital atrophy Predisposing factors: Anxiety disorders Maintaining factors When a couple continue trying to have intercourse despite the pain: reinforce spasm of the musculature. ABOUBAKR ELNASHAR
  • 12. 5. DIAGNOSIS A. History • Medical • Psychosocial • Sexual history, including any episodes of traumatic sexual experience (Crowley et al, 2009). A clear description of the pain, fear, and avoidance responses. The woman’s ability to tolerate genital exploration by herself or another. History of severe pain during intercourse or intercourse being impossible. ABOUBAKR ELNASHAR
  • 13.  Sexual history (Crowley, 2009) 1. Is penetration possible? 2. If so, is it painful? 3. Is it painful only at penetration? 4. How anxious does she feel at the thought of penetration? 5. Can she insert tampons or fingers? ABOUBAKR ELNASHAR
  • 14. B. Genital examination To exclude organic pathology: herpes virus, lichen sclerosis, and others [Crowley, 2009) Several consultations may be needed before the woman is ready to be examined ABOUBAKR ELNASHAR
  • 15. 6. CLASSIFICATION Lamont and Pacik Stratifying the severity of vaginismus {success in tt is related to the severity} depends on: 1. Degree of vaginal spasm 2. Degree of fear and anxiety ABOUBAKR ELNASHAR
  • 17. 7. TREATMENT Aim: •Exercise her mind: •Make the women feels that she owns her vagina and can share it for sexual activity should she wish. : sexual counseling •Exercise her body: •prove that something can go into the vaginal without pain: Dilator. •Break the vicious cycle (Fear – ms spams – pain): •Botox ABOUBAKR ELNASHAR
  • 19.  Lines of treatment: PS MD BO 1. Phobia: Exploration History False beliefs 2. Sex: Education Anatomy Physiology 3. Muscle: Control Adductors: Relaxation exercise P coccygeus: Kegel s exerciseABOUBAKR ELNASHAR
  • 20. 4. Desensitization: Systematic vaginal Step 1:Insertion of a trainers under controlled relaxation Step 2: Sharing of control with husband Step 3: Insertion of penis with the woman in control Step 4: Transfer control of insertion of penis to husband 5. BOTOX= Botulinum toxin 6. Other modalities ABOUBAKR ELNASHAR
  • 21. 1. PHOBIA: EXPLORATION Difficult 1. History of psychological causes should be addressed. History of childhood traumatic experience: recalled & the emotions which accompanied it relived in order to help the woman to come to terms with them ABOUBAKR ELNASHAR
  • 22. 2. Dealing with false beliefs: (common myths): 1. Vagina is too small to allow penetration In fact: vagina is a “potential space”. At rest, the walls of the vagina lie touching each other, but separates to make room for something entering it Baby is able to travel through the vaginal canal during childbirth Vagina lengthens by 50% during sexual arousal: accommodating almost any penis size. ABOUBAKR ELNASHAR
  • 23. 2. Fear of tearing of the hymen: pain, bleeding. In fact most women:  minor and temporary discomfort ± happen without her awareness ABOUBAKR ELNASHAR
  • 24. 2. SEX EDUCATION Woman and her husband More effective than condescending remarks in decreasing patient anxiety [Huber et al,2009]. 1. Genital anatomy PC (pubococcygeus) muscles, that tightens involuntarily when vaginismus is experienced. ABOUBAKR ELNASHAR
  • 25. Self exploration of sexual anatomy (guided tour) Semi-sitting position legs apart mirror placed in front of her vulva, she explores her genitalia (with the doctor) explaining the anatomy & physiology. ABOUBAKR ELNASHAR
  • 26. 2. Sexual physiology & behavior How their genital organs are put together how they both function. The vagina muscles do not contract on their own, the reasons of their contraction are the negative thoughts and beliefs about sexuality and sexual intercourse. Brain responsible of vaginismus,not vagina: name of this sexual dysfunction must be brainismus, not vaginismus. ABOUBAKR ELNASHAR
