Transdermal drug delivery systems (TDDS), also known as patches, deliver drugs across the skin for systemic distribution providing several advantages over other routes of administration. TDDS can provide constant drug levels, avoid first-pass metabolism, and allow for self-administration and unrestricted patient activity. Drugs are delivered through the skin layers, with the rate of absorption influenced by factors like skin properties, drug properties, and the environment. Various TDDS technologies have been developed using polymer membranes, matrices, reservoirs, or microreservoirs to control drug release. Evaluation of TDDS involves testing for interactions, thickness, drug content, and other parameters.
Transdermal Drug Delivery System (TDDS) is the one of the novel technology to deliver the molecules through the skin for long period of time.
Transdermal Drug Delivery System (TDDS) are defined as self contained, discrete dosage forms which are also known as “patches” 2, 3 when patches are applied to the intact skin, deliver the drug through the skin at a controlled rate to the systemic circulation
Transdermal Drug Delivery System SG.pptxSneha Gaurkar
Transdermal drug delivery systems (TDDS), are dosage forms designed to deliver a
therapeutically effective amount of drug across a patient’s skin.
It delivers a drug through intact skin at a controlled rate into the systemic circulation.
Delivery rate is controlled by the skin or membrane in the delivery system.
Transdermal Drug Delivery System (TDDS) is the one of the novel technology to deliver the molecules through the skin for long period of time.
Transdermal Drug Delivery System (TDDS) are defined as self contained, discrete dosage forms which are also known as “patches” 2, 3 when patches are applied to the intact skin, deliver the drug through the skin at a controlled rate to the systemic circulation
Transdermal Drug Delivery System SG.pptxSneha Gaurkar
Transdermal drug delivery systems (TDDS), are dosage forms designed to deliver a
therapeutically effective amount of drug across a patient’s skin.
It delivers a drug through intact skin at a controlled rate into the systemic circulation.
Delivery rate is controlled by the skin or membrane in the delivery system.
Various approaches to Targeted Drug Delivery Systems (TDDS) in its formuation and evaluation in a pharmaceutical industry and research is outlined in this presentation.
TDDS, Anatomy of Skin, Advantages and disadvantages,Permeation of Drug Molecule through Skin, Factors affecting Transdermal Permeation, Design of transdermal system, Evaluation of TDDS
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
Various approaches to Targeted Drug Delivery Systems (TDDS) in its formuation and evaluation in a pharmaceutical industry and research is outlined in this presentation.
TDDS, Anatomy of Skin, Advantages and disadvantages,Permeation of Drug Molecule through Skin, Factors affecting Transdermal Permeation, Design of transdermal system, Evaluation of TDDS
This presentation includes introduction, physiology of GIT, factors affecting GRDDS, Advantages and disadvantages, approaches to GRDDS and their mechanism, some of the marketed products using GRDDS mechanism.
Mucoadhesive drug delivery system interact with the mucus layer covering the mucosal epithelial surface, & mucin molecules & increase the residence time of the dosage form at the site of the absorption.
Mucoadhesive drug delivery system is a part of controlled delivery system.
Since the early 1980,the concept of Mucoadhesion has gained considerable interest in pharmaceutical technology.
combine mucoadhesive with enzyme inhibitory & penetration enhancer properties & improve the patient complaince.
MDDS have been devloped for buccal ,nasal,rectal &vaginal routes for both systemic & local effects.
Hydrophilic high mol. wt. such as peptides that cannot be administered & poor absorption ,then MDDS is best choice.
Mucoadhesiveinner layers called mucosa inner epithelial cell lining is covered with viscoelasticfluid
Composed of water and mucin.
