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This document discusses cerebral malaria (CM), a severe complication of Plasmodium falciparum infection that is a major cause of death in children under 5 years old in parts of Africa and Asia. It notes that platelets play a crucial role in malaria infection, with reduced platelet count often preceding clinical symptoms. Specifically, it discusses how the platelet-derived chemokine PF4 drives the development of CM by promoting immune stimulation and T cell trafficking. It also describes how PF4 mediates KLF4 expression and activation in monocytes, leading to their activation and contributing to the progression of diseases like CM.
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Aml flt3 itd
This document discusses emerging treatment paradigms for acute myeloid leukemia (AML) using FLT3 inhibitors. It describes how mutations in the FLT3 gene are common in AML and drive proliferation. Several generations of FLT3 inhibitors have been developed, including lestaurtinib, sorafenib, midostaurin, quizartinib, crenolanib, and gilteritinib. Clinical trials show that midostaurin and chemotherapy improves survival for FLT3 mutated AML. Quizartinib improves outcomes for relapsed AML. Ongoing research continues to evaluate FLT3 inhibitors in combination with chemotherapy.
ACUTE MYELOID / MYELOGENOUS LEUKEMIA 2016
1. Acute myelogenous leukemia (AML) is a clonal, malignant disease characterized by accumulation of abnormal blast cells in the bone marrow and impaired production of normal blood cells.
2. AML results from a series of somatic mutations in a primitive hematopoietic progenitor cell. Additional mutations are required for progression to AML.
3. Standard induction treatment involves "7+3" chemotherapy with cytarabine and an anthracycline, achieving remission in 55-90% of patients. Post-remission therapy aims to prolong remission.
"Rare diseases as platform to develop novel therapeutic strategies: the examp...
"Rare diseases as platform to develop novel therapeutic strategies: the examp...Vall d'Hebron Institute of Research (VHIR)
La recerca bàsica i traslacional en malalties rares és fonamental per entendre la fisiologia humana i per desenvolupar teràpies innovadores sovint útils també per malalties molt més prevalents. L’anèmia de Fanconi, caracteritzada per disfunció de la medul·la òssia i predisposició tumoral, n’és un exemple edificant. El primer transplantament de cordó umbilical de la història de la medicina fou en un pacient Fanconi. El primer nen medicament va néixer per curar un pacient Fanconi. El primer cop que s’han generat teixits sans per auto-transplantament curant, desprogramant i re-diferenciant cèl·lules de la pell d’un malalt ha estat en anèmia de Fanconi. I els primers assajos clínics de teràpia gènica s’estan desenvolupat també en malalties de la sang com l’anèmia de Fanconi. Aquests són alguns exemples de com l’estudi de malalties rares por transcendir més enllà del pacient afecte en benefici de tota la societat.Acute lymphoblastic leukemia
This document discusses acute lymphoblastic leukemia (ALL). It defines ALL as a malignant disorder of hematopoietic stem cells characterized by an increased number of white blood cells in the bone marrow or peripheral blood. ALL is classified based on the type of cell affected (lymphoblastic or myeloid) and whether the disease is acute or chronic. The document describes the epidemiology, risk factors, clinical presentation, investigations including blood tests and bone marrow biopsy, classification systems, treatment involving induction, consolidation and maintenance phases, supportive care, medications used, and prognosis for ALL patients.
Samir rafla. syncope in brugada syndrome
1. Patients initially presenting with aborted sudden death have the highest recurrence rate of cardiac events at 69%, while those presenting with syncope have a lower recurrence rate of 19%.
2. Among asymptomatic patients, those with a spontaneously appearing Brugada ECG pattern are at highest risk, while those only showing the pattern after sodium channel blockers appear to be at minimal risk.
3. Implantable cardioverter defibrillators (ICDs) are recommended for symptomatic patients with a Type 1 Brugada ECG pattern to prevent sudden cardiac death, while asymptomatic patients may undergo electrophysiological study to determine risk.
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The document describes analyzing data sets of patients diagnosed with Familial Dilated Cardiomyopathy. The analysis involved aligning the data sets to a reference genome, marking duplicates, calling variants using GATK, quality filtering results, annotating variants using Annovar and 1000g project. Familial Dilated Cardiomyopathy is characterized by thinning of the heart muscle and chamber enlargement which can lead to heart failure. More than 30 genes are associated with the condition, with the TTN gene associated with 20% of cases. The next steps outlined are to investigate annotation results, research alternative views on variant relevance, create a script to extract specific filtered results, and prepare a list of around 10 variants stating their details
Chapter11
This table summarizes common genetic abnormalities and affected oncogenes in several hematological cancers. It shows that cancers like acute myeloid leukemia, chronic myeloid leukemia, B-acute lymphoblastic leukemia, follicular lymphoma, mantle cell lymphoma, and Burkitt lymphoma often involve chromosomal translocations that activate specific oncogenes like AML1, BCR-ABL1, MYC, BCL2, and cyclin D1. Other genetic changes like deletions, mutations, or insertions also contribute to diseases such as acute myeloid leukemia, myelodysplasia, chronic lymphocytic leukemia by disrupting genes like P53, ATM, NPM, FLT3, and TET
Updates in acute lymphoblastic leukemia therapy in young adults
This document summarizes recent advances in therapy for acute lymphoblastic leukemia (ALL) in young adults. It discusses how overall survival rates for ALL are much poorer in adults compared to children. Recent developments discussed include new cytotoxic agents approved for relapsed/refractory ALL, as well as antibody-based therapies targeting antigens like CD19, CD20, CD22, and CD52. Promising results are shown for therapies like inotuzumab ozogamicin, blinatumomab, and chimeric antigen receptor (CAR) T-cell therapies. CAR T-cell therapies in particular achieved high rates of remission and minimal residual disease negative complete remission in trials for relapsed/refractory ALL
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Aml flt3 itd
This document discusses emerging treatment paradigms for acute myeloid leukemia (AML) using FLT3 inhibitors. It describes how mutations in the FLT3 gene are common in AML and drive proliferation. Several generations of FLT3 inhibitors have been developed, including lestaurtinib, sorafenib, midostaurin, quizartinib, crenolanib, and gilteritinib. Clinical trials show that midostaurin and chemotherapy improves survival for FLT3 mutated AML. Quizartinib improves outcomes for relapsed AML. Ongoing research continues to evaluate FLT3 inhibitors in combination with chemotherapy.
