1.Stereotactic Radiosurgery (SRS)
SRS is a precise and focused delivery of a single, high dose of irradiation to a small and critically located intracranial volume while sparing normal structure
2.Stereotactic Body Radiation Therapy (SBRT)
SBRT is a treatment procedure similar to SRS, except that it deals extra-cranial radiosurgery
3.Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
1.Stereotactic Radiosurgery (SRS)
SRS is a precise and focused delivery of a single, high dose of irradiation to a small and critically located intracranial volume while sparing normal structure
2.Stereotactic Body Radiation Therapy (SBRT)
SBRT is a treatment procedure similar to SRS, except that it deals extra-cranial radiosurgery
3.Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
Flattening Filter Free (FFF) mode
FFF beam is produced without the use of flattening Filter
In the 1990s, several groups studied about FFF high-energy photon beams. The main interest for that, is to increase the dose rate for radiosurgery or the "physics interest”.
Need of increase in dose rate from traditional 300-600 to 1400-2400MU/min to overcome time-inefficiency and to improve patients comfort specially in SRS/SBRT
A summary of recent innovations in radiation oncology focussing on the priniciples of different techniques and their application. An overview of clinical results has also been given
Conventional radiotherapy treatments are delivered with radiation beams that are of uniform intensity across the field (within the flatness specification limits). Wedges or compensators are used to modify the intensity profile to offset contour in irregularities and produce more uniform composite dose distributions such as in techniques using wedges. This process of changing beam intensity profile to meet the goals of a composite plan is called intensity modulation
IMRT refers to a radiation therapy technique in which nonuniform fluence is delivered to the patient from any given position of the treatment beam to optimize the composite dose distribution. The optimal fluence profiles for a given set of beam directions are determined through inverse planning. The fluence files thus generated are electronically transmitted to the linear accelerator, which is computer controlled, to deliver intensity modulated beams (IMBs) as calculated.
The vmat vs other recent radiotherapy techniquesM'dee Phechudi
VMAT is a new type of intensity-modulated radiation therapy (IMRT) treatment technique that uses the same hardware (i.e. a digital linear accelerator) as used for IMRT or conformal treatment, but delivers the radiotherapy treatment using a rotational or arc geometry rather than several static beams.
This technique uses continuous modulation (i.e. moving the collimator leaves) of the multileaf collimator (MLC) fields, continuous change of the fluence rate (the intensity of the X rays) and gantry rotation speed across a single or multiple 360 degree rotations
This is a made easy summary of ICRU 89 guidelines for gynecological brachytherapy. Extra practical questions for MD/DNB Radiotherapy exams are also attached.
A summary of recent innovations in radiation oncology focussing on the priniciples of different techniques and their application. An overview of clinical results has also been given
Conventional radiotherapy treatments are delivered with radiation beams that are of uniform intensity across the field (within the flatness specification limits). Wedges or compensators are used to modify the intensity profile to offset contour in irregularities and produce more uniform composite dose distributions such as in techniques using wedges. This process of changing beam intensity profile to meet the goals of a composite plan is called intensity modulation
IMRT refers to a radiation therapy technique in which nonuniform fluence is delivered to the patient from any given position of the treatment beam to optimize the composite dose distribution. The optimal fluence profiles for a given set of beam directions are determined through inverse planning. The fluence files thus generated are electronically transmitted to the linear accelerator, which is computer controlled, to deliver intensity modulated beams (IMBs) as calculated.
The vmat vs other recent radiotherapy techniquesM'dee Phechudi
VMAT is a new type of intensity-modulated radiation therapy (IMRT) treatment technique that uses the same hardware (i.e. a digital linear accelerator) as used for IMRT or conformal treatment, but delivers the radiotherapy treatment using a rotational or arc geometry rather than several static beams.
This technique uses continuous modulation (i.e. moving the collimator leaves) of the multileaf collimator (MLC) fields, continuous change of the fluence rate (the intensity of the X rays) and gantry rotation speed across a single or multiple 360 degree rotations
This is a made easy summary of ICRU 89 guidelines for gynecological brachytherapy. Extra practical questions for MD/DNB Radiotherapy exams are also attached.
Comparative dosimetry of forward and inverse treatment planning for Intensity...iosrjce
IOSR Journal of Applied Physics (IOSR-JAP) is a double blind peer reviewed International Journal that provides rapid publication (within a month) of articles in all areas of physics and its applications. The journal welcomes publications of high quality papers on theoretical developments and practical applications in applied physics. Original research papers, state-of-the-art reviews, and high quality technical notes are invited for publications.