Thickness varies from 40 μm to 300 μm
General composition of mucus
Water…………………………………..95%
Glycoproteinsand lipids……………..0.5-5%
Mineral salts……………………………1%
Free proteins…………………………..0.5-1%
The mechanism responsible in the formation of mucoadhesive bond
Step 1 : Wetting and swelling of the polymer(contact stage)
Step 2 : Interpenetration between the polymer chains and the mucosal membrane
Step 3 : Formation of bonds between the entangled chains (both known as consolidation stage)
Electronic theory
Wetting theory
Adsorption theory
Diffusion theory
Fracture theory
Advantages over other controlled oral controlled release systems by virtue of prolongation of residence of drug in GIT.
Targeting & localization of the dosage form at a specific site
-Painless administration.
-Low enzymatic activity & avoid of first pass metabolism
If MDDS are adhere too tightlgy because it is undesirable to exert too much force to remove the formulation after use,otherwise the mucosa could be injured.
-Some patient suffers unpleasent feeling.
-Unfortunately ,the lack of standardized techniques often leads to unclear results.
-costly drug delivery system
Overview of Transdermal Drug Delivery Systemijtsrd
Transdermal drug delivery systems are topically administered medicaments. Transdermal drug transport structures TDDS are the dosage shape of adhesive patch this is positioned on the skin to deliver specific dose of medication through the skin and in to the blood stream. The main objective of transdermal drug delivery system is to deliver drug into systemic circulation through skin at predetermined rate with minimal inter and intrapatients variation. This article gives a brief overview over principles behind transdermal drug delivery, as well as the advantages and disadvantages of transdermal therapeutic system and the recent innovations in the field of transdermal drug delivery and also describe the methods of preparation of different types of transdermal patches, evaluation parameters and some available marketed products. Sayali Dhepe | Manisha Sukre | Vikram Veer "Overview of Transdermal Drug Delivery System" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-6 | Issue-4 , June 2022, URL: https://www.ijtsrd.com/papers/ijtsrd50107.pdf Paper URL: https://www.ijtsrd.com/pharmacy/pharmaceutics/50107/overview-of-transdermal-drug-delivery-system/sayali-dhepe
TDDS are topically administered medicaments in the form of patches that deliver drugs for systemic effects at predetermined and controlled rate.
Transdermal patch is an adhesive patch, that has a coating of medicine (drug), that is placed on the skin to deliver specific dose of the medicine, into the blood over a period of time.
Transdermal drug delivery system- structure of skinAkankshaPatel55
Transdermal drug delivery systems (TDDS) have transcended the realm of simple nicotine patches and entered an exciting era of innovation. Gone are the days of bulky, uncomfortable adhesives; in their place stand sophisticated systems capable of delivering a myriad of therapeutic agents through the seemingly impregnable barrier of the skin. To truly understand the magic behind this technology, we delve deeper, exploring its intricate mechanisms and promising future. The journey begins with a microscopic waltz at the skin's outermost layer, the stratum corneum. Drug molecules, meticulously formulated into miniscule particles, are incorporated into a semi-permeable patch. This patch acts as a launchpad, adhering snugly to the skin and initiating the drug's odyssey. Guided by the principles of Fick's Law of Diffusion, the drug embarks on a clandestine mission. Driven by a concentration gradient, it permeates the intercellular lipids of the stratum corneum, navigating a labyrinthine path formed by keratinocytes. This passive journey, governed by factors like drug lipophilicity and skin thickness, determines the rate and extent of absorption. However, diffusion plays just the first act in this multi-part drama. Once traversing the stratum corneum, the drug encounters the viable epidermis, a dynamic landscape teeming with enzymes and metabolic pathways. Here, some compounds may undergo degradation, limiting their systemic bioavailability. To overcome this hurdle, scientists devise ingenious strategies:
Penetration Enhancers: Chemical agents like propylene glycol or oleic acid temporarily disrupt the skin's lipid packing, easing the drug's passage.
Iontophoresis: Electric current gently guides charged molecules through the skin, bypassing enzymatic barriers and boosting delivery.