  • 27. 3. MUSCLES CONTROL a. Relaxation exercises  to the adductor muscles To help her to relax when anticipates vaginal penetration. The doctor hold the woman ‘s knees together firmly while she attempts to separate them, then slowly she is allowed to succeed. ABOUBAKR ELNASHAR
  • 28. b. Contraction /relaxation exercise (Kegel ‘s exercise) To gain control over the muscles surrounding her introits . 1. The patient must learn first how to identify the muscle for herself. 2. She is advised to sit on the toilet with her legs spread as far apart as possible. 3. If she then starts & stops the flow of urine, she becomes aware of the pubococcygeus action. ABOUBAKR ELNASHAR
  • 29. 4. Once the muscle is identified, the woman can practice contracting it repeatedly whenever she has time or 10-15 times a day ABOUBAKR ELNASHAR
  • 30. Recommended for every woman especially • To strengthen or restore pelvic floor muscle tone. • To increase sexual health and sexual confidence with her partner. • To avoid incontinence or are currently experiencing urinary stress/urge incontinence. •Giving or has given birth. • Going through menopause. ABOUBAKR ELNASHAR
  • 32. 4. DESENSITIZATION: SYSTEMATIC VAGINAL DESENSITIZATION OF THE FEAR OF VAGINAL PENETRATION Vaginal dilatation exercises are a misnomer {vagina is not physically stretched} Behavioural therapy to treat phobias and other behavioural problems that involve anxiety. ABOUBAKR ELNASHAR
  • 33. Trainers: Fingers commercial dilators Tampons specifically designed specula Simms, Amiell, Stanley. •The choice depend on the patient preference & comfort level. •Fingers are preferred {allow to feel the muscles contracting. easy to remove if she starts to feel any discomfort}.
  • 35. Approaches 1. Gradual using vaginal self-dilatation Starting with the smallest one she inserts larger vaginal trainers over time until one the size of a penis can be inserted comfortably. Rapid using vaginal mould insertion. Duration: 2-6 weeks (2-15 sessions) Rapid desensitization is preferred (Biswas & Ratnam,1995) ABOUBAKR ELNASHAR
  • 36. 2. In-vitro: The dilator is introduced by the doctor or In-vivo: the dilator is introduced by the patient No differences between the 2 forms of systematic desensitization (Cochrane SR, 2002) ABOUBAKR ELNASHAR
  • 37. Success rate: 72-100% success in uncontrolled trials and case series. limited evidence to recommend the use of systematic desensitisation (Cochrane SR, 2001) ABOUBAKR ELNASHAR
  • 38.  Program Step 1: Insertion of a trainers under controlled relaxation: In private, in a relaxed & nonsexual setting at home. do the exercises with a finger inside the vagina. clip your fingernails and use a lubricating jelly. Or do the exercises in a bathtub, where water can be a natural lubricant. Your finger needs to be inserted 5-6 cm. That's up to about the first knuckle joint. Start with one finger and work your way up to 3 The insertion of digits is a slow and graduated process and can take weeks of nightly exercises. ABOUBAKR ELNASHAR
  • 40. Step 2: Sharing of control with husband. When she has become comfortable with this process, her partner’s fingers are introduced. while she maintains control how quickly the fingers are placed. The husband becomes active in the vaginal dilatation exercises only when the patient is emotionally & physically ready & after anxiety of being touched is extinguished. When she is comfortable inserting the larger dilators, she can instruct her husband how to place the dilator in her vagina ABOUBAKR ELNASHAR
  • 41. Step 3: Insertion of penis with the woman in control. Sitting or kneeling over her husband, female superior position & inserting his penis herself. ABOUBAKR ELNASHAR
