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1. ANTIHYPERTENSIVE DRUGS
Here are the choice of drugs given during
pregnancy are:-
1. Alpha and Beta blockers- Labetalol
hydrochloride
2. calcium channel blockers-Nifedipine
3. alpha blockers-Methyldopa
4. vasodilators-Hydralazine hydrochloride

2. Labetalol Hydrochloride
Preparation
1. Injection-5mg/ml in 2oml vial
2. Tablets- 100mg, 200mg ,300mg
Action
• Reduced peripheral vascular resistance
as a result of alpha and beta blockade.

3. Adverse effects
1. Dizziness
2. Fatigue
3. Nausea or vomiting
4. Headache
5. Vertigo
Dosage and route of administration
50mg or 100mg tablet OD orally
20mg/20ml Inj IV bolus wait for 10min if no response
then give 40mg slow bolus.

4. NIFEDIPINE
Preparations
1. Capsule-10mg,20mg
2. Tablet-20mg,30mg,60mg,90mg
Action
• Thought to inhibit calcium ion reflex across cardiac and
smooth muscle cells, decreasing contractility and
oxygen demand and also dilates arteries and arterioles.
Dosage and route of administrations
5-20mg OD orally.

5. METHYLDOPA
Preparations
1. Tablet-250mg,500mg
2. Inj-50mg/ml
Action
• Inhibit the central vasomotor centre,
decreasing sympathetic outflow to the heart,
kidney and peripheral vasculature.
Dosage and routes of administration
250mg BD or TDS max 2g daily titrated by BP

6. Hydralazine Hydrochloride
Preparation
Inj-20mg/ml in 1ml vial
Tablet-10mg,25g,50mg,100mg
Action
Direct acting peripheral vasodilator that relaxes arteriolar
smooth muscle.
Dosage and route of administration
25mg tablet BD and if necessary may increase to
50mg BD
5mg diluted in 10ml of NS slow IV at 15-
20minutes interval.