Effective technology integration for 21st century learners involves using technology to promote active engagement, participation in groups, interaction and feedback, and connections to real-world experts. Some strategies discussed include using online forums for debate and dialogue, having students collaborate on podcasts, utilizing concept mapping software for research projects, blogging for self-expression, and providing online courses and tutorials for structured learning that students can revisit. The document also mentions technologies teachers can use like smart boards, PowerPoint, marking tools, videos, and facilitating discussions.