“HEAT”
Heat is a form of energy that flows from warmer bodies to colder bodies.
It is viewed as a form of energy that is transferred from one body to another due to a difference in temperature.
The SI unit of heat is joule (J).
Common unit of heat is calorie.
CALORIE the amount of heat needed to change the temperature of one gram of water from the pressure of the atmosphere.
TEMPERATURE
LAYMAN’S TERM
- It is the degree of hotness or coldness of an object.
Molecular level
- A measure of the average kinetic energy of these molecules.
Based from our sensory experiences:
“Can we use our senses to determine temperature?”
THERMOMETER
TYPES OF THERMOMETER
The most common type of the thermometer.
THERMOCOUPLE
-two different metals (usually copper and iron) that are twisted together
INFRARED THERMOGRAMS
-a device (camera) that measures the amount of radiant energy given off by an object
TEMPERATURE SCALES
TEMPERATURE SCALES
“HEAT”
Heat is a form of energy that flows from warmer bodies to colder bodies.
It is viewed as a form of energy that is transferred from one body to another due to a difference in temperature.
The SI unit of heat is joule (J).
Common unit of heat is calorie.
CALORIE the amount of heat needed to change the temperature of one gram of water from the pressure of the atmosphere.
TEMPERATURE
LAYMAN’S TERM
- It is the degree of hotness or coldness of an object.
Molecular level
- A measure of the average kinetic energy of these molecules.
Based from our sensory experiences:
“Can we use our senses to determine temperature?”
THERMOMETER
TYPES OF THERMOMETER
The most common type of the thermometer.
THERMOCOUPLE
-two different metals (usually copper and iron) that are twisted together
INFRARED THERMOGRAMS
-a device (camera) that measures the amount of radiant energy given off by an object
TEMPERATURE SCALES
TEMPERATURE SCALES
This PowerPoint is one small part of the Astronomy Topics unit from www.sciencepowerpoint.com. This unit consists of a five part 3000+ slide PowerPoint roadmap, 12 page bundled homework package, modified homework, detailed answer keys, 8 pages of unit notes for students who may require assistance, follow along worksheets, and many review games. The homework and lesson notes chronologically follow the PowerPoint slideshow. The answer keys and unit notes are great for support professionals. The activities and discussion questions in the slideshow and meaningful. The PowerPoint includes built-in instructions, visuals, and follow up questions. Also included are critical class notes (color coded red), project ideas, video links, and review games. This unit also includes four PowerPoint review games (110+ slides each with Answers), 38+ video links, lab handouts, activity sheets, rubrics, materials list, templates, guides, and much more. Also included is a 190 slide first day of school PowerPoint presentation. Teaching Duration = 5+ weeks. Areas of Focus in the Astronomy Topics Unit: The Solar System and the Sun, Order of the Planets, Our Sun, Life Cycle of a Star, Size of Stars, Solar Eclipse, Lunar Eclipse, The Inner Planets, Mercury, Venus, Earth, Moon, Craters, Tides, Phases of the Moon, Mars and Moons, Rocketry, Asteroid Belt, NEOs, The Torino Scale, The Outer Planets and Gas Giants, Jupiter / Moons, Saturn / Moons, Uranus / Moons, Neptune / Moons, Pluto's Demotion, The Kuiper Belt, Oort Cloud, Comets / Other, Beyond the Solar System, Types of Galaxies, Blackholes, Extrasolar Planets, The Big Bang, Dark Matter, Dark Energy, The Special Theory of Relativity, Hubble Space Telescope, Constellations, Spacetime and much more. If you have any questions please feel free to contact me. Thanks again and best wishes. Sincerely, Ryan Murphy M.Ed www.sciencepowerpoint@gmail.com
Energy is the ability to do work.
Everything that happens in the world uses energy!
Most of the time we can’t see energy, but it is
everywhere around us!
