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TYPE TWO AND TYPE ONE DIABETES IN THE
AGE
GROUP 18-40 YEARS
Presented by :Shahid Nawaz
Researcher,
King Saud University
Riyadh,
Saudi Arabia
• Published by
Department of Diabetes and Internal Medicine,
 Victor Babes University of Medicine and Pharmacy, Timisoara,
 Type- 2 Diabetes Clinic, Clinical Emergency County Hospital, Timisoara
 Received for publication: Nov. 18, 2008, Mar. 15, 2009
BACKGROUND
• A global diabetes epidemic is currently ongoing,
with the number of cases increasing worldwide in
all age groups and all socio-economic classes.
• Young adults with early onset T2DM are more likely
to develop chronic Microvascular and
Macrovascular complications than older adults with
type 2 diabetes.
AIMS
• The present study aims to characterize
clinically, biologically and therapeutically
cases with T2DM and to and compare them
with type 1 DM (T1DM) patients in the same
age group .
• To establish the prevalence of cardiovascular
risk factors in both diabetes types.
PATIENTS AND METHODS
• STUDY GROUPS CONSISTED OF 283 T2DM Males ( age : 18 - 40
years) and same period 48 T1DM Males ( age : 18 - 40 years) were
included in the study.
• Patients data was recorded From the follow-up charts .
It consisted of
 Gender Age
 Diabetes type Diagnosis circumstances
 Height Weight at diagnosis
 maximal weight Blood Glucose
 lipid panel Presence of hypertension
 diabetes treatment Presence of chronic diabetes complications,
PATIENTS AND METHODS
• For Each Group we Calculated
 Gender distribution
 Mean age at onset
 Distribution depending on the type of onset
 Average BMI
 Distribution based on weight status
 Mean TC, TG and HDLc
 Prevalence of cardiovascular risk factors
 Metabolic syndrome (MetS)
 Chronic complications.
• Data was statistically processed with a threshold for
significance of 0.05.
RESULTS
• Patients with T1DM were significantly younger compared to those
With T2 DM
(30.2±17.0 years vs. 36.3±3.6 years, p<0.0001).
• Most patients from the T2DM Group were diagnosed by
 Fasting Plasma Glucose
 OGTT (Oral Glucose Tolerance Test)
• T1DM Patients was most commonly diagnosed in the
 Presence of ketosis/ketoacidosis
 Hypertension
 Chronic complications were rarely encountered.
MetS was present in 67.8% of T2DM patients vs. 10.5% in T1DM Subgroup
(p<0.001).
RESULTS
Patients’ characteristics are presented in Table 1.
• No differences were found regarding gender
distribution and background between T2DM and
T1DM.
• Patients with T1DM were significantly younger
compared to those with T2 DM (30.2±17.0 years
vs. 36.3±3.6 years, p<0.0001).
• In T2DM group, 17 (6%) were between 18 and 30
years, while in T1DM 41.7% were aged between
18 and 30 years.
RESULTS
• Almost half of T2DM patients have at least
one relative with T2DM, compared to only
30% in T1DM.
RESULTS
• Most patients from the T2DM group were
diagnosed by routine fasting plasma glucose
measurement (65.0%)
AND
Oral Glucose Tolerance Test (OGTT) (14.1%).
DISCUSSIONS
• Subjects with T2DM are at increased risk for
cardiovascular disorders and often exhibit
various cardiovascular risk factors such as
abnormal lipid levels, hypertension and obesity.
• T2DM is a common disease in the 18-40 years
age group. It affects mostly obese and
overweight individuals and is very frequently
associated with other cardiovascular risk factors,
even from the diagnosis.
• Cardiovascular risk factors are also present in
T1DM

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Type two and type one diabetes in the

  • 1. TYPE TWO AND TYPE ONE DIABETES IN THE AGE GROUP 18-40 YEARS Presented by :Shahid Nawaz Researcher, King Saud University Riyadh, Saudi Arabia
  • 2. • Published by Department of Diabetes and Internal Medicine,  Victor Babes University of Medicine and Pharmacy, Timisoara,  Type- 2 Diabetes Clinic, Clinical Emergency County Hospital, Timisoara  Received for publication: Nov. 18, 2008, Mar. 15, 2009
  • 3. BACKGROUND • A global diabetes epidemic is currently ongoing, with the number of cases increasing worldwide in all age groups and all socio-economic classes. • Young adults with early onset T2DM are more likely to develop chronic Microvascular and Macrovascular complications than older adults with type 2 diabetes.
  • 4. AIMS • The present study aims to characterize clinically, biologically and therapeutically cases with T2DM and to and compare them with type 1 DM (T1DM) patients in the same age group . • To establish the prevalence of cardiovascular risk factors in both diabetes types.
  • 5. PATIENTS AND METHODS • STUDY GROUPS CONSISTED OF 283 T2DM Males ( age : 18 - 40 years) and same period 48 T1DM Males ( age : 18 - 40 years) were included in the study. • Patients data was recorded From the follow-up charts . It consisted of  Gender Age  Diabetes type Diagnosis circumstances  Height Weight at diagnosis  maximal weight Blood Glucose  lipid panel Presence of hypertension  diabetes treatment Presence of chronic diabetes complications,
  • 6. PATIENTS AND METHODS • For Each Group we Calculated  Gender distribution  Mean age at onset  Distribution depending on the type of onset  Average BMI  Distribution based on weight status  Mean TC, TG and HDLc  Prevalence of cardiovascular risk factors  Metabolic syndrome (MetS)  Chronic complications. • Data was statistically processed with a threshold for significance of 0.05.
  • 7. RESULTS • Patients with T1DM were significantly younger compared to those With T2 DM (30.2±17.0 years vs. 36.3±3.6 years, p<0.0001). • Most patients from the T2DM Group were diagnosed by  Fasting Plasma Glucose  OGTT (Oral Glucose Tolerance Test) • T1DM Patients was most commonly diagnosed in the  Presence of ketosis/ketoacidosis  Hypertension  Chronic complications were rarely encountered. MetS was present in 67.8% of T2DM patients vs. 10.5% in T1DM Subgroup (p<0.001).
  • 8. RESULTS Patients’ characteristics are presented in Table 1. • No differences were found regarding gender distribution and background between T2DM and T1DM. • Patients with T1DM were significantly younger compared to those with T2 DM (30.2±17.0 years vs. 36.3±3.6 years, p<0.0001). • In T2DM group, 17 (6%) were between 18 and 30 years, while in T1DM 41.7% were aged between 18 and 30 years.
  • 9. RESULTS • Almost half of T2DM patients have at least one relative with T2DM, compared to only 30% in T1DM.
  • 10.
  • 11.
  • 12. RESULTS • Most patients from the T2DM group were diagnosed by routine fasting plasma glucose measurement (65.0%) AND Oral Glucose Tolerance Test (OGTT) (14.1%).
  • 13.
  • 14.
  • 15.
  • 16. DISCUSSIONS • Subjects with T2DM are at increased risk for cardiovascular disorders and often exhibit various cardiovascular risk factors such as abnormal lipid levels, hypertension and obesity. • T2DM is a common disease in the 18-40 years age group. It affects mostly obese and overweight individuals and is very frequently associated with other cardiovascular risk factors, even from the diagnosis. • Cardiovascular risk factors are also present in T1DM