TCA cycle overview
Glycolysis converts glucose to pyruvate
Produces 2 molecules of 2ATP per glucose
Large amounts of potential energy from glucose remains unused
Aerobic oxidation of pyruvate ensures that this energy is not lost
The TCA cycle is the final common pathway for the oxidation of fuel molecules such as amino acids, fatty acids and carbohydrates
The cycle is also an important source of precursors, not only for the storage forms of fuel, but also for the building blocks of many other molecules such as amino acids, nucleotides bases and sterols
Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle - PDH and TCAChetan Ganteppanavar
1. The document discusses the pyruvate dehydrogenase complex (PDC) which transforms pyruvate into acetyl-CoA, linking glycolysis to the citric acid cycle.
2. PDC is a multienzyme complex located in the mitochondrial matrix consisting of three enzymes and 60 subunits.
3. The citric acid cycle (TCA cycle) is the final common pathway for the oxidation of acetyl-CoA derived from carbohydrates, fatty acids, and amino acids. It operates under aerobic conditions.
1) Most molecules enter the citric acid cycle as acetyl-CoA. The cycle has three stages: acetyl-CoA production, acetyl-CoA oxidation, and electron transfer.
2) The cycle uses oxygen as the ultimate electron acceptor, completely oxidizes organic substrates to CO2 and H2O, and conserves energy as ATP. Reactions occur in the mitochondrial matrix.
3) Key steps include the condensation of acetyl-CoA and oxaloacetate to form citrate, and a series of oxidation and decarboxylation reactions that generate NADH and FADH2 and regenerate oxaloacetate, completing the cycle.
citric acid cycle -overview and process to know aboutvarinder kumar
The citric acid cycle (TCA cycle or Krebs cycle) is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle produces carbon dioxide, NADH, FADH2, and GTP that drive ATP production. Intermediates of the cycle are also precursors for amino acid, fatty acid, and nucleotide biosynthesis. Regulation occurs through substrate availability and product inhibition to control metabolic energy production and anabolic processes.
The document summarizes key aspects of the citric acid cycle (also known as the Krebs cycle or TCA cycle):
1) The cycle involves 8 steps that oxidize acetyl groups from carbohydrates, fats, and proteins to produce carbon dioxide and reduce NAD+ to NADH to generate energy in the form of ATP.
2) Two carbon atoms from acetyl-CoA enter the cycle per turn and two carbon dioxide molecules exit, while NADH, FADH2, and GTP that power oxidative phosphorylation are produced.
3) The cycle occurs in the mitochondrial matrix and is regulated by feedback inhibition of citrate synthase, isocitrate dehydrogenase, and α-ketog
The document discusses the citric acid cycle, also known as the Krebs cycle or TCA cycle. It provides information on:
1) The cycle occurs in the mitochondrial matrix and involves a series of chemical reactions that oxidize acetyl-CoA derived from carbohydrates, fats, and proteins to produce carbon dioxide, NADH, and FADH2 to generate energy.
2) Pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex in the mitochondria, providing the two-carbon unit that enters the Krebs cycle.
3) The cycle is amphibolic, meaning it is both catabolic, breaking down molecules, and anabolic,
the citric acid cycle or krab cycle in plant physiologyUmehabiba502674
The citric acid cycle is a key metabolic pathway that generates energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle involves 8 steps where two-carbon acetyl groups from acetyl-CoA are oxidized and carbon dioxide is released, yielding reduced coenzymes like NADH and FADH2 that are used to generate ATP through oxidative phosphorylation. The cycle takes place in the mitochondrial matrix and is tightly regulated by feedback inhibition and allosteric effectors to balance energy production with biosynthetic needs.
The citric acid cycle is the central metabolic hub of the cell.
It is the final common pathway for the oxidation of fuel molecule such as amino acids, fatty acids, and carbohydrates.
Pyruvate Dehydrogenase and Tricarboxylic Acid Cycle - PDH and TCAChetan Ganteppanavar
1. The document discusses the pyruvate dehydrogenase complex (PDC) which transforms pyruvate into acetyl-CoA, linking glycolysis to the citric acid cycle.
2. PDC is a multienzyme complex located in the mitochondrial matrix consisting of three enzymes and 60 subunits.
3. The citric acid cycle (TCA cycle) is the final common pathway for the oxidation of acetyl-CoA derived from carbohydrates, fatty acids, and amino acids. It operates under aerobic conditions.
1) Most molecules enter the citric acid cycle as acetyl-CoA. The cycle has three stages: acetyl-CoA production, acetyl-CoA oxidation, and electron transfer.
2) The cycle uses oxygen as the ultimate electron acceptor, completely oxidizes organic substrates to CO2 and H2O, and conserves energy as ATP. Reactions occur in the mitochondrial matrix.
3) Key steps include the condensation of acetyl-CoA and oxaloacetate to form citrate, and a series of oxidation and decarboxylation reactions that generate NADH and FADH2 and regenerate oxaloacetate, completing the cycle.
citric acid cycle -overview and process to know aboutvarinder kumar
The citric acid cycle (TCA cycle or Krebs cycle) is a series of chemical reactions that release stored energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle produces carbon dioxide, NADH, FADH2, and GTP that drive ATP production. Intermediates of the cycle are also precursors for amino acid, fatty acid, and nucleotide biosynthesis. Regulation occurs through substrate availability and product inhibition to control metabolic energy production and anabolic processes.
The document summarizes key aspects of the citric acid cycle (also known as the Krebs cycle or TCA cycle):
1) The cycle involves 8 steps that oxidize acetyl groups from carbohydrates, fats, and proteins to produce carbon dioxide and reduce NAD+ to NADH to generate energy in the form of ATP.
2) Two carbon atoms from acetyl-CoA enter the cycle per turn and two carbon dioxide molecules exit, while NADH, FADH2, and GTP that power oxidative phosphorylation are produced.
