This document provides an overview of the approach to brain trauma management in the intensive care unit. It discusses:
1. Using a multidisciplinary team approach and following protocols to consistently provide great care for traumatic brain injury patients.
2. Identifying and treating both primary brain injuries from the initial trauma and secondary injuries that can develop over time through techniques like intracranial pressure monitoring and control, seizure prophylaxis, and infection prevention.
3. Preventing secondary injuries like herniation, edema, and reduced blood flow through careful monitoring, normalization of physiology, and medical or surgical interventions when needed. The goal is to prevent further brain damage after the initial trauma.
PPT on all important trials of traumatic brain injury. - includes design, setting, statistical analysis,outcome, strength, limitations, conclusion#DECRA#RESCUEicp#BEST TRIP#CRASH1#CRASH3#SAFE TBI#EUROTHERM3939#POLAR TRIAL
Also includes trial related BTF guidelines
Debate: Neurocritical Care Improves Outcomes in Severe TBISMACC Conference
Martin Smith and Mark Wilson debate whether neurocritical care improves outcomes in severe TBI.
Martin argues in favour of neurocritical care.
He concedes that longstanding and established practices are not as efficacious or innocuous as previously believed.
Very few specific interventions have been shown to improve outcomes in large randomised controlled trials. With the possible exception of avoidance of hypotension and hypoxaemia, most are based on analysis of physiology and pathophysiology.
Further, the substantial temporal and regional pathophysiological heterogeneity after TBI means that some interventions may be ineffective, unnecessary, or even harmful in certain patients at certain times.
Martin however, contends that improved understanding of pathophysiology and advances in neuromonitoring and imaging techniques have led to more effective and individualised treatment strategies. Ultimately, this has led to improved outcomes for patients.
In particular, the sole goal of identifying and treating intracranial hypertension has been superseded by a focus on the prevention of secondary brain insults. This is done by using a systematic, stepwise approach to maintenance of adequate cerebral perfusion and oxygenation.
Similarly, multimodal neuromonitoring also gives clinicians confidence to withhold potentially dangerous therapy. Particuarly in those with no evidence of brain ischemia/hypoxia or metabolic disturbance.
Mark Wilson on the other hand argues there is no benefit in neurocritical care following severe TBI.
The New England Journal of Medicine has published several articles that demonstrate no benefit from classic neurotrauma interventions (ICP monitoring, cooling, decompression). This is because factors such as ICP and CPP associate with bad outcomes by association rather than causation.
This debate will demonstrate that critical care just complicates things. Evidently, it is high time for the randomised trial between the very best neurocritical care and NOB therapy (Naso-pharyngeal, Oxygen and a Blanket).
Join Martin and Mark as they discuss the pros and cons of neurocritical care in the management of severe TBI.
For more like this, head to our podcast page. #CodaPodcast
A brief review of traumatic brain injury. Slides made specifically for medical professionals and student (trauma and surgery). We will review some of the important caveats, a review of the literature and discuss some management treatment options.
PPT on all important trials of traumatic brain injury. - includes design, setting, statistical analysis,outcome, strength, limitations, conclusion#DECRA#RESCUEicp#BEST TRIP#CRASH1#CRASH3#SAFE TBI#EUROTHERM3939#POLAR TRIAL
Also includes trial related BTF guidelines
Debate: Neurocritical Care Improves Outcomes in Severe TBISMACC Conference
Martin Smith and Mark Wilson debate whether neurocritical care improves outcomes in severe TBI.
Martin argues in favour of neurocritical care.
He concedes that longstanding and established practices are not as efficacious or innocuous as previously believed.
Very few specific interventions have been shown to improve outcomes in large randomised controlled trials. With the possible exception of avoidance of hypotension and hypoxaemia, most are based on analysis of physiology and pathophysiology.
Further, the substantial temporal and regional pathophysiological heterogeneity after TBI means that some interventions may be ineffective, unnecessary, or even harmful in certain patients at certain times.
