This document is an index for a 5 volume pharmacopoeia. It lists all contents by page number across the volumes, including preliminaries, general notices, monographs, spectra, appendices and supplementary chapters. Page numbers in bold relate to individual monograph titles. The index covers contents from A to Z and includes common abbreviations used in the pharmacopoeia.
Quality control tests for Syrups and Elixirs.Umair hanif
The document discusses various quality control tests performed on syrups and elixirs, including testing the water used, visual inspection, measuring pH, testing for sucrose concentration using HPLC or UV spectroscopy, determining alcohol concentration, and measuring viscosity. Viscosity can be measured using various methods like U-tube viscometers, capillary viscometers, rotating viscometers, concentric cylinder viscometers, cone-plate viscometers, and spindle viscometers. Maintaining quality standards is important to ensure purity, appearance, stability, and proper concentration of ingredients in syrups and elixirs.
IPQC Tests for capsules As per IP, BP & USPPramod Ramane
IPQC- In Process Quality Control Tests for Capsules are
1. Uniformity Of Content
2. Disintigration Test
3. Weight Variation Test
4. Dissolution Test
The tests are with Acceptance limits/Criteria as per Indian Pharmacopoeia (IP), British Pharmacopoeia (BP) & United States Pharmacopoeia (USP)
Pharmaceutical Good Manufacturing PracticesPharmaceutical
When you are in healthcare, Then GMP is must. Regulatory philosophy for product Quality have been changed from "Quality by Testing QbT" to "Quality by Design QbD". Quality is to be built in product and that only can be done by GMP.
In Process Quality Control Tests (IPQC) for Solid Dosage FromSagar Savale
This document discusses in-process quality control tests that are performed during the manufacturing of solid oral dosage forms such as tablets and capsules. It provides details about common tests like weight variation, hardness, friability, disintegration and dissolution. The tests help to identify any issues during production so that corrective actions can be taken. Specific test methods, acceptance criteria and instruments used for tests are outlined for various types of oral dosage forms including immediate release tablets, sustained release tablets, capsules and suppositories. Maintaining quality during manufacturing is important to deliver consistent drug levels in patients.
PIC/S is a combine term used for the execution of activities of Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme
harmonize, educate, and update aspects relating to Good Manufacturing Practice among member countries
harmonized relation among regulatory authorities and governments
members
history
role
objective and function
guidlines
Impurities in Drug Substance & in Drug ProductKamal Ambalia
The document provides guidance on impurities in drug substances and products. It discusses the classification of impurities into organic, inorganic, and residual solvents. It describes the rationale for reporting and controlling impurities and outlines identification thresholds, reporting thresholds, and qualification thresholds based on maximum daily dose. Analytical procedures for impurity detection and identification must be validated. Impurities above thresholds require identification and qualification. The new drug specification must include impurities above reporting thresholds. Residual solvent limits are based on ICH Q3C guidelines.
This document summarizes the ICH guideline for stability testing. The ICH provides guidance on stability testing to ensure drug quality over time under various environmental conditions. Key aspects covered include the objectives of stability testing, variables that affect stability, terminology, and ICH guidelines Q1A through Q1F which provide detailed recommendations on stability testing procedures, data evaluation, and submissions for registration.
Quality control tests for Syrups and Elixirs.Umair hanif
The document discusses various quality control tests performed on syrups and elixirs, including testing the water used, visual inspection, measuring pH, testing for sucrose concentration using HPLC or UV spectroscopy, determining alcohol concentration, and measuring viscosity. Viscosity can be measured using various methods like U-tube viscometers, capillary viscometers, rotating viscometers, concentric cylinder viscometers, cone-plate viscometers, and spindle viscometers. Maintaining quality standards is important to ensure purity, appearance, stability, and proper concentration of ingredients in syrups and elixirs.