3) The cycle occurs in the mitochondrial matrix and is regulated by feedback inhibition of citrate synthase, isocitrate dehydrogenase, and α-ketog
The document discusses the citric acid cycle, also known as the Krebs cycle or TCA cycle. It provides information on:
1) The cycle occurs in the mitochondrial matrix and involves a series of chemical reactions that oxidize acetyl-CoA derived from carbohydrates, fats, and proteins to produce carbon dioxide, NADH, and FADH2 to generate energy.
2) Pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex in the mitochondria, providing the two-carbon unit that enters the Krebs cycle.
3) The cycle is amphibolic, meaning it is both catabolic, breaking down molecules, and anabolic,
the citric acid cycle or krab cycle in plant physiologyUmehabiba502674
The citric acid cycle is a key metabolic pathway that generates energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle involves 8 steps where two-carbon acetyl groups from acetyl-CoA are oxidized and carbon dioxide is released, yielding reduced coenzymes like NADH and FADH2 that are used to generate ATP through oxidative phosphorylation. The cycle takes place in the mitochondrial matrix and is tightly regulated by feedback inhibition and allosteric effectors to balance energy production with biosynthetic needs.
The citric acid cycle is the central metabolic hub of the cell.
It is the final common pathway for the oxidation of fuel molecule such as amino acids, fatty acids, and carbohydrates.
The TCA cycle, also known as the Krebs cycle or citric acid cycle, involves the oxidation of acetyl-CoA to carbon dioxide and water and occurs in the mitochondrial matrix. It is the final common pathway for carbohydrates, fats, and proteins and generates energy in the form of ATP, NADH, and FADH2. The cycle consists of 8 steps where citrate is regenerated at the end to continue the cycle. The cycle supplies energy and intermediates for biosynthesis and is regulated by substrate availability and product inhibition.
The TCA cycle, also known as the Krebs cycle or citric acid cycle, is the central metabolic pathway that catalyzes the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to produce carbon dioxide, water, and energy in the form of ATP, NADH, and FADH2. The TCA cycle occurs in the mitochondrial matrix and is the final common pathway for the oxidation of these three macronutrient types. Through a series of chemical reactions, acetyl-CoA is oxidized, producing carbon dioxide and hydrogen ions that will be used in the electron transport chain to generate ATP through oxidative phosphorylation.
Krebs cycle or tricarboxylic cycle or citric acid cycleNeha Agarwal
The citric acid cycle is the final common pathway for the oxidation of fuel molecules — amino acids, fatty acids, and carbohydrates.
Hans Adolf Krebs. Biochemist; born in Germany. Worked in Britain. His discovery in 1937 of the ‘Krebs cycle’ of chemical reactions was critical to the understanding of cell metabolism and earned him the 1953 Nobel Prize for Physiology or Medicine.
The document summarizes the Krebs cycle (also known as the citric acid cycle or TCA cycle). It describes how Hans Krebs discovered the cycle through his research on pigeon muscle tissue in the 1930s. The 8-step cycle occurs in the mitochondria and involves the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to carbon dioxide. This releases energy in the form of NADH and FADH2 that is later used to generate large amounts of ATP through oxidative phosphorylation. The cycle also generates precursor molecules that can be used for other biological processes like fatty acid and amino acid synthesis.
The document discusses the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It provides three key points:
1. The TCA cycle involves the oxidation of acetyl-CoA to carbon dioxide and water and is the final common pathway for carbohydrates, fats, and amino acids.
2. The cycle generates energy in the form of ATP, NADH, and FADH2 and provides precursors for biosynthesis.
3. The cycle occurs in the mitochondrial matrix and is tightly regulated by enzymes and cellular energy levels to integrate major metabolic pathways.
The document discusses the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It provides three key points:
1. The TCA cycle is the final common pathway for the oxidation of carbohydrates, fats, and proteins to produce energy in the form of ATP. It involves the oxidation of acetyl-CoA to carbon dioxide and generates reduced cofactors NADH and FADH2 that feed into the electron transport chain.
2. The cycle occurs in the mitochondrial matrix and is tightly regulated. It generates 3 NADH and 1 FADH2 per acetyl-CoA molecule oxidized, which can ultimately produce around 12 ATP
The citric acid cycle (TCA cycle) was discovered by Hans Krebs in 1937. It is a series of reactions in the mitochondria that oxidizes acetyl-CoA derived from carbohydrates, fats, and proteins to carbon dioxide, producing reduced co-enzymes that drive ATP production. The cycle consists of 8 steps catalyzed by different enzymes, with oxidative decarboxylation steps producing NADH and FADH2. The cycle plays important biosynthetic and anaplerotic roles in addition to its main role in energy production. Key control points ensure regulation of flux through the cycle.
Hans Adolf Krebs was a German-British biochemist who discovered the citric acid cycle (also known as the Krebs cycle) in 1937 while working in Britain. The Krebs cycle is a series of chemical reactions that is critical for cell metabolism and the production of energy in cells. It involves the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to produce carbon dioxide, water, and energy in the form of ATP. Krebs' discovery of this cycle was pivotal to understanding how cells generate energy and earned him the Nobel Prize in Physiology or Medicine.
The citric acid cycle is the final common pathway for the oxidation of molecules like amino acids, fatty acids, and carbohydrates. Most of these molecules enter the cycle as acetyl-CoA. The cycle was discovered in 1937 by Hans Krebs and involves 8 steps where acetyl-CoA condenses with oxaloacetate to form citrate and regenerate oxaloacetate. The cycle harvests energy in the form of ATP, NADH, and FADH2 and provides precursors for biosynthesis. Key enzymes in the cycle are regulated by factors like the levels of NADH and ATP.