Martin however, contends that improved understanding of pathophysiology and advances in neuromonitoring and imaging techniques have led to more effective and individualised treatment strategies. Ultimately, this has led to improved outcomes for patients.
In particular, the sole goal of identifying and treating intracranial hypertension has been superseded by a focus on the prevention of secondary brain insults. This is done by using a systematic, stepwise approach to maintenance of adequate cerebral perfusion and oxygenation.
Similarly, multimodal neuromonitoring also gives clinicians confidence to withhold potentially dangerous therapy. Particuarly in those with no evidence of brain ischemia/hypoxia or metabolic disturbance.
Mark Wilson on the other hand argues there is no benefit in neurocritical care following severe TBI.
The New England Journal of Medicine has published several articles that demonstrate no benefit from classic neurotrauma interventions (ICP monitoring, cooling, decompression). This is because factors such as ICP and CPP associate with bad outcomes by association rather than causation.
This debate will demonstrate that critical care just complicates things. Evidently, it is high time for the randomised trial between the very best neurocritical care and NOB therapy (Naso-pharyngeal, Oxygen and a Blanket).
Join Martin and Mark as they discuss the pros and cons of neurocritical care in the management of severe TBI.
For more like this, head to our podcast page. #CodaPodcast
A brief review of traumatic brain injury. Slides made specifically for medical professionals and student (trauma and surgery). We will review some of the important caveats, a review of the literature and discuss some management treatment options.
Research guru and PI for the ARISE study, college examiner and semi-professional forrest-based carpenter, Anthony always gives a fascinating talk. This time he gives an intelligent and considered breakdown on the nebulous topic of cerebral protection.
Nursing Case Study of a Patient with Severe Traumatic Brain Injuryrubielis
This details the critical care nurse's role in caring for a patient with severe traumatic brain injury, managing ICP and brain oxygenation. Ties in closely with Orem's self-care deficit theory for nursing.
Research guru and PI for the ARISE study, college examiner and semi-professional forrest-based carpenter, Anthony always gives a fascinating talk. This time he gives an intelligent and considered breakdown on the nebulous topic of cerebral protection.
Nursing Case Study of a Patient with Severe Traumatic Brain Injuryrubielis
This details the critical care nurse's role in caring for a patient with severe traumatic brain injury, managing ICP and brain oxygenation. Ties in closely with Orem's self-care deficit theory for nursing.
One of the hardest specialties is neuro anesthesia. When I initially started, I were so dumb founded. The things in brain did not only change, they become instantly harder. The drugs which were supposed to work now did not because the brain had developed edema or there was no blood supply. I worked real hard on this presentation. Took help from the textbooks and my teachers and has helped me. I hope you will found it somewhat helpful. Some of the answers are beyond the scope of this presentation due to the diversity of the field.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journey
TBI Management
1. Approach to Brain
Trauma in the ICU
David B. Seder MD, FCCM, FCCP, FNCS
Pulmonary and Neurological Critical Care
Chief, Maine Medical Center Department
of Critical Care Services
Associate Professor of Medicine – Tufts
University School of Medicine
2. Disclosures
No financial conflicts
Clinical neurocritical care, clinical research
Research funding:
PCORI CER-1602-34137
NIH CTR grant through NNE consortium
Maine Brain Aneurysm Awareness Committee
3. Overview
Toolbox
Neuro exam, anatomy, disease-specific knowledge
Identifying and treating primary and secondary
injuries after brain trauma
Guidelines – what we should all do
Test prep – what should you study?
Cases
4. TBI management
Team approach
Neurosurgery, critical care, nursing, rehab
medicine, therapy
Protocols, algorithms, pathways – deviate
when necessary, but start with the basics!
Family support
Goal should be consistently great care
5. Toolbox: Neurological exam
Elements of a good neuro exam depend on the
patient
Comatose:
LOA, cranial nerves, motor x5, reflexes, tone,
movements
Awake
Add orientation, speech, cognitive assessment,
memory, strength, affect and behavior, other
Spinal cord injury:
Motor and sensory levels, reflexes
6. Toolbox: Neuroanatomy
Parts of the brain/what they do
Compartments
Arterial supply
Venous drainage
CSF compartments and flow
Specific injuries give specific
patterns of injury
Pattern recognition!