IPQC Tests for capsules As per IP, BP & USPPramod Ramane
IPQC- In Process Quality Control Tests for Capsules are
1. Uniformity Of Content
2. Disintigration Test
3. Weight Variation Test
4. Dissolution Test
The tests are with Acceptance limits/Criteria as per Indian Pharmacopoeia (IP), British Pharmacopoeia (BP) & United States Pharmacopoeia (USP)
Pharmaceutical Good Manufacturing PracticesPharmaceutical
When you are in healthcare, Then GMP is must. Regulatory philosophy for product Quality have been changed from "Quality by Testing QbT" to "Quality by Design QbD". Quality is to be built in product and that only can be done by GMP.
In Process Quality Control Tests (IPQC) for Solid Dosage FromSagar Savale
This document discusses in-process quality control tests that are performed during the manufacturing of solid oral dosage forms such as tablets and capsules. It provides details about common tests like weight variation, hardness, friability, disintegration and dissolution. The tests help to identify any issues during production so that corrective actions can be taken. Specific test methods, acceptance criteria and instruments used for tests are outlined for various types of oral dosage forms including immediate release tablets, sustained release tablets, capsules and suppositories. Maintaining quality during manufacturing is important to deliver consistent drug levels in patients.
PIC/S is a combine term used for the execution of activities of Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme
harmonize, educate, and update aspects relating to Good Manufacturing Practice among member countries
harmonized relation among regulatory authorities and governments
members
history
role
objective and function
guidlines
Impurities in Drug Substance & in Drug ProductKamal Ambalia
The document provides guidance on impurities in drug substances and products. It discusses the classification of impurities into organic, inorganic, and residual solvents. It describes the rationale for reporting and controlling impurities and outlines identification thresholds, reporting thresholds, and qualification thresholds based on maximum daily dose. Analytical procedures for impurity detection and identification must be validated. Impurities above thresholds require identification and qualification. The new drug specification must include impurities above reporting thresholds. Residual solvent limits are based on ICH Q3C guidelines.
This document summarizes the ICH guideline for stability testing. The ICH provides guidance on stability testing to ensure drug quality over time under various environmental conditions. Key aspects covered include the objectives of stability testing, variables that affect stability, terminology, and ICH guidelines Q1A through Q1F which provide detailed recommendations on stability testing procedures, data evaluation, and submissions for registration.
ICH Q6A Specifications by Chandra MohanChandra Mohan
The document provides guidelines on specifications for new drug substances and products. It defines specifications and outlines universal tests that should be included for both drug substances and products, such as description, identification, assay, and impurities. It also describes specific tests that may be included depending on the dosage form, such as dissolution, disintegration, hardness/friability for solid oral dosage forms. The guidelines provide information on justifying acceptance criteria and setting specifications based on development data and stability studies.
WHO Guideline & Stability Protocols for Liquid Dosage FormsAnindya Jana
This document summarizes WHO guidelines for stability testing of liquid dosage forms. It outlines the key aspects that should be covered in stability protocols, including specifications tested, storage conditions and minimum time periods for long term, intermediate and accelerated studies. Specific recommendations are provided for drug substances, oral solutions, suspensions, small volume parenterals and other dosage forms. The purpose of stability testing is to provide evidence of a product's quality over time under various environmental factors and establish a re-test period or shelf life. Ongoing stability studies are also required to monitor products throughout their shelf life.
Accelerated stability testing is used to predict the shelf life of pharmaceutical formulations by subjecting them to elevated temperatures and humidity to accelerate any degradation. The key steps involve conducting studies at different temperatures, determining the reaction order, calculating rate constants (k) at each temperature, determining the energy of activation using the Arrhenius equation, and extrapolating to room temperature to estimate shelf life. Limitations include changes in degradation mechanism or order at higher temperatures that limit the accuracy of shelf life predictions.
This document discusses quality control testing for suppositories. It describes several tests used to evaluate suppositories, including appearance tests to check odor, color, shape and surface condition. Weight uniformity, melting range, disintegration, liquefaction/softening time, hardness/breaking, dissolution and stability tests are also summarized. The tests ensure suppositories meet specifications for attributes like weight variation, melting/disintegration time and release of the active ingredient. Maintaining proper storage conditions can prevent issues like hardening or surface deposits on suppositories over time.