The citric acid cycle (Krebs cycle or TCA cycle) is an important metabolic pathway that generates energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. It occurs in the matrix of mitochondria and involves 8 steps where acetyl-CoA derived from pyruvate combines with oxaloacetate to form citrate. As the citrate undergoes oxidation, NADH, FADH2, and GTP are produced, leading to the generation of 12 ATP per acetyl-CoA molecule. The cycle regenerates oxaloacetate and continues.
The document discusses the citric acid (TCA) cycle, which occurs in the mitochondria and involves 8 steps to completely oxidize acetyl-CoA derived from carbohydrates, fats, and proteins, producing carbon dioxide and reducing equivalents in the form of NADH and FADH2. These reducing equivalents are used to generate ATP through oxidative phosphorylation. The TCA cycle also serves as a hub to integrate various metabolic pathways and provides precursors for many biosynthetic processes. Regulation of the cycle occurs through feedback inhibition by products of high energy states like ATP and NADH.
The citric acid cycle is a series of chemical reactions in the mitochondria that break down acetyl groups from carbohydrates, fats, and proteins into carbon dioxide, generating reduced coenzymes used in oxidative phosphorylation to produce ATP. Pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex, then the citric acid cycle oxidizes acetyl-CoA in 8 steps, producing NADH, FADH2, and GTP or ATP while releasing CO2. This cycling of intermediates allows for the efficient breakdown of fuels to generate energy.
The Krebs cycle summarizes a circular series of reactions in the mitochondria to metabolize AcCoA to two molecules of CO2 with the resultant generation of one molecule of GTP, three molecules of NADH, and one molecule of FADH2. GTP is equivalent to ATP in terms of energy charge.
FUNCTION: The main function of the Krebs cycle is to produce energy, stored and transported as ATP or GTP. The cycle is also central to other biosynthetic reactions where the intermediates produced are required to make other molecules, such as amino acids, nucleotide bases, and cholesterol.
citric acid cycle or TCA cycle.
krebs cycle is amphibolic in nature and its important reactions.
occurs in mitochondrial matrix in close proximity to ETC.
5 types of vitamins are involved in this cycle. also inhibitors are present . regulation of TCA cycle is governed by mainly 3 enzymes
and there is mention the energies of every step that takes place in citric acid cycle.
citric acid cycle produces 24 molecules of ATP in every cycle
The citric acid cycle (TCA cycle) is a central metabolic pathway that oxidizes acetyl-CoA derived from carbohydrates, fats, and proteins, producing carbon dioxide and reducing equivalents in the form of NADH and FADH2. The TCA cycle consists of 8 steps that occur in the mitochondrial matrix and ultimately generate 12 ATP per acetyl-CoA molecule. Regulation of the TCA cycle occurs through three enzymes and is influenced by levels of ATP, NADH, and other metabolites. While the TCA cycle functions primarily in energy production, it also interfaces with many anabolic pathways through various intermediates.
The document summarizes the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It discusses that the TCA cycle involves the oxidation of acetyl-CoA to carbon dioxide and water and is the final common pathway for carbohydrates, fats, and amino acids. The cycle occurs in the mitochondrial matrix and generates energy in the form of NADH and FADH2 that are used in the electron transport chain to produce ATP. Key enzymes and reactions in the cycle are described, including the generation of citrate, isocitrate, alpha-ketoglutarate, succinyl-CoA, fumarate, oxaloacetate
The citric acid cycle (CAC) is a key metabolic pathway that occurs in the mitochondria of cells. It involves the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to carbon dioxide. During each turn of the cycle, NAD+ and FAD are reduced to NADH and FADH2 to generate energy in the form of ATP through oxidative phosphorylation. Overall, the complete oxidation of one acetyl-CoA molecule in the CAC and respiratory chain produces 12 ATP molecules, capturing the energy from nutrients. The cycle plays a central role in cellular respiration and the production of energy.
The Krebs cycle, also known as the citric acid cycle or tricarboxylic acid (TCA) cycle, is a series of chemical reactions in the mitochondria that produces energy through oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle is made up of eight successive steps that begin with the addition of acetyl-CoA to oxaloacetate to form citrate and end with the regeneration of oxaloacetate. The cycle generates high-energy electron carriers NADH and FADH2 that fuel oxidative phosphorylation to produce ATP.
The document summarizes the key steps in the citric acid cycle. It begins by explaining how pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex, providing the link between glycolysis and the citric acid cycle. It then outlines the six steps of the citric acid cycle, including the condensation of acetyl-CoA and oxaloacetate to form citrate, and the subsequent oxidation and decarboxylation reactions that generate NADH and FADH2 and regenerate oxaloacetate to restart the cycle.
Chapter 16 - The citric acid cycle - BiochemistryAreej Abu Hanieh
The document discusses cellular respiration, which occurs in three stages: 1) acetyl-CoA production from organic fuels like glucose and fatty acids, 2) acetyl-CoA oxidation in the citric acid cycle (CAC) to produce NADH, FADH2, and GTP, and 3) oxidative phosphorylation to generate large amounts of ATP. The citric acid cycle involves a series of chemical reactions that generate energy in the form of ATP, NADH, and FADH2. These stages capture energy from nutrients and transfer it to ATP via electron transport chains located in cellular organelles like mitochondria.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
The TCA cycle, also known as the Krebs cycle or citric acid cycle, involves the oxidation of acetyl-CoA to carbon dioxide and water and occurs in the mitochondrial matrix. It is the final common pathway for carbohydrates, fats, and proteins and generates energy in the form of ATP, NADH, and FADH2. The cycle consists of 8 steps where citrate is regenerated at the end to continue the cycle. The cycle supplies energy and intermediates for biosynthesis and is regulated by substrate availability and product inhibition.