Waves (Grade 7, Quarter 3) Suggested Guide for DiscussionRachel Espino
A suggested powerpoint presentation guide for discussion for Gr.7 teachers on the characteristics and categories of waves. It also includes a simple quiz (under knowledge category) as an assessment
This PowerPoint is one small part of the Astronomy Topics unit from www.sciencepowerpoint.com. This unit consists of a five part 3000+ slide PowerPoint roadmap, 12 page bundled homework package, modified homework, detailed answer keys, 8 pages of unit notes for students who may require assistance, follow along worksheets, and many review games. The homework and lesson notes chronologically follow the PowerPoint slideshow. The answer keys and unit notes are great for support professionals. The activities and discussion questions in the slideshow and meaningful. The PowerPoint includes built-in instructions, visuals, and follow up questions. Also included are critical class notes (color coded red), project ideas, video links, and review games. This unit also includes four PowerPoint review games (110+ slides each with Answers), 38+ video links, lab handouts, activity sheets, rubrics, materials list, templates, guides, and much more. Also included is a 190 slide first day of school PowerPoint presentation. Teaching Duration = 5+ weeks. Areas of Focus in the Astronomy Topics Unit: The Solar System and the Sun, Order of the Planets, Our Sun, Life Cycle of a Star, Size of Stars, Solar Eclipse, Lunar Eclipse, The Inner Planets, Mercury, Venus, Earth, Moon, Craters, Tides, Phases of the Moon, Mars and Moons, Rocketry, Asteroid Belt, NEOs, The Torino Scale, The Outer Planets and Gas Giants, Jupiter / Moons, Saturn / Moons, Uranus / Moons, Neptune / Moons, Pluto's Demotion, The Kuiper Belt, Oort Cloud, Comets / Other, Beyond the Solar System, Types of Galaxies, Blackholes, Extrasolar Planets, The Big Bang, Dark Matter, Dark Energy, The Special Theory of Relativity, Hubble Space Telescope, Constellations, Spacetime and much more. If you have any questions please feel free to contact me. Thanks again and best wishes. Sincerely, Ryan Murphy M.Ed www.sciencepowerpoint@gmail.com
Energy is the ability to do work.
Everything that happens in the world uses energy!
Most of the time we can’t see energy, but it is
everywhere around us!
Waves (Grade 7, Quarter 3) Suggested Guide for DiscussionRachel Espino
A suggested powerpoint presentation guide for discussion for Gr.7 teachers on the characteristics and categories of waves. It also includes a simple quiz (under knowledge category) as an assessment
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Transfer of heat: Conduction & Convection - Class 7
1. TRANSFER OF HEAT: CONDUCTION &
CONVECTION
Suman Kumar Krishna
Integrated B.Sc. B.Ed. (Medical)
2. • Heat flows from a body at a higher temperature to
a body at a lower temperature. This is called
transfer of heat. Heat is transferred in three
different ways.
They are :-
i) Conduction
ii) Convection
iii) Radiation
TRANSFER OF HEAT
3. Conduction
• Conduction is the transfer of heat from a
hotter part to a colder part of an object due
to the collision of its particles without actual
movement of the particles from their
position.
4. CONDUCTORS AND
INSULATORS
• Conductors :- Conductors are
materials which allow heat to
pass through them easily. E.g. :-
iron, aluminum, copper etc.
• Insulators :- Insulators are
materials which do not allow
heat to pass through them
easily. E.g. :- wood, plastic,
glass, rubber, air, water etc.
5. Just think: Will heat be transferred if temperature
of two objects are the same.
6. Convection
• The transfer of heat in liquids and gases is called Convection.
• The molecules of the liquid or gases that are near the source of the heat get
heated first. They become lighter due to the heat and move upwards.
• The colder particles being heavier take the place and this process continues
until the whole liquid or the gas gets heated.
• That is why the area above the flame of a candle always feels hot but the
area on the sides of the candle does not.
7. • Air is a very poor conductor of
heat, Air transfers heat from its
hotter parts to the colder parts
by the process of convection.
Convection in Air
8. • Water is a poor conductor of
heat. So, due to this reason, it
cannot transfer heat by
conduction but it transfers heat
by the process of convection.
Convection in Water
9. • What would happen if there is no
conduction of heat?
• What would happen if all object
around us become good conductor of
heat?
• What things that you see in your
surrounding which is related to
convection of heat?
10. Choose the Correct Option:
• Transfer of heat happens: -
a. hot to cold
b. cold to hot
c. hot to hot
d. cold to cold
11. State True or False:
• The materials which allow heat to pass through them
easily are conductors of heat. [True/ False].
• The water and air are poor conductors of heat.
[True/ False].
12. So, today we have learnt about ‘Transfer of heat: Conduction
& Convection’ and now let’s summarize today’s class:
Define the term Conduction of heat and Convection of
heat.
Tell one example of conduction of heat and one of
convection of heat.
Name two types of heat transfer.
State a difference between conductor of heat and
insulator of heat.
13. Homework
Take a sheet of paper. Draw a spiral on it
as shown in the Fig. Cut out the paper
along the line. Suspend the paper as
shown in Fig. 4.14 above a lighted
candle. Observe what happens. Think of
an explanation