This document provides information about quality control testing of ointments. It discusses the types of ointments and their bases. Quality control tests are categorized into universal tests like description, identification and assay. Specific tests include pH, viscosity and particle size determination. Special tests involve phase separation, uniformity between containers and in-vitro drug release studies. Evaluation tests measure the rate of absorption, irritancy and rate of penetration. The document outlines the procedures and acceptance criteria for various quality control and evaluation tests performed on ointment formulations.
In Process Quality Control Tests (IPQC) For Parenteral or Sterile Dosage FormsSagar Savale
These are the tests performed between QA and QC and provides for the authorization of approved raw materials for manufacturing based on actual laboratory testing generally called as IPQC such as physical, chemical, microbiologic and biologic tests.
In process quality control of suspensions and emulsionsceutics1315
This document discusses in-process quality control of suspensions and emulsions. It defines in-process quality control as controlling manufacturing procedures from raw materials to final product packaging. Key tests for suspensions include appearance, particle size, zeta potential, viscosity, sedimentation rate and redispersibility. Maintaining proper pH, drug content uniformity and monitoring manufacturing areas are also important. Tests for emulsions include appearance, droplet size, viscosity, creaming index and phase separation. Proper documentation of quality control procedures and parameters is necessary to ensure batch uniformity and quality.
This document outlines 8 key tests for evaluating ointments and creams: [1] Physical appearance to check for cracking, changes in viscosity, or microbial growth. [2] Particle size determination under a microscope. [3] Weight variation testing of labeled amounts. [4] Solubility testing in water and alcohol. [5] Viscosity determination using specified methods. [6] Assay of active ingredients within official limits. [7] Microbial contamination testing using inoculation or membrane filtration. [8] Testing for metal particles in ophthalmic ointments under a microscope.
In process & finished products quality control test for pharmaceuticalsSuraj Ghorpade
This document discusses in-process quality control (IPQC) and finished product quality control (FPQC) for pharmaceutical products. It defines IPQC and outlines its objectives to optimize processes, monitor operations, and inspect raw materials, equipment, environment and more. Key IPQC tests are described including physical/chemical tests (identity, quality, purity, potency), biological/microbiological tests. Specific IPQC parameters and checks are provided for tablets, including tests for size/shape, color, thickness, assay, dissolution and more. Acceptance criteria are defined according to pharmacopeial standards. The importance of IPQC for ensuring quality products is emphasized.
The document discusses aseptic processing, which involves bringing together sterile products, containers, and closures that have been separately sterilized and assembling them in a highly controlled environment using specialized personnel and equipment. Key elements of aseptic processing include facility design and control, equipment sterilization and material handling, the aseptic processing itself, personnel training, process verification through media fills and environmental monitoring, finished product testing, and comprehensive documentation.
Manufacturing Flow Chart And IPQC Test Of SUSPENSIONAditi Roy
This document discusses in-process quality control tests for pharmaceutical suspensions. Some key tests mentioned include visual inspection of appearance and purity, measuring properties like density, pH, clarity and sedimentation volume over time. Electrokinetic methods like zeta potential measurement and microscopic analysis of particle size distribution are also described. Content uniformity testing and ensuring redispersibility upon shaking are emphasized for control during production.
This document defines and discusses parenteral preparations and administration. Parenteral preparations are sterile preparations intended for administration by injection, infusion, or implantation rather than orally. They must be sterile, pyrogen-free, and packaged to ensure sterility. Common routes of parenteral administration include intravenous, intramuscular, subcutaneous, and intradermal injection. Requirements for parenteral preparations include sterility, freedom from pyrogens and particulates, isotonicity, stability, and compatibility.
Process validation of liquid orals (pharmaceutical process validation)sarikakkadam
This document discusses process validation for liquid oral drug products such as suspensions and emulsions. It describes the key unit operations involved in manufacturing such products including mixing, blending, and dispersing. It identifies important process parameters for each unit operation that can influence critical quality attributes. It also discusses monitoring of critical quality attributes like appearance, pH, viscosity and content uniformity. Finally, it covers validation of raw materials and filling/packaging operations for liquid oral products.