The TCA cycle, also known as the Krebs cycle or citric acid cycle, is the central metabolic pathway that catalyzes the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to produce carbon dioxide, water, and energy in the form of ATP, NADH, and FADH2. The TCA cycle occurs in the mitochondrial matrix and is the final common pathway for the oxidation of these three macronutrient types. Through a series of chemical reactions, acetyl-CoA is oxidized, producing carbon dioxide and hydrogen ions that will be used in the electron transport chain to generate ATP through oxidative phosphorylation.
Krebs cycle or tricarboxylic cycle or citric acid cycleNeha Agarwal
The citric acid cycle is the final common pathway for the oxidation of fuel molecules — amino acids, fatty acids, and carbohydrates.
Hans Adolf Krebs. Biochemist; born in Germany. Worked in Britain. His discovery in 1937 of the ‘Krebs cycle’ of chemical reactions was critical to the understanding of cell metabolism and earned him the 1953 Nobel Prize for Physiology or Medicine.
The document summarizes the Krebs cycle (also known as the citric acid cycle or TCA cycle). It describes how Hans Krebs discovered the cycle through his research on pigeon muscle tissue in the 1930s. The 8-step cycle occurs in the mitochondria and involves the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to carbon dioxide. This releases energy in the form of NADH and FADH2 that is later used to generate large amounts of ATP through oxidative phosphorylation. The cycle also generates precursor molecules that can be used for other biological processes like fatty acid and amino acid synthesis.
The document discusses the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It provides three key points:
1. The TCA cycle involves the oxidation of acetyl-CoA to carbon dioxide and water and is the final common pathway for carbohydrates, fats, and amino acids.
2. The cycle generates energy in the form of ATP, NADH, and FADH2 and provides precursors for biosynthesis.
3. The cycle occurs in the mitochondrial matrix and is tightly regulated by enzymes and cellular energy levels to integrate major metabolic pathways.
The document discusses the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It provides three key points:
1. The TCA cycle is the final common pathway for the oxidation of carbohydrates, fats, and proteins to produce energy in the form of ATP. It involves the oxidation of acetyl-CoA to carbon dioxide and generates reduced cofactors NADH and FADH2 that feed into the electron transport chain.
2. The cycle occurs in the mitochondrial matrix and is tightly regulated. It generates 3 NADH and 1 FADH2 per acetyl-CoA molecule oxidized, which can ultimately produce around 12 ATP
The citric acid cycle (TCA cycle) was discovered by Hans Krebs in 1937. It is a series of reactions in the mitochondria that oxidizes acetyl-CoA derived from carbohydrates, fats, and proteins to carbon dioxide, producing reduced co-enzymes that drive ATP production. The cycle consists of 8 steps catalyzed by different enzymes, with oxidative decarboxylation steps producing NADH and FADH2. The cycle plays important biosynthetic and anaplerotic roles in addition to its main role in energy production. Key control points ensure regulation of flux through the cycle.
Hans Adolf Krebs was a German-British biochemist who discovered the citric acid cycle (also known as the Krebs cycle) in 1937 while working in Britain. The Krebs cycle is a series of chemical reactions that is critical for cell metabolism and the production of energy in cells. It involves the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to produce carbon dioxide, water, and energy in the form of ATP. Krebs' discovery of this cycle was pivotal to understanding how cells generate energy and earned him the Nobel Prize in Physiology or Medicine.
The citric acid cycle is the final common pathway for the oxidation of molecules like amino acids, fatty acids, and carbohydrates. Most of these molecules enter the cycle as acetyl-CoA. The cycle was discovered in 1937 by Hans Krebs and involves 8 steps where acetyl-CoA condenses with oxaloacetate to form citrate and regenerate oxaloacetate. The cycle harvests energy in the form of ATP, NADH, and FADH2 and provides precursors for biosynthesis. Key enzymes in the cycle are regulated by factors like the levels of NADH and ATP.
The citric acid cycle (Krebs cycle or TCA cycle) is an important metabolic pathway that generates energy through the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. It occurs in the matrix of mitochondria and involves 8 steps where acetyl-CoA derived from pyruvate combines with oxaloacetate to form citrate. As the citrate undergoes oxidation, NADH, FADH2, and GTP are produced, leading to the generation of 12 ATP per acetyl-CoA molecule. The cycle regenerates oxaloacetate and continues.
The document discusses the citric acid (TCA) cycle, which occurs in the mitochondria and involves 8 steps to completely oxidize acetyl-CoA derived from carbohydrates, fats, and proteins, producing carbon dioxide and reducing equivalents in the form of NADH and FADH2. These reducing equivalents are used to generate ATP through oxidative phosphorylation. The TCA cycle also serves as a hub to integrate various metabolic pathways and provides precursors for many biosynthetic processes. Regulation of the cycle occurs through feedback inhibition by products of high energy states like ATP and NADH.
The citric acid cycle is a series of chemical reactions in the mitochondria that break down acetyl groups from carbohydrates, fats, and proteins into carbon dioxide, generating reduced coenzymes used in oxidative phosphorylation to produce ATP. Pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex, then the citric acid cycle oxidizes acetyl-CoA in 8 steps, producing NADH, FADH2, and GTP or ATP while releasing CO2. This cycling of intermediates allows for the efficient breakdown of fuels to generate energy.
The Krebs cycle summarizes a circular series of reactions in the mitochondria to metabolize AcCoA to two molecules of CO2 with the resultant generation of one molecule of GTP, three molecules of NADH, and one molecule of FADH2. GTP is equivalent to ATP in terms of energy charge.
FUNCTION: The main function of the Krebs cycle is to produce energy, stored and transported as ATP or GTP. The cycle is also central to other biosynthetic reactions where the intermediates produced are required to make other molecules, such as amino acids, nucleotide bases, and cholesterol.
citric acid cycle or TCA cycle.
krebs cycle is amphibolic in nature and its important reactions.
occurs in mitochondrial matrix in close proximity to ETC.
