Tranquilizers act on the central nervous system and are used to treat mental illnesses involving psychosis or behavioral disorders. They reduce anxiety, fear, tension and agitation. Tranquilizers are classified as either minor tranquilizers, also called anxiolytics, or major tranquilizers, also known as antipsychotics. Major tranquilizers are further divided into first generation and second generation drugs from different classes such as phenothiazines, butyrophenones, thioxanthenes and others.

1. TRANQUILLIZERS
NIDHI SHARMA

2. INTRODUCTION-
• It act on CNS.
• Sometimes they make people and animal sleepy.
• These drugs are depressants because they suppress the CNS & slow
the body down.
• They are used to treat mental illness that are characteristic of the
psychosis which is a behavioural disorder.
• These are the drug that reduce- Anxiety, Fear, Tension, Agitation,
Related state of Mental Disturbances

3. Contt….
• Tranquilizer term, was brought into existence by F.F. Yonkman
(1953), from the conclusions of investigative studies using the
drug Reserpine, showed the drug had a calming effect on all animals it
was administered to.
• Reserpine, is a Centrally Acting Rauwolfia Alkaloid.The word directly
refers to the state of tranquility in a person and other animals.
• The term is thought to belong to a lexicon of words thought popular or
so-called common, and so is therefore accordingly thought as not
generally in use within the field of medicine, specifically in reference
to the group of medications known as anti-psychotic or neuroleptics.
They are of Two types-
1. Minor Tranquillizers- usually refer to Anxiolytics.
2. Major Tranquillizers- refers to as Antipsychotics

4. CLASSIFICATION-
• FIRST GENERATION-
1. Phenothiazine derivatives-
a) Triflupromazine
b) Thioridazine
c) Mesoridazine
d) Chlorpromazine HCl
Chlorpromazine Triflupromazine

5. Thioridazine a) Mesoridazine
2. Butyrophenones-
a) Haloperidol
b) Droperidol
c) Resoperidone
Haloperidol Droperidol

6. Resoperidone
3. Thioxanthenes-
a) Flupenthixol
b) Clopenthixol
c) Zuclopenthixol
Clopenthixol
Zuclopenthixol

7. SECOND GENERATION-
a) Zotepine
b) Risperidone
c) Clozapine
d) Olanzapine
Zotepine Risperidone
Clozapine
Olanzapine

8. THANK YOU