Capsules are solid dosage forms that contain a drug or mixture of drugs enclosed within a shell. The shell is typically made of gelatin but can also be other materials. Capsules are intended for oral administration and provide rapid release of contents unless they are modified or enteric release capsules. Capsules can be filled using various methods like auger, dosator, or dosing disc systems. Tests are conducted to ensure uniformity of contents, weight, and dissolution based on pharmacopeial standards.
Capsules are solid dosage forms that enclose a drug formulation within a shell. There are two main types - hard gelatin capsules used for powders and soft gelatin capsules used for semisolids and liquids. Quality control tests are performed during capsule manufacturing and filling to ensure specifications are met. These include in-process tests like weight variation and dissolution testing, and finished product tests such as disintegration, potency, content uniformity, and microbial testing. Capsules offer advantages like masking unpleasant tastes, easy swallowing, and protection from light, but are not suitable for hygroscopic or concentrated drugs that may irritate the stomach.
This document summarizes the standards and testing methods for different types of tablets according to the Indian Pharmacopoeia. It describes 10 types of tablets and the standards that apply to all tablets, including content uniformity, weight variation, disintegration, friability, and dissolution testing. The document provides details on the acceptance criteria and testing procedures for each of these standards.
This document provides guidelines for assessing and controlling elemental impurities in drug products. It establishes permitted daily exposure (PDE) levels for various elemental impurities based on toxicity data. It then describes a risk-based approach to control elemental impurities in drug products by identifying potential sources, evaluating risks, and defining necessary controls. The guidelines apply to new drug products and do not expect existing products to tighten limits unless exceeding PDEs.
This document discusses process validation for pharmaceutical products. It defines process validation, outlines current regulatory approaches, and describes the role of dossier assessment in process validation. Key points covered include risk assessment as part of process validation, validation schemes involving monitoring and sampling, specific topics like blend uniformity and compression step validation, and process validation for different dosage forms. Guidelines from FDA, WHO, and EMA on process validation approaches like traditional, continuous, and hybrid are summarized. The document provides examples of process validation protocols, monitoring plans, sampling methods and acceptance criteria for various steps in manufacturing like blending, drying, lubrication, and compression.
The document discusses guidelines from the International Council for Harmonisation (ICH) related to quality, safety, efficacy, and multidisciplinary aspects of pharmaceutical development. It provides an overview of ICH guidelines in four categories (Q, S, E, M) and describes some of the key guidelines within the Quality (Q) and Safety (S) categories in more detail. The Quality guidelines address issues like stability testing, impurities, biotechnology products, and good manufacturing practices. The Safety guidelines cover topics such as carcinogenicity, genotoxicity, reproductive toxicity, and non-clinical safety evaluation.
This document is an index for Volume VI of the British Pharmacopoeia for Veterinary Use (BP(Vet)). It lists monograph titles in bold page numbers and other topics from A-Z. The index contains over 450 entries including monograph titles, general notices topics, and abbreviations. It provides a table of contents to navigate the information contained in BP(Vet) Volume VI.
2015 geriatric pharma chapter 1 fundamentals of geriatric pharmacotherapyROBERTO CARLOS NIZAMA
This document discusses the challenges of caring for the geriatric population. It begins by noting there is no universally agreed upon definition of "geriatric," as age alone is an imperfect measure. The elderly population can be stratified by age, health status, and living environment to better understand individual needs and how clinical evidence applies. Healthcare for the elderly involves many providers across different settings, from independent living to nursing homes. Close scrutiny of a patient's individual characteristics is needed to ensure care is optimally tailored and potential issues addressed.
ICH Q6A Specifications by Chandra MohanChandra Mohan
The document provides guidelines on specifications for new drug substances and products. It defines specifications and outlines universal tests that should be included for both drug substances and products, such as description, identification, assay, and impurities. It also describes specific tests that may be included depending on the dosage form, such as dissolution, disintegration, hardness/friability for solid oral dosage forms. The guidelines provide information on justifying acceptance criteria and setting specifications based on development data and stability studies.
