This document summarizes a study that developed two prototype hospital designs that achieve at least a 60% reduction in energy usage compared to typical hospitals, meeting the 2030 Challenge goal for 2010. Both designs were able to achieve energy usage indices of under 100 KBtu/SF year through integrated architectural, mechanical, and central plant systems strategies. These high performance designs were estimated to cost approximately 2% more than a code-baseline design, a premium that could be recouped within a short payback period. The strategies employed provide a conceptual framework for hospitals to significantly reduce energy usage and associated costs through an integrated design approach.