Urinary alkalinizers work by reducing the acidity of urine to treat painful and burning urination caused by acidic urine from bacterial infections. They are also used to treat acidosis from kidney failure by raising urine pH levels and dissolving uric acid stones. Sodium bicarbonate is commonly used as it breaks down into sodium and bicarbonate ions, making the urine more alkaline and increasing excretion of alkaline bicarbonate ions in the urine to raise pH.