5 types of vitamins are involved in this cycle. also inhibitors are present . regulation of TCA cycle is governed by mainly 3 enzymes
and there is mention the energies of every step that takes place in citric acid cycle.
citric acid cycle produces 24 molecules of ATP in every cycle
The citric acid cycle (TCA cycle) is a central metabolic pathway that oxidizes acetyl-CoA derived from carbohydrates, fats, and proteins, producing carbon dioxide and reducing equivalents in the form of NADH and FADH2. The TCA cycle consists of 8 steps that occur in the mitochondrial matrix and ultimately generate 12 ATP per acetyl-CoA molecule. Regulation of the TCA cycle occurs through three enzymes and is influenced by levels of ATP, NADH, and other metabolites. While the TCA cycle functions primarily in energy production, it also interfaces with many anabolic pathways through various intermediates.
The document summarizes the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle or citric acid cycle. It discusses that the TCA cycle involves the oxidation of acetyl-CoA to carbon dioxide and water and is the final common pathway for carbohydrates, fats, and amino acids. The cycle occurs in the mitochondrial matrix and generates energy in the form of NADH and FADH2 that are used in the electron transport chain to produce ATP. Key enzymes and reactions in the cycle are described, including the generation of citrate, isocitrate, alpha-ketoglutarate, succinyl-CoA, fumarate, oxaloacetate
The citric acid cycle (CAC) is a key metabolic pathway that occurs in the mitochondria of cells. It involves the oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins to carbon dioxide. During each turn of the cycle, NAD+ and FAD are reduced to NADH and FADH2 to generate energy in the form of ATP through oxidative phosphorylation. Overall, the complete oxidation of one acetyl-CoA molecule in the CAC and respiratory chain produces 12 ATP molecules, capturing the energy from nutrients. The cycle plays a central role in cellular respiration and the production of energy.
The Krebs cycle, also known as the citric acid cycle or tricarboxylic acid (TCA) cycle, is a series of chemical reactions in the mitochondria that produces energy through oxidation of acetyl-CoA derived from carbohydrates, fats, and proteins. The cycle is made up of eight successive steps that begin with the addition of acetyl-CoA to oxaloacetate to form citrate and end with the regeneration of oxaloacetate. The cycle generates high-energy electron carriers NADH and FADH2 that fuel oxidative phosphorylation to produce ATP.
The document summarizes the key steps in the citric acid cycle. It begins by explaining how pyruvate is converted to acetyl-CoA by the pyruvate dehydrogenase complex, providing the link between glycolysis and the citric acid cycle. It then outlines the six steps of the citric acid cycle, including the condensation of acetyl-CoA and oxaloacetate to form citrate, and the subsequent oxidation and decarboxylation reactions that generate NADH and FADH2 and regenerate oxaloacetate to restart the cycle.
Chapter 16 - The citric acid cycle - BiochemistryAreej Abu Hanieh
The document discusses cellular respiration, which occurs in three stages: 1) acetyl-CoA production from organic fuels like glucose and fatty acids, 2) acetyl-CoA oxidation in the citric acid cycle (CAC) to produce NADH, FADH2, and GTP, and 3) oxidative phosphorylation to generate large amounts of ATP. The citric acid cycle involves a series of chemical reactions that generate energy in the form of ATP, NADH, and FADH2. These stages capture energy from nutrients and transfer it to ATP via electron transport chains located in cellular organelles like mitochondria.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Histololgy of Female Reproductive System.pptxAyeshaZaid1
Dive into an in-depth exploration of the histological structure of female reproductive system with this comprehensive lecture. Presented by Dr. Ayesha Irfan, Assistant Professor of Anatomy, this presentation covers the Gross anatomy and functional histology of the female reproductive organs. Ideal for students, educators, and anyone interested in medical science, this lecture provides clear explanations, detailed diagrams, and valuable insights into female reproductive system. Enhance your knowledge and understanding of this essential aspect of human biology.
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
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share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
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share - Lions, tigers, AI and health misinformation, oh my!.pptx
The Tricarboxylic Acid Cycle
1. Prof. Riaan den Haan
Hans Adolf Krebs. Biochemist;
born in Germany. Worked in
Britain. His discovery in 1937 of
the ‘Krebs cycle’ of chemical
reactions was critical to the
understanding of cell
metabolism and earned him
the 1953 Nobel Prize for
Physiology or Medicine.
2. Aerobic cells use a metabolic “wheel”, the citric acid-/Krebs-
/tricarboxylic acid cycle to generate energy from pyruvate
In eukaryotes the reactions of the citric acid cycle take place
inside mitochondria
3. Glycolysis converts glucose to pyruvate
Produces 2 molecules of ATP per glucose
Large amounts of potential energy from glucose remains
unused
Aerobic oxidation of pyruvate ensures that this energy is
not lost
The TCA cycle is the final common pathway for the
oxidation of fuel molecules such as amino acids, fatty acids
and carbohydrates
The cycle is also an important source of precursors, not
only for the storage forms of fuel, but also for the building
blocks of many other molecules such as amino acids,
nucleotide bases and sterols
4. The TCA cycle consists of a series of
oxidation-reduction reactions in the
mitochondria
Under aerobic conditions pyruvate from
glycolysis is oxidatively decarboxylated to
acetyl-coenzyme A (acetyl-CoA)
Acetyl-CoA is oxidized to two molecules of
carbon dioxide
This involves a 24-electron oxidation process
This oxidation process results in the
reduction of coenzymes NAD+ NADH and
FAD FADH2, some ATP (or equivalent) is
also produced
The coenzymes are transported to the
electron transport pathway, where they are
oxidized to drive the synthesis of ATP
The function of the TCA cycle is the harvesting
of high-energy electrons from carbon fuels
5.
6. The TCA cycle seems like a complicated way to oxidize acetate units to
CO2 – why?
