1. Tetracycline
Presented by :
Sayan Basu (18601916048)
&
Sayak Banerjee(18601916049)
GURUNANAK INSTITUTE OF
PHARMACEUTICAL SCIENCE &
TECHNOLOGY
2. Contents :
❑ Introduction
❑ Classification and there structures
❑ Mechanism of action
❑ Spectrum of activity
❑ Mechanism of Resistance
❑ Pharmacokinetics
❑ Administration
❑ Adverse Drug Reactions of tetracycline
antibiotics
❑ Uses and Drug Interaction
❑ Storage
3. Introduction :
•Tetracyclines are a class of antibiotic, which
are chemical substances produced by a
microorganism that are able to kill other
microorganisms without being toxic to the
person, animal or plant.
•Tetracyclines are derived directly from a
bacterium known as Streptomyces
coelicolor.
•Tetracycline were discovered in 1940.
6. Mechanism of action :
❖Tetracyclines are specific inhibitors of
bacterial
protien synthesis.
❖ They bind to the 30s ribosomal subunit and
thereby prevent the binding of aminoacyl
tRNA to the mRNA ribosome complex.
❖Tetracyclines also inhibit protein synthesis
in the host, but are less likely to reach the
concentration required because eukaryotic
cells do not have a tetracycline uptake
mechanism.
7. Spectrum of activity
Tetracyclines are broad spectrum
antibiotics, active against Gram positive
and Gram negative
bacteria, spirochetes, mycoplasma, rickettsie
and chalmydiae.
8. Mechanism of
Resistance :
Cell become resistance to tetracycline 3
mechanisms
✔ Enzymatic rarest type of resistance,
where an
acetyl group is added to the molecule,
causing
inactivation of drug.
✔ Efflux resistance gene encodes a
membrane
protien that actively pumps tetracycline out
of
9. Administration
▪Oral capsules is the dosage form in
which tetracyclines are most commonly
administered.
▪The capsule should be taken 1/2hr before
or 2hr after food.
▪Not recommended for i.m. route of
administration.
10. Uses of tetracyclines :
oTetracycline is used to treat wide
variety of infections, including
acne. It is an antibiotic that works by
stopping the growth of bacteria.
o Venerel disease
o Atypical pneumonia
o Cholera
o Relapsing fever
o Rickettsial,infections,plague
11. Drug interaction :
❖Tetracycline may interact with other
medicine. Effects of one or both of drugs
may change or rick of side effect may
be greater.
❖ Calcium supplements
❖ Mineral supplements
❖ Mutivitamine
❖ Cholesterol lowering drugs
❖ Penicillin compounds
12. Storage
Keep at room temperature 68 and 77
Degree F.
Keep away from heat, moisture and
light.
13. Essentials of Medical pharmacology, Kd
Tripathi, 7th edition, Page no- 733-739.
References