Microneedle Technology: Tiny, painless needles create transient microchannels, facilitating the delivery of larger molecules like proteins and peptides. The Symphony of Controlled Release:
A key advantage of TDDS lies in their ability to sustain drug release over extended periods. This controlled release symphony is orchestrated by sophisticated reservoir systems:
Matrix Systems: The drug is homogeneously dispersed within a polymer matrix, gradually diffusing out over time.
Reservoir Systems: A distinct drug reservoir separates from the adhesive layer, allowing for precise and prolonged delivery.
Programmable Systems: Advanced patches incorporate microfluidic channels and microchips, enabling customized release profiles and even pulsatile delivery for specific therapeutic needs.
Benefits Beyond Convenience:
The charm of TDDS extends far beyond the mere convenience of avoiding needles. They offer distinct advantages over traditional oral and parenteral routes:
Enhanced Bioavailability: By bypassing first-pass metabolism in the liver, certain drugs achieve higher systemic concentrations through transdermal delivery.
Improved Patient Compliance: Continuous, hassle-free adminis
Transdermal drug delivery system-1-1.pptxBhavanaNalge
Seminar on transdermal drug delivery system was delivered in NDDS lecture.Points such as introduction, permeation through skin,factors affecting, permeation enhancers,basic components, approaches of TDDS were covered.It was a wonderful experience.In introduction basic anatomy and physiology of skin, definition of Transdermal drug delivery system, advantages and disadvantages mechanism of Transdermal patch,Routes of skin permeation,ficks law was covered.Approaches was also taken in detail.factors was explained, components of Transdermal drug delivery was made clear point wise.
Formulation and evaluation of transdermal drug delivery system (TDDS)SanketPawar47
This is slide about formulation and evaluations of transdermal drugs delivery system . Introduction , general structure of TDDS , basic components of TDDS , approch for formulation of TDDS , manufacturing processes for TDDS ,and evaluations of TDDS
the all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
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Transdermal drug delivery has made an important contribution to medical practice, but has yet to fully achieve its potential as an alternative to oral delivery and hypodermic injections. First-generation transdermal delivery systems have continued their steady increase in clinical use for delivery of small, lipophilic, low-dose drugs. Second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in clinical products; the ability of iontophoresis to control delivery rates in real time provides added functionality. Third-generation delivery systems target their effects to skin’s barrier layer of stratum corneum using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound. Microneedles and thermal ablation are currently progressing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. Using these novel second- and third-generation enhancement strategies, transdermal delivery is poised to significantly increase impact on medicine.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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1. TRANSDERMAL DRUG DELIVERY SYSTEM
(TDDS)
Presented By;
Mr. Trilok D. Shahare
M.Pharm, I Semester
Department of Pharmaceutics
D. B. C. O. P. Besa, Nagpur
Guided By;
Dr. N. M. Mahajan
Department of pharmaceutics
D. B. C. O. P. Besa, Nagpur
1
2. CONTENTS
2
1 Introduction
2 Advantages
3 Disadvantages
4 Skin And Structure Of Skin
5 Function Of Skin
6 Factor Affecting TDDS
7 Type/Technology For Development Of TDDS
8 Evaluation Parameters
9 Reference
3. INTRODUCTION
- Transdermal drug delivery system (TDDS), also known as
patches.
- Transdermal is a rout of administration wherein active
ingredient are delivered across the skin for systemic
distribution.
- It is a dosage forms designed to deliver a therapeutically
effective amount of drug across a patient’s skin.
- Transdermal system, was approved by FDA in 1979 for the
prevention of nausea and vomiting.
3
5. General Patches….
Backing – protect the patch from environment.
Membrane – Control the release of drug.
Adhesive – Adher the component of patch together adhere the patch release.
Liner- Protect the patch during storage
5
6. TDDS offers…
Iv Oral TDDS
Reduced first-pass
effect.