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1. Acute myelogenous leukemia (AML) is a clonal, malignant disease characterized by accumulation of abnormal blast cells in the bone marrow and impaired production of normal blood cells.
2. AML results from a series of somatic mutations in a primitive hematopoietic progenitor cell. Additional mutations are required for progression to AML.
3. Standard induction treatment involves "7+3" chemotherapy with cytarabine and an anthracycline, achieving remission in 55-90% of patients. Post-remission therapy aims to prolong remission.
"Rare diseases as platform to develop novel therapeutic strategies: the examp...
"Rare diseases as platform to develop novel therapeutic strategies: the examp...Vall d'Hebron Institute of Research (VHIR)
La recerca bàsica i traslacional en malalties rares és fonamental per entendre la fisiologia humana i per desenvolupar teràpies innovadores sovint útils també per malalties molt més prevalents. L’anèmia de Fanconi, caracteritzada per disfunció de la medul·la òssia i predisposició tumoral, n’és un exemple edificant. El primer transplantament de cordó umbilical de la història de la medicina fou en un pacient Fanconi. El primer nen medicament va néixer per curar un pacient Fanconi. El primer cop que s’han generat teixits sans per auto-transplantament curant, desprogramant i re-diferenciant cèl·lules de la pell d’un malalt ha estat en anèmia de Fanconi. I els primers assajos clínics de teràpia gènica s’estan desenvolupat també en malalties de la sang com l’anèmia de Fanconi. Aquests són alguns exemples de com l’estudi de malalties rares por transcendir més enllà del pacient afecte en benefici de tota la societat.Acute lymphoblastic leukemia
This document discusses acute lymphoblastic leukemia (ALL). It defines ALL as a malignant disorder of hematopoietic stem cells characterized by an increased number of white blood cells in the bone marrow or peripheral blood. ALL is classified based on the type of cell affected (lymphoblastic or myeloid) and whether the disease is acute or chronic. The document describes the epidemiology, risk factors, clinical presentation, investigations including blood tests and bone marrow biopsy, classification systems, treatment involving induction, consolidation and maintenance phases, supportive care, medications used, and prognosis for ALL patients.
Samir rafla. syncope in brugada syndrome
1. Patients initially presenting with aborted sudden death have the highest recurrence rate of cardiac events at 69%, while those presenting with syncope have a lower recurrence rate of 19%.
2. Among asymptomatic patients, those with a spontaneously appearing Brugada ECG pattern are at highest risk, while those only showing the pattern after sodium channel blockers appear to be at minimal risk.
3. Implantable cardioverter defibrillators (ICDs) are recommended for symptomatic patients with a Type 1 Brugada ECG pattern to prevent sudden cardiac death, while asymptomatic patients may undergo electrophysiological study to determine risk.
Bioinformatics
The document describes analyzing data sets of patients diagnosed with Familial Dilated Cardiomyopathy. The analysis involved aligning the data sets to a reference genome, marking duplicates, calling variants using GATK, quality filtering results, annotating variants using Annovar and 1000g project. Familial Dilated Cardiomyopathy is characterized by thinning of the heart muscle and chamber enlargement which can lead to heart failure. More than 30 genes are associated with the condition, with the TTN gene associated with 20% of cases. The next steps outlined are to investigate annotation results, research alternative views on variant relevance, create a script to extract specific filtered results, and prepare a list of around 10 variants stating their details
Chapter11
This table summarizes common genetic abnormalities and affected oncogenes in several hematological cancers. It shows that cancers like acute myeloid leukemia, chronic myeloid leukemia, B-acute lymphoblastic leukemia, follicular lymphoma, mantle cell lymphoma, and Burkitt lymphoma often involve chromosomal translocations that activate specific oncogenes like AML1, BCR-ABL1, MYC, BCL2, and cyclin D1. Other genetic changes like deletions, mutations, or insertions also contribute to diseases such as acute myeloid leukemia, myelodysplasia, chronic lymphocytic leukemia by disrupting genes like P53, ATM, NPM, FLT3, and TET
Updates in acute lymphoblastic leukemia therapy in young adults
This document summarizes recent advances in therapy for acute lymphoblastic leukemia (ALL) in young adults. It discusses how overall survival rates for ALL are much poorer in adults compared to children. Recent developments discussed include new cytotoxic agents approved for relapsed/refractory ALL, as well as antibody-based therapies targeting antigens like CD19, CD20, CD22, and CD52. Promising results are shown for therapies like inotuzumab ozogamicin, blinatumomab, and chimeric antigen receptor (CAR) T-cell therapies. CAR T-cell therapies in particular achieved high rates of remission and minimal residual disease negative complete remission in trials for relapsed/refractory ALL
Jc, Ph-like acute lymphoblastic leukemia (ALL)
This document summarizes a study on kinase-activating lesions in Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL). The study found that 91% of Ph-like ALL cases had genetic alterations activating kinase signaling, with subgroups involving kinases like ABL1, CSF1R, PDGFRB, EPOR, JAK2, CRLF2 and others. Patients with Ph-like ALL had poorer outcomes than those without, and the presence of alterations like IKZF1 deletions conferred even worse prognosis. In vitro experiments showed that fusions involving ABL1, ABL2 and CSF1R were sensitive to tyrosine kinase inhibitors like imatinib and dasatinib.