The oxidation of acetate to CO2 is used to reduce NAD+ to NADH
But, this cannot happen in a single step because acetate can’t be
directly oxidized into CO2
Oxidation of an acetyl group to CO2 requires a C-C cleavage
This has to be done in an energetically favorable way under cellular
conditions
7. C-C cleavage reactions in biological systems can only occur in one of
two ways:
◦ Between carbons Cs α and β to a carbonyl group
◦ α -cleavage of an α -hydroxyketone (between COO- and C-OH)
8. Neither of these strategies suitable for acetate (or Acetyl-CoA)
◦ No β-carbon
◦ No hydroxyl (OH) group
Instead: acetate is condensed with oxaloacetate to form citrate
Citrate contains a β-carbon and can undergo β-cleavage
Therefore
◦ During the TCA cycle, 2 carbons flow into the cycle via acetyl-CoA
◦ Acetyl-CoA cannot be oxidized directly
◦ These 2 carbons condense with the final substrate of TCA cycle (oxaloacetate)
to form a 6-carbon structure citrate
◦ Citrate can undergo oxidation
◦ This oxidation leads to the generation of 2 carbon dioxide molecules
TCA cycle combines β-cleavage reaction with oxidation to form CO2,
regenerate oxaloacetate and capture liberated energy in NAD and ATP
9. Sources: glucose (through pyruvate), fatty acids, amino acids, ketone
bodies
Central role in citric acid cycle, oxidative phosphorylation, fatty acid
metabolism, cholesterol biosynthesis
10. Glycolysis occurs in the cytoplasm and the TCA cycle and oxidative
phosphorylation in the mitochondria
Pyruvate must enter the mitochondria to enter the TCA cycle
Pyruvate is then converted to acetyl-CoA by the process of oxidative
decarboxylation via the pyruvate dehydrogenase enzyme complex
11. Multi-enzyme complex (series of enzymes linked
together), noncovalent assembly of three enzymes in
this case – uses 5 co-enzymes
Catalyzes oxidative decarboxylation of pyruvate to
acetyl-CoA
◦ Combines a redox reaction (pyruvate donates electron, NAD+
receives electron) and decarboxylation (loss of carbons in
form of carbon dioxide)
12. Large multi-enzyme complex
Multiple copies of three enzymes: E1, E2, E3
E1: pyruvate dehydrogenase
E2: dihydrolipoamide acetyltransferase
E3: dihydrolipoamide dehydrogenase
Inner core
◦ Icosahedral structure
◦ 60 copies of E2
◦ 12 copies of E3 binding protein (E3BP) that links E3 to E2
Periphery:
◦ 30 copies of E1 (tetramer of subunits a2b2)
◦ 12 copies of E3 (homodimer)
13. Eukaryotic PDH is one of the largest multi-enzyme
complexes known, ~50nM and ~9.5 mega-Daltons
14. Coenzyme = Cofactor which is loosely bound to the
enzyme
Prosthetic group = Cofactor which is tightly bound to
the enzyme
Enzyme Abbreviated Prosthetic group
Pyruvate dehydrogenase E1 Thiamine pyrophosphate (TPP)
Dihydrolipoyl transacetylase E2 Lipoic Acid (Lipoamide)
Dihydrolipoyl dehydrogenase E3 FAD
Other Coenzymes
Coenzyme A
NADH and NADPH
15. Thiamine pyrophosphate (TPP)
◦ Prosthetic group on E1
◦ Synthesized from Thiamine (Vitamin B1)
◦ Assists in the decarboxylation process
The flavin coenzyme (FAD)
◦ Prosthetic group on E3
◦ Synthesized from riboflavin (Vitamin B2)
◦ Involved in one or two electron transfer reactions
The nicotinamine coenzyme (NAD)
◦ Synthesized from nicotinamide (Vitamin B3)
◦ NAD+/NADH carry out hydride transfer reactions
Lipoic acid (Lipoamide)
◦ Prosthetic group on E2
◦ Contains a disulfide and acts as an arm to transfer acetyl group
Coenzyme A
◦ Synthesized from cysteamine, panthothenate and ATP
◦ In TCA cycle it carries the acetyl group in acetyl-CoA
16. 1. Pyruvate reacts with TPP and is decarboxylated (E1)
• Carbon dioxide is released
• Hydroxyethyl-TPP is formed
2. Hydroxyethyl-TPP reacts with lipoamide (E1/E2)
• Hydroxyethyl group is transferred to lipoic acid (lipoamide)
• Oxidized to form acetyl dihydrolipoate (-lipoamide)
3. Acetyl group is transferred to CoA to form acetyl-CoA and lipoamide-
dithiol (reduced disulfide) (E2)
4. The reduced lipoamide is reoxidized by FAD to form FADH2 (E3)
5. The FADH2 is reoxidized by NAD+ to form NADH
17. Thus the final products of the PDH complex reaction are
◦ Acetyl-CoA
◦ NADH
◦ CO2
All other reactants are regenerated back to their original form
18.