CT Dose Issues.pptx on the factors to be considered on radiation protectionsanyengere
summary, mobile radiography allows for the diagnostic imaging of patients who are unable to be seen in the X-ray examination room. Therefore, mobile X-ray equipment is useful for patients who have difficulty with movement. However, staff are exposed to scattered radiation from the patient, and can receive potentially harmful radiation doses during radiography. The protection of staff is of utmost importance; therefore, we investigated the occupational radiation doses received by RTs, particularly eye doses, using phantom measurements. RTs can be located close to a patient (i.e., the source of scattered radiation) during mobile radiography. As eye doses can be significant, protective measures are essential for RTs. Protective aprons are important for protecting RTs, as is increasing the distance from the radiation source (i.e., the patient). Lead glasses may also be necessary for protecting the eyes of RTs. To reduce RT radiation exposure, RTs should remain distant from the patient if possible. However, because this distance may hinder verification of the patient’s condition, RTs sometimes work in close proximity to patients. This is a patient phantom study. In future, the data may need validation by comparison with personal RT dosimeter records. It is important to evaluate the radiation doses delivered to RTs during mobile radiography, as well as the scattered radiation distribution, to ensure adequate protection. Further comparison studies may be needed using the Monte Carlo method.
radiographers and nurses have a responsibility to ensure that no one is within the radiation field during the X-ray exposure of the patient. This is achieved by informing all persons in the immediate area that an X-ray exposure is about to be made and asking them to stand a safe distance from the radiation field area.
Shielding
Placing a barrier of lead or concrete between the radiation source and an individual provides protection from X-radiation (Jones and Taylor, 2006; Ehrlich and Coakes, 2017). During mobile radiography, anyone assisting in an examination and staying in the radiation field should wear a lead-rubber apron or stand behind a mobile lead screen. Generally, walls in special care units where ionising radiation is used are designed to contain the radiation produced by the mobile X-ray tube within a set of criteria and limits determined by relevant legislation (Hart et al, 2002).
Radiation protection during mobile radiography
Nurses' understanding and adherence to radiation protection control measures during mobile radiography is of paramount importance in protecting patients, themselves and members of the public visiting the ward/unit. However, some research studies have found limited awareness and non-adherence to radiation protection control measures among nurses during mobile radiography (Anim-Sampong et al, 2015; Luntsi et al, 2016; Azimi et al, 2018). This can be attributed to a lack of radiation protection awareness programmes for nurses working
The use of high frequency radiation to shrink tumor cells and kill cancer cells is Radiation Oncology. Austin Journal of Radiation Oncology and Cancer is an open access, peer reviewed scholarly journal committed to publication of unique contributions concerned with the cancer and its therapy.
Austin Journal of Radiation Oncology and Cancer accepts original research articles, review articles, case reports, clinical images and rapid communication on all the aspects of radiation therapy and oncology.
The Computed Tomography (CT) dose output of some selected hospitals in the Federal capital Territory, Abuja, Nigeria have been determined by calculating the Effective doses of CT Chest and Abdomen-Pelvis of selected hospitals and compared its average with the Mean Reference Dose of CT Chest and Abdomen-Pelvis from four hospitals in the Federal Capital Territory, Abuja, Nigeria. Effective Dose and Scan type were extracted from the CT Chest and Abdomen-Pelvis examinations recorded. The Effective Dose of each patient undergoing the Chest and Abdomen-Pelvis examinations were calculated using the coefficient factor and the DLP values. Patients’ CT dose data from the ages of 18 to 60years from each of the 4 centres for each study type from January, 2013 to December, 2014 was extracted. A total of 112 patients’ CT dose data was extracted. Chest CT Effective Dose ranged from 9.0 to 34.0mSv, while Abdomen-Pelvis CT Effective Dose ranged from 15.9 to 61.0 for all the Centres in Federal Capital Territory, Abuja. This is higher than the recommended Reference Effective Dose range for CT Chest which is from 5 – 7mSv. and for CT Abdomen-Pelvis is from 8 – 14mSv. The mean effective dose from the Chest CT is 21.8mSv and from the Abdomen-Pelvis is 31.9mSv.