Fanconi anemia
Fanconi anemia is a rare genetic disorder that affects DNA repair and increases cancer risk. It is caused by mutations in one of several genes involved in the FA DNA repair pathway. Symptoms include bone marrow failure, physical abnormalities, and blood cancers. While there is no cure, treatment focuses on managing symptoms and complications through blood transfusions, antibiotics, bone marrow transplants, and cancer therapies.
Detection of heterogeneous flt3 itd mutant variants in
This document discusses the FLT3 gene, which encodes a receptor tyrosine kinase involved in hematopoiesis. Mutations in this gene, especially internal tandem duplications (ITDs), can cause leukemia. ITD mutations involve duplications in the juxtamembrane domain and are associated with poor prognosis in acute myeloid leukemia. The allelic ratio of mutant to wild-type FLT3 is a prognostic indicator, with ratios below 0.5 indicating more favorable outcomes. Several FLT3 inhibitors have been developed that compete with ATP binding and inhibit mutant FLT3 signaling. The document then describes a specific case where two ITD variants were detected with low allelic ratios, suggesting a favorable prognosis.
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This document discusses a study that compared accounts from doctors and nurses on how they provide emotional care for parents of children with acute lymphoblastic leukemia. The study found that doctors focused on clinical care and explanations of treatment to reassure parents, while nurses relied more on psychological skills and explicit discussion of parents' emotions. Both doctors and nurses saw ensuring emotional care as a team effort rather than the responsibility of individual practitioners.
Acute promyelocytic leukemia
This document provides an overview of acute promyelocytic leukemia (APL). APL accounts for 5-8% of acute myeloid leukemia cases in younger patients. It is characterized by the presence of abnormal promyelocytes in the bone marrow and blood. APL represents a medical emergency due to a high risk of hemorrhage from disseminated intravascular coagulation. The diagnosis of APL is confirmed by identifying the characteristic t(15;17) translocation resulting in the PML-RARA fusion gene. Modern treatment with differentiation therapy has improved outcomes, with younger patients and those with lower white blood cell counts having a superior prognosis.
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1) Retrospective studies have found the incidence of hematuria after kidney transplant to be higher than in the general population, around 12-13%, though the causes are generally similar.
2) Persistent hematuria after transplant has been associated with worse graft outcomes like failure, though not necessarily increased mortality.
3) Malignancies found in patients with persistent hematuria post-transplant have been located in the native urinary tract, not the transplant kidney. Longer hematuria duration increases cancer risk.
Management of untreated cll for web (2015)
This represents my current thinking on how to treat patients with previously untreated chronic lymphocytic leukemia. New research changing fast so possibly outdated soon.
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Partha Choudhary, a 48-year-old male, developed progressive anemia after a liver transplant in 2011. His hemoglobin levels gradually decreased from 9.2 to 5.4 over a year despite EPO treatment. Testing found he was positive for Parvovirus B19 and negative for other potential causes. A bone marrow biopsy showed an absence of erythroblasts, consistent with a diagnosis of pure red cell aplasia caused by Parvovirus B19 infection. Treatment for this type of virus-induced PRCA typically involves intravenous immunoglobulin therapy.
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1) The document discusses Acute Myeloid Leukemia (AML), including its classification, epidemiology, etiology, clinical presentation, laboratory findings, and specific subtypes defined by genetic abnormalities such as AML with t(8;21), inv(16), and t(15;17).
2) It describes the key features of different AML subtypes including their morphology, immunophenotype, genetics, and prognosis. Specific attention is given to abnormal cells, staining patterns, and genetic translocations that characterize each subtype.
3) The FAB and WHO classification systems are introduced and compared, noting the WHO system incorporates immunophenotyping, cytogenetics, and molecular characteristics
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Acute Lymphoblastic Leukemia/Lymphomas (ALLs)
Learning Objectives
Introduction
Definition
Difference between lymphoblast & myeloblast
Incidence
Classification
Pathogenesis
Clinical features
Prognosis
Lab Diagnosis
Treatment
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Present and Future Impact of Cytogenetics on Acute Myeloid Leukemia
Cytogenetics is an advancement in which clinicians can look for specific genetic mutations of chromosomal DNA and use that information to determine patient prognosis and individualize therapy. In this presentation I cover what cytogenetics are, how they impact patient risk, what therapies to use based on risk, and how genetically targeted agents may be used in the future.
Acute promyelocytic leukemia NCCN LATEST 2014 Guidelines
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation between chromosomes 15 and 17, resulting in the PML-RARα fusion gene in leukemic cells. This causes life-threatening coagulopathy and differentiation of promyelocytes into neutrophils in response to all-trans retinoic acid (ATRA). Treatment involves ATRA and chemotherapy, with monitoring for differentiation syndrome as a potential complication. Prognosis depends on initial white blood cell count, with high counts associated with worse outcomes.
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This document discusses the case of a 35-year-old female patient presenting with fever, fatigue, and shortness of breath. Her medical history includes a hysterectomy for menorrhagia and treatment for genitourinary tuberculosis. On examination, she has pallor and tachycardia. Laboratory tests show pancytopenia and blasts in her peripheral blood smear. A bone marrow biopsy confirms the diagnosis of acute myeloid leukemia. The discussion reviews the epidemiology, etiology, classification, clinical presentation, diagnostic workup, and initial treatment evaluation for AML.
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1. The document provides OT instructions for checking equipment, supplies, and medications needed for a surgery.
2. It includes checking the patient identification and consent forms, surgical equipment like lights and cautery, trays with necessary items, medications for anesthesia and antibiotics, and various dressings and bandages.
3. The instructions are intended to ensure all necessary equipment, supplies, and medications are prepared and functional prior to the surgical procedure.
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- The document summarizes a webinar presented by Greg Plum from Contactually and Jeff Kuei from Kixie about how their phone and CRM integration product can turbocharge sales.
- The webinar covered an overview of Contactually, best sales practices using it, and a live demo of how the Kixie team uses the Contactually integration.
- Key benefits discussed included automatically organizing and prioritizing leads, initiating customized follow-up strategies, and guiding daily actions to be consistent with contact goals.
