Types of capsules by Sakshi Lodha
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The document discusses two main types of capsules - hard gelatin capsules and soft gelatin capsules. Hard gelatin capsules are two-piece caps consisting of a cap and body that are used to encapsulate powders. Soft gelatin capsules are one-piece capsules that can encapsulate liquids, suspensions, or semisolids. The manufacturing processes of each type are described along with their advantages and disadvantages. Hard gelatin capsules are more suitable for powders while soft gelatin capsules can encapsulate liquids and provide fast drug release.
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Review on “Mouth Dissolving Tablet as Fast Dissolving Drug Delivery System”
Numerous formulations with enhanced performance and acceptability have been developed in response to the need for greater palatability in oral given medications. Over the past several decades, demand for mouth dissolving tablets MDTs has grown steadily, and the pharmaceutical sector has seen a tremendous expansion in this field. One of the special qualities of mouth dissolving tablets is that they dissolve quickly and release the medication as soon as they come into contact with saliva. This eliminates the need for water when administering the medication. The applications and techniques of taste masking in the past are reviewed in this article, which also focuses on the most current advancements in bitterness reduction for drugs taken orally. In addition to the conventional methods of manufacturing, this review offers a thorough understanding of a few distinct patents these technologies created and commercialised formulations of mouth dissolving tablets MDTs . Adesh Karale | Aditya Karale | Sanket Kachare | Vijay Tarade "Review on “Mouth Dissolving Tablet as Fast Dissolving Drug Delivery System”" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-6 , December 2023, URL: https://www.ijtsrd.com/papers/ijtsrd61260.pdf Paper Url: https://www.ijtsrd.com/pharmacy/other/61260/review-on-“mouth-dissolving-tablet-as-fast-dissolving-drug-delivery-system”/adesh-karale
Capsules
This document discusses different types of capsules used in pharmaceutical formulations. It describes hard gelatin capsules, the process used to manufacture their shells and fill them. It also covers soft gelatin capsules, their production process, and quality control testing. Finally, it briefly mentions pellets and the requirements for their formulation and manufacturing.
Tablet manufacturing process
The document summarizes the key steps in the tablet manufacturing process, including weighing, milling, mixing, granulation, drying, compression, coating, and packaging. It describes the main methods of tablet production as wet granulation, dry granulation, and direct compression. Quality control tests mentioned are content uniformity, disintegration testing, and dissolution testing. Personnel required are production pharmacists, manufacturing chemists, analytical chemists, and machine operators. Common equipment used includes mills, mixers, granulators, dryers, tablet presses, and coating pans.
capsule manufacturing and ipqc.pptx
This document provides information on the manufacturing process, flowcharts, and in-process quality control (IPQC) tests for non-sterile capsule dosage forms. It describes the manufacturing of hard and soft gelatin capsule shells using plate and rotary die processes. Key steps include dipping pins in gelatin solution, drying, stripping, and trimming shells. Capsules are filled and quality tests conducted including appearance, size, disintegration time, weight variation, moisture permeation, content uniformity, and dissolution. The document aims to provide an overview of capsule manufacturing and quality assurance.
Tablets
This document provides information about tablets, including their definition, advantages, types, and manufacturing process. It begins with definitions of tablets from pharmacopoeias and discusses how they are the most popular dosage form, comprising 70% of pharmaceutical preparations. It describes various types of tablets including compressed, sugar-coated, film-coated, enteric-coated, and effervescent tablets. The document outlines the tablet manufacturing process using tableting machines and discusses characteristics and specifications of compressed tablets.
Capsules
Solid unit dosage forms the drug is enclosed within the water-soluble shell or an envelope either a hard or soft shell. Shell is typically made of gelatin primarily intended for oral delivery and provides a rapid release of contents.
Generally, the shells are formed from gelatin.
capsules.ppt
Capsules can be solid or soft gelatin shells that enclose drug substances. There are two main types - hard gelatin capsules which have a two-piece shell and soft gelatin capsules which are one-piece and hermetically sealed. Capsules offer benefits like being tasteless, odorless, easy to administer and fill, and allow combination of powders. They are evaluated for quality using tests like weight variation, content uniformity, disintegration and dissolution.
Hard gelatin capsules
Hard gelatin capsules are solid dosage forms containing medicinal ingredients enclosed in gelatin shells. They come in two-piece hard shells or one-piece soft shells and can contain liquids, semisolids or powders. The document discusses the manufacturing process for hard capsules including production of the gelatin shell through dipping and drying, filling powder or liquid contents using various machines, and sealing. It notes advantages like masking tastes but also challenges like incompatibility with hygroscopic drugs. Various excipients, defects and special techniques are also outlined.