WHO Guideline & Stability Protocols for Liquid Dosage FormsAnindya Jana
This document summarizes WHO guidelines for stability testing of liquid dosage forms. It outlines the key aspects that should be covered in stability protocols, including specifications tested, storage conditions and minimum time periods for long term, intermediate and accelerated studies. Specific recommendations are provided for drug substances, oral solutions, suspensions, small volume parenterals and other dosage forms. The purpose of stability testing is to provide evidence of a product's quality over time under various environmental factors and establish a re-test period or shelf life. Ongoing stability studies are also required to monitor products throughout their shelf life.
Accelerated stability testing is used to predict the shelf life of pharmaceutical formulations by subjecting them to elevated temperatures and humidity to accelerate any degradation. The key steps involve conducting studies at different temperatures, determining the reaction order, calculating rate constants (k) at each temperature, determining the energy of activation using the Arrhenius equation, and extrapolating to room temperature to estimate shelf life. Limitations include changes in degradation mechanism or order at higher temperatures that limit the accuracy of shelf life predictions.
This document discusses quality control testing for suppositories. It describes several tests used to evaluate suppositories, including appearance tests to check odor, color, shape and surface condition. Weight uniformity, melting range, disintegration, liquefaction/softening time, hardness/breaking, dissolution and stability tests are also summarized. The tests ensure suppositories meet specifications for attributes like weight variation, melting/disintegration time and release of the active ingredient. Maintaining proper storage conditions can prevent issues like hardening or surface deposits on suppositories over time.
This document provides information about quality control testing of ointments. It discusses the types of ointments and their bases. Quality control tests are categorized into universal tests like description, identification and assay. Specific tests include pH, viscosity and particle size determination. Special tests involve phase separation, uniformity between containers and in-vitro drug release studies. Evaluation tests measure the rate of absorption, irritancy and rate of penetration. The document outlines the procedures and acceptance criteria for various quality control and evaluation tests performed on ointment formulations.
In Process Quality Control Tests (IPQC) For Parenteral or Sterile Dosage FormsSagar Savale
These are the tests performed between QA and QC and provides for the authorization of approved raw materials for manufacturing based on actual laboratory testing generally called as IPQC such as physical, chemical, microbiologic and biologic tests.
In process quality control of suspensions and emulsionsceutics1315
This document discusses in-process quality control of suspensions and emulsions. It defines in-process quality control as controlling manufacturing procedures from raw materials to final product packaging. Key tests for suspensions include appearance, particle size, zeta potential, viscosity, sedimentation rate and redispersibility. Maintaining proper pH, drug content uniformity and monitoring manufacturing areas are also important. Tests for emulsions include appearance, droplet size, viscosity, creaming index and phase separation. Proper documentation of quality control procedures and parameters is necessary to ensure batch uniformity and quality.
This document outlines 8 key tests for evaluating ointments and creams: [1] Physical appearance to check for cracking, changes in viscosity, or microbial growth. [2] Particle size determination under a microscope. [3] Weight variation testing of labeled amounts. [4] Solubility testing in water and alcohol. [5] Viscosity determination using specified methods. [6] Assay of active ingredients within official limits. [7] Microbial contamination testing using inoculation or membrane filtration. [8] Testing for metal particles in ophthalmic ointments under a microscope.
In process & finished products quality control test for pharmaceuticalsSuraj Ghorpade
This document discusses in-process quality control (IPQC) and finished product quality control (FPQC) for pharmaceutical products. It defines IPQC and outlines its objectives to optimize processes, monitor operations, and inspect raw materials, equipment, environment and more. Key IPQC tests are described including physical/chemical tests (identity, quality, purity, potency), biological/microbiological tests. Specific IPQC parameters and checks are provided for tablets, including tests for size/shape, color, thickness, assay, dissolution and more. Acceptance criteria are defined according to pharmacopeial standards. The importance of IPQC for ensuring quality products is emphasized.
The document discusses aseptic processing, which involves bringing together sterile products, containers, and closures that have been separately sterilized and assembling them in a highly controlled environment using specialized personnel and equipment. Key elements of aseptic processing include facility design and control, equipment sterilization and material handling, the aseptic processing itself, personnel training, process verification through media fills and environmental monitoring, finished product testing, and comprehensive documentation.