  • 42. Step 4: Transfer control of insertion of penis to husband ABOUBAKR ELNASHAR
  • 43. 5. BOTULINUM NEUROTOXIN A (BOTOX) Produced by: Clostridium botulinum, Mechanism: Prevention of acetylcholine release: prevents neuromuscular transmission: muscle weakness Temporary muscle paralysis Onset: 3-7 d after injection Duration: 3-4 months. ABOUBAKR ELNASHAR
  • 44. First described by Brin and Vapnek [Brin, Vapnek, 1997] although it is not licensed for this condition (Eccleston , Woolley, 2008) Other indications: Treating a number of clinical conditions associated with neuromuscular dysfunction, such as focal dystonias, upper motor neuron syndromes, and muscle hyperactivity. ABOUBAKR ELNASHAR
  • 45. Technique: 150-400 mIU injected into the puborectalis muscles in 3 sites on each side of the vagina 1. A vial of 500 U botulinum toxin type A (Dysport; Ipsen Ltd, UK) is diluted with 1.5 mL of normal saline solution. 2. A total dose of 150–400 U equally injected in puborectalis muscles. 3 points on each side with a 23-gauge needle. 3. Light sedation of 1–5 mg midazolam and 50– 150 mg fentanyl. Oxygen (6–8 L/min) given via face mask. Monitoring of SpO2 via pulse oximetry. The sedation was not deep; some extent of muscular contraction was required to be visible to find the exact location of muscles for injection. 4. Patients were discharged on the same day. They were followed up after 1 w to check the vaginal muscle resistance, and were thenABOUBAKR ELNASHAR
  • 46. it covers the vestibular bulb it is innervated by the deep/muscular branch of the perineal nerve, which is a branch of the pudendal nerve ABOUBAKR ELNASHAR
  • 47. Indications Severe or refractory cases. ?Mild and severe cases of vaginismus Contraindications Hypersensitivity to albumin, botulinum toxin, or any component of the formulation Infection at the proposed injection site(s) Pregnancy Diseases of neuromuscular transmission Coagulopathy or therapeutic anticoagulation. ABOUBAKR ELNASHAR
  • 48. Side effects: No major 1. Fecal and urinary incontinence lasting 3 to 4 months 2. Unusual pressure pain in the vagina separate from the vaginismus pain. ABOUBAKR ELNASHAR
  • 49. Results: No RCT More rapid effect Most of the success after 1 tt, but occasionally repeat tts were required. Success: 75% (Pacik, 2011) ABOUBAKR ELNASHAR
  • 50. Ineffective treatments Hymenectomy doesn’t solve the problem but makes it worse: avoidance of sex completely Kegel exercises alone ABOUBAKR ELNASHAR
  • 51. Drugs: Lubricants, topical anesthetics, anti-depressants, sedatives, excess alcohol, hallucinogenic drugs, muscle relaxants, antispasmodics The only indication: when vaginismus is a part of a more generalized syndrome of sexual phobia. imipramine 30-75 mg daily Benzodiazepines to aid both relaxation & interviews ABOUBAKR ELNASHAR
  • 52. What can be done to prevent Vaginismus  Sexual education  Pre-marital sexual counseling and guidance ABOUBAKR ELNASHAR
  • 53.  Vaginismus, and superficial dyspareunia overlap  Vaginal muscle spasm is not a valid or reliable diagnostic criterion for vaginismus.  Clinical syndrome that consists of overlapping elements of hypertonic pelvic floor muscles Pain Anxiety, and Difficulty in penetration. ABOUBAKR ELNASHAR
  • 54.  Lines of treatment of vaginismus: 1. Phobia Exploration 2. Sex education 3. Muscle Control 4. Desensitization: Systematic vaginal desensitization 5. Botox Injection ABOUBAKR ELNASHAR
  • 55. ABOUBAKR ELNASHAR ‫من‬ ‫المحاضره‬ ‫علي‬ ‫الحصول‬ ‫يمكن‬ 1.My scientific page on Face book: Aboubakr Elnashar Lectures. https://www.facebook.com/group s/227744884091351/ 2.Slide share web site 3.elnashar53@hotmail.com