Recommended
Review on “Mouth Dissolving Tablet as Fast Dissolving Drug Delivery System”
Numerous formulations with enhanced performance and acceptability have been developed in response to the need for greater palatability in oral given medications. Over the past several decades, demand for mouth dissolving tablets MDTs has grown steadily, and the pharmaceutical sector has seen a tremendous expansion in this field. One of the special qualities of mouth dissolving tablets is that they dissolve quickly and release the medication as soon as they come into contact with saliva. This eliminates the need for water when administering the medication. The applications and techniques of taste masking in the past are reviewed in this article, which also focuses on the most current advancements in bitterness reduction for drugs taken orally. In addition to the conventional methods of manufacturing, this review offers a thorough understanding of a few distinct patents these technologies created and commercialised formulations of mouth dissolving tablets MDTs . Adesh Karale | Aditya Karale | Sanket Kachare | Vijay Tarade "Review on “Mouth Dissolving Tablet as Fast Dissolving Drug Delivery System”" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-6 , December 2023, URL: https://www.ijtsrd.com/papers/ijtsrd61260.pdf Paper Url: https://www.ijtsrd.com/pharmacy/other/61260/review-on-“mouth-dissolving-tablet-as-fast-dissolving-drug-delivery-system”/adesh-karale
Capsules
This document discusses different types of capsules used in pharmaceutical formulations. It describes hard gelatin capsules, the process used to manufacture their shells and fill them. It also covers soft gelatin capsules, their production process, and quality control testing. Finally, it briefly mentions pellets and the requirements for their formulation and manufacturing.
Tablet manufacturing process
The document summarizes the key steps in the tablet manufacturing process, including weighing, milling, mixing, granulation, drying, compression, coating, and packaging. It describes the main methods of tablet production as wet granulation, dry granulation, and direct compression. Quality control tests mentioned are content uniformity, disintegration testing, and dissolution testing. Personnel required are production pharmacists, manufacturing chemists, analytical chemists, and machine operators. Common equipment used includes mills, mixers, granulators, dryers, tablet presses, and coating pans.
capsule manufacturing and ipqc.pptx
This document provides information on the manufacturing process, flowcharts, and in-process quality control (IPQC) tests for non-sterile capsule dosage forms. It describes the manufacturing of hard and soft gelatin capsule shells using plate and rotary die processes. Key steps include dipping pins in gelatin solution, drying, stripping, and trimming shells. Capsules are filled and quality tests conducted including appearance, size, disintegration time, weight variation, moisture permeation, content uniformity, and dissolution. The document aims to provide an overview of capsule manufacturing and quality assurance.
Tablets
This document provides information about tablets, including their definition, advantages, types, and manufacturing process. It begins with definitions of tablets from pharmacopoeias and discusses how they are the most popular dosage form, comprising 70% of pharmaceutical preparations. It describes various types of tablets including compressed, sugar-coated, film-coated, enteric-coated, and effervescent tablets. The document outlines the tablet manufacturing process using tableting machines and discusses characteristics and specifications of compressed tablets.
Capsules
Solid unit dosage forms the drug is enclosed within the water-soluble shell or an envelope either a hard or soft shell. Shell is typically made of gelatin primarily intended for oral delivery and provides a rapid release of contents.
Generally, the shells are formed from gelatin.
capsules.ppt
Capsules can be solid or soft gelatin shells that enclose drug substances. There are two main types - hard gelatin capsules which have a two-piece shell and soft gelatin capsules which are one-piece and hermetically sealed. Capsules offer benefits like being tasteless, odorless, easy to administer and fill, and allow combination of powders. They are evaluated for quality using tests like weight variation, content uniformity, disintegration and dissolution.
Hard gelatin capsules
Hard gelatin capsules are solid dosage forms containing medicinal ingredients enclosed in gelatin shells. They come in two-piece hard shells or one-piece soft shells and can contain liquids, semisolids or powders. The document discusses the manufacturing process for hard capsules including production of the gelatin shell through dipping and drying, filling powder or liquid contents using various machines, and sealing. It notes advantages like masking tastes but also challenges like incompatibility with hygroscopic drugs. Various excipients, defects and special techniques are also outlined.
Capsules
This document discusses capsules as a drug delivery system. It defines capsules as solid dosage forms where the drug is enclosed within a gelatin shell, primarily for oral delivery providing rapid release. There are two main types - hard gelatin capsules which contain dry powders, granules or tablets, and soft gelatin capsules which can contain liquids and are formed, filled and sealed in one operation. The document outlines the capsule manufacturing process and filling methods, as well as advantages and disadvantages of capsules relative to other delivery forms.