19. Glycolysis converts glucose to pyruvate
Pyruvate is fed into TCA cycle under aerobic conditions
Pyruvate is converted to acetyl-CoA via the multi-
enzyme pyruvate dehydrogenase
Pyruvate dehydrogenase consists of 3 enzymes and
needs 5 different coenzymes
End products are CO2, acetyl-CoA, and NADH
https://www.youtube.com/watch?v=_cXVleFtzeE
20. First 4 reactions in TCA cycle ends in the
production of succinyl-CoA and 2
molecules of CO2
Substrate Product Enzyme Other
Oxaloacetate +
Acetyl-CoA
Citrate Citrate synthase
Citrate Isocitrate Aconitase
Isocitrate α-ketoglutarate Isocitrate
dehydrogenase
CO2
α-ketoglutarate Succinyl-CoA α-ketoglutarate
dehydrogenase
CO2
21. First reaction in TCA cycle is a synthase reaction - a new molecule is
made but ATP is not used
Oxaloacetate + Acetyl-CoA + H2O Citrate + CoA
Initiates TCA cycle
Acetyl-CoA condenses with oxaloacetate to form citrate
Citrate synthase is a dimer – each subunit binds oxaloacetate and
acetyl-CoA
◦ Binding of oxaloacetate induces a conformational change which
facilitates the binding of acetyl-CoA
22. Reaction is irreversible due to large energy of forward
reaction (large negative ∆G)
NADH is an allosteric inhibitor
◦ NADH is a product of the TCA cycle
◦ TCA cycle will slow down if too much NADH
Succinyl-CoA is an allosteric inhibitor
◦ Later intermediate in cycle
◦ Analog of acetyl-CoA
◦ Can bind citrate synthase but not react with oxaloacetate =
inhibition of reaction
23. Citrate is a poor substrate for oxidation
Aconitase isomerizes citrate to yield isocitrate which has a secondary -OH, which
can be readily oxidized
Isomerization of citrate (tertiary alcohol) to isocitrate (secondary alcohol)
Citrate [H2O + cis-Aconitate ]Isocitrate
Aconitase contains an iron-sulfur center as a prosthetic group which facilitates the
rearrangement reaction
Dehydration reaction followed by a hydration with an aconitate intermediate
◦ Water is abstracted from citrate to yield aconitate (dehydration)
◦ H and OH are added back in opposite positions to produce isocitrate
Citrate needs to become isocitrate so that in next step decarboxylation is possible
24. Oxidative decarboxylation of isocitrate yields α-ketoglutarate
Isocitrate α-ketoglutarate
Oxidation of isocitrate linked to reduction of NAD+ NADH
Isocitrate is oxidatively decarboxylated (carbon removed to
yield CO2)
Isocitrate dehydrogenase is a link to the electron transport
pathway through the production of NADH
25. Reaction is irreversible due to large energy of forward
reaction (large negative ∆G)
NADH and ATP are allosteric inhibitors (high energy)
ADP is allosteric activator (low energy)
26. A second oxidative decarboxylation
α-ketoglutarate succinyl-CoA
Oxidative decarboxylation (oxidative removal of a carbon to yield
CO2 and NADH)
Multi-enzyme complex similar to pyruvate dehydrogenase
◦ α-ketoglutarate dehydrogenase
◦ Dihydrolipoyl transsuccinylase
◦ Dihydrolipoyl dehydrogenase
27. Reaction is identical to pyruvate dehydrogenase - structurally and
mechanistically
Instead of acetyl-CoA, succinyl-CoA (an analog) is formed
Five coenzymes used - TPP, CoASH, lipoic acid, NAD+, and FAD
28. Last 4 reactions in TCA cycle produces GTP,
FADH2 and NADH
Oxaloacetate is regenerated and cycle begins
again
Substrate Product Enzyme Other
Succinyl-CoA Succinate Succinyl-CoA
synthetase
GDP GTP
Succinate Fumarate Succinate
dehydrogenase
FAD FADH2
Fumarate Malate Fumarase
Malate Oxaloacetate Malate
dehydrogenase
NAD+ NADH
29. A nucleoside triphosphate is made
This is possible because succinyl-CoA is a high-energy intermediate
The reaction removes the CoA group and yields succinate – energy
used to drive the phosphorylation of GDP to GTP
Substrate level phosphorylation – substrate rather than electron-
transport chain provides the energy for phosphorylation
GTP produced by mammals in this reaction is converted to ATP via
nucleoside diphosphate kinase
GTP + ADP ATP + GDP
30. An FAD-dependent oxidation of a single bond to a double bond
Succinate dehydrogenase catalyses the conversion of succinate to
fumarate and reduction of FAD to FADH2
Dehydrogenase – thus removal of hydrogen atoms
This enzyme is bound to the inner mitochondrial membrane
Is part of BOTH TCA cycle AND electron transport pathway
The electrons transferred from succinate to FAD (to form FADH2) are
passed directly to ubiquinone (UQ) in the electron transport pathway
Succinate dehydrogenase is a dimeric protein = two subunits, one large
one small
FAD covalently bound to larger subunit
31. Succinate dehydrogenase contains 3 different iron-sulfur clusters:
These iron-sulfur clusters receive the electrons captured by FAD
and pass them onto the electron transport chain
32. Hydration of fumarate to malate (addition of water)
Hydration involves trans-addition of the elements of water
across the double bond
Prepares structure so it can donate electrons to NAD+ in next
reaction
33. Malate Dehydrogenase completes the cycle by oxidizing malate to
oxaloacetate
Hydrogen donated by malate to reduce NADH
The carbon that gets oxidized is the one that received the -OH in the
previous reaction
This reaction is energetically expensive:
∆Go' = +30 kJ/mol
Thus the concentration of oxaloacetate in the mitochondrial matrix is
quite low (though ∆G is close to 0 in cellular conditions)
However, the malate dehydrogenase reaction is pulled forward by the
favorable citrate synthase reaction
34. TCA cycle involves a flow of carbon
molecules in and out of the cycle.
TCA cycle starts with the addition of 2-
carbon molecules from acetyl-CoA to the
TCA cycle intermediate oxaloacetate,
which contains 4-carbons, to make a 6-
carbon molecule citrate.