Manufacturing Flow Chart And IPQC Test Of SUSPENSIONAditi Roy
This document discusses in-process quality control tests for pharmaceutical suspensions. Some key tests mentioned include visual inspection of appearance and purity, measuring properties like density, pH, clarity and sedimentation volume over time. Electrokinetic methods like zeta potential measurement and microscopic analysis of particle size distribution are also described. Content uniformity testing and ensuring redispersibility upon shaking are emphasized for control during production.
This document defines and discusses parenteral preparations and administration. Parenteral preparations are sterile preparations intended for administration by injection, infusion, or implantation rather than orally. They must be sterile, pyrogen-free, and packaged to ensure sterility. Common routes of parenteral administration include intravenous, intramuscular, subcutaneous, and intradermal injection. Requirements for parenteral preparations include sterility, freedom from pyrogens and particulates, isotonicity, stability, and compatibility.
Process validation of liquid orals (pharmaceutical process validation)sarikakkadam
This document discusses process validation for liquid oral drug products such as suspensions and emulsions. It describes the key unit operations involved in manufacturing such products including mixing, blending, and dispersing. It identifies important process parameters for each unit operation that can influence critical quality attributes. It also discusses monitoring of critical quality attributes like appearance, pH, viscosity and content uniformity. Finally, it covers validation of raw materials and filling/packaging operations for liquid oral products.
Capsules are solid dosage forms that contain a drug or mixture of drugs enclosed within a shell. The shell is typically made of gelatin but can also be other materials. Capsules are intended for oral administration and provide rapid release of contents unless they are modified or enteric release capsules. Capsules can be filled using various methods like auger, dosator, or dosing disc systems. Tests are conducted to ensure uniformity of contents, weight, and dissolution based on pharmacopeial standards.
Capsules are solid dosage forms that enclose a drug formulation within a shell. There are two main types - hard gelatin capsules used for powders and soft gelatin capsules used for semisolids and liquids. Quality control tests are performed during capsule manufacturing and filling to ensure specifications are met. These include in-process tests like weight variation and dissolution testing, and finished product tests such as disintegration, potency, content uniformity, and microbial testing. Capsules offer advantages like masking unpleasant tastes, easy swallowing, and protection from light, but are not suitable for hygroscopic or concentrated drugs that may irritate the stomach.
This document summarizes the standards and testing methods for different types of tablets according to the Indian Pharmacopoeia. It describes 10 types of tablets and the standards that apply to all tablets, including content uniformity, weight variation, disintegration, friability, and dissolution testing. The document provides details on the acceptance criteria and testing procedures for each of these standards.
This document provides guidelines for assessing and controlling elemental impurities in drug products. It establishes permitted daily exposure (PDE) levels for various elemental impurities based on toxicity data. It then describes a risk-based approach to control elemental impurities in drug products by identifying potential sources, evaluating risks, and defining necessary controls. The guidelines apply to new drug products and do not expect existing products to tighten limits unless exceeding PDEs.
This document discusses process validation for pharmaceutical products. It defines process validation, outlines current regulatory approaches, and describes the role of dossier assessment in process validation. Key points covered include risk assessment as part of process validation, validation schemes involving monitoring and sampling, specific topics like blend uniformity and compression step validation, and process validation for different dosage forms. Guidelines from FDA, WHO, and EMA on process validation approaches like traditional, continuous, and hybrid are summarized. The document provides examples of process validation protocols, monitoring plans, sampling methods and acceptance criteria for various steps in manufacturing like blending, drying, lubrication, and compression.
The document discusses guidelines from the International Council for Harmonisation (ICH) related to quality, safety, efficacy, and multidisciplinary aspects of pharmaceutical development. It provides an overview of ICH guidelines in four categories (Q, S, E, M) and describes some of the key guidelines within the Quality (Q) and Safety (S) categories in more detail. The Quality guidelines address issues like stability testing, impurities, biotechnology products, and good manufacturing practices. The Safety guidelines cover topics such as carcinogenicity, genotoxicity, reproductive toxicity, and non-clinical safety evaluation.