Thesis / Doctoral Project / Dissertation Proposal
Student Information:
Student GUID Number:
833168318
Student Name: (As it appears on your transcript)
Abdullatif Abdullah
Address:
1850 Columbia Pike Apt 406, Arlington, Virginia, 22204
E-Mail Address:
[email protected]
Phone Number:
571-340-6065
Degree:
Masters in Health Physics
Expected Graduation Month/Year
05 / 2022
Dept./Major:
Health Physics
I. Title:
Estimation of Peak Skin Dose and Its Relation to the Size Specific Dose Estimate
II. Problem or Hypothesis:
The CT Dose Index (CTDIvol) was originally designed as an index of dose associated with various CT diagnostic procedures not as a direct dosimetry method for individual patient dose assessments. There is no current method for calculating peak skin dose (PSD) using the key metrics provided from the radiation dose structure report of a CT scanner. Every CT study is required to output the kVp and mAs that were used, the dose length product and CT dose index volume which will all be shown on the CT console, but there is no direct method to go straight to the PSD. This project will test the hypothesis that the SSDE has a sufficiently strong linear relationship with PSD to allow direct calculation of the PSD directly from the SSDE.
III. Review of Related Literature:
The highest radiation dose accruing at a single site on a patient’s skin is referred to as the peak skin dose (PSD) which is related to the Computed Tomography dose index (CTDIvol) that is displayed on the console of CT scanners. However, the CT Dose Index was originally designed as an index not as a direct dosimetry method for patient dose assessment. More recently, modifications to original CTDI concept have attempted to convert it into to patient dosimetry method, but have with mixed results in terms of accuracy. Nonetheless, CTDI-based dosimetry is the current worldwide standard for estimation of patient dose in CT. Therefore, CTDIvol is often used to enable medical physicists to compare the dose output between different CT scanners.
Fearon, Thomas (2011) explained that current estimation of radiation dose from CT scans on patients has relied on the measurement of Computed Tomography Dose Index (CTDI) in standard cylindrical phantoms, and calculations based on mathematical representations of “standard man.” The purpose of this study was to investigate the feasibility of adapting a radiation treatment planning system (RTPS) to provide patient-specific CT dosimetry. A radiation treatment planning system was modified to calculate patient-specific CT dose distributions, which can be represented by dose at specific points within an organ of interest, as well as organ dose-volume (after image segmentation) for a GE Light Speed Ultra Plus CT scanner. Digital representations of the phantoms (virtual phantom) were acquired with the GE CT scanner in axial mode. Thermoluminescent dosimeter (TLDs) measurements in pediatric anthropomorphic phantoms were utilized t ...
Investigations have been done concerning computed tomography (CT) dose output of some selected hospitals in the Federal capital Territory, Abuja, Nigeria by calculating the Effective doses of CT head in some selected hospitals and compare its average with the Mean Reference Dose of CT Head. Data was collected at five hospitals in the Federal Capital Territory, Abuja, Nigeria. The Effective Dose of each of the patients undergoing CT Head examination was calculated using the coefficient factor and the DLP values. Patients’ CT dose data from the ages of 18 to 60years from each of the 5 centres for each study types from January, 2013 to December, 2014 were extracted. A total of 181 patients’ CT dose data was extracted. The effective dose range for CT Head examination in Abuja, Federal Capital Territory is 1.8 to 6.8mSv.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Introduction
VMAT is a type of IMRT technique.
VMAT stands for Volumetric Arc Therapy. VMAT can also be called Rapid
Arc.
VMAT is different to normal IMRT in that the radiotherapy machine
rotates around the patient during a radiotherapy beam in an arc shape.
Why QA is important in Radiotherapy?
To ensure consistency and accuracy in dose delivery as prescribed by
radiation oncologist and to give correct prescribed dose to target volume
and minimum dose to normal tissues, minimum exposure to occupational
workers.
In VMRT there are two types of QA – Machine QA and Patients Specific QA
3. Why patients specific QA is required ?
To identify discrepancies/errors between planned and
delivered doses
To check the accuracy of VMAT plan Dose Calculation
Detect gross errors in the radiation deliver
Ensuring the safety of patient, fidelity of treatment.
4. Different types of Patient Specific QA
1) Portal Imaging
2)Point Dose
3)Film Analysis
In this study Point Dose verification plan calculated
in Treatment Planning System is compared with
Measured Dose using Cheese phantom and A1SL
Chamber.
5. Creating Patient Specific Point Dose in
TPS
1) Firstly we choose a point on virtual cheese phantom
which encompasses the PTV , in the Eclipse Software ,
Version 15.1 Varian computer Treatment Planning system.
2)After Choosing the point in such a way that it should be
any slot of virtual cheese phantom where dose distribution
should be uniform and electron density of surrounding
tissues is almost equivalent.
3)Specify the slot on virtual Cheese phantom and then
calculate the dose by Anisotropic Analytical Algorithm(Version
15.1.51) on that slot.
4)Calculated TPS dose will be cGy.