A PROJECT REPORT ON
This document provides an overview of capsule production in 3 sentences: It discusses the production process at Bengal School of Technology in India for a student named Ankush Biswas. It acknowledges the contributions of his supervisor and others who supported his project on capsule production. It then outlines the contents of the report which will cover topics like capsule types, manufacturing processes, quality control, and conditions maintained for capsule production.
Oral Dispersible Tablets - A Review
This document provides a review of oral dispersible tablets. It begins with an introduction that defines oral dispersible tablets as solid dosages that disintegrate rapidly, usually within seconds, when placed on the tongue. It describes the advantages of these tablets for patients who have difficulty swallowing conventional tablets. The document then reviews various technologies used to manufacture oral dispersible tablets, including lyophilization, molding, cotton candy process, and spray drying. It also discusses commonly used excipients and superdisintegrants and their mechanisms of action in rapidly disintegrating tablets.
FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF AMLODIPINE BESILATEIj...
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This document discusses the design and formulation of capsules. It begins by defining capsules and describing their history. There are two main types of capsules: hard gelatin capsules and soft gelatin capsules. Hard gelatin capsules have two pieces and typically contain powders, granules or pellets, while soft gelatin capsules are one piece and sealed and can contain liquids or suspensions. The document goes on to cover the advantages and disadvantages of capsules, as well as the formulation of the gelatin shell and capsule contents for both hard and soft gelatin capsules. Key components include gelatin, plasticizers, colorants, fillers and various other excipients.
DESIGN AND FORMULATION OF CAPSULES
The document discusses the design and formulation of capsules. It describes capsules as solid dosage forms where the drug is enclosed in a soluble shell, usually made of gelatin. The two main types of capsules are hard gelatin capsules and soft gelatin capsules. Hard gelatin capsules have two pieces (body and cap) and are filled with powders, granules or pellets. Soft gelatin capsules have a more flexible, plasticized shell and can contain liquid or semi-solid fillings. The document outlines the ingredients, manufacturing process, advantages and disadvantages of both hard and soft gelatin capsules.
Capsule
Its All About Capsule...
i tried to explain in short...
hope you liked it..
please like and share to all students,
which are want to more study in minimum time..
Thank You..
also join on whatsapp to bring newthings
contact no. 9765763626
Capsule
Capsules are solid dosage forms that enclose medicinal or inert substances within a soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules and soft gelatin capsules. Hard capsules have two cylindrical sections that are joined together, while soft capsules are one-piece shells containing liquids or semisolids. Capsules offer advantages like rapid drug release, flexibility in formulation, and taste masking, but have disadvantages related to size limitations, moisture control issues, and potential difficulty swallowing large sizes. Quality control tests evaluate attributes like shape, size, disintegration time, and drug content uniformity.
powder-211021064722.pptx
The document discusses powders as a pharmaceutical dosage form. It defines powders as finely divided solid drugs or chemicals meant for internal or external use. It describes various methods of preparing powders, including spatulation, trituration, geometric dilution, sifting, and tumbling. Powders are classified based on their intended use, such as bulk powders, simple/compound powders, powders in capsules/cachets, and compressed powders. Weighing techniques and packaging of powders are also outlined.
Soft and hard gelatin capsules
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
Industrial training report 2 United institute of pharmacy
This document is an industrial training report submitted by Abhinav Kumar Yadav to fulfill requirements for a Bachelor of Pharmacy degree. It discusses his training at Oxford Pharma in Roorkee Dehradun under the supervision of Dr. Anil Kumar Singh. The report includes an introduction to capsules, definitions of hard and soft gelatin capsules, manufacturing processes for capsules, common defects in capsule manufacturing, and raw materials used to produce hard gelatin capsule shells.
Role of Retail Pharmacist for Product Stability.ppt
This PPT would be helpful to retail pharmacist for drug product stability. It contains various factors those are responsible for drug degradation and improve drug product stability. So it would be highly used in the field of registered retail pharmacist and pharmacy graduate in diploma pharmacy graduate.
Capsules
Capsules are solid dosage forms that enclose drug substances within hard or soft soluble shells, usually made of gelatin. There are two main types - hard gelatin capsules, which have two pieces, and soft gelatin capsules, which are one-piece and hermetically sealed. Capsules offer advantages like being tasteless, odorless, and easy to administer, and allow for flexible dosing. Key steps in production include dipping, spinning, drying, stripping, trimming, joining, and filling. Capsules are evaluated for weight variation, content uniformity, and dissolution.
