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A 68 year old woman with a past history of hypertension,
hypercholesterolaemia, smoking and panic disorder presented to ED
in the morning with a 12 hour history of central chest pain and
shortness of breath. Her ECG showed T wave inversion in leads V3
to V6 and her Troponin I was elevated at 1.1µg/L. The clinical
diagnosis was a nonSTEMI so she went to the cathlab that morning.
Her systolic ventriculogram image is shown.
•Describe and interpret the image
•What is the underlying cause of this disorder ?
•What is the likely prognosis ?
The ventriculogram shows the classic form of so called “Takotsubo”
cardiomyopathy with normal basal contraction but ballooning of the apex. (Compare
this to a normal ventriculogram which is shown on the picture underneath this page).
The same features are visible on echocardiography and indeed this can be used as a
diagnostic or confirmatory test. This pattern could also be caused by localised
myocardial ischaemia or infarction but in this case the coronary arteries were normal
on angiography effectively confirming the diagnosis.
Another name for Takotsubo is “broken heart syndrome”. It is thought to be a stress
induced cardiomypoathy, probably due to inappropriately high circulating
catecholamine levels. It has been reported after a number of life stresses such as
bereavement, natural disasters and serious illnesses. The initial clinical presentation
including the pain and ECG changes may be indistinguishable from that of typical
myocardial ischaemia so it is a difficult diagnosis to make at ED presentation.
The mortality for Takotsubo is much better than that for typical STEMI or
nonSTEMI presentations. There may be early heart failure and the decreased left
ventricular ejection may persist for weeks, but recovery is typical and the mortality
is only reported as 1-3%.
Normal ventriculogram in both diastole (A) & Systole (B)

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Takotsubo cardiomyopathy 2019

  • 1. A 68 year old woman with a past history of hypertension, hypercholesterolaemia, smoking and panic disorder presented to ED in the morning with a 12 hour history of central chest pain and shortness of breath. Her ECG showed T wave inversion in leads V3 to V6 and her Troponin I was elevated at 1.1µg/L. The clinical diagnosis was a nonSTEMI so she went to the cathlab that morning. Her systolic ventriculogram image is shown. •Describe and interpret the image •What is the underlying cause of this disorder ? •What is the likely prognosis ?
  • 2.
  • 3. The ventriculogram shows the classic form of so called “Takotsubo” cardiomyopathy with normal basal contraction but ballooning of the apex. (Compare this to a normal ventriculogram which is shown on the picture underneath this page). The same features are visible on echocardiography and indeed this can be used as a diagnostic or confirmatory test. This pattern could also be caused by localised myocardial ischaemia or infarction but in this case the coronary arteries were normal on angiography effectively confirming the diagnosis. Another name for Takotsubo is “broken heart syndrome”. It is thought to be a stress induced cardiomypoathy, probably due to inappropriately high circulating catecholamine levels. It has been reported after a number of life stresses such as bereavement, natural disasters and serious illnesses. The initial clinical presentation including the pain and ECG changes may be indistinguishable from that of typical myocardial ischaemia so it is a difficult diagnosis to make at ED presentation. The mortality for Takotsubo is much better than that for typical STEMI or nonSTEMI presentations. There may be early heart failure and the decreased left ventricular ejection may persist for weeks, but recovery is typical and the mortality is only reported as 1-3%.
  • 4. Normal ventriculogram in both diastole (A) & Systole (B)