Acute pancreatitis can be diagnosed with two of the following three criteria: severe abdominal pain, lipase or amylase levels over three times the normal limit, or imaging findings consistent with acute pancreatitis. Lipase elevations occur earlier and last longer than amylase, making it a more sensitive marker. Other conditions besides acute pancreatitis can also cause elevated lipase, including renal failure, gallstones, bowel obstruction, and pancreatic tumors. Imaging may show a heterogeneous pancreas, fat stranding, homogeneous enhancement of the pancreas, or peripancreatic necrosis.