6. Fig: Creation of Point dose on Virtual Cheese Phantom by
TPS using Anisotropic Analytical Algorithm(Version 15.1.51)
7. Measured Dose with Phantom Based
1)Initially set up Cheese Phantom on the couch.
2)Match the laser with Phantom, Centre and then cross check
with cross pairs of field light.
3)Insert the A1SL chamber to specific slot as per the position ,
calculated in the TPS.
5)Measure temperature, pressure at that time.
6)Note down the electrometer reading of the delivery of DQA.
7)Calculate the measured dose using the following Formula.
8)Measured Point Dose = MR(reading)*(N(d, w)*Ktp*Kqq0)
Where N (d, w) =calibration factor in terms of absorbed dose
to water, Ktp =Correction factor of temperature and pressure
Kqq0=chamber specific factor beam quality
8. Left to Right-1.Arrangement of Laser with Phantom ,(2) Chamber inserted in
Slot in Phantom ,(3) Source to Phantom Distance (85cm)
10. Fig: Ionisation Chamber AISL
Cylindrical Ionisation Chamber(A1SL)
It has high stability, linear response to absorbed dose, small directional dependence, beam
quality response independence, and traceability to a primary calibration standard.
It has 0.057cc volume
11. Observation
In this Study Plans done for seven different anatomical /diseases sites of
body for calculation of point dose deviation of Measured dose and TPS
calculated dose
Different Sites and number of patients taken as follows as
1)Lung- 7 (Patients)
2)Brain- 3 (Patients)
3)Prostrate- 5 (Patients)
4)Buccal Mucosa-4 (patients)
5)Tongue- 6 (Patients)
7)Glioblastoma-5(Patients)
8)Astrocytoma-2(Patients)
12. V Fig: Calculation of measured dose of different diagnostics sites (1)Lungs.(2) Brain, (3)
Prostrate
13. Fig: Calculation of measured dose of
different diagnostics sites (5)Tongue ,(6)
Glioblastoma ,(7) Astrocytoma
14. Conclusion
According to AAPM Task Group No. 218 .
All the % deviation of different diagnostics sites is
within 5% of the mean chamber dose .
It has gold standard.
15. If there will be more deviation in Point dose
calculation,Possible error may be happens …
Phantom/device setup
Beam characteristics
MLC
Treatment Planning System (TPS)
16. Future of Work
The strength of point-dose measurements with ICs is that
they can be used to verify the accuracy of the MU
calculations conducted by the TPS because they measure
the absolute dose rather than just the relative dose.
17. Limitation
It is only suitable for point dose Calculation in PTV where dose
distribution should be uniform.
The limitation is that ICs measure the dose at only one point
(actually a small volume-averaged region), and while this
measured dose is compared against the treatment plan, it does
not provide enough information to validate overall plan
accuracy.
Two-dimensional and three-dimensional dose measurement
methods give a more comprehensive picture of plan delivery
than point-dose measurements.
18. References
TG-119 IMRT Commissioning Tests Instructions for Planning, Measurement, and Analysis.
Quantitative analysis of patient-specific dosimetric IMRT verification G J Budgell, B A
Perrin, J H L Mott, J Fairfoul and R I Mackay North Western Medical Physics, Christie
Hospital NHS Trust, Manchester M20 4BX, Uk
Patient specific quality assurance for the delivery of intensity modulated radiotherapy
Nzhde Agazaryan, 1 Timothy D. Solberg, 1 and John J. DeMarco 1
A six-year review of more than 13,000 patient-specific IMRT QA
results from 13 different treatment sites
Kiley B. Pulliam1, David Followill2, Laurence Court2, Lei Dong1,3, Michael Gillin2, Karl
Prado4, and Stephen F. Kry2,a
Stephen F. Kry: sfkry@mdanderson.org
1The University of Texas Graduate School of Biomedical Sciences at Houston, Houston,
TX Department of Radiation Physics, The University of Texas MD Anderson Cancer
Center, Houston, TX 3Department of Radiation Oncology, Scripps Proton Therapy
Center, San Diego, CA
Pre-treatment 3D dose verification for intensity modulated radiotherapy (IMRT)
-Ruurd Visser
Tolerance limits and methodologies for IMRT measurement-based verification
QA: Recommendations of AAPM Task Group No. 218
QA for helical tomotherapy: Report of the AAPM Task Group 148 for cheese phantom.
Patient specific quality assurance for the delivery of intensity modulated radiotherapy
Nzhde Agazaryan,* Timothy D. Solberg,† and John J. DeMarco‡
Department of Radiation Oncology, UCLA School of Medicine, 200 UCLA Medical Plaza,
19. Thank you
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