Capsules. Their Types, manufacturing and packaging.pdf
Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell, usually formed from gelatin.
The capsule may be considered a container drug delivery system that provides a tasteless and odorless dosage form without need for a secondary coating step, as may be required for tablets. Their availability in a wide variety of colors makes capsules aesthetically pleasing. Gelatin is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue, and bones of animals.
Gelatin capsule shells may be hard or soft, depending on their composition.
Hard Gelatin Capsules
Soft Gelatin Capsules
The shells may be composed of two pieces, a body and a cap, or they may be composed of a single piece. hard-shell capsules are two piece capsules whereas soft shell capsules are one piece capsules.
Hard Gelatin Capsules:
Most capsule products manufactured today are of the hard gelatin type.
The community pharmacist also uses hard gelatin capsules in the extemporaneous compounding. The empty capsule shells are made of gelatin, sugar, and water.
Normally, hard gelatin capsules contain 13% to 16% of moisture. However, if stored in an environment of high humidity, additional moisture is absorbed by the capsules, and they may become distorted and lose their rigid shape. In an environment of extreme dryness, some of the moisture normally present in the gelatin capsules is lost, and the capsules may become brittle and crumble when handled. Therefore, it is desirable to maintain hard gelatin capsules in an environment free from excessive humidity or dryness.
Advantages for HGC:
Hard gelatin capsules often have been assumed to have better bioavailability than tablets.
Hard shell capsules allow a degree of flexibility of formulation not obtainable with tablets.
Modern capsule filling equipment makes possible the multiple filling of diverse systems such as beads, granules, small tablets and powders.
Hard gelatin capsules are ideally suited for clinical trials and are widely used in preliminary drug studies. For comparative bioequivalence studies tablets can even be hidden in capsules to ensure the test being blinded.
Disadvantages of HGC:
The number of suppliers of shells is limited.
Filling equipment is slower than tableting.
Generally, hard gelatin capsule products tend to be more costly.
Highly soluble salts (e.g., iodides, bromides, and chlorides) generally should not be dispensed in hard gelatin capsules. Their rapid release may cause gastric irritation owing to the formation of a high drug concentration in localized areas.
Manufcaturing of HGC:
Hard gelatin capsule shells are manufactured in two sections, the capsule body and a shorter cap. The two parts overlap when joined, with the cap fitting snugly over the open end of the capsule body. Some capsule shells are designed to lock in place when closed. Hard gelatin shells are manufactured by a process in which stainless steel mold pins are
Capsule's
Capsules are solid dosage forms that contain a drug enclosed within a hard or soft soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules, which consist of two pieces that are joined, and soft gelatin capsules, which have a soft, one-piece shell. Capsules offer benefits like being tasteless, odorless, and easy to administer, and allow for flexible dosing. However, some drugs are not suitable for capsules due to stability issues. Capsules are manufactured through various processes depending on the type, including dipping, spinning, drying, filling, and sealing. They must pass quality tests like weight variation and content uniformity testing.
Capsule
This document provides information about hard gelatin capsules, including their introduction, advantages, disadvantages, raw materials, manufacturing process, sizes, properties of filled materials, filling equipment, and evaluation standards. It discusses that hard capsules consist of two pieces (cap and body) made of gelatin, and are filled with powders. The key steps in manufacturing include dipping molds in hot gelatin solution, drying, stripping, trimming, and joining. Capsules range in size from 000 to 5 and are evaluated based on parameters like weight variation, content uniformity, and dissolution testing. Common filling equipment includes Rotosort, Rotofill, and Accogel.
Capsules
The document discusses capsules and the capsule manufacturing process. It provides details on:
- The parts of capsules including the cap and body.
- The two main types of capsules - hard gelatin capsules and soft gelatin capsules.
- The manufacturing process for hard gelatin capsules including dipping, spinning, drying, filling, sealing and cleaning steps.
- Capsule sizes ranging from size 000 to size 5.
- The production of soft gelatin capsules using plate, rotary die and Accogel processes.
A Review on Dispersible Tablets A Novel Drug Delivery System for Pedietrics a...