8. Toolbox: Know the diseases!
Some different pathologies within TBI…
Brain contusion
Subdural hematoma
Epidural hematoma
Arterial dissection
Vasospasm
Stroke
Diffuse axonal injury
Different diseases have different courses
Help family know what to expect
Allows you to pace yourself, provide the right support
10. Different injuries require
different management
Surgery
Hematoma evacuation
Arterial repair
CSF diversion (shunt, EVD, lumbar drainage)
Cranial reconstruction
Seizure medications
Temperature management
ICP control…etc.
11. 1. Catalogue the injuries
Look for hemorrhages
Consider the mechanism of injury, and look for
trouble
Dissection, spinal injury, CSF leak?
Injuries evolve over time – anticipate!
Edema, hematoma expansion, hydrocephalus, arterial
emboli, venous thrombosis, herniation
Think of each injury individually, not just “TBI”
If you don’t look, you may not find…
13. 2. Treat the primary injuries
Early surgical/endovascular procedures to
address
Mass effect, compression, bleeding, thrombosis
ICP/PbtO2/metabolic brain monitoring and CSF
drainage
Bony stabilization and reconstruction
Relieve ischemia
Delayed surgery for complications and
prevention of secondary injury
14.
15. Early brain injury management
Stabilize & transfer/triage
Surgery – or not
Normalize physiology
Oxygen, pH/CO2, glucose, BP/CPP, temperature
Monitoring
Family: trust, expectations, immediate needs
Creating the right treatment milieu – do we
have the right team in place?
16. 3. Prevent, identify, and treat
secondary injuries
Reverse anticoagulants
Prevent seizures
Heparin or antiplatelet therapy for arterial
injuries
Electrolyte corrections
Antibiotics…sometimes
Normalize physiology
17. Prevent…
Reverse anticoagulants
Warfarin with PCC, vitamin K, maybe FFP
DOACs with PCC, targeted therapy
Involve an expert
Dosing interval matters – when was the last dose?
Heparins with protamine sulfate
Antiplatelet agents with…?
Platelets, DDAVP, nothing
18.
19. Prevent
Seizures with AEDs x 7
days
Often levitiracetam,
phenytoin
BUT…these drugs are also
associated with worse
cognitive outcomes in a
dose-dependent manner!
We don’t know what to do
Alternative is monitor and
treat seizures when they
occur
20. Normalize physiology!
Deranged physiology worsens secondary injury
at a biochemical level
Very high levels of oxygen increase oxygen-free
radical production in tissues
Low levels of oxygen or glucose worsen ischemic
injury
Very high glucose creates oxidative stress in tissues
and bloodstream
Hypotension strongly associated with worse
neurological outcomes
Severe hypertension can worsen edema
21. Identify…
Look for seizures
May be nonconvulsive (subtle) – check EEG!
Consider arterial injuries
Prevent stroke!
Consider venous thrombosis
Low threshold for imaging when the exam
deficits do not match the imaging, or there
is an acute change in the exam
22. Treat…
Treatments for TBI depend on the individual
physiology
Some patients may benefit from surgery
All patients benefit from good ICU care:
Normalization of physiology
Frequent accurate exams (identify new problems)
All families need support and social work
Mild injuries may not be so mild – rehab is key
23. Herniation syndromes
1. Subfalcine
Asymmetric motor posturing
2. Uncal
CN 3 palsy, contralateral
motor posturing
3. Transtentorial
Coma, symmetric posturing,
rostral-caudal loss of
brainstem reflexes
4. Posterior fossa
Cerebellar (up or down)
Coma, bilateral motor
posturing
J Intensive Care Med 2002;17:55-67
24. “Brain sag”
72 yo man with
facial fractures after
a fall
Pneumocephalus
Neurological
decline due to SDH
“Not waking up”,
“posturing”
