Thyroid drugs

1. Anti-thyroid drugs
Dr.sunil kumar
Master in Emergency Medicine

2. Objective
Définition
Classification
Mechanism of action
Dose &Therapeutic uses
Side effects
Contraindication

3. Defination
“Anti thyroid drugs are
used to lower the functional capacity of
the hyperactive thyroid gland.”

4. Classification
Drugs that inhibit thyroid
hormone synthesis
(thioamides)
Propylthiouracil Mithimazol Carmimazol

5. Drugs that
Inhibit Iodide
Trapping (Ionic
inhibitors)
Thiocyanate Thiocyanate

6. Drugs that
Inhibit Hormone
Release
Iodides Lithium

8. Drugs that Inhibit
Peripheral
Conversion of T4 to
T3
Amiodarone
β-blockers
Corticosteroids
Propylthiouracil

9. Mechanism of action

10. uses
Non-operative therapy of
hyperthyroidism
Pre-operative therapy of
hyperthyroidism
Thyrotoxic crisis

11. Side effects of antithyroid
drugs
Minor
Skin reactions 4–6% Urticarial or macular reactions
Arthralgias 1–5% May be harbinger of more severe
arthritis
Gastrointestinal effects 1–5% Includes gastric distress and nausea
Abnormal sense of taste
Polyarthritis 1–2% So-called antithyroid arthritis syndrome

12. Major side effects

13. Hyperthyroidisms in pregnancy
Only 0.2 -0.4 % case
Due to geave’s disease ,toxic nodules, thyroditis.
Risk- Low birth weight, pre-eclemsia
Choice of treatment –Medical management
- surgical after 2nd
trimester
Drugs of choice - Propylthiouracil

14. Thank you