International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Analysis of Transport Properties and Acoustical Parameters of Sulphanilamide ...IOSR Journals
Sulphanilamide is the parent compound of all the sulpha-durgs which is important in urinary tract infections and meningococcal meningitis profilaxes. Ultrasonic velocity measurements are highly sensitive to molecular interactions and used to provide qualitative informations about the physical nature and strength of the molecular ∕inter-ionic interactions. In the present work, non-aqueous solutions of Sulphanilamide have been prepared with different concentrations and the experiments were carried out from a low temperature of 50c to a high temperature of 550c. The ultrasonic velocity data combined with density and viscosity provides the standard means for determining the internal pressure, free volume and acoustical parameters. The various interactions occurring in the solutions are interpreted interms of ion-ion and ion-solvent interactions. An attempt is made to identify the entry of solvate into the samples and the entry of drug molecules into the solvate which supports to identify the molecular structure.
ER Publication,
IJETR, IJMCTR,
Journals,
International Journals,
High Impact Journals,
Monthly Journal,
Good quality Journals,
Research,
Research Papers,
Research Article,
Free Journals, Open access Journals,
erpublication.org,
Engineering Journal,
Science Journals,
International Journal of Pharmaceutical Science Invention (IJPSI) is an international journal intended for professionals and researchers in all fields of Pahrmaceutical Science. IJPSI publishes research articles and reviews within the whole field Pharmacy and Pharmaceutical Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Analysis of Transport Properties and Acoustical Parameters of Sulphanilamide ...IOSR Journals
Sulphanilamide is the parent compound of all the sulpha-durgs which is important in urinary tract infections and meningococcal meningitis profilaxes. Ultrasonic velocity measurements are highly sensitive to molecular interactions and used to provide qualitative informations about the physical nature and strength of the molecular ∕inter-ionic interactions. In the present work, non-aqueous solutions of Sulphanilamide have been prepared with different concentrations and the experiments were carried out from a low temperature of 50c to a high temperature of 550c. The ultrasonic velocity data combined with density and viscosity provides the standard means for determining the internal pressure, free volume and acoustical parameters. The various interactions occurring in the solutions are interpreted interms of ion-ion and ion-solvent interactions. An attempt is made to identify the entry of solvate into the samples and the entry of drug molecules into the solvate which supports to identify the molecular structure.
ER Publication,
IJETR, IJMCTR,
Journals,
International Journals,
High Impact Journals,
Monthly Journal,
Good quality Journals,
Research,
Research Papers,
Research Article,
Free Journals, Open access Journals,
erpublication.org,
Engineering Journal,
Science Journals,
Spectrophotometric Determination of Cardiovascular DrugsIJMER
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Introduction
Effect of bonding on solubility
Importance of Solubility
Types of Solutions
Factor affecting Solubility
Phase Solubility Analysis
Need for solubility enhancement
Technique for solubility enhancement
Reference
Phase is a form of matter that is uniform with respect to chemical composition and the state of aggregation on both microscopic and macroscopic length scales.
Determination of Hess’s Law (Direct or Indirect)
Oxidative Coupling: A Tranquil Approach for Determination of Selexipag by Vis...Ratnakaram Venkata Nadh
The present study is a first report on development of a spectrophotometric method for determination of selexipag (used to cure pulmonary arterial hypertension) in bulk and tablet formulation and its validation. The basis of the proposed method is formation of a chromophore (of λ max 600 nm) in presence of acidic ferric chloride by oxidative coupling reaction between selexipag and MBTH (3-methylbenzo-thiazolin-2-one hydrazone) solution. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (5 – 30 μg mL-1). As per the existing guidelines of ICH, various parameters of the method were tested for validation. Low values of R.S.D. (< 2%) were observed indicating that the proposed method is reproducible, accurate and precise
What is colligative property?
Types of colligative property
Lowering Vapour Pressure (∆P) of solutions.
Boiling point elevation.
Freezing point depression
Osmotic pressure of the solution
Colligative properties of dilute solution is important topic of physical chemistry. mainly cover types with application of it day to day life... must to watch and share
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Viscosities and deviations in viscosity for binary mixtures of tetrahydrofura...eSAT Journals
Abstract
The viscosities, η of pure tetrahydrofuran, propanol-1 and butanol-1and some of their binary mixtures covering the whole
composition range have been measured at temperatures 303.15 K. From the experimental η, the deviations in viscosity (Δη) have
been calculated. Excess free energy for viscous flow, ΔG#E has also been evaluated. The concentration dependences of η were
correlated to polynomial expressions, whereas, Δη and ΔG#E were fitted to the Redlich–Kister equation. For all systems, Δη were
found to be negative in the whole range of composition with a single lobe.
