The document discusses transplantation and the immune response. It begins by defining transplantation as moving cells, tissues, or organs from one site to another, either within an individual or between donors and recipients. There are several types of transplantation - autografts within an individual, isografts between identical twins, allografts between non-identical individuals of the same species, and xenografts between different species. Rejection can be acute, occurring within 6 months, or chronic with repeated acute episodes ultimately causing transplant failure. Immunosuppressive drugs are used to reduce rejection by dampening the immune response.
History
Introduction
Classification of grafts
The Immunology of Allogeneic Transplantation
Genetics of graft rejection
Types of rejection
Recognition of Alloantigens
Effector Mechanisms of Allograft Rejection
Prevention of graft rejection
Graft versus host reaction
History
Introduction
Classification of grafts
The Immunology of Allogeneic Transplantation
Genetics of graft rejection
Types of rejection
Recognition of Alloantigens
Effector Mechanisms of Allograft Rejection
Prevention of graft rejection
Graft versus host reaction
T-Cell Activation
• Concept of immune response
• T cell-mediated immune response
• B cell-mediated immune response
I. Concept of immune response
• A collective and coordinated response to the introduction of foreign substances in an individual mediated by the cells and molecules in the immune system.
II. T cell-mediated immune response
• Cell-mediated immunity is the arm of the adaptive immune response whose role is to combat infection of intracellular pathogens, such as intracellular bacteria (mycobacteria, listeria monocytogens), viruses, protozoa, etc.
T-Cell Activation
• Concept of immune response
• T cell-mediated immune response
• B cell-mediated immune response
I. Concept of immune response
• A collective and coordinated response to the introduction of foreign substances in an individual mediated by the cells and molecules in the immune system.
II. T cell-mediated immune response
• Cell-mediated immunity is the arm of the adaptive immune response whose role is to combat infection of intracellular pathogens, such as intracellular bacteria (mycobacteria, listeria monocytogens), viruses, protozoa, etc.
Involves the principles of organ transplantation - basics of immunology and organ donation, preservation and eventual transplantation in the recipient.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
A Strategic Approach: GenAI in EducationPeter Windle
Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
"Protectable subject matters, Protection in biotechnology, Protection of othe...
TRANSPLANTATION IMMUNOLOGY
1. PRESENTED TO :
PROF.(DR.) ASHA KHANNA
DEPARTMENT OF BIO-SCIENCE
PRESENTED BY :
ATUL PATEL
MSc. 2nd SEM MICROBIOLOGY
2. TRANSPLANTATION
Transplantation is the process of moving cells,
tissues, or organs, from one site to another,
either within the same person or between a
donor and a recipient.
If an organ system fails, or becomes damaged
as a consequence of disease or injury, it can
be replaced with a healthy organ or tissue
from a donor.
3. • Alexis Carrel- study of transplantation in 1908; he
interchanged both kidneys in a series of nine cats. cats
maintained urinary output for up to 25 days. Although all
the cats eventually died.
• The first human kidney transplant, attempted
in 1935 by a Russian surgeon, failed because there was a
mismatch of blood types between donor and recipient.
• The first successful human kidney transplant, which was
between identical twins, was accomplished in Boston in
1954.
5. Autograft :-
Transplantation of cells, tissues or organs between sites
within the same individual e.g. skin graft.
Isograft:-
Isograft is tissue transferred between genetically identical
individuals. This occurs in inbred strains of mice or
identical human twins.
Allograft :-
Transplantation of organs or tissues from a donor to a non-
genetically identical individual of the
same species. Allografts are the most common type
of transplant.
6. Xenograft:-
It is the tissue transferred between different species. This
graft is also normally rejected. Pigs’ hearth valve usually
transplanted to humans.
ABO incompatible
ABO refers to blood group, which can vary between
individuals. For most transplant types, matching of blood
group between donor and recipient is a key strategy in
reducing rejection risk.
Stem cell transplant
Stem cells are cells that have the capacity to develop into a
range of different types of cells in the body.
11. Clinical stages of rejection
Hyperacute rejection
This occurs within minutes or hours after a transplantation
and is caused by the presence of pre-existing antibodies of
the recipient, that match the foreign antigens of the donor,
triggering an immune response against the transplant.
Acute rejection
This occurs within the first 6 months after transplantation.
Some degree of acute rejection will occur in all
transplantations, except between identical twins.
Chronic rejection
Repeated episodes of acute rejection can ultimately lead to
chronic rejection of the graft and failure of the transplant.
13. Factors favoring allograft
survival(Rejection
Prevention)
HLA typing of potential donors
and a recipient can be
accomplished with a
microcytotoxicity test. In this
test, white blood cells from
the potential donors and
recipient are distributed into a
series of wells on a microtiter
plate, and then antibodies
specific for various class I and
class II MHC alleles are added
to different wells. After
incubation, complement is
added to the wells, and
cytotoxicity is assessed by the
uptake or exclusion of various
dyes (e.g., trypan blue or
eosin Y) by the cells.
Reference :kuby immunology
14. Finding an eligible donor-recipient match:-
Rejection can be minimized by carefully matching the
donor and recipient for compatibility prior to
transplantation.
Compatibility between donor and recipient is assessed
using a combination of tests, including:
• ABO blood group compatibility
• Tissue typing
• Cross matching
• Panel reactive antibody test
• Serology screening
15. General Immunosuppressive
Therapy
To reduce the risk of transplant rejection, patients are treated
with immunosuppressive drugs that will dampen their immune
response.
• Mitotic Inhibitors Thwart T-Cell Proliferation –
Azathioprine (Imuran), a potent mitotic inhibitor, is often
given just before and after transplantation to diminish T-cell
proliferation in response to the alloantigen's of the graft.
• Corticosteroids Suppress Inflammation
corticosteroids, such as prednisone and dexamethasone, are
potent anti-inflammatory agents. It prevent acute episodes of
graft rejection.
• Certain Fungal Metabolites Are Immunosuppressant
Cyclosporin A (CsA), FK506 (tacrolimus), and rapamycin
(sirolimus) are fungal metabolites with immunosuppressive
properties.
16. Clinical Transplantation
Since the first kidney transplant was performed in the 1950s,
approximately 400,000 kidneys have been transplanted worldwide.
The next most frequently transplanted solid organ is the liver
(52,000), followed by the heart (42,000) and, more distantly, by the
lung (6,000) and pancreas (2,000). Bone-marrow transplants
number around 80,000.
The frequency with which a given organ or
tissue is transplanted depends on a number of factors:
• Clinical situations in which transplantation is indicated.
• Availability of tissue or organs.
• Difficulty in performing transplantation and caring for
post-transplantation patients.
• Specific factors that aid or hinder acceptance of the
particular transplant.