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This document summarizes a study on kinase-activating lesions in Philadelphia chromosome-like (Ph-like) acute lymphoblastic leukemia (ALL). The study found that 91% of Ph-like ALL cases had genetic alterations activating kinase signaling, with subgroups involving kinases like ABL1, CSF1R, PDGFRB, EPOR, JAK2, CRLF2 and others. Patients with Ph-like ALL had poorer outcomes than those without, and the presence of alterations like IKZF1 deletions conferred even worse prognosis. In vitro experiments showed that fusions involving ABL1, ABL2 and CSF1R were sensitive to tyrosine kinase inhibitors like imatinib and dasatinib.
Fanconi anemia
Fanconi anemia is a rare genetic disorder that affects DNA repair and increases cancer risk. It is caused by mutations in one of several genes involved in the FA DNA repair pathway. Symptoms include bone marrow failure, physical abnormalities, and blood cancers. While there is no cure, treatment focuses on managing symptoms and complications through blood transfusions, antibiotics, bone marrow transplants, and cancer therapies.
Detection of heterogeneous flt3 itd mutant variants in
This document discusses the FLT3 gene, which encodes a receptor tyrosine kinase involved in hematopoiesis. Mutations in this gene, especially internal tandem duplications (ITDs), can cause leukemia. ITD mutations involve duplications in the juxtamembrane domain and are associated with poor prognosis in acute myeloid leukemia. The allelic ratio of mutant to wild-type FLT3 is a prognostic indicator, with ratios below 0.5 indicating more favorable outcomes. Several FLT3 inhibitors have been developed that compete with ATP binding and inhibit mutant FLT3 signaling. The document then describes a specific case where two ITD variants were detected with low allelic ratios, suggesting a favorable prognosis.
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This document contains images and captions showing various types of glioma (brain tumor) cells at different magnifications and contexts. The images depict human glioma cell lines and cultures stained with markers, individual glioma cells, gliomas growing in mouse brains expressing stem cell markers, gross anatomy of glioblastoma, and glioma cells migrating along blood vessels in brain tissue. The final caption notes that glioma originates from glial cells in the brain.
Acute Lymphoblastic Leukemia-Brief
This document discusses a study that compared accounts from doctors and nurses on how they provide emotional care for parents of children with acute lymphoblastic leukemia. The study found that doctors focused on clinical care and explanations of treatment to reassure parents, while nurses relied more on psychological skills and explicit discussion of parents' emotions. Both doctors and nurses saw ensuring emotional care as a team effort rather than the responsibility of individual practitioners.
Acute promyelocytic leukemia
This document provides an overview of acute promyelocytic leukemia (APL). APL accounts for 5-8% of acute myeloid leukemia cases in younger patients. It is characterized by the presence of abnormal promyelocytes in the bone marrow and blood. APL represents a medical emergency due to a high risk of hemorrhage from disseminated intravascular coagulation. The diagnosis of APL is confirmed by identifying the characteristic t(15;17) translocation resulting in the PML-RARA fusion gene. Modern treatment with differentiation therapy has improved outcomes, with younger patients and those with lower white blood cell counts having a superior prognosis.
Hematuria post transplant
1) Retrospective studies have found the incidence of hematuria after kidney transplant to be higher than in the general population, around 12-13%, though the causes are generally similar.
2) Persistent hematuria after transplant has been associated with worse graft outcomes like failure, though not necessarily increased mortality.
3) Malignancies found in patients with persistent hematuria post-transplant have been located in the native urinary tract, not the transplant kidney. Longer hematuria duration increases cancer risk.
Management of untreated cll for web (2015)
This represents my current thinking on how to treat patients with previously untreated chronic lymphocytic leukemia. New research changing fast so possibly outdated soon.
PRCA post renal transplant-a case and review
Partha Choudhary, a 48-year-old male, developed progressive anemia after a liver transplant in 2011. His hemoglobin levels gradually decreased from 9.2 to 5.4 over a year despite EPO treatment. Testing found he was positive for Parvovirus B19 and negative for other potential causes. A bone marrow biopsy showed an absence of erythroblasts, consistent with a diagnosis of pure red cell aplasia caused by Parvovirus B19 infection. Treatment for this type of virus-induced PRCA typically involves intravenous immunoglobulin therapy.
acute myeloid luekemia: Dr Arun Haldia
1) The document discusses Acute Myeloid Leukemia (AML), including its classification, epidemiology, etiology, clinical presentation, laboratory findings, and specific subtypes defined by genetic abnormalities such as AML with t(8;21), inv(16), and t(15;17).
2) It describes the key features of different AML subtypes including their morphology, immunophenotype, genetics, and prognosis. Specific attention is given to abnormal cells, staining patterns, and genetic translocations that characterize each subtype.
3) The FAB and WHO classification systems are introduced and compared, noting the WHO system incorporates immunophenotyping, cytogenetics, and molecular characteristics
Leukaemia lecture 02 ALL transcript
Leukaemia lecture 02 Dr. Rabiul Haque
Acute Lymphoblastic Leukemia/Lymphomas (ALLs)
Learning Objectives
Introduction
Definition
Difference between lymphoblast & myeloblast
Incidence
Classification
Pathogenesis
Clinical features
Prognosis
Lab Diagnosis
Treatment
血小板 Itp
Immune Thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet count due to increased platelet destruction and impaired production. The bone marrow findings in ITP show increased immature megakaryocytes with scant cytoplasm and absent lobulation in the nucleus. Dysplastic megakaryocytes with separated nuclei and micromegakaryocytes are also seen. Megakaryocytes in ITP frequently show emperipolesis of lymphocytes or lymphocytes and nucleated red blood cells within the cytoplasm. These bone marrow findings are sensitive and specific for diagnosing ITP.
