This document discusses the role of vitamin D in reducing cancer risk and progression. It summarizes that vitamin D3 is converted to calcitriol, which regulates genes in most tissues and has been associated with reduced cancer risk in some studies. Calcitriol is synthesized locally in tissues and cancer cells, where it regulates pathways involved in cancer development. While cell and animal models support vitamin D's role in retarding cancer, data from human trials are inconsistent, though observational studies link vitamin D deficiency to worse cancer outcomes. Further randomized trials are needed to demonstrate vitamin D's effects on cancer risk and progression in humans.