This document is an index for Volume VI of the British Pharmacopoeia for Veterinary Use (BP(Vet)). It lists monograph titles in bold page numbers and other topics from A-Z. The index contains over 450 entries including monograph titles, general notices topics, and abbreviations. It provides a table of contents to navigate the information contained in BP(Vet) Volume VI.
2015 geriatric pharma chapter 1 fundamentals of geriatric pharmacotherapyROBERTO CARLOS NIZAMA
This document discusses the challenges of caring for the geriatric population. It begins by noting there is no universally agreed upon definition of "geriatric," as age alone is an imperfect measure. The elderly population can be stratified by age, health status, and living environment to better understand individual needs and how clinical evidence applies. Healthcare for the elderly involves many providers across different settings, from independent living to nursing homes. Close scrutiny of a patient's individual characteristics is needed to ensure care is optimally tailored and potential issues addressed.
2015 geriatric pharma frontmatter fundamentals of geriatric pharmacotherapyROBERTO CARLOS NIZAMA
Fundamentals of Geriatric Pharmacotherapy, Second Edition - 2015
Author: Lisa C. Hutchison, Rebecca B. Sleeper
Publisher: American Society of Health-System Pharmacists - ASHP
Publication date: 2015
Format: Paperback, 1 volume
Pages: 500 pp.
Handbook on Injectable Drugs, 18th Edition - ASHP
Author: American Society of Health-System Pharmacists - ASHP
Publisher: American Society of Health-System Pharmacists - ASHP
Handbook on Injectable Drugs, 18th Edition - ASHP
Author: American Society of Health-System Pharmacists - ASHP
Publisher: American Society of Health-System Pharmacists - ASHP
Ceritinib is an antineoplastic agent approved for the treatment of adults with ALK-positive metastatic non-small cell lung cancer (NSCLC) whose cancer has progressed on crizotinib. The recommended dosage is 750 mg once daily. Dosage reductions may be necessary due to common adverse effects like gastrointestinal toxicity, hepatotoxicity, interstitial lung disease, QT prolongation, hyperglycemia, and bradycardia. Ceritinib carries warnings for severe gastrointestinal toxicity, hepatotoxicity, interstitial lung disease, QT prolongation, hyperglycemia, and bradycardia.
Sample chapter - Competence Assessment Tools for Health-System PharmaciesROBERTO CARLOS NIZAMA
Antibiotic streamlining refers to changing patients from broad-spectrum antibiotics to narrower ones that specifically target the identified infecting organism. It involves monitoring culture results and the patient's clinical response to evaluate if therapy can be optimized. The benefits of streamlining include reducing resistance, adverse effects, costs, and secondary infections while improving outcomes. Pharmacists play an important role in streamlining by interpreting culture data and making recommendations to physicians.
Competence Assessment Tools for Health-System Pharmacies, 5th EditionROBERTO CARLOS NIZAMA
Competence Assessment Tools for Health-System Pharmacies, 5th Edition
Author: Lee B. Murdaugh
Publisher: American Society of Health-System Pharmacists - ASHP
Published: 2015
Hardback, 1 volume
Pages: 700 pp.
Product Dimensions: 28.20 cm x 22.00 cm
Mannitol is a sugar alcohol used widely as an excipient in pharmaceutical formulations and food products. It is commonly used as a diluent in tablet formulations due to its lack of hygroscopicity. Mannitol is also used as a lyophilization aid, plasticizing agent, sweetening agent, and tonicity agent. It has various applications in tablets, capsules, oral dispersible tablets, suspensions, dry powder inhalers, and lyophilized preparations. Mannitol is stable, non-hygroscopic, and well-tolerated but can cause laxation in large quantities.
PAINT AND COATING TESTING MANUAL, 15th Edition - ASTM
Edited by Joseph Koleske.
