Kingdom Protista comprises unicellular eukaryotic organisms with distinct nuclei and membrane-bound organelles, serving as the ancestral lineage for fungi, plants, and animals. It includes diverse groups like animal-like, plant-like, and fungus-like protists, each with unique characteristics, habitats, and methods of reproduction. Protists can also be pathogenic, with notable examples such as malaria caused by Plasmodium and African sleeping sickness caused by Trypanosoma.