This document discusses beta-blockers, including their discovery, mechanism of action, uses, side effects, and current research. Beta-blockers were discovered in 1962 and work by blocking beta-1 and beta-2 adrenoceptors. They are used to treat various cardiovascular conditions like hypertension, angina, and arrhythmias. While generally effective, they can cause side effects like bradycardia, bronchospasm, and hypoglycemia. Current research is exploring their potential roles in cancer treatment and fracture prevention.
Introduction to diuretics.
Therapeutic approaches.
Normal physiology of urine formation.
Classification of drugs .
Mechanism of action of Acetazolamide.
Mechanism of action of Thiazides.
Mechanism of action of Loop diuretics.
Mechanism of action of potassium sparing diuretics &aldosterone antagonists.
Hello everyone.....I shared a pdf file containing the deep knowledge about HYPERLIPIDEMIA AND THE PHARMACOLOGY OF ANTI-HYPERLIPIDEMIC DRUGS . In the B.pharma 5th semester...there is an most important topic ANTI-HYPERLIPIDEMIC DRUGS in the subject Pharmacology -II so i uploaded this file to help the students about this most important topic.....if u want this assignment in any format....feel free to DM me on my gmail id.....careof22@gmail.com.....THANK YOU
5-Hydroxytryptamine & it’s Antagonist is a Topic in Pharmacology which will defiantly Help You in pharmacy field All information is related to pharmacology drug acting and it's effect on body. it is collage project given by our department i would like to share with you.
General introduction about hypertension and structure activity relationship of Different types of antihypertensive drugs, and related questions that were asked in exams.
detailed SAR and mode of action of ACE inhibitors
Introduction to diuretics.
Therapeutic approaches.
Normal physiology of urine formation.
Classification of drugs .
Mechanism of action of Acetazolamide.
Mechanism of action of Thiazides.
Mechanism of action of Loop diuretics.
Mechanism of action of potassium sparing diuretics &aldosterone antagonists.
Hello everyone.....I shared a pdf file containing the deep knowledge about HYPERLIPIDEMIA AND THE PHARMACOLOGY OF ANTI-HYPERLIPIDEMIC DRUGS . In the B.pharma 5th semester...there is an most important topic ANTI-HYPERLIPIDEMIC DRUGS in the subject Pharmacology -II so i uploaded this file to help the students about this most important topic.....if u want this assignment in any format....feel free to DM me on my gmail id.....careof22@gmail.com.....THANK YOU
5-Hydroxytryptamine & it’s Antagonist is a Topic in Pharmacology which will defiantly Help You in pharmacy field All information is related to pharmacology drug acting and it's effect on body. it is collage project given by our department i would like to share with you.
General introduction about hypertension and structure activity relationship of Different types of antihypertensive drugs, and related questions that were asked in exams.
detailed SAR and mode of action of ACE inhibitors
ANTI HYPERTENSIVE AGENTS [MEDICINAL CHEMISTRY] BY P.RAVISANKAR, HYPERTENSION,...Dr. Ravi Sankar
ANTI HYPERTENSIVE AGENTS [MEDICINAL CHEMISTRY] BY P.RAVISANKAR, HYPERTENSION,TYPES,CAUSES OF HYPERTENSION, CLASSIFICATION, MECHANISM OF ACTION, SAR, ACE INHIBITORS, ARB , DIURETICS(WATER PILLS), TIPS TO STOP SILENT KILLER.
BY P. RAVISANKAR, VIGNAN PHARMACY COLLEGE, VADLAMUDI, GUNTUR,A.P, INDIA.
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
This presentation contains drugs which blocks the adrenergic system e.g receptor blockers like alpha and beta receptor antagonists, adrenergic neuron blocking agents in details.various animated pictures are also included to make the presentation interesting as well as i have used various diagrams and tables to have better understanding of the topic. Thank you.
Antihypertensives | Classes of Drugs | Baro ReceptorChetan Prakash
This Presentation provides a knowledge about Antihypertensives, types of blood pressure, hypertension types, normal blood pressure regulation, baro receptors, classes of antihypertensive drugs,recent discovery on hypertension. This is an assignment for the subject, Advanced Pharmacology-I, 1st year M.Pharm, 1st semester.
This presentation deals with the beta blockers commonly used in day-to-day practice alongwith some interesting mnemonics to remember their names & site of action
Chemistry of Anti Anginal Drugs by Professor BeubenzProfessor Beubenz
This presentation will give you an idea about the chemistry of Anti-anginal drugs along with its classification, mechanism of action & Structural Activity Relationship.