00. AMP Company June 2016
AMP Pharmaceuticals is a clinical-phase biotech company focused on developing drugs for rare aging-related diseases. It has 10 candidate drugs in its pipeline targeting conditions like Fragile X syndrome, X-Adrenoleukodystrophy, Idiopathic Pulmonary Fibrosis, Dyskeratosis Congenita, Ataxia Telangiectasia, and others. Two drugs have completed Phase III trials, one is finishing Phase III, one is in Phase I, and others are in preclinical testing. The company owns worldwide commercialization rights for all its drugs and has an experienced scientific team working to develop patented molecules and therapies for diseases currently lacking effective treatments.
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To amyloid and beyond
This document is a slide presentation on cardiac amyloidosis given by Dr. Kyle Klarich at the ACC conference in March 2015. It discusses cardiac amyloidosis, how to diagnose it, the different types including AL and TTR amyloidosis, and treatments. The presentation uses patient cases to illustrate clues to diagnosis and shows imaging findings. It emphasizes that amyloidosis is underdiagnosed and diagnostic delay worsens prognosis, and discusses new treatments for both AL and TTR amyloidosis.
Present and Future Impact of Cytogenetics on Acute Myeloid Leukemia
Cytogenetics is an advancement in which clinicians can look for specific genetic mutations of chromosomal DNA and use that information to determine patient prognosis and individualize therapy. In this presentation I cover what cytogenetics are, how they impact patient risk, what therapies to use based on risk, and how genetically targeted agents may be used in the future.
Acute promyelocytic leukemia NCCN LATEST 2014 Guidelines
Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia characterized by a translocation between chromosomes 15 and 17, resulting in the PML-RARα fusion gene in leukemic cells. This causes life-threatening coagulopathy and differentiation of promyelocytes into neutrophils in response to all-trans retinoic acid (ATRA). Treatment involves ATRA and chemotherapy, with monitoring for differentiation syndrome as a potential complication. Prognosis depends on initial white blood cell count, with high counts associated with worse outcomes.
Acute myeloid leukemia
This document discusses the case of a 35-year-old female patient presenting with fever, fatigue, and shortness of breath. Her medical history includes a hysterectomy for menorrhagia and treatment for genitourinary tuberculosis. On examination, she has pallor and tachycardia. Laboratory tests show pancytopenia and blasts in her peripheral blood smear. A bone marrow biopsy confirms the diagnosis of acute myeloid leukemia. The discussion reviews the epidemiology, etiology, classification, clinical presentation, diagnostic workup, and initial treatment evaluation for AML.
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2. It includes checking the patient identification and consent forms, surgical equipment like lights and cautery, trays with necessary items, medications for anesthesia and antibiotics, and various dressings and bandages.
3. The instructions are intended to ensure all necessary equipment, supplies, and medications are prepared and functional prior to the surgical procedure.
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- The webinar covered an overview of Contactually, best sales practices using it, and a live demo of how the Kixie team uses the Contactually integration.
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• Managing customer expectations better than before
• Maximising service levels via innovation and training
• Massaging the cost agenda to ensure delivery of promises to the customerDropsuite Datasheet for Dropmysite
Dropmysite, by Dropsuite, is a cloud-based website backup and monitoring service that website owners can use independently to schedule automatic backups, monitor website availability and performance, and restore lost or corrupted data in a single click. Dropmysite is always ready to safeguard files, website, database and emails. Just ask for it from your web hosting company.
Souq.com
This document appears to be notes related to a job or business. It includes a number, what seems to be a company name or location, duty hours from 9am to 8pm from Saturday to Thursday, and an unclear reference.
Avaliação recuperação
O documento discute a recuperação da aprendizagem, incluindo sua importância para reapropriação do conhecimento, os desafios em sua implantação devido a mudanças nas leis educacionais e concepções de avaliação, e a necessidade de preparo dos professores e apoio da gestão pedagógica para superar problemas e garantir o progresso dos alunos.
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Outsourcing AP can reduce costs, but can it improve your service delivery too?
Outsourcing AP can reduce costs, but can it improve your service delivery too?
Building Your Network: Online and Off with Dorie Clark
Building Your Network: Online and Off with Dorie Clark
Customer service management under the new economic conditions – a time for focus
Customer service management under the new economic conditions – a time for focus
Similar to T cell work
MALARIA AND OTHER COCCIDIO.pptx
There are nearly 100 viruses of the herpes group that infect many different animal species.
Official name of herpesviruses that commonly infect human is Humans herpesvirus (HHV)
herpes simplex virus types 1 (HHV 1)
Herpes simplex virus type 2 (HHV 2)
Varicella-zoster virus (HHV 3)
Epstein-Barr virus, (HHV 4)
Cytomegalovirus (HHV 5)
Human herpesvirus 6 (HHV 6)
Human herpesvirus 7 (HHV 7)
Human herpesvirus 8 (HHV 8) (Kaposi's sarcoma-associated herpesvirus).
Herpes B virus of monkeys can also infect humans
hELMINTHS#corona virus#Aspergillosis#BUGANDO#CUHAS#CUHAS#CUHAS
Cerebral malaria
1. Cerebral malaria is a severe complication of malaria caused by Plasmodium falciparum parasites sequestering in the brain. This can lead to coma and potentially death.
2. Parasites adhere to brain endothelial cells causing hypoxia, endothelial damage, and blood-brain barrier dysfunction. Cytokines also contribute to pathogenesis.
3. Treatment involves prompt parenteral antimalarial drugs like artesunate or quinine to prevent death. Managing complications and preventing neurological deficits are also important objectives.
SSC4a Report (final)
This study investigated the effects of noradrenaline (NA) on human B cells in vitro to explore its potential role in post-stroke infection. Peripheral blood mononuclear cells were isolated from healthy volunteers and cultured with varying concentrations of NA. Flow cytometry was used to identify and analyze B cell subpopulations. The results showed that higher NA concentrations increased the total number of B cells but decreased their viability. NA also significantly reduced the number of marginal zone B cells, which are important for innate immune defense, at 48 hours. This suggests that NA exposure may impair B cell function and contribute to post-stroke immunosuppression and increased risk of infection through its effects on marginal zone B cells and other innate-like lymphocytes.
