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Thermodynamics   and life Ilya Prigogine 1917 - 2003 Lectures on Medical Biophysics Dept. Biophysics, Medical faculty,  Masaryk University in Brno
Lecture outline ,[object Object],[object Object],[object Object]
Basic concepts of non-equilibrium thermodynamics of living systems ,[object Object],[object Object]
Prigogin e  principle   ,[object Object],[object Object],[object Object]
Difference between an equilibrium and stationary state Is it possible to maintain a state with different temperatures in an isolated system?
Difference between an equilibrium and stationary state The temperature difference can be maintained only in an open system involving a  heat pump  which requires an energy input to function. Heat pump
Difference between an equilibrium and stationary state The ion pump maintains a constant difference in concentration of ions and but requires energy.
Fluctuations and generalised le Chatelier principle ,[object Object],[object Object],[object Object],[object Object]
Dissipative structures ,[object Object]
Autocatalytic reactions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Belousov-Zhabotinsky reaction http://www.jkrieger.de/bzr/2_4_versuch_raeuml.html#2_4
Examples of thermodynamic approach to problem solution: ,[object Object],[object Object],[object Object],[object Object]
Diffusion as an irreversible process ,[object Object],[object Object],[object Object],S  (often A) is total area of the boundary,  dt  is a small time interval during which substance amount  dn  is transported.
1st Fick law A.E. Fick  (1885): (substance moves in the direction of the x-axis, one-dimensional case of diffusion): D  -  diffusion coefficient  [m 2 .s -1 ] Typical values of D: from 1.10 -9  for small molecules to  1.10 -12  for big macromolecules Concentration gradient
Diffusion coefficient ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
2 nd  Fick law The 1 st  Fick law holds when the concentration gradient is constant over time. This condition is not fulfilled for most real processes, so that we need the 2 nd  Fick law to describe such diffusion: The term  d 2 c / dx 2  (second derivative of concentration  c  with respect to position  x,  d ( d c /d x) /d x , or an infinitesimal change of concentration gradient along x-axis. We can say: the rate of change with time of substance concentration at a given point is proportional to the spatial change of the concentration gradient. The proportionality constant D is again the diffusion coefficient.
Osmosis and osmotic pressure ,[object Object],[object Object]
Pfeffer experiment
van't Hoff formula ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
van't Hoff formula ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Tonicity of solutions ,[object Object],[object Object],[object Object],[object Object],[object Object]
How does it look? Echinocytes – erythrocytes exposed to a hypertonic solution.   http://webteach.mccs.uky.edu/COM/pat823/online_materials/diglectures/rbcs/imgshtml/image36.html Plasmolysis of epidermal cells of onion in hypertonic medium. http://www.pgjr.alpine.k12.ut.us/science/whitaker/Cell_Chemistry/Plasmolysis.html
Author:  Vojtěch Mornstein L anguage revision:  Carmel J. Caruana Presentation design:  - - - Last revision:  June  200 9

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Thermodynamics andlife fin

  • 1. Thermodynamics and life Ilya Prigogine 1917 - 2003 Lectures on Medical Biophysics Dept. Biophysics, Medical faculty, Masaryk University in Brno
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  • 5. Difference between an equilibrium and stationary state Is it possible to maintain a state with different temperatures in an isolated system?
  • 6. Difference between an equilibrium and stationary state The temperature difference can be maintained only in an open system involving a heat pump which requires an energy input to function. Heat pump
  • 7. Difference between an equilibrium and stationary state The ion pump maintains a constant difference in concentration of ions and but requires energy.
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  • 14. 1st Fick law A.E. Fick (1885): (substance moves in the direction of the x-axis, one-dimensional case of diffusion): D - diffusion coefficient [m 2 .s -1 ] Typical values of D: from 1.10 -9 for small molecules to 1.10 -12 for big macromolecules Concentration gradient
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  • 16. 2 nd Fick law The 1 st Fick law holds when the concentration gradient is constant over time. This condition is not fulfilled for most real processes, so that we need the 2 nd Fick law to describe such diffusion: The term d 2 c / dx 2 (second derivative of concentration c with respect to position x, d ( d c /d x) /d x , or an infinitesimal change of concentration gradient along x-axis. We can say: the rate of change with time of substance concentration at a given point is proportional to the spatial change of the concentration gradient. The proportionality constant D is again the diffusion coefficient.
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  • 22. How does it look? Echinocytes – erythrocytes exposed to a hypertonic solution. http://webteach.mccs.uky.edu/COM/pat823/online_materials/diglectures/rbcs/imgshtml/image36.html Plasmolysis of epidermal cells of onion in hypertonic medium. http://www.pgjr.alpine.k12.ut.us/science/whitaker/Cell_Chemistry/Plasmolysis.html
  • 23. Author: Vojtěch Mornstein L anguage revision: Carmel J. Caruana Presentation design: - - - Last revision: June 200 9