The urethra is the tube that carries urine from the bladder to the outside of the body. It has some differences between males and females. The male urethra is longer (18-20 cm) and curved, serving the dual functions of urination and ejaculation. It has two parts - the posterior urethra near the bladder and anterior urethra in the penis. The female urethra is shorter (4 cm) and straight, serving only urination. It opens between the clitoris and vaginal opening. Catheterization is easier in females due to the straight course of the urethra.
Anatomy of urinary bladder. surfaces, border of urinary bladder its relation , ligament support, peritoneal relation in male and females, pouches, blood supply of bladder, nerve supply of bladder, true and false ligament of urinary bladder,
Anatomy of urinary bladder. surfaces, border of urinary bladder its relation , ligament support, peritoneal relation in male and females, pouches, blood supply of bladder, nerve supply of bladder, true and false ligament of urinary bladder,
location, length, and relation of right an left ureter, raletion of male an female ureter, n physiological site of ureteric constriction, bloo supply an inerve supply of ureter, clinical sinificance of ureter with hysteriectpomy
location, length, and relation of right an left ureter, raletion of male an female ureter, n physiological site of ureteric constriction, bloo supply an inerve supply of ureter, clinical sinificance of ureter with hysteriectpomy
The urethra is a passageway located in your body's pelvic region. The walls of the tube are thin and made up of epithelial tissue, smooth muscle cells and connective tissue. The urethra has two different types of sphincters, or muscles that act as valves that open or close
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
2. URETHRA
• A tubular structure emerging
from the neck of bladder
and opens to the exterior
• It is outlet of bladder &
eliminates urine to outside
• Present in both male &
female but there are some
differences b/w the two
3. differenceMale urethra
1 Long
2 Length= 18- 20 cm
3 Function—
i) urination
ii) ejaculation of semen
4 Course– curved (double)
Female urethra
1 Short,,
2 Length= 4 cm
3 Function—only urination
4 Course– nearly straight
5 Foley cathetarisation is easy
5. Male urethra
• It is 18-20 cm in length
Extends from internal urethral orifice(in
bladder
to
external urethral orifice (meatus)
[ at the tip of glans penis]
6. Course------ is not straight
-------is curved( double)
emerges from the neck of
urinary bladder
enters into
prostate
passes
through
the urogenital
diaphragm
enters into
bulb of penis
then body of penis
• ---finally opens at the tip
of glans penis
simplified
fig.
8. How to insert foleys catheter & why
you have to lift up the penis to
insert foley catheter
9. PARTS OF URETHRA
• Two parts—
• 1] Posterior urethra (proximal urethra)
• 2] Anterior urethra (distal urethra)
10. PARTS OF URETHRA……
1] Posterior urethra
(proximal urethra)- near
to bladder
i) 4cm in length
ii) Lies in the pelvis
iii) It has 3 parts-----
a) pre-prostatic part—b/w
bladder & prostate
b) prostatic part—within
prostate
c) membranous part–
through perineal
membrane
11. PARTS OF URETHRA……
2] Anterior urethra (distal
urethra)---
i) 16 cm long
i) Lies in perineum &
penis
ii) It has 2 parts--
a) bulbar urethra–
within bulb of penis
b)penile/pendulus
urethra/spongy urethra
–
--within body of penis
14. 1. pre-prostatic part
i) 1-1.5 cm in length
ii) Extends vertically from bladder neck to prostate
iii) Surrounded by proximal/internal urethral sphincter
--- made up of smooth muscle bundle
iv) Function of internal urethral sphincter—
a) maintains the urinary continence
b) prevents retrograde flow of seminal ejaculate into
bladder
v) Applied– this part can be damage by
a) bladder neck surgery,
b) TURP(transurethral resection of prostate)
vi) So retrograde ejaculation of semen occur in such
patient ,, may lead to infertility
16. 2. prostatic part
i) 3-4 cm in length
ii) It passes through the substance of prostate
iii) Posterior wall of this part– presents
a) urethral crest – midline ridge/mucosal fold
b) prostatic sinus– depression on both side of crest
----prostatic ducts –open in sinus
c) verumontanum / colliculus seminalis–
---an elevation at urethral crest,,
---- prostatic utricle open here
----- ejaculatory duct – open here
* prostatic utricle – small blind sac,,develop from
paramesonephric duct or urogenital sinus,, homologus to
vagina of female,, also k/a vagina musculine
*Ejaculatory duct= vas deferens + duct of seminal vesicle
19. 3. Membranous part
i) shortest part ,, 1.5 cm long
ii) 2nd most narrowest part
(most narrowest part is external urethral
orifice)
iii) Passes through perineal membrane
iv) surrounded by distal / external urethral sphincter
-----has voluntary control
-----maintains urinary continence
---made up of urethral smooth muscle,,urethral
striated muscle,,pubourethral part of levator ani
muscle
20. 4.Anterior urethra
• It extends from
membranous urethra to
external urethral orifice .