Breaking tolerance to invoke an immune response to cancer
This document discusses breaking immune tolerance to cancer (melanoma) by targeting regulatory T cells (Tregs). It suggests that Tregs suppress anti-tumor immune responses by secreting cytokines like TGF-β and IL-10. Depleting Tregs using cyclophosphamide or blocking CTLA-4 with ipilimumab can help activate the immune system. However, some tumors lack "danger signals" like inflammatory cytokines needed to recruit T cells. Stimulating toll-like receptor 4 on macrophages may induce cytokines like IL-6, IL-1β, and TNFα that create an inflammatory microenvironment and promote anti-tumor immunity.
BACTERIAL MENINGITIS present today.pptx
This document provides an overview of meningitis beyond the neonatal period. It discusses the epidemiology, etiology, pathogenesis, clinical manifestations, diagnosis, treatment, complications and prognosis of meningitis. The most common causative organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Clinical features may include fever, headache, vomiting, and signs of meningeal irritation. Diagnosis involves lumbar puncture and culture of CSF. Empiric antibiotic treatment is initiated while awaiting culture results. Complications can be early like seizures or late like hearing loss. Prognosis depends on causative organism, age of presentation, and presence of co-morbidities.
Cell death
Apoptosis is a genetically programmed form of cell death that is essential for sculpting body structures during development, removing excess or harmful cells, and serving immune system functions. Key morphological changes during apoptosis include membrane blebbing, chromatin condensation, cytoplasmic condensation, DNA fragmentation, and the cell being phagocytosed. Signaling pathways such as TNF, Fas, and TRAIL induce apoptosis through caspase activation and regulation by pro-apoptotic and anti-apoptotic Bcl-2 family members. Apoptosis is important in many clinical contexts like cancer, autoimmune disease, and neurodegeneration.
Communicable Disease_ Review Malaria paper
This document summarizes the host and parasite factors involved in the immunopathogenesis of malaria. It discusses how infected red blood cells sequester in organs by binding to endothelial cells, which can lead to organ dysfunction. Parasite factors like cytoadherence and host factors like inflammatory cytokines both contribute to endothelial activation and disruption of the blood-brain barrier. Immunopathological changes and cytokine dysregulation play a central role in the pathogenesis and severity of malaria. The roles of platelets, histones, and the parasite pigment hemozoin are also described. Understanding these complex interactions can help identify new treatment targets for severe malaria.
Apoptosis vs necrosis
1) The document discusses apoptosis and necrosis, two types of cell death. Apoptosis is programmed cell death where cells shrink and fragment in an orderly process. Necrosis is unprogrammed cell death caused by external injury or damage where cells swell and leak.
2) Apoptosis can be triggered internally through mitochondrial pathways or externally through death receptor pathways and leads to caspase activation and cell fragmentation. Cancer cells develop ways to avoid apoptosis like inhibiting proteins in these pathways.
3) Necrosis occurs when cells are damaged by external factors like toxins and involves cell and organelle swelling without fragmentation. Cancer cells and viruses can interfere with apoptosis to allow cancer progression.
Thrombotic Microangiopathies and AntiPhospholipid Syndrome
This document discusses various thrombotic microangiopathies (TMAs) including their causes, pathophysiology, clinical findings, and treatments. It covers hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, atypical hemolytic uremic syndrome, and antiphospholipid syndrome. The key pathological finding in all TMAs is endothelial injury and thrombus formation in small blood vessels. Recent research suggests dysregulation of the alternative complement pathway may be a unifying factor. Emerging treatments targeting complement, such as eculizumab, show promise in halting disease progression.
LUKEMIA
The document discusses hematological malignancies and acute leukemias. It defines hematological malignancies as clonal expansion of hematopoietic cells that have undergone genetic mutations. It describes the main types and subtypes of acute leukemias, including ALL and AML, and how they are classified and diagnosed based on blood counts, bone marrow aspiration, immunophenotyping and cytogenetics. Environmental and genetic factors that influence the development of hematological malignancies are also summarized.
medicine.Bleeding disorders.(dr.sabir) (new powerpoint)
1. The document discusses various bleeding disorders, their causes, symptoms, and treatments. It describes disorders of platelets like idiopathic thrombocytopenic purpura (ITP) and disorders of coagulation factors like hemophilia A.
2. Diagnostic tests for bleeding disorders include complete blood count, platelet count, aPTT, PT, and bleeding time. Treatment depends on the underlying cause but may include platelet transfusions, steroids, IVIG, splenectomy, clotting factor replacement, and controlling any precipitating conditions.
3. Disseminated intravascular coagulation (DIC) can be triggered by sepsis, trauma, malignancy and results from activation
Haemostasis
Haemostasis
Primary Plug Formation
Coagulation(Clotting)
Related Investigations
Related Diseases
Drugs Therapy
Fibrinolysis
Pediatrics 5th year, 4th lecture/part one (Dr. Jamal)
The document discusses paediatric oncology and acute leukemia. It notes that acute leukemia is the most common childhood malignancy, representing 35% of cases, with acute lymphoblastic leukemia (ALL) making up 27% specifically. ALL is most common in children aged 2-6 years old and presents with pallor, bruising, hepatosplenomegaly and lymphadenopathy. Proper treatment can cure approximately 70% of children with ALL. Treatment involves induction of remission, consolidation therapy, and 2-3 years of maintenance therapy to eliminate remaining leukemia cells.
Apoptosis seminar f
Apoptosis, or programmed cell death, plays an important role in development, immunity, and maintenance of genomic integrity. Disruption of apoptosis can lead to diseases like cancer, autoimmune disorders, and neurodegenerative diseases. The document discusses the key stages and molecular mechanisms of apoptosis, including the roles of caspases, Bcl-2 family proteins, and death receptors. It also covers the importance of apoptosis in processes like immune system development, tissue remodeling, and response to DNA damage. Therapeutic strategies aim to either inhibit inappropriate apoptosis or induce apoptosis in conditions like cancer.