6-carbon citrate is rearranged (isocitrate)
6-carbon isocitrate is decarboxylated (loses a carbon in form of
carbon dioxide) to 5-carbon molecule (α-ketoglutarate) and then
again to a 4-carbon molecule (succinyl-CoA)
Next 4 molecules contain 4-carbons
And then cycle starts again
35. One acetate through the cycle produces two CO2, one ATP, four reduced
coenzymes
Energy released through oxidation of acetyl-CoA is conserved in the
reduction of NAD+, FAD+ and the synthesis of GTP which can be converted
to ATP
The TCA cycle is exergonic, with a net ΔGº' for one pass around the cycle
of -40 kJ/mol
The combination of glycolysis and TCA produce 12 reduced coenzymes,
which can eventually produce over 32 molecules of ATP
Two carbon molecules enter the cycle as acetyl-CoA and leave as two
carbon dioxide molecules
The carbonyl C of acetyl-CoA becomes CO2 only in
the second turn of the cycle (following entry of
acetyl-CoA )
The methyl C of acetyl-CoA survives two cycles
completely, but half of what's left exits the cycle
on each turn after that
36. 1. Citrate synthase: catalyzes the condensation of acetyl-CoA and
oxaloacetate to yield citrate.
2. Aconitase: isomerizes citrate to the easily oxidized isocitrate.
3. Isocitrate dehydrogenase: oxidizes & decarboxylates isocitrate to form
-ketoglutarate. (1st NADH and CO2).
4. -ketoglutarate dehydrogenase: oxidatively decarboxylates -
ketoglutarate to succinyl-CoA. (2nd NADH and CO2).
5. Succinyl-CoA synthetase converts succinyl-CoA to succinate. Forms
GTP.
6. Succinate dehydrogenase: catalyzes the oxidation of central single bond
of succinate to a trans double bond, yielding fumarate and FADH2.
7. Fumarase: catalyzes the hydration of the double bond to produce
malate.
8. Malate dehydrogenase: reforms oxaloacetate by oxidizing secondary
OH group to ketone (3rd NADH).
The function of the TCA cycle is the harvesting of high-energy electrons from
carbon fuels
Final products of citric acid cycle: 2 CO2 molecules. 3 NADH, 1 FADH2, and 1
GTP
37. - You need to be able to
draw a flow diagram of
the citric acid cycle
showing substrates,
enzymes, coenzymes and
products
- You don’t need to know
the structures or
mechanisms
- You need to be able to
write a short sentence
describing each reaction
https://www.youtube.co
m/watch?v=_cXVleFtzeE
38. TCA cycle not only functions to convert carbon to electrons and energy,
but also provides many intermediates for other biosynthetic pathways
α-Ketoglutarate transaminated to make glutamate, which is used to make
nucleotides, as well as arginine and proline
Succinyl-CoA is used to make porphyrins (e.g. of a porphyrine is heme,
found in hemoglobin)
Fumarate is a precursor in production of aspartate which is used to make
nucleotides, as well as other amino acids threonine, methionine,
isoleucine and lysine
39. Oxaloacetate also precursor in aspartate production, can also be
decarboxylated to form PEP (fed back into glycolysis) as well as aromatic
amino acids
Citrate exported from mitochondria and broken down to oxaloacetate
and acetyl-CoA
◦ Acetyl-CoA functions in cytoplasm as precursor in fatty acid synthesis
◦ Oxaloacetate is reduced to malate, which is either transported back to
mitochondria or decarboxylated to pyruvate
40. All 20 common amino acids can be made from metabolites
derived from glycolysis & the TCA cycle (highlighted in orange).
41.
42. TCA cycle lies between glycolysis and the electron transport
chain
Must be tightly controlled to prevent wasting metabolic
energy in production of unnecessary ATP or to prevent
energy shortage in cell
TCA cycle also important producer of precursors for other
pathways, which would also be effected if TCA cycle went
uncontrolled
Regulation occurs at 4 important points:
◦ Pyruvate converted to acetyl-CoA (not part of TCA cycle but input of
acetyl-CoA is needed for cycle to occur)
◦ 3 enzymatic steps in the TCA cycle: citrate synthase, isocitrate
dehydrogenase, α-ketoglutarate dehydrogenase
43. Changes in free energy of the reactions of TCA cycle indicates 3
irreversible steps – the key regulatory sites
◦ A step is irreversible when the free energy for the forward reaction
is so large that it occurs spontaneously and is not in equilibrium with
the reverse reaction = large negative free energy
Citrate synthase
Isocitrate dehydrogenase
α-ketoglutatrate dehydrogenase complex
44. Pyruvate is an important metabolite
Under aerobic conditions, pyruvate is converted to acetyl-CoA
by pyruvate dehydrogenase
This is an irreversible step, and must be tightly regulated
Pyruvate dehydrogenase is allosterically regulated
◦ High concentrations of ATP, NADH, acetyl-CoA inhibit
◦ High concentrations of NAD+, CoA activate
High concentrations of acetyl-CoA inhibits the transacetylase
component of E2
High concentrations of NADH inhibits the dihydrolipoyl
dehydrogenase component of E3
45. Pyruvate dehydrogenase kinase is a
regulatory enzyme that is part of the
pyruvate dehydrogenase complex in
mammals
◦ Dehydrogenase kinase is allosterically
activated by NADH and acetyl-CoA
◦ Pyruvate dehydrogenase is
phosphorylated on E1
◦ This blocks the first step of catalysis,
the decarboxylation of pyruvate
Pyruvate dehydrogenase phosphatase
is associated with the dehydrogenase
complex when NADH and acetyl-CoA
levels are low
◦ Keeps E1 dephosphorylated and thus
active
◦ Is inactivated by high NADH or acetyl-
CoA
46. TCA cycle is regulated by
feedback inhibition
Feedback inhibition = products
from the system inhibit enzymes
in the same system
The principle signals are acetyl-
CoA, succinyl-CoA, ATP, ADP,
AMP, NAD+ and NADH.
Enzyme Activators Inhibitors
Pyruvate
dehydrogenase
NAD+, CoA Acetyl CoA,
NADH, ATP
Citrate synthase ATP, NADH,
succinyl-CoA
Isocitrate
dehydrogenase
NAD+, ADP ATP, NADH
α-ketoglutarate
dehydrogenase
AMP NADH,
succinyl-CoA