Keywords: Viscosity, Tetrahydrofuran, Propanol-1, Butanol-1.
Behavioral and Biochemical Studies of Piperidine Related Adrenolytic Compound...IJRESJOURNAL
ABSTRACT: The present study concerns behavioral and biochemical effects of 4 amino methyl piperidine substituted 2-bromo ethyl benzene derivative compounds. With intraperitoneal injection in rats, locomotor activity was significantly decreased in open field experiment, anxiolytic effect observed in light and dark apparatus significantly increased while stimulatory activity of compound monitor in home cage apparatussignificantly decreased. Moreover, blood glucose and cholesterol level also examined. Presentsynthetic compound decreases blood glucose level and also decreases the total serum cholesterol, suggested that these 4 amino methyl piperidine substituted 2-bromo ethyl benzene compounds may be effective as a drug for treatment of anxiety, enhancement of locomotion. It is also beneficial for cardiac and diabetic patient.
Spectrophotometric Determination of Cardiovascular DrugsIJMER
International Journal of Modern Engineering Research (IJMER) is Peer reviewed, online Journal. It serves as an international archival forum of scholarly research related to engineering and science education.
Synthesis, characterization and antimicrobial evaluation of novel diethyl (2-...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
Introduction
Effect of bonding on solubility
Importance of Solubility
Types of Solutions
Factor affecting Solubility
Phase Solubility Analysis
Need for solubility enhancement
Technique for solubility enhancement
Reference
Phase is a form of matter that is uniform with respect to chemical composition and the state of aggregation on both microscopic and macroscopic length scales.
Determination of Hess’s Law (Direct or Indirect)
Oxidative Coupling: A Tranquil Approach for Determination of Selexipag by Vis...Ratnakaram Venkata Nadh
The present study is a first report on development of a spectrophotometric method for determination of selexipag (used to cure pulmonary arterial hypertension) in bulk and tablet formulation and its validation. The basis of the proposed method is formation of a chromophore (of λ max 600 nm) in presence of acidic ferric chloride by oxidative coupling reaction between selexipag and MBTH (3-methylbenzo-thiazolin-2-one hydrazone) solution. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (5 – 30 μg mL-1). As per the existing guidelines of ICH, various parameters of the method were tested for validation. Low values of R.S.D. (< 2%) were observed indicating that the proposed method is reproducible, accurate and precise
What is colligative property?
Types of colligative property
Lowering Vapour Pressure (∆P) of solutions.
Boiling point elevation.
Freezing point depression
Osmotic pressure of the solution
Colligative properties of dilute solution is important topic of physical chemistry. mainly cover types with application of it day to day life... must to watch and share
I hope You all like it. I hope It is very beneficial for you all. I really thought that you all get enough knowledge from this presentation. This presentation is about materials and their classifications. After you read this presentation you knowledge is not as before.
Viscosities and deviations in viscosity for binary mixtures of tetrahydrofura...eSAT Journals
Abstract
The viscosities, η of pure tetrahydrofuran, propanol-1 and butanol-1and some of their binary mixtures covering the whole
composition range have been measured at temperatures 303.15 K. From the experimental η, the deviations in viscosity (Δη) have
been calculated. Excess free energy for viscous flow, ΔG#E has also been evaluated. The concentration dependences of η were
correlated to polynomial expressions, whereas, Δη and ΔG#E were fitted to the Redlich–Kister equation. For all systems, Δη were
found to be negative in the whole range of composition with a single lobe.
Keywords: Viscosity, Tetrahydrofuran, Propanol-1, Butanol-1.
Behavioral and Biochemical Studies of Piperidine Related Adrenolytic Compound...IJRESJOURNAL
ABSTRACT: The present study concerns behavioral and biochemical effects of 4 amino methyl piperidine substituted 2-bromo ethyl benzene derivative compounds. With intraperitoneal injection in rats, locomotor activity was significantly decreased in open field experiment, anxiolytic effect observed in light and dark apparatus significantly increased while stimulatory activity of compound monitor in home cage apparatussignificantly decreased. Moreover, blood glucose and cholesterol level also examined. Presentsynthetic compound decreases blood glucose level and also decreases the total serum cholesterol, suggested that these 4 amino methyl piperidine substituted 2-bromo ethyl benzene compounds may be effective as a drug for treatment of anxiety, enhancement of locomotion. It is also beneficial for cardiac and diabetic patient.