Woke when placed
in Trendelenberg
25. Outcomes with herniation events
Survivable, but causes secondary
neurological injury
Compression of large arteries,
worsening of ischemia where
small vessels are underperfused
Stretch injury
Contralateral compression injury
2008 Hopkins series
68 patients (76 events) with TTH
treated with 30-60cc 23.4%
saline
32% survival, 7.4% good neuro
outcome
17% transient hypotension
2000 Hopkins series
28 pts with 32 episodes TTH
Mannitol
Intubation/Hyperventilation
Hypertonic saline
Barbiturates
Possible Surgery
25% good neuro outcome
Crit Care Med 2000;28:1556 Neurology 2008;70:1023
26. Acute herniation: Brain Code!
1. Hyperventilate
2. Augment BP
3. Osmotherapy
Mannitol 1-1.5g/kg
23.4% 0.5cc/kg slow IV push (slow! 5-10 min)
Identify underlying process
Initiate long-term strategies: “stepwise
approach” to intracranial hypertension
28. Monroe – Kellie Doctrine
Cranial vault is fixed
in size
Brain volume and
arterial blood volume
do not change
Venous blood and
CSF reflect the
capacitance of the
system
ICP CompensationICP Compensation
29. ICP waveforms
During conditions
of decreased IC
compliance, the
second / third
elements of the ICP
wave become
increased
Often noted prior to
elevation of ICP
aveformsaveforms
32. Management of ICP: CPP
optimization
Vasopressors
increase MAP and
improve both CPP
and metabolic
indices of perfusion
BP is not equal to
CBF – verify with
functional
evaluation of CO/CI
“look ma, no mannitol”
33. Management of ICP -
Osmotherapy
Mannitol
Standard therapy
1-1.5 mg/kg IV infusion
Osmotic diuretic
Pseudohyponatremia
Follow serum osms to
prevent ARF (<320)
Hypertonic saline
(23.4%)
30-60cc bolus
Volume expander
Rapid increase in preload
10-20% incidence transient
hypotension
Hypertonic saline (3%
infusion)
Hypernatremia
Salt and volume overload
Associated with VAP, CHF
34. Management of ICP –
hyperventilation causes ischemia
Decreased pCO2 causes rapid
cerebral arteriolar constriction
Decreased CBF and CBV
cause a decrease in ICP
Brief hyperventilation, weaned
over 3-6 hours, is standard with
herniation syndromes, but…
Prolonged hyperventilation
associated with brain ischemia
Low normal may help a lot!
35. Management of ICP -
Pentobarbitol
Metabolic therapy:
Decreases CMRO2
Decreases CBF
Powerful, rapid effect
on ICP
Unclear duration of
infusion
5-20 mg/kg bolus
followed by 1-
4mg/kg/hr
Adverse effects:
Loss of exam
Deep, prolonged
sedation
Infection
Cardiac dysfunction
Unclear effect on
outcomes
36. Management of ICP -
Hypothermia
Metabolic therapy
Decreases CMRO2
35ºC or 33ºC
Must suppress shivering
Caution regarding infections
Especially in conjunction with
barbiturates
Prophylactic hypothermia
after TBI is associated with
WORSE outcome
38. Spinal fluid leak
Due to disruption of meninges
Skull fracture, postop, spontaneous
Can lead to intracranial hypotension,
herniation, brain sag, subdural hematoma,
terrible headache, etc
Infection risk (meningitis)
Often treated (paradoxically) by FLAT
positioning and CSF diversion
39. Brain tissue oxygen monitoring
ICP/CPP based-therapy
alone or ICP/CPP/PbtO2
based therapy?
Many centers moving to
PbtO2 monitoring
BOOST-III now underway!