1) bulbar urethra–
---lies in the bulbospongiosus
(of penis)
---widest part of urethra
---Bulbourethral glands
open in it
2)Penile urethra-
---lies in corpus spongiosum
--- its terminal part is dilated
in glans penis –k/a
navicular fossa
--- numerous urethral glands
open in it
bulbar
urethra
navicular
fossa
22. Transverse section of different part of
urethra
i) pre- prostatic part– stellate shape--
ii) prostatic part– crescentic shape/semilunar-
iii) membranous part--- stellate shape
iv) bulbar & penile part– transverse slit shape
v) external urethral orifice– sagittal slit shape
**Significance of different shape is ----
----Mentain the continuous stream of urine flow
( projectile stream)
23. Arterial supply
1) urethral artery– br. of internal pudendal
artery
2) dorsal artery of penis- br. of internal
pudendal artery
Venous drainage---
1) Anterior urethra—drained by dorsal vein of
penis----internal pudendal vein--- prostatic
venous plexus
2)Posterior urethra— drained by prostatic and
vesicle -venous plexus-----internal iliac veins
24. Lymphatic drainage
i)prostatic urethra---- internal iliac LN
ii)membranous urethra---- internal iliac LN
iii) anterior urethra--&glans ---deep inguinal LN
Nerve supply— by autonomic nerve mainly
i-sympathetic fibres from superior hypogastric
plexus [L1-L2segment]
ii-parasympathetic fibres-S2 to S4 sp. Segments
iii-somatic fibres from pudendal nerves
Source of development— vesicourethral canal of
primitive urogenital sinus
25. applied
1-urethritis– infection &
inflammation of urethra
--N.gonorrhoea
2 rupture of urethra–
------due to injury by
a fall astride/straddle
3 hypospadias—urethra opens at
under surface(ventral)of penis
4 epispadias– urethra opens on the
dorsum of penis
*fall astride= fall on surface keeping
legs apart so that injury goes to
perineum
33. FEMALE URETHRA
• It is 4cm long & 6mm in width
• Homologus to prostatic urethra
• It begins from internal urethral orifice and
passes downwards & forwards
• Opens in the vestibule b/w clitoris & vaginal
orifice
• Ext. urethral opening lies 2.5 cm behind the
glans clitoris
*clitoris = homologus organ to penis
36. Sphincter of female urethra
• It has also internal &
external urethral
sphincter
37. Glands around the female
urethra
• These glands open in female urethra—
1 urethral glands– mucous glands
2 para-urethral glands== corresponds to
prostate
3 greater vestibular glands—
39. Epithelium of urethra
• Epithelium of urethra
– Transitional epithelium at the proximal end
(near the bladder)
– Stratified and pseudostratified columnar – mid
urethra (in males)
– Stratified squamous epithelium at the distal end
(near the urethral opening)
52. PARTS OF URETHRA
• Two parts—
1] Posterior urethra (proximal urethra)- near to bladder
i) short , 4cm in length
ii) Lies in the pelvis
iii) It has 3 parts
a) pre-prostatic part—b/w bladder & prostate
b) prostatic part—within prostate
c)membranous part– through perineal
membrane
2] Anterior urethra (distal urethra)
i) Long , 16 cm long
ii) Lies in perineum & penis
iii) It has 2 parts--
a) bulbar urethra– within bulb of penis
b)penile/pendulus urethra/spongy urethra –
within body of penis
55. function
• Kidney– formation of urine
• Ureter– carrying of urine from kidney to
bladder
• Urinary bladder– storage of urine
• Urethra– voiding /elimination of urine