Thrombotic microangiopathy and the kidney - Dr. Mohamed Mamdouh AbdAlBary
TTP is characterized by unusually large von Willebrand factor multimers and platelet-rich thrombi in capillaries and arterioles due to ADAMTS13 deficiency, while aHUS is typically caused by dysregulated complement activation on endothelial cells from genetic mutations or autoantibodies. TMA can be caused by a variety of conditions including infections, drugs, pregnancy, transplantation, and other diseases, with manifestations varying depending on the organs involved but commonly involving renal failure, neurological symptoms, and thrombocytopenia.
medicine.Acute leukemias.(dr.sabir)
Acute leukemias are clonal malignant disorders characterized by the accumulation of immature blast cells in the bone marrow, which replaces normal marrow tissue. This results in bone marrow failure and peripheral blood cytopenias. Acute leukemias are classified as either acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) based on the affected cell lineage. Treatment involves intensive chemotherapy aimed at inducing remission followed by consolidation therapy to eradicate residual leukemia cells. Supportive care is also important to manage complications such as infection during treatment. Long term side effects can include second malignancies, organ dysfunction, and infertility. Prognosis depends on factors like age, white blood cell count, and response to initial
Hemostasis
The document discusses several hemostasis problems commonly seen in critical illness, including critical illness coagulopathies, uncontrolled bleeding and massive transfusion, anticoagulation-associated problems, and case scenarios. It provides details on acquired hypocoagulable states, the coagulation cascade, disseminated intravascular coagulation, sepsis-associated coagulopathy, heparin-induced thrombocytopenia, immune thrombocytopenic purpura, and pregnancy-related thrombocytopenias. Treatment involves addressing the underlying cause, transfusing blood products, and considering anticoagulants or direct thrombin inhibitors depending on the clinical situation.
DIC.pptx
Disseminated Intravascular coagulation is a very common and life endangering pathological condition due to consumptive coagulopathy.
This is a very serious disease and prompt diagnosis may help in early initiation of treatment.
Medicine.Bleeding disorders.(dr.sabir)
1. The document discusses various bleeding disorders including their causes, symptoms, diagnostic tests, and treatment options. It covers disorders of platelets like ITP and coagulation factors deficiencies like hemophilia A.
2. Evaluation of bleeding disorders involves taking a thorough history and physical exam followed by screening tests like CBC, PT, aPTT. Specific disorders are then diagnosed and treated.
3. Treatment depends on the underlying cause but may include platelet transfusions, coagulation factor replacement, steroids, IVIG, splenectomy, antifibrinolytics, desmopressin, and managing precipitating conditions like infections.
Apoptosis and cancer stem cell
Apoptosis, role of p53 in apoptosis and cancer stem cell discription.
Different pathways of apoptosis.
Similar to T cell work (20)
Breaking tolerance to invoke an immune response to cancer
Breaking tolerance to invoke an immune response to cancer
Thrombotic Microangiopathies and AntiPhospholipid Syndrome
Thrombotic Microangiopathies and AntiPhospholipid Syndrome
medicine.Bleeding disorders.(dr.sabir) (new powerpoint)
medicine.Bleeding disorders.(dr.sabir) (new powerpoint)
Pediatrics 5th year, 4th lecture/part one (Dr. Jamal)
Pediatrics 5th year, 4th lecture/part one (Dr. Jamal)
Thrombotic microangiopathy and the kidney - Dr. Mohamed Mamdouh AbdAlBary
Thrombotic microangiopathy and the kidney - Dr. Mohamed Mamdouh AbdAlBary
Recently uploaded
JAMES WEBB STUDY THE MASSIVE BLACK HOLE SEEDS
The pathway(s) to seeding the massive black holes (MBHs) that exist at the heart of galaxies in the present and distant Universe remains an unsolved problem. Here we categorise, describe and quantitatively discuss the formation pathways of both light and heavy seeds. We emphasise that the most recent computational models suggest that rather than a bimodal-like mass spectrum between light and heavy seeds with light at one end and heavy at the other that instead a continuum exists. Light seeds being more ubiquitous and the heavier seeds becoming less and less abundant due the rarer environmental conditions required for their formation. We therefore examine the different mechanisms that give rise to different seed mass spectrums. We show how and why the mechanisms that produce the heaviest seeds are also among the rarest events in the Universe and are hence extremely unlikely to be the seeds for the vast majority of the MBH population. We quantify, within the limits of the current large uncertainties in the seeding processes, the expected number densities of the seed mass spectrum. We argue that light seeds must be at least 103 to 105 times more numerous than heavy seeds to explain the MBH population as a whole. Based on our current understanding of the seed population this makes heavy seeds (Mseed > 103 M⊙) a significantly more likely pathway given that heavy seeds have an abundance pattern than is close to and likely in excess of 10−4 compared to light seeds. Finally, we examine the current state-of-the-art in numerical calculations and recent observations and plot a path forward for near-future advances in both domains.
The debris of the ‘last major merger’ is dynamically young
The Milky Way’s (MW) inner stellar halo contains an [Fe/H]-rich component with highly eccentric orbits, often referred to as the
‘last major merger.’ Hypotheses for the origin of this component include Gaia-Sausage/Enceladus (GSE), where the progenitor
collided with the MW proto-disc 8–11 Gyr ago, and the Virgo Radial Merger (VRM), where the progenitor collided with the
MW disc within the last 3 Gyr. These two scenarios make different predictions about observable structure in local phase space,
because the morphology of debris depends on how long it has had to phase mix. The recently identified phase-space folds in Gaia
DR3 have positive caustic velocities, making them fundamentally different than the phase-mixed chevrons found in simulations
at late times. Roughly 20 per cent of the stars in the prograde local stellar halo are associated with the observed caustics. Based
on a simple phase-mixing model, the observed number of caustics are consistent with a merger that occurred 1–2 Gyr ago.
