2. • Introduction
• Classification
• Structure of tetracycline
• Mechanism of action
• Mechanism of resistance
• Uses of tetracycline
• Side effects of tetracycline
• Drug interaction
• Storage
Contents
3. Introduction
Tetracycline are broad spectrum antibiotics, which are chemical substances
produced by a microorganism that are able to kill other microorganisms
without being toxic to the person, animal or plant.
Tetracycline are derived directly from a bacterium knows as Streptomyces
coelicolor.
Tetracycline were discovered in 1940.
4. Tetracyclines
(according to the during of action)
Short-acting
(half-life is 6-8 hrs)
Tetracycline
chlortetracycline
Intermediate-acting
(half-life 12 hrs)
Demeclocycline
methacycline
Long-acting
(half-life 16 hrs)
Doxycycline
minocycline
Classification of tetracycline
7. Mechanism of Resistance
Cell become resistant to tetracycline 3 mechanisms
• Enzymatic rarest type of resistance, where an acetyl group is added to the
molecule , causing inactivation of drug.
• Efflux resistance gene encodes a membrane protein that actively pumps
tetracycline out of the cell.
• Ribosomal protection which blocking tetracycline from binding to the
ribosome
8. Uses ofTetracycline
• Antibacterial resistance
• Non antibacterial resistance like inflammation
• Tissue destructive disease like antifibrilogenics
• Parkinson and other neurodegeneration disease
• Antiviral and anti cancer
• Upper/lower respiratory tract infections
• Skin and soft tissue infections
• Relapsing fever
• Cholera
• Urinary tract infection
• anthrak
9. Side effects of tetracycline
• Upset stomach
• Diarrhea
• Itching of rectum or vagina
• Sore mouth
• Redness of the skin
• Change in skin colour
• Nail discoloratiom
• Difficulty in breathing or swallowing
• Extreme weakness
• Premanent discoloration of teeth
10. Drug interaction
Tetracycline may interact with other medicine. Effects of one or both of drugs
may change or rick of side effect may be greater.
• Calcium supplement
• Mineral supplement
• Multivitamine
• Cholesterol-lowering drugs
• Pencillin compounds
Storage:
Keep at room temperature 68 and 77 degrees F.
Keep away from heat, moisture and light.