Tetracycline Antibiotics

1. Tetracycline antibiotics
By
Dr. Nidhi Gupta
MM College of Pharmacy
M.M. (Deemed to be University), Mullana, Haryana

2.  Tetracyclines are a class of antibiotic, which are chemical
substances produced by a microorganism that are able to kill
other microorganisms without being toxic to the person,
animal or plant.
 Tetracyclines are derived directly from a bacterium
known as Streptomyces coelicolor.
 Tetracycline were discovered in 1940.
TETRACYCLINE

3. Tetracyclines
(according to
duration of
action)
Short acting
(half life is 6-
8hrs)
Tetracycline
Oxytetracycline,
chlortetracycline
Intermediate-
acting
(half-life 12hrs)
Demeclocycline
Methacycline
Long acting
(half-life 16hrs)
Doxycycline
Minocycline

5. R1
R2 R3 R4
NAME R1 R2 R3 R4
Tetracycline H CH3 OH H
Chlortetracycline Cl CH3 OH H
Oxytetracycline H CH3 OH OH
Doxycycline H H CH3 OH
Minocycline N(CH3)2 H H H

6.  Tetracyclines are specific inhibitors of bacterial
protein synthesis.
 They bind to the 30s ribosomal subunit and
thereby prevent the binding of aminoacyl tRNA
to the mRNA ribosomecomplex.

13. Tetracyclines are broad spectrum
antibiotics,active against Gram positive and
Gram negative bacteria, spirochetes,
mycoplasma, rickettsie and chalmydiae.

15. Oral capsules is the dosage form in
which tetracyclines are most commonly
administered.
The capsule should be taken 1/2hr before
or 2hr after food.
 Not recommended for i.m. route of
administration.

16. ADVERSE DRUG REACTIONS
1. DISCOLORATION OF TEETHS.
2. STOMATITIS
3. NAUSEA
4. ERYTHEMATOUS RASH
5. SORE THROAT
6. HEADACHE
7. PHOTOSENSTIVITY
8. NAIL DISCOLORATION
9. EXFOLIATIVE DERMATITIS.

17. Tetracycline is used to treat wide
variety of infections,including
acne.It is an antibiotic that works by
stopping the growth of bacteria.
 Venerel disease
 Atypical pneumonia
 Cholera
 Relapsing fever
 Rickettsial infections,plague

18. Tetracycline may interact with other
medicine.Effects of one or both of drugs
may change or rick of side effect may
be greater.
 Calcium supplements
 Mineral supplements
 Mutivitamine
 Cholestrol lowering drugs
 Penicillin compounds