Yes No Yes
Constant drug level Yes No* Yes
Self-administration No Yes Yes
Unrestricted patient
activity
No Yes Yes
6
7. Advantages :
Easy to use.
Self medication is possible.
Avoidance of first pass metabolism, Salivary
metabolism and intestinal metabolism.
Avoidance of gastrointestinal incompatibility.
No interaction with food or drink, and enzyme.
Prolong duration of action (ranging from few hrs. to one
week)
7
8. Disadvantages :
Local irritation at site of application.
Allergic reaction.
Difficult in long time adherence.
Cannot deliver ionic drug.
The adhesive used may not adhere well to all type of
skin.
Difficult to administer large dose.
8
9. About Skin :
Skin is the largest organ in the body.
Primary site of delivery.
It consist of 6% of total body weight (e.g 50kg person-3kg of
skin).
Skin pH acidic 4.2-5.6 pH.
The skin contains a protein called keratin which is also in
found in hair and nails.
Each 5 square cm of skin may have up to 600 sweat gland.
9
10. Structure of skin :
• I. Epidermis
Stratum corneum (Horny cell layer)
Stratum granulosum ( Granular Layer)
Stratum spinosum (Prickly layer)
Stratum basale
• II. Dermis
• III. Hypodermis or Subcutaneous layer
10
11. I. Epidermis :
Outer most layer
Composed of stratified squamous
epithelial cell.
Epidermis layer provides a
barrier to infection from
environmental pathogen.
And regulate amount of water
release from the body.
11
12. a) Stratum corneum :
This is the outermost layer of skin called as horny layer with
approximately 10 mm thickness.
Which comprises of 15–30 sheet of non-viable, but
biochemically active corneocytes.
b) Stratum granulosum : is the middle layer of epidermis and
chiefly involved in providing waterproof function. It also
contributes keratinization process of the skin.
c) Stratum spinosum : composed of 8–10 sheet of keratinocytes
with limited dividing capacity.
12
13. c) Stratum spinosum : composed of 8–10 sheet of keratinocytes
with limited dividing capacity and is also a seat for langerhan’s cell
d) Stratum basal : is a hub for maturing/aging keratinocytes,
melanocytes, Merkel cells referred as a receptor cells.
13
14. II. Dermis
Dermis is a layer of skin between the epidermis and subcutaneous tissues.
It’s major role to provide the much needed responsible for the tensile
strength of skin.
It is a 3 to 5 mm thick layer, composed of matrix connective tissue which
contains blood vessels, lymph vessels and nerves.
In which mechanoreceptors that provides the sense of touch and heat.
Primarily regulates temp. and also provide nutrients and oxygen to the skin.
Major components include :
I. Hair follicles
II. Connective tissue
III. Sweat gland
IV. Blood vessels 14
15. III) Subcutaneous layer :
Subcutaneous tissue, which also known as the hypodermis,
hypoderm is the inner most layer of skin.
It’s is made up of fat and connective tissues that house larger
blood vessels and nerves.
Subcutaneous tissue act as an insulator and regulate body
temperature.
The subcutaneous tissue layer its function to protect the muscle
and bones.
For transdermal drug delivery drug has to penetrate through all
these three layers and reach into systemic circulation.
15
16. Function of Skin :
Protection
Sensation e.g. heat, cold, touch, pressure, vibration, tissue injury.
Regulation of body temperature
Formation of vitamin D – by the action of UV on certain parts of skin.
Absorption
Excretion – sweat.
16
17. Fig . Diagram showing absorption of molecules through skin layers
17
19. MECHANISM OF ABSORPTION
(through skin)
Mechanism involved is passive diffusion.
This can be expressed by FICK’s steady state diffusion,
J = KD/h (co – ci )
Where,
• J = flux per unit area,
• K = stratum corneum –formulation partition coefficient of
drug,
• D = diffusion coefficient in the stratum corneum of path length ‘h’; Co
= Conc. of drug applied to skin & ci = conc. inside the skin.