Novel Drug Delivery system offer great chance to invent new drug delivery system for the betterment of the life. Oral dispersible tablets are modern day technology and extensively used for those formulations which are required for pediatrics and geriatrics. Dispersible tablet disintegrates rapidly into the mouth in presence of saliva, as they don't require water for disintegration. Such rapid disintegration is helpful for the person having problem of dysphasia. Dispersible tablet requires a key ingredient called supradisintegrants for such rapid and effective disintegration. There are various methodologies used for preparing such effective dispersible tablets like – Compaction method, Freeze Drying, Molding Method, Sublimation, all such methods are effective to make dispersible tablets. There is need of evaluation of each and every tablet after manufacturing which requires evaluation parameters such as weight variation, Disintegration test, Dissolution Test, Hardness, and Thickness. This article discuss about dispersible tablets, methods of preparation for dispersible tablets, evaluation parameters and advantages and disadvantages. Nutan Prakash Sharma | Shivam Pandey | Hariom Sharma | Jaya Singh ""A Review on Dispersible Tablets: A Novel Drug Delivery System for Pedietrics and Geriatrics"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25098.pdf
Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/25098/a-review-on-dispersible-tablets-a-novel-drug-delivery-system-for-pedietrics-and-geriatrics/nutan-prakash-sharma
In process quality control test (IPQC) test for capsule.pptx
Presentation on in process quality control test for capsule
FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CARVEDILOL
ABSTRACT
The aim of the present research work was to enhance the solubility of
Carvedilol by solid dispersion method and to formulate a mouth
dissolving tablet. Drugs are more frequently taken by oral
administration. The solubility of Carvedilol enhanced with different
ratios of PVP by the solvent evaporation method .In-vitro release
profile of solid dispersion obtained in SGF without enzymes and Ph
6.8 phosphate buffer indicate that 100% drug release found within 20
min. These solid dispersion were directly compressed into tablets using
Crospovidone, sodium starch glycol ate, croscarmellose sodium and
polyacrylic potassium in different concentrations as a super
disintegrants. The prepared tablets containing the solid dispersion of
Carvedilol having sufficient strength of 2.5-4 kg/cm2. The
disintegrated in the oral cavity with in 21 sec. contain Crospovidone
(5%) as super disintegrant.
KEYWORDS: Carvedilol, PVP, Super Disintegrants, Mouth Dissolving Tablet.
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Capsules
This document discusses capsules as a drug delivery system. It defines capsules as solid dosage forms where the drug is enclosed within a gelatin shell, primarily for oral delivery providing rapid release. There are two main types - hard gelatin capsules which contain dry powders, granules or tablets, and soft gelatin capsules which can contain liquids and are formed, filled and sealed in one operation. The document outlines the capsule manufacturing process and filling methods, as well as advantages and disadvantages of capsules relative to other delivery forms.
A PROJECT REPORT ON
This document provides an overview of capsule production in 3 sentences: It discusses the production process at Bengal School of Technology in India for a student named Ankush Biswas. It acknowledges the contributions of his supervisor and others who supported his project on capsule production. It then outlines the contents of the report which will cover topics like capsule types, manufacturing processes, quality control, and conditions maintained for capsule production.
Oral Dispersible Tablets - A Review
This document provides a review of oral dispersible tablets. It begins with an introduction that defines oral dispersible tablets as solid dosages that disintegrate rapidly, usually within seconds, when placed on the tongue. It describes the advantages of these tablets for patients who have difficulty swallowing conventional tablets. The document then reviews various technologies used to manufacture oral dispersible tablets, including lyophilization, molding, cotton candy process, and spray drying. It also discusses commonly used excipients and superdisintegrants and their mechanisms of action in rapidly disintegrating tablets.
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FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF AMLODIPINE BESILATEIj...International journal of pharmacy research and science (IJPRSONLINE)
The document summarizes a study that formulated orodispersible tablets of amlodipine besilate using different superdisintegrants to improve patient compliance. Nine formulations of amlodipine orodispersible tablets were prepared using croscarmellose sodium, crospovidone, or sodium starch glycolate by direct compression method. The tablets were evaluated for hardness, friability, drug content, wetting time, water absorption ratio, and in vitro dispersion time. Tablets containing higher concentrations of croscarmellose sodium had shorter wetting and dispersion times, while those with sodium starch glycolate took longer to wet and disperse. Tablets with 8% croscarmellose sodium dispersed within 28 seconds and released 98.DESIGN & FORMULATION OF CAPSULES
This document discusses the design and formulation of capsules. It begins by defining capsules and describing their history. There are two main types of capsules: hard gelatin capsules and soft gelatin capsules. Hard gelatin capsules have two pieces and typically contain powders, granules or pellets, while soft gelatin capsules are one piece and sealed and can contain liquids or suspensions. The document goes on to cover the advantages and disadvantages of capsules, as well as the formulation of the gelatin shell and capsule contents for both hard and soft gelatin capsules. Key components include gelatin, plasticizers, colorants, fillers and various other excipients.