40. Diffuse axonal injury (DAI)
Scan doesn’t look
bad, exam is bad
Injury is at the
microscopic level –
axons of neurons are
torn
Cell bodies die
No test is very good
to establish
diagnosis – MRI as
shown – other
causes excluded
Beware mimics…
Gasparotti - Insights Imaging (2011)
42. BTF Guidelines
28 recommendations
1 level 1
7 level IIa
10 level IIb
10 level III
Not that helpful…
43. BTF Guidelines
Bifrontal DHC does not improve outcomes, but
decreases ICP and ICU LOS (IIa)
Large DHC is better than small DHC (IIa)
Prophylactic hypothermia not recommended for
patients with diffuse injury (IIb)
Continuous drainage of CSF reduces ICP more
than intermittent drainage (III)
CSF drainage to lower ICP may be considered in
patients with GCS<6) (III)
44. BTF Guidelines
Prolonged hyperventilation not recommended (IIb)
Barbiturates to prevent ICP elevation not
recommended
Barbiturates are recommended to control refractory
ICP elevation
Corticosteroids increase mortality and do not help
control ICP
Feed patients ≤ day 5 and not after day 7 decreases
mortality (IIa)
Transgastric jejunal feeds are recommended (IIb)
45. BTF Guidelines
Early tracheostomy reduces duration of
mechanical ventilation but not mortality
Antimicrobial EVDs may reduce infection
Consider early (7d) seizure prophylaxis
ICP monitoring recommended in Severe TBI
to reduce early mortality
GCS 3-8 with abnormal CT scan (mass effect)
Or, age >40, posturing, or SBP<90mmHg
46. BTF Guidelines
SBP>100 (age 50-69)
SBP> 110 (AGE 18-49, or > 70)
Treat ICP > 22mmHg
Target CPP 60-70
No compelling data for a specific form of
DVT prophylaxis
47. Test Prep: What should you
study?
Anatomy:
Basic neuroanatomy, brainstem, function of
cerebral hemispheres, motor and sensory
pathways, blood and CSF circulation
LOC, Motor exam, sensory exam
Integration: Deficits caused by specific
lesions
Cerebral autoregulation
48. Test Prep: What should you
study?
ICP, CPP, Monroe-Kellie doctrine
How to manage ICP elevation
Primary
HOB up and neck midline, CSF drainage, ventilation to
pCO2 30-35, CPP 50-70mmHg, normothermia
Secondary
Mannitol
Hypertonic saline
Tertiary
Surgery, hypothermia, barbiturates
49. Test Prep: What should you
study?
Types of traumatic brain injuries
Where in the brain
Usual complications
Usual management
Hospital course
Seizures
Primary problem or a complication of all other
brain injuries
50. Brain death
History
Neurological examination
Apnea testing
Some patients may require confirmatory
neuroimaging
Glasgow Coma Scale
Test Prep: What should you
study?
51. Cases / Practice questions
45 yo♂ with HA, R arm and facial weakness,
aphasia: where’s the lesion?
R parietal lobe
L temporal lobe
R frontal lobe
L frontal lobe
52. Cases / Practice questions
64 yo♀ presented 4h prior with SDH –
evacuated. ICP monitor now shows ICP
24mmHg, MAP is 88. After draining CSF,
the most appropriate intervention is:
Lower HOB
Give osmotherapy
Pentobarbitol coma
Hyperventilate to pCO2 28
53. Cases / Practice questions
34♂ yo severe TBI – on day 4 UOP increases
to 1000cc/hr. MAP decreases to 75mmHg
and ICP increases to 30mmHg. What is the
next intervention?
500cc IVF
50g mannitol
Nicardipine infusion
No intervention – numbers look OK.
54. Cases / Practice questions
24 yo♂ with epidural hematoma and diffuse
petechial hemorrhages on CT after severe TBI.
GCS 1-3-1. To OR – returns with ICP/PbtO2
monitor: MAP 80, ICP 10, CPP 70, PbtO2 12,
PCO2 26, CVP 10. What is your intervention?
250cc NS
Mannitol 25gm
Decrease Vt or RR to increase PCO2
Nothing – data look OK