Extractive Spectrophotometric Determination of Ulipristal Acetate using Napht...Ratnakaram Venkata Nadh
Ulipristal acetate is used to treat uterine fibroids and for emergency birth control. The present study is a first report on development of a visible spectrophotometric method for determination of Ulipristal acetate present in bulk and tablet formulation. The method involves the sequential addition of HCl (0.1 N) and Napthol Blue Black solution to Ulipristal acetate. Cation formed on tertiary amine group of Ulipristal acetate attracts anion of naphthol blue black (an acid dye) to develop a coloured ion-association complex. From the aqueous phase, the chromophore is extractable into chloroform, which exhibits λmax at 640 nm. As per the existing guidelines of ICH, various parameters of the method were tested for validation. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (2.50 – 15.00 μg mL-1). The % recovery values falls in 99.80 – 100.72 range. %RSD results of both precision studies were observed in the range 0.007 – 0.560, indicating the satisfactory precision of the method. Low values of R.S.D. (< 1 %) were observed indicating that the proposed method is reproducible, accurate and precise. The proposed method can be used in quality control laboratories for routine analysis of Ulipristal acetate (bulk drug and pharmaceutical dosage forms) without requirement of expensive instruments.
Extractive Spectrophotometric Determination of Ulipristal Acetate using Napht...Ratnakaram Venkata Nadh
Ulipristal acetate is used to treat uterine fibroids and for emergency birth control. The present study is a first report on development of a visible spectrophotometric method for determination of Ulipristal acetate present in bulk and tablet formulation. The method involves the sequential addition of HCl (0.1 N) and Napthol Blue Black solution to Ulipristal acetate. Cation formed on tertiary amine group of Ulipristal acetate attracts anion of naphthol blue black (an acid dye) to develop a coloured ion-association complex. From the aqueous phase, the chromophore is extractable into chloroform, which exhibits λmax at 640 nm. As per the existing guidelines of ICH, various parameters of the method were tested for validation. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (2.50 – 15.00 μg mL-1). The % recovery values falls in 99.80 – 100.72 range. %RSD results of both precision studies were observed in the range 0.007 – 0.560, indicating the satisfactory precision of the method. Low values of R.S.D. (< 1 %) were observed indicating that the proposed method is reproducible, accurate and precise. The proposed method can be used in quality control laboratories for routine analysis of Ulipristal acetate (bulk drug and pharmaceutical dosage forms) without requirement of expensive instruments.
Preparation, In Vitro and In Vivo Characterization of Solid Dispersions of La...iosrphr_editor
The IOSR Journal of Pharmacy (IOSRPHR) is an open access online & offline peer reviewed international journal, which publishes innovative research papers, reviews, mini-reviews, short communications and notes dealing with Pharmaceutical Sciences( Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy & Phytochemistry, Pharmacology, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest........more details on Aim & Scope).
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD TO SEPARATE...MeherAlam2
Slide share on DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD TO SEPARATE LOW LEVELS OF ATOLTIVIMAB, MAFTIVIMAB & ODESIVIMAB AND OTHER RELATED COMPOUNDS
~ Meher Unissa
Oxidative Coupling: A Tranquil Approach for Determination of Selexipag by Vis...Ratnakaram Venkata Nadh
The present study is a first report on development of a spectrophotometric method for determination of selexipag (used to cure pulmonary arterial hypertension) in bulk and tablet formulation and its validation. The basis of the proposed method is formation of a chromophore (of λ max 600 nm) in presence of acidic ferric chloride by oxidative coupling reaction between selexipag and MBTH (3-methylbenzo-thiazolin-2-one hydrazone) solution. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (5 – 30 μg mL-1). As per the existing guidelines of ICH, various parameters of the method were tested for validation. Low values of R.S.D. (< 2%) were observed indicating that the proposed method is reproducible, accurate and precise.