DESIGN AND FORMULATION OF CAPSULES
The document discusses the design and formulation of capsules. It describes capsules as solid dosage forms where the drug is enclosed in a soluble shell, usually made of gelatin. The two main types of capsules are hard gelatin capsules and soft gelatin capsules. Hard gelatin capsules have two pieces (body and cap) and are filled with powders, granules or pellets. Soft gelatin capsules have a more flexible, plasticized shell and can contain liquid or semi-solid fillings. The document outlines the ingredients, manufacturing process, advantages and disadvantages of both hard and soft gelatin capsules.
Capsule
Its All About Capsule...
i tried to explain in short...
hope you liked it..
please like and share to all students,
which are want to more study in minimum time..
Thank You..
also join on whatsapp to bring newthings
contact no. 9765763626
Capsule
Capsules are solid dosage forms that enclose medicinal or inert substances within a soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules and soft gelatin capsules. Hard capsules have two cylindrical sections that are joined together, while soft capsules are one-piece shells containing liquids or semisolids. Capsules offer advantages like rapid drug release, flexibility in formulation, and taste masking, but have disadvantages related to size limitations, moisture control issues, and potential difficulty swallowing large sizes. Quality control tests evaluate attributes like shape, size, disintegration time, and drug content uniformity.
powder-211021064722.pptx
The document discusses powders as a pharmaceutical dosage form. It defines powders as finely divided solid drugs or chemicals meant for internal or external use. It describes various methods of preparing powders, including spatulation, trituration, geometric dilution, sifting, and tumbling. Powders are classified based on their intended use, such as bulk powders, simple/compound powders, powders in capsules/cachets, and compressed powders. Weighing techniques and packaging of powders are also outlined.
Soft and hard gelatin capsules
Capsules are tasteless, odorless and can easily be
administered.
Combination of powders we can use
There are attractive in appearance.
The drugs having un-pleasant odor and taste are
enclosed in a tasteless shell.
They can be filled quickly and conveniently.
Physician can change the dose and combination of drug
according to patient requirement.
They are economical.
They are easy to handle and carry.
Industrial training report 2 United institute of pharmacy
This document is an industrial training report submitted by Abhinav Kumar Yadav to fulfill requirements for a Bachelor of Pharmacy degree. It discusses his training at Oxford Pharma in Roorkee Dehradun under the supervision of Dr. Anil Kumar Singh. The report includes an introduction to capsules, definitions of hard and soft gelatin capsules, manufacturing processes for capsules, common defects in capsule manufacturing, and raw materials used to produce hard gelatin capsule shells.
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This PPT would be helpful to retail pharmacist for drug product stability. It contains various factors those are responsible for drug degradation and improve drug product stability. So it would be highly used in the field of registered retail pharmacist and pharmacy graduate in diploma pharmacy graduate.
Capsules
Capsules are solid dosage forms that enclose drug substances within hard or soft soluble shells, usually made of gelatin. There are two main types - hard gelatin capsules, which have two pieces, and soft gelatin capsules, which are one-piece and hermetically sealed. Capsules offer advantages like being tasteless, odorless, and easy to administer, and allow for flexible dosing. Key steps in production include dipping, spinning, drying, stripping, trimming, joining, and filling. Capsules are evaluated for weight variation, content uniformity, and dissolution.
Capsules. Their Types, manufacturing and packaging.pdf
Capsules are solid dosage forms in which the drug substance is enclosed within either a hard or soft soluble shell, usually formed from gelatin.
The capsule may be considered a container drug delivery system that provides a tasteless and odorless dosage form without need for a secondary coating step, as may be required for tablets. Their availability in a wide variety of colors makes capsules aesthetically pleasing. Gelatin is obtained by the partial hydrolysis of collagen obtained from the skin, white connective tissue, and bones of animals.
Gelatin capsule shells may be hard or soft, depending on their composition.
Hard Gelatin Capsules
Soft Gelatin Capsules
The shells may be composed of two pieces, a body and a cap, or they may be composed of a single piece. hard-shell capsules are two piece capsules whereas soft shell capsules are one piece capsules.
Hard Gelatin Capsules:
Most capsule products manufactured today are of the hard gelatin type.
The community pharmacist also uses hard gelatin capsules in the extemporaneous compounding. The empty capsule shells are made of gelatin, sugar, and water.
Normally, hard gelatin capsules contain 13% to 16% of moisture. However, if stored in an environment of high humidity, additional moisture is absorbed by the capsules, and they may become distorted and lose their rigid shape. In an environment of extreme dryness, some of the moisture normally present in the gelatin capsules is lost, and the capsules may become brittle and crumble when handled. Therefore, it is desirable to maintain hard gelatin capsules in an environment free from excessive humidity or dryness.