Publisher: ASTM International
Year Edition: 2012
Pages: 1000 pages
FormatType: Hardcover Book
Country: Estados Unidos
This document is the 15th edition of the Paint and Coating Testing Manual, also known as the Gardner-Sward Handbook. It contains 29 chapters written by different authors on various topics related to paints and coatings, including regulations, naturally occurring materials, synthetic materials, plasticizers, solvents, pigments, and additives. The editor is Joseph V. Koleske. It is published by ASTM International and provides technical information for testing and analyzing paint and coating materials.
ISO/IEC 27001, ISO/IEC 42001, and GDPR: Best Practices for Implementation and...PECB
Denis is a dynamic and results-driven Chief Information Officer (CIO) with a distinguished career spanning information systems analysis and technical project management. With a proven track record of spearheading the design and delivery of cutting-edge Information Management solutions, he has consistently elevated business operations, streamlined reporting functions, and maximized process efficiency.
Certified as an ISO/IEC 27001: Information Security Management Systems (ISMS) Lead Implementer, Data Protection Officer, and Cyber Risks Analyst, Denis brings a heightened focus on data security, privacy, and cyber resilience to every endeavor.
His expertise extends across a diverse spectrum of reporting, database, and web development applications, underpinned by an exceptional grasp of data storage and virtualization technologies. His proficiency in application testing, database administration, and data cleansing ensures seamless execution of complex projects.
What sets Denis apart is his comprehensive understanding of Business and Systems Analysis technologies, honed through involvement in all phases of the Software Development Lifecycle (SDLC). From meticulous requirements gathering to precise analysis, innovative design, rigorous development, thorough testing, and successful implementation, he has consistently delivered exceptional results.
Throughout his career, he has taken on multifaceted roles, from leading technical project management teams to owning solutions that drive operational excellence. His conscientious and proactive approach is unwavering, whether he is working independently or collaboratively within a team. His ability to connect with colleagues on a personal level underscores his commitment to fostering a harmonious and productive workplace environment.
Date: May 29, 2024
Tags: Information Security, ISO/IEC 27001, ISO/IEC 42001, Artificial Intelligence, GDPR
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A review of the growth of the Israel Genealogy Research Association Database Collection for the last 12 months. Our collection is now passed the 3 million mark and still growing. See which archives have contributed the most. See the different types of records we have, and which years have had records added. You can also see what we have for the future.
This presentation was provided by Steph Pollock of The American Psychological Association’s Journals Program, and Damita Snow, of The American Society of Civil Engineers (ASCE), for the initial session of NISO's 2024 Training Series "DEIA in the Scholarly Landscape." Session One: 'Setting Expectations: a DEIA Primer,' was held June 6, 2024.
How to Build a Module in Odoo 17 Using the Scaffold MethodCeline George
Odoo provides an option for creating a module by using a single line command. By using this command the user can make a whole structure of a module. It is very easy for a beginner to make a module. There is no need to make each file manually. This slide will show how to create a module using the scaffold method.
The simplified electron and muon model, Oscillating Spacetime: The Foundation...RitikBhardwaj56
Discover the Simplified Electron and Muon Model: A New Wave-Based Approach to Understanding Particles delves into a groundbreaking theory that presents electrons and muons as rotating soliton waves within oscillating spacetime. Geared towards students, researchers, and science buffs, this book breaks down complex ideas into simple explanations. It covers topics such as electron waves, temporal dynamics, and the implications of this model on particle physics. With clear illustrations and easy-to-follow explanations, readers will gain a new outlook on the universe's fundamental nature.
it describes the bony anatomy including the femoral head , acetabulum, labrum . also discusses the capsule , ligaments . muscle that act on the hip joint and the range of motion are outlined. factors affecting hip joint stability and weight transmission through the joint are summarized.
How to Add Chatter in the odoo 17 ERP ModuleCeline George
In Odoo, the chatter is like a chat tool that helps you work together on records. You can leave notes and track things, making it easier to talk with your team and partners. Inside chatter, all communication history, activity, and changes will be displayed.
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Main Java[All of the Base Concepts}.docxadhitya5119
This is part 1 of my Java Learning Journey. This Contains Custom methods, classes, constructors, packages, multithreading , try- catch block, finally block and more.