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hallucinogens
1
College of Pharmaceutical Sciences
2
• These are also called as Psychotomimeties, Psychedelics,
Psychodysleptics, Psychotogens
• These are drugs which alter mood, behaviour, thought and perception
in a manner similar to that seen in psychosis.
• The important ones are :
• INDOLE AMINES --- Eg: Lysergic acid diethylamide (LSD)
Lysergic acid amide
Psifocybin
Harmine
• PHENYLALKYLAMINES ---- Eg: Mescafine
Ecstasy
• ARYLCYCLOHEXYL AMINES ------ Eg: Phencyclidine .
• CANNABINOID -------------------- Eg: Tetrahydrocannabinol
1. Lysergic acid diethylamide (LSD):
• It is Synthesized by Hofmann who was working on chemistry of ergot
alkaloids, and himself experienced its hallucinogenic effect.
• It is the most potent psychedelic, 25-50 pg produces all the effects.
• In addition to the mental effects, it produces pronounced central
sympathetic stimulation.
• Its action appears to involve serotonergic neuronal systems in brain.
College of Pharmaceutical Sciences
3
Ecstasy
• Methylene dioxy methamphetamine (MDMA) is an amphetamine-like
synthetic compound with stimulant and hallucinogenic propertres,
that has been abused as a recreational and euphoriant drug.
• Other synthetic phenylalkylamines with hallucinogenic property are-
• Dimethoxymethyl amphetamine (DOM) and
• Methylene dioxyamphetamine (MDA) .
• High doses and repeated use of amphetamine can also cause
psychosis
College of Pharmaceutical Sciences
4
College of Pharmaceutical Sciences
5

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Hallucinogens.ppt

  • 2. College of Pharmaceutical Sciences 2 • These are also called as Psychotomimeties, Psychedelics, Psychodysleptics, Psychotogens • These are drugs which alter mood, behaviour, thought and perception in a manner similar to that seen in psychosis. • The important ones are : • INDOLE AMINES --- Eg: Lysergic acid diethylamide (LSD) Lysergic acid amide Psifocybin Harmine • PHENYLALKYLAMINES ---- Eg: Mescafine Ecstasy • ARYLCYCLOHEXYL AMINES ------ Eg: Phencyclidine . • CANNABINOID -------------------- Eg: Tetrahydrocannabinol
  • 3. 1. Lysergic acid diethylamide (LSD): • It is Synthesized by Hofmann who was working on chemistry of ergot alkaloids, and himself experienced its hallucinogenic effect. • It is the most potent psychedelic, 25-50 pg produces all the effects. • In addition to the mental effects, it produces pronounced central sympathetic stimulation. • Its action appears to involve serotonergic neuronal systems in brain. College of Pharmaceutical Sciences 3
  • 4. Ecstasy • Methylene dioxy methamphetamine (MDMA) is an amphetamine-like synthetic compound with stimulant and hallucinogenic propertres, that has been abused as a recreational and euphoriant drug. • Other synthetic phenylalkylamines with hallucinogenic property are- • Dimethoxymethyl amphetamine (DOM) and • Methylene dioxyamphetamine (MDA) . • High doses and repeated use of amphetamine can also cause psychosis College of Pharmaceutical Sciences 4