Advantages for HGC:
Hard gelatin capsules often have been assumed to have better bioavailability than tablets.
Hard shell capsules allow a degree of flexibility of formulation not obtainable with tablets.
Modern capsule filling equipment makes possible the multiple filling of diverse systems such as beads, granules, small tablets and powders.
Hard gelatin capsules are ideally suited for clinical trials and are widely used in preliminary drug studies. For comparative bioequivalence studies tablets can even be hidden in capsules to ensure the test being blinded.
Disadvantages of HGC:
The number of suppliers of shells is limited.
Filling equipment is slower than tableting.
Generally, hard gelatin capsule products tend to be more costly.
Highly soluble salts (e.g., iodides, bromides, and chlorides) generally should not be dispensed in hard gelatin capsules. Their rapid release may cause gastric irritation owing to the formation of a high drug concentration in localized areas.
Manufcaturing of HGC:
Hard gelatin capsule shells are manufactured in two sections, the capsule body and a shorter cap. The two parts overlap when joined, with the cap fitting snugly over the open end of the capsule body. Some capsule shells are designed to lock in place when closed. Hard gelatin shells are manufactured by a process in which stainless steel mold pins are
Capsule's
Capsules are solid dosage forms that contain a drug enclosed within a hard or soft soluble shell, usually made of gelatin. There are two main types: hard gelatin capsules, which consist of two pieces that are joined, and soft gelatin capsules, which have a soft, one-piece shell. Capsules offer benefits like being tasteless, odorless, and easy to administer, and allow for flexible dosing. However, some drugs are not suitable for capsules due to stability issues. Capsules are manufactured through various processes depending on the type, including dipping, spinning, drying, filling, and sealing. They must pass quality tests like weight variation and content uniformity testing.
Capsule
This document provides information about hard gelatin capsules, including their introduction, advantages, disadvantages, raw materials, manufacturing process, sizes, properties of filled materials, filling equipment, and evaluation standards. It discusses that hard capsules consist of two pieces (cap and body) made of gelatin, and are filled with powders. The key steps in manufacturing include dipping molds in hot gelatin solution, drying, stripping, trimming, and joining. Capsules range in size from 000 to 5 and are evaluated based on parameters like weight variation, content uniformity, and dissolution testing. Common filling equipment includes Rotosort, Rotofill, and Accogel.
Capsules
The document discusses capsules and the capsule manufacturing process. It provides details on:
- The parts of capsules including the cap and body.
- The two main types of capsules - hard gelatin capsules and soft gelatin capsules.
- The manufacturing process for hard gelatin capsules including dipping, spinning, drying, filling, sealing and cleaning steps.
- Capsule sizes ranging from size 000 to size 5.
- The production of soft gelatin capsules using plate, rotary die and Accogel processes.
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Novel Drug Delivery system offer great chance to invent new drug delivery system for the betterment of the life. Oral dispersible tablets are modern day technology and extensively used for those formulations which are required for pediatrics and geriatrics. Dispersible tablet disintegrates rapidly into the mouth in presence of saliva, as they don't require water for disintegration. Such rapid disintegration is helpful for the person having problem of dysphasia. Dispersible tablet requires a key ingredient called supradisintegrants for such rapid and effective disintegration. There are various methodologies used for preparing such effective dispersible tablets like – Compaction method, Freeze Drying, Molding Method, Sublimation, all such methods are effective to make dispersible tablets. There is need of evaluation of each and every tablet after manufacturing which requires evaluation parameters such as weight variation, Disintegration test, Dissolution Test, Hardness, and Thickness. This article discuss about dispersible tablets, methods of preparation for dispersible tablets, evaluation parameters and advantages and disadvantages. Nutan Prakash Sharma | Shivam Pandey | Hariom Sharma | Jaya Singh ""A Review on Dispersible Tablets: A Novel Drug Delivery System for Pedietrics and Geriatrics"" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-4 , June 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25098.pdf
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In process quality control test (IPQC) test for capsule.pptx
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FORMULATION AND EVALUATION OF MOUTH DISSOLVING TABLETS OF CARVEDILOL
ABSTRACT
The aim of the present research work was to enhance the solubility of
Carvedilol by solid dispersion method and to formulate a mouth
dissolving tablet. Drugs are more frequently taken by oral
administration. The solubility of Carvedilol enhanced with different
ratios of PVP by the solvent evaporation method .In-vitro release
profile of solid dispersion obtained in SGF without enzymes and Ph
6.8 phosphate buffer indicate that 100% drug release found within 20
min. These solid dispersion were directly compressed into tablets using
Crospovidone, sodium starch glycol ate, croscarmellose sodium and
polyacrylic potassium in different concentrations as a super
disintegrants. The prepared tablets containing the solid dispersion of
Carvedilol having sufficient strength of 2.5-4 kg/cm2. The
disintegrated in the oral cavity with in 21 sec. contain Crospovidone
(5%) as super disintegrant.