#Professor_Beubenz
For more such videos do
#Subscribe
#Share
#Like
to the Channel Professor Beubenz
Thank You.
https://www.youtube.com/watch?v=-7yjQm4zzX8&t=1183s
ANTI HYPERTENSIVE AGENTS [MEDICINAL CHEMISTRY] BY P.RAVISANKAR, HYPERTENSION,...Dr. Ravi Sankar
ANTI HYPERTENSIVE AGENTS [MEDICINAL CHEMISTRY] BY P.RAVISANKAR, HYPERTENSION,TYPES,CAUSES OF HYPERTENSION, CLASSIFICATION, MECHANISM OF ACTION, SAR, ACE INHIBITORS, ARB , DIURETICS(WATER PILLS), TIPS TO STOP SILENT KILLER.
BY P. RAVISANKAR, VIGNAN PHARMACY COLLEGE, VADLAMUDI, GUNTUR,A.P, INDIA.
Seretonin (5HT) and Its Antagonists PharmacologyPranatiChavan
Serotonin is a chemical that has a wide variety of functions in the human body. It is sometimes called the happy chemical, because it contributes to wellbeing and happiness.
The scientific name for serotonin is 5-hydroxytryptamine, or 5-HT. It is mainly found in the brain, bowels, and blood platelets.
Serotonin is used to transmit messages between nerve cells, it is thought to be active in constricting smooth muscles, and it contributes to wellbeing and happiness, among other things. As the precursor for melatonin, it helps regulate the body’s sleep-wake cycles and the internal clock.
It is thought to play a role in appetite, the emotions, and motor, cognitive, and autonomic functions. However, it is not known exactly if serotonin affects these directly, or if it has an overall role in co-ordinating the nervous system.
This presentation contains drugs which blocks the adrenergic system e.g receptor blockers like alpha and beta receptor antagonists, adrenergic neuron blocking agents in details.various animated pictures are also included to make the presentation interesting as well as i have used various diagrams and tables to have better understanding of the topic. Thank you.
Antihypertensives | Classes of Drugs | Baro ReceptorChetan Prakash
This Presentation provides a knowledge about Antihypertensives, types of blood pressure, hypertension types, normal blood pressure regulation, baro receptors, classes of antihypertensive drugs,recent discovery on hypertension. This is an assignment for the subject, Advanced Pharmacology-I, 1st year M.Pharm, 1st semester.
This presentation deals with the beta blockers commonly used in day-to-day practice alongwith some interesting mnemonics to remember their names & site of action
Chemistry of Anti Anginal Drugs by Professor BeubenzProfessor Beubenz
This presentation will give you an idea about the chemistry of Anti-anginal drugs along with its classification, mechanism of action & Structural Activity Relationship.
#Professor_Beubenz
For more such videos do
#Subscribe
#Share
#Like
to the Channel Professor Beubenz
Thank You.
https://www.youtube.com/watch?v=-7yjQm4zzX8&t=1183s
antipsychotics history, managment of psychosis,side effect of antipsychotics, mechanism of antipsychotics, atypical antipsychotics,2nd generation antipsychotics.
This slides describes the concept of bivalent compounds. It improve the potency significantly by simply joining two compounds by flexible or rigid linker. PROTAC and Molecular glue is gaining lot of interest is basically an extension of this idea . My personal journey of designing dual inhibitors started in 1996, when we worked on combining Steroids with Enediyne. Later during my professional journey, we have tried to make compounds like DDP4-ACE, GyraseB-Topo4, HNE Bivalent and many other undisclosed work. My interest in this area is never weaning out. Recently, i am observing a lot of interest in RNA-PROTAC, Antibody Oligo or Aptamer Oligo conjugates. Hope to witness successful launch of a blockbuster compound form this kind of combination approach.
FINAL.. beta blockers in cardiovascular disease.pptxdkapila2002
beta blockers have an ever increasing role in many cardiovascular disorders like heart failure,heart attacks,hypertension & SIHD. With new_generation beta-blockers,their efficacy has increased with fewer side effects.They now have a very important role in heart-failure & CAD,while lesser role in management of hypertension.Their present status in CV disorders according to latest guidelines is highlighted.The so called thierd generation betablockers have shown better efficacy with fewer side-effects though large scale randomized trials are lacking
A slide series to learn and appreciate the importance and the potential of Personalized/Individualized Genomic Medicine. It briefly goes through the idea of biotechnology and the advancements we have made in biology and technology. A series of applications for genomic medicine is then explored, not failing to mention the challenges we have to overcome as well, for the next medical revolution.
