Tuberculosis is caused by bacteria that usually affects the lungs. It spreads through the air when people who have TB cough, sneeze or spit. While it is contagious, it typically requires prolonged exposure to spread. Those with weakened immune systems, like people with HIV/AIDS or undergoing chemotherapy, are more at risk of active TB infection. TB bacteria can spread beyond the lungs to other parts of the body if not treated. Proper treatment can cure TB despite its serious potential effects.