KEYWORDS: Carvedilol, PVP, Super Disintegrants, Mouth Dissolving Tablet.
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Types of capsules by Sakshi Lodha
- 1. Presented By : Lodha Sakshi Mahendra Roll no : 31 Class : T.Y B.Pharmacy Assig. Topic : Types of capsules Guided by : Mrs. N.S.Baste Mam SNJB’S SSDJ COLLEGE OF PHARMACY , CHANDWAD. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 1
- 2. TYPES OF CAPSULE :- 1. Hard Gelatin Capsule 2. Soft Gelatin Capsule 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) CAPSULES💊 Hard capsules Soft Capsules
- 3. 1. HARD GELATIN CAPSULES :- • The hard gelatin capsule consists of two pieces in the form of cylinders closed at one end. • The shorter piece is called the cap. This cap fits over the open end of longer piece called body. • Hard gelatin capsules are also known as dry-filled capsules or two piece capsules. • This capsules are used in extemporaneous compounding of Rx. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 3
- 4. • This capsules are made up of gelatin , sugar and water. • HGC are tasteless. • Colour with various FD & C and D & C dyes. • They made opaque by addition of Titanium Dioxide. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 4
- 5. •Manufacturing of Hard gelatin capsules :- Steps involved in making empty gelatin capsules : 1.Dipping 2.Spinning 3.Drying 4.Stripping 5.Trimming 6.Joining 7.Polishing 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 5
- 6. Manufacturing process of HGC 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 6
- 7. •ADVANTAGES OF HGC :- 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 7 1. Capsules are tasteless, odorless. 2. Combination of powders we can use. 3. They are attractive in appearance. 4. They can be filled quickly and conveniently. 5. They are economical. 6. They are easy to handle and carry. 7. Easy to swallow. 8. Physician can change the dose and combination of drug according to patient requirement.
- 8. • DISADVANTAGE OF HGC :- 1. Capsules are not suitable for liquids that dissolve gelatin, such as aqueous or hydro alcoholic solutions. 2. The concentrated solutions which require previous dilution are unsuitable for capsules because if administered as such lead to irritation into stomach. 3. Not useful for efflorescent or deliquescent materials. 4. Efflorescent cause capsules to soften & Deliquescent may dry the capsule shell to brittleness. 5. More expensive. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 8
- 9. 2. SOFT GELATIN CAPSULE :- • Soft Gelatin capsules are one piece, hermetically sealed, soft gelatin shells containing a liquid, a suspension, or a semisolid. • Soft gelatin is mainly composed of gelatin, plasticizers, preservative, colouring and opacifying agents, flavoring agents and sugars. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 9
- 10. • Manufacturing process of soft gelatin capsule :- Methods for manufacturing of SGC :- 1. Plate – process 2. Rotary die method 3. Norton capsule machine 4. Accogel capsule machine 5. Globex method 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 10
- 11. Manufacturing process 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 11
- 12. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 12 • ADVANTAGES OF SGC :- 1. They are easy to administer. 2. Easy to manufacture. 3. Liquid can be encapsulated. 4. Small to large sizes possible. 5. Elegance 6. Portability 7. Odour & taste masking 8. Ready availability of drug hence gives fast action.
- 13. • DISADVANTAGES OF SGC :- 1. Water soluble material & are difficult to incorporate. 2. Highly moisture sensitive. 3. Efflorescent material can be incorporated , they may cause softening. 4. Deliquescent material not used. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 13
- 14. • APPLICATIONS OF SGC :- 1. Wate immisable, volatile & non-volatile liq. such as vegetable & aromatic oils,aromatic & aliphatic hydrocarbon , Chlorinated hydrocarbon, ether, ester, alcohol. 2. Water miscible non volatile liq. Such as polyethylene glycol, nonionic surface active agent as poly sorbate 80. 3. Water miscible & relatively non vol.Compounds 4. As a suppository dosage form. 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 14
- 15. Difference between SGC & HGC 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 15
- 16. ....Thank you.... 28 March 2023 SNJB's SSDJ College of Pharmacy, Chandwad (Nasik) 16