A case for personalized medicine is presented.
Running Head GASTROINTESTINAL TRACT1GASTROINTESTINAL TRACT3.docxjeanettehully
Running Head: GASTROINTESTINAL TRACT 1
GASTROINTESTINAL TRACT 3
GastroIntestinal Tract
Name
Institution
Course
Date
GastroIntestinal Disorders
Introduction
Normally, gastric acids are produced and stimulated so that the body can break down consumed foods and digest them easily. The major component of gastric juice is hydrochloric acid, which is produced by oxyntic cells. The secretion of these acids takes place in three phases namely: the cephalic phase, the gastric phase and the intestinal phase. The cephalic phase starts when someone has an urge to eat or smells food. The brain signals the parietal cells to secrete gastric acids and the ECL to secrete histamine. The gastric phase is when someone has eaten and the amino acids present in the food stimulates the production of these acids. The last phase is stimulated by the distention in the small intestines and the amino acids too and the secretion takes place when chime enters the small intestines (Testani et al., 1996).
Gastroesophageal Reflex Disease (GERD)
There are gastrointestinal orders that exist, such as Gastroesophageal Reflex Disease (GERD), Peptic Ulcer Disease (PUD) and Gastritis disorders. Patients suffering from GERD have a complex gastric acid secretion caused by frequent acid reflux. There are cases where HCL frequently flows back to the esophagus and when this happens, the lining of the esophagus becomes irritated. The age factor is visible in this disorder. Older people are more likely to experience this disease than young. However, symptoms are less visible in the elderly. The fact that there is no serious warning symptom of GERD among the elderly makes the disorder more complicated in them. GERD can be diagnosed by a probe test, upper endoscopy or x-ray of the upper digestive system. For the elderly, adequate doses of medication that do not harm the digestive system are effective. Medical therapeautic agents, including PPIs such as pantoprazole and Omeprazole, can also cure GERD.
Peptic Ulcer Disease (PUD)
PUD is caused by an imbalance between the secretion of gastric acid and duodenal mucous defence. When the balance between the two is disrupted, there is a consequence of mucousal injury and hence peptic ulcers. PUD among the elderly is associated by complications and when administering medication, special attention should be given to the elderly since they respond negatively to medications and surgery. PUD can be diagnosed by carrying out both physical and diagnostic tests (Okello, et. al, 2016) . Once it has been diagnosed, laboratory tests can then be undertaken such as breath tests, stool and blood tests. There are two main factors that contribute to the high rate of PUD among the elderly are the high rates of H. Pylori and prescription of drugs that increase damage in the gastroduodenal drugs. Elderly patients receive medical treatment of PUD
Gastritis Disorders
Gastritis disorders basically results from mucous injury that may have been caused by ...
2. Background
Mechanism of action
Structure-activity relationship
Clinical information
Current research
Summary
References
2
3. Discovered by Sir James Black in 1962
Awarded the Nobel Prize for Medicine in 1988
Propranolol and pronethalol were the first
clinically significant beta-blockers (van der Vring et
al., 1999)
All beta-blockers end in ‘-lol’, e.g. labetalol,
timolol, bisoprolol, etc.
3
Nobel Media,
2014
4. β1- and β2-adrenoceptor inverse agonists
Drugs vary in inverse agonist activity
Selectivity vs. specificity
Panesar and
Guzman,
2009
4
5. Part of the sympathetic nervous system
Metabotropic, G-protein-coupled receptors
Linked to the Gs protein
β1-adrenoceptors
◦ Heart, kidneys
β2-adrenoceptors
◦ Bladder detrusor muscle, eye ciliary muscle, GI
tract, liver, pancreas, smooth muscle, skeletal
muscle (Lechat, 2008)
5
8. Essential for binding to receptors (Lechat, 2008)
◦ Oxymethylene
Essential for activity (Gorre and Vanderkerckhove, 2010)
◦ Aromatic ring
◦ β-ethanolamine
Adapted from Mehvar and Brocks, 2001
8
11. Second- or third-degree heart block
Worsening unstable heart failure
Renal impairment
◦ Dose reduction of water-soluble beta-blockers, e.g.