19
25. 1. Polymers Membrane Partition-Controlled TDDS
In this type of systems, the drug reservoir is sandwiched between a drug
impermeable metallic-plastic lamination and rate controlling polymeric
membrane.
25
26. Drug mixed with
polymeric solution
Containing unleachable
viscous fluid
That forms
paste like
suspension
Upper coat- drug impermeable metallic-plastic lamination
Middle coat- rate controlling membrane
Lower coat- thin adhesive polymer layer
Molding as TDD System
Packaging machinery
Primary packaging
Secondary packaging
26
27. The intrinsic drug release from this type of TDDS is defined by :
𝑑𝑄
𝑑𝑡
=
𝐾𝑚/𝑟
𝐾𝑚/𝑟
𝐾𝑎/𝑚𝐷𝑎𝐷𝑚
𝐷𝑚ℎ𝑎+𝐾𝑎/𝑚𝐷𝑎ℎ𝑚
𝐶𝑟
Where,
Cr – Drug conc. in reservoir compartment.
Km/r & Ka/m – partition coefficient for the interfacial partitioning of drug
from reservoir to membrane & membrane to adhesive respectively.
Da & Dm – Diffusion coefficient in rate control membrane & adhesive
layer.
ha & hm – Thickness of rate controlled membrane and adhesive layer.
27
31. The rate of drug release from this type of TDDS is defined.
Where,
Ld – Drug loading dose initially dispersed in polymer matrix
Cp – Solubility of drug in polymer matrix
Dp – Diffusivity of drug in polymer matrix
example :
Nitro-dur II system for angina pectoris
31
32. 3. Drug Reservoir Gradient-Controlled TDDS
Drug-impermeable laminate
Drug
Reservoir
Gradient
Adhesive layer
Drug molecules
32
33. Drug release from this type can be expressed by-
𝑑𝑄
𝑑𝑡
=
𝐾𝑎/𝑟𝐷𝑎
ℎ𝑎(𝑡)
𝐿𝑑 (ℎ𝑎)
Where,
Ka/r – Partition coefficient for interfacial partitioning of drug from the
reservoir layer to adhesive layer.
Example :
Verapamil for Hypertension
33
34. 4. Microreservoir Dissolution-Controlled TDDS
This is combination of reservoir and matrix diffusion type of DDS.
Microreservoir dissolution controlled patch is ready
This medication disc positioned at the centered and surrounded by an
adhesive rim
Drug suspension dispersed into lipophilic polymer to form unleachable
microspheres of drug reservoir
Solid drug suspended in aq. Solution of water soluble polymer
Drug suspension
By polymeric cross linkingUnstable dispersion converted to stable
34
36. • The rate of drug release from this system is defined by :
where,
Kl – liquid compartment to polymer matrix
Km – polymer matrix to polymer compartment
Kp – polymer coating membrane
Dl – liquid compartment
Dp – polymer coating membrane
Ds – elution solution
Sl – liquid compartment
Sp – polymer matrix 36
37. hl – liquid layer surround drug particles.
hp – polymer membrane coating around polymer matrix
hd – hydrodynamic diffusion layer surrounding the polymer coating
membrane.
Examples :
Nitro-disc for angina pectoris.
37
38. EVALUATION OF TDDS
1) Interaction Studies
2) Thickness of the Patch
3) Weight Uniformity
4) Folding Endurance
5) % Moisture Content
6) % Moisture Uptake
7) Drug Content
8) Polariscope Examination
38
40. REFERENCE :
Novel drug delivery systems, 2nd edition, by Y.W. Chien
page no : 301 – 375.
Tanwar, Transdermal drug delivery system : A review,
International Science and Research 2016, 7(6) : 2274-
2290.
Novel drug delivery system, Nirali Prakashan, by Dr.
Dheeraj T. Baviskar, page no : 6.1 to 6.36
40