Formulation and In-Vitro Evaluation of Fluconazole Loaded Microsponge Gel For...iosrjce
IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of Pharmacy and Biological Science. The journal welcomes publications of high quality papers on theoretical developments and practical applications in Pharmacy and Biological Science. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
Synthesis of Novel Piperidine Compounds As Anticholinesterase Agentsinventionjournals
Donepezil is a piperidine based agent that is used for treatment of Alzheimer’s diseases. This agent acts as acetylcholine esterase inhibitor and therefore, synthesis of piperidine compounds to evaluate anticholinesterase activity is very popular field in medicinal chemistry. Thus, in this study some novel piperidine derivatives were synthesized in order to observe their probable anticholinesterase effects. Structures of obtained compounds were confirmed by IR, NMR and Mass spectroscopic methods. Anticholinesterase activity of the synthesized compounds were tested by using Ellman’s method. Some of the compounds in the series indicated good enzyme inhibitory activity
Synthesis and Pharmacological evaluation of new Benzoxozole DerivativesSriramNagarajan15
Benzoxazoles1 are usually prepared by heating 2-Aminophenol with formic acids in the presence of Boric acid under reflux. Condensation of these two substances under milder conditions. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. It is found within the chemical structures of pharmaceutical drugs such as flunoxaprofen. Benzoxazole derivatives are provided a protection against noxious UV radiation.Benzoxazole derivatives are also used in cosmotic compositions, such as for examples mainly cinnamic acid, 4-aminobenzoic acid.Benzoxazole derivatives are also used in the optical brighteners.These derivatives are used as Anticonvulsant and Neurotoxicity2 , Anti-inflammatory agents3, “Antibacterial activity”4, Cholesteryl ester transfer Protein inhibitors5, Antimicrobial activity6,7, Antifungal activity’8, Cyclooxygenase inhibitors9, hair treatment products and also used as a skin protectants.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
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2. Methods and Materials Topical Administration Drugs were applied topically and analgesia was assessed as previously described (Kolesnikov et al., 2000; Kolesnikov et al., 2004). Briefly, the distal portion of the tail (2-3cm) was immersed in propylene glycol/dH 2 O(9:1 ratio) alone or propylene glycol (PG) and a lauric acid (LA) combination (9:1) solution containing the indicated drugs for the stated time, usually 2 min. In our initial studies we have demonstrated that propylene glycol alone has no significant analgesic effect when tested in this manner in the radiant heat tail-flick assay. Furthermore, the addition of lauric acid provides an effective way of solubilizing a wide range of drugs and significantly facilita ting their penetration into the skin . . Radiant Heat Tail-Flick Test Testing was performed on the portion of the tail immersed in the treatment solution, since the analgesic actions of agents administered in this manner are restricted to the exposed part of the tail ( proximal regions are not affected) (Kolesnikov et al., 2000). Analgesia was defined quantally as the tail-flick latency for an individual animal that was twice its baseline latency or greater using tailflick apparatus (Ugo Basile, Italy) . This assay is especially useful in examining topical analgesics, since thermal stimulus usually applies to the superficial surface of the skin, and the thermal energy absorbed in the skin is concentrated in the dermal/epidermal junction where nerve terminals are located. Baseline latencies typically ranged from 2.5 to 3.5 s, with a maximum cutoff latency of 10 s to minimize tissue damage in analgesic animals. Since analgesia was assessed quantally, group comparisons were performed with the Fisher`s exact test (Kolesnikov et al. 1999). ED 50 values were determined with GraphPad Software. Potential interactions between opioids, ibuprophen and diclofenac were assessed using a fixed, low dose of each drug. Groups comparisons were performed with the Fisher`s test.
8. Table 1 Addition of lauric acid to propylene glycol enhances the potency of topical drugs in radiant heat tail flick assay Octanol water partition coefficients (OWPC) were derived from Goodman&Gilman. The pharmacological basis of therapeutics. Eleven Edition. 2006 Groups of mice (n ≥ 10) received topical opioids and NSAIDs dissolved either in propylene glycol (PG) alone or in combination with lauric acid(LA) and analgesia was assessed in the tail-flick assay, as described under Methods. At least three doses of the drugs were used to calculate the ED 50 value with 95% CL. Drugs OWPC PG alone PG+LA Shift P value Lidocaine 2.6 2.4 (1.6-3.2)mM 0.35 (0.2-0.42) mM 6.8 <0.0001 Morphine 6.0 7.6 (4.2-10.9)mM 0.40 (0.33-0.54)mM 19 <0.00001 Methadone 117 6.7(4.8-8.8)mM 1.0 (0.8-1.2) mM 6.7 <0.001 Hydrocodone 816 1.6 (1.1-2.2) mM 1.2 (0.8-1.8) mM 1.3 >0.05 S-ibuprophen 12 9.3 (6.1-16.5) mM 2.1 (0.88-3.3) mM 4.4 <0.001 Diclofenac 13.4 3.3 (1.7-5.3) mM 1.1 (0.6-1.78) mM 3.0 < 0.02
9. We next plan is to set the translational study up. Pilot clinical studies have shown, that some opioid /NSAIDs formulations produse analgesia for peripheral neuropathic pain syndrome. The targeted patient population is: Patients with peripheral neuropathic pain syndrome -painful diabetic neuropathie -postherpatic pain syndrome -chronic postsurgical pain -chemotherapie induced neuropathic pain Pilot clinical studies have shown
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