atenolol and sotalol
Asthma or COPD
◦ Treatment should be initiated by a specialist
Diabetes
◦ Cardioselective beta-blockers are preferred
◦ Avoid altogether if hypoglycaemia occurs frequently
(Joint Formulary Committee, 2014)
11
12. Adrenaline and noradrenaline
Antihypertensives, e.g. ACE inhibitors,
angiotensin-II-receptor antagonists, alpha-blockers,
calcium-channel blockers, diuretics
Anti-arrhythmics, e.g. amiodarone, flecainide
Anti-psychotics
◦ Increased risk of arrhythmias with sotalol
Insulins
12
13. Conflicting research on use of beta-blockers
in cancers
◦ Use of beta-blockers pre-mastectomy in breast
cancer patients was associated with improved
recurrence-free survival (Melhem-Bertrand et al., 2011)
◦ Increased survival time of patients with melanoma
receiving beta-blockers (Lemeshow et al., 2011)
◦ No association between exposure to beta-blockers
and improved survival for breast, lung, or colorectal
cancer in hypertensive patients (Musselman et al. 2014)
13
14. Beta-blockers reduce platelet aggregation
◦ Non-selective lipophilic beta-blockers cause a
greater reduction than selective hydrophilic beta-blockers
(Bonten et al., 2014)
Beta-blockers reduced risk of fractures (Toulis et
al., 2014)
Mortality reduced post-acute traumatic brain
injury by beta-blockers (Alali et al., 2014)
14
15. All beta-blocker drug names end in ‘-lol’
β1- and β2-adrenoceptor inverse agonists
Decrease cAMP concentration
Different mechanisms of action in different
muscle types
Importance of chemical structure
Indications, adverse effects, cautions,
contraindications, drug interactions
Current research
15
16. Alali AS, McCredie VA, Golan E, Shah PS, and Nathens AB. (2014) Beta Blockers for Acute
Traumatic Brain Injury: A Systematic Review and Meta-analysis. Neurocrit Care 20 (3):
514-523.
Bonten TN, Plaizier CEI, Snoep JJD, Stijnen T, Dekkers OM, and van der Bom JG. (2014)
Effect of β-blockers on platelet aggregation: a systematic review and meta-analysis. Br J
Clin Pharmacol 78 (5): 940-949.
Gorre F, Vanderkerckhove H. (2010) Beta-blockers: focus on mechanism of action. Which
beta-blocker, when and why? Acta Cardiol 65 (5):565–570.
Joint Formulary Committee. (2014) Beta-adrenoceptor blocking drugs. In: Joint
Formulary Committee. British National Formulary. 68th ed. London: BMJ Group and
Pharmaceutical Press.
Klabunde RE. (2013) Beta-Adrenoceptor Antagonists (Beta-Blockers). Available:
http://cvpharmacology.com/cardioinhibitory/beta-blockers.htm. Last accessed 24th Oct
2014.
Lechat P. (2008) Clinical pharmacology of beta-blockers in cardiology: trial results and
clinical applications. Hot Topics in Cardiology 10 (7):7-44.
Lemeshow S, Sørensen HT, Phillips G, Yang EV, Antonsen S, Riis AH, Lesinski GB, Jackson
R, and Glaser R. (2011) β-Blockers and survival among Danish patients with malignant
melanoma: a population-based cohort study. Cancer Epidemiol Biomarkers Prev 20 (10):
2273-2279.
16
17. Mehvar R, Brocks DR. (2001) Stereospecific Pharmacokinetics and Pharmacodynamics of
Beta-Adrenergic Blockers in Humans. J Pharm Pharmaceutical Sci 4 (2):185-200.
Musselman RP, Li W, Gomes T, Mamdani M, Haggar F, Mollo H, Boushey RP, Al-Omran M,
Al-Obeed O, VanWalraven C, and Auer RC. (2014) Association Between Beta Blocker
Usage and Cancer Survival in a Large, Matched Population Study Among Hypertensive
Patients. J Surg Res 186 (2): 639-640.
Nobel Media AB. (2014) Sir James W. Black – Facts. Available:
http://www.nobelprize.org/nobel_prizes/medicine/laureates/1988/black-facts.html.
Last accessed 10th Nov 2014.
Toulis KA, Hemming S, Stergianos S, Nirantharakumar K, and Bilezikian JP. (2014) β-
adrenergic receptor antagonists and fracture risk: a meta-analysis of selectivity, gender,
and site-specific effects. Osteoporos Int 25 (1): 121-129.
van der Vring JAFM, Daniëls MCG, Holwerda NJH, Withagen PJAM, Schelling A, Cleophas
TJ, Hendriks MGC. (1999) Combination of Calcium Channel Blockers and Beta Blockers
for Patients with Exercise-Induced Angina Pectoris: A Double-Blind Parallel-Group
Comparison of Different Classes of Calcium Channel Blockers. Angiology 50 (6):447-
454.
17