We also compare the observed phase-space distribution to FIRE-2 Latte simulations of GSE-like mergers, using a quantitative
measurement of phase mixing (2D causticality). The observed local phase-space distribution best matches the simulated data
1–2 Gyr after collision, and certainly not later than 3 Gyr. This is further evidence that the progenitor of the ‘last major merger’
did not collide with the MW proto-disc at early times, as is thought for the GSE, but instead collided with the MW disc within
the last few Gyr, consistent with the body of work surrounding the VRM.
Alternate Wetting and Drying - Climate Smart Agriculture
Alternate Wetting and Drying - Climate Smart AgricultureInternational Food Policy Research Institute- South Asia Office
PPT on Alternate Wetting and Drying presented at the three-day 'Training and Validation Workshop on Modules of Climate Smart Agriculture (CSA) Technologies in South Asia' workshop on April 22, 2024. MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...
MICROBIAL INTERACTION PPT/ MICROBIAL INTERACTION AND THEIR TYPES // PLANT MIC...ABHISHEK SONI NIMT INSTITUTE OF MEDICAL AND PARAMEDCIAL SCIENCES , GOVT PG COLLEGE NOIDA
Microbial interaction
Microorganisms interacts with each other and can be physically associated with another organisms in a variety of ways.
One organism can be located on the surface of another organism as an ectobiont or located within another organism as endobiont.
Microbial interaction may be positive such as mutualism, proto-cooperation, commensalism or may be negative such as parasitism, predation or competition
Types of microbial interaction
Positive interaction: mutualism, proto-cooperation, commensalism
Negative interaction: Ammensalism (antagonism), parasitism, predation, competition
I. Mutualism:
It is defined as the relationship in which each organism in interaction gets benefits from association. It is an obligatory relationship in which mutualist and host are metabolically dependent on each other.
Mutualistic relationship is very specific where one member of association cannot be replaced by another species.
Mutualism require close physical contact between interacting organisms.
Relationship of mutualism allows organisms to exist in habitat that could not occupied by either species alone.
Mutualistic relationship between organisms allows them to act as a single organism.
Examples of mutualism:
i. Lichens:
Lichens are excellent example of mutualism.
They are the association of specific fungi and certain genus of algae. In lichen, fungal partner is called mycobiont and algal partner is called
II. Syntrophism:
It is an association in which the growth of one organism either depends on or improved by the substrate provided by another organism.
In syntrophism both organism in association gets benefits.
Compound A
Utilized by population 1
Compound B
Utilized by population 2
Compound C
utilized by both Population 1+2
Products
In this theoretical example of syntrophism, population 1 is able to utilize and metabolize compound A, forming compound B but cannot metabolize beyond compound B without co-operation of population 2. Population 2is unable to utilize compound A but it can metabolize compound B forming compound C. Then both population 1 and 2 are able to carry out metabolic reaction which leads to formation of end product that neither population could produce alone.
Examples of syntrophism:
i. Methanogenic ecosystem in sludge digester
Methane produced by methanogenic bacteria depends upon interspecies hydrogen transfer by other fermentative bacteria.
Anaerobic fermentative bacteria generate CO2 and H2 utilizing carbohydrates which is then utilized by methanogenic bacteria (Methanobacter) to produce methane.
ii. Lactobacillus arobinosus and Enterococcus faecalis:
In the minimal media, Lactobacillus arobinosus and Enterococcus faecalis are able to grow together but not alone.
The synergistic relationship between E. faecalis and L. arobinosus occurs in which E. faecalis require folic acid
Evidence of Jet Activity from the Secondary Black Hole in the OJ 287 Binary S...
Wereport the study of a huge optical intraday flare on 2021 November 12 at 2 a.m. UT in the blazar OJ287. In the binary black hole model, it is associated with an impact of the secondary black hole on the accretion disk of the primary. Our multifrequency observing campaign was set up to search for such a signature of the impact based on a prediction made 8 yr earlier. The first I-band results of the flare have already been reported by Kishore et al. (2024). Here we combine these data with our monitoring in the R-band. There is a big change in the R–I spectral index by 1.0 ±0.1 between the normal background and the flare, suggesting a new component of radiation. The polarization variation during the rise of the flare suggests the same. The limits on the source size place it most reasonably in the jet of the secondary BH. We then ask why we have not seen this phenomenon before. We show that OJ287 was never before observed with sufficient sensitivity on the night when the flare should have happened according to the binary model. We also study the probability that this flare is just an oversized example of intraday variability using the Krakow data set of intense monitoring between 2015 and 2023. We find that the occurrence of a flare of this size and rapidity is unlikely. In machine-readable Tables 1 and 2, we give the full orbit-linked historical light curve of OJ287 as well as the dense monitoring sample of Krakow.
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
在线办理(salfor毕业证书)索尔福德大学毕业证毕业完成信一模一样
学校原件一模一样【微信：741003700 】《(salfor毕业证书)索尔福德大学毕业证》【微信：741003700 】学位证，留信认证（真实可查，永久存档）原件一模一样纸张工艺/offer、雅思、外壳等材料/诚信可靠,可直接看成品样本，帮您解决无法毕业带来的各种难题！外壳，原版制作，诚信可靠，可直接看成品样本。行业标杆！精益求精，诚心合作，真诚制作！多年品质 ,按需精细制作，24小时接单,全套进口原装设备。十五年致力于帮助留学生解决难题，包您满意。
本公司拥有海外各大学样板无数，能完美还原。
1:1完美还原海外各大学毕业材料上的工艺：水印，阴影底纹，钢印LOGO烫金烫银，LOGO烫金烫银复合重叠。文字图案浮雕、激光镭射、紫外荧光、温感、复印防伪等防伪工艺。材料咨询办理、认证咨询办理请加学历顾问Q/微741003700
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一.毕业证【q微741003700】成绩单、使馆认证、教育部认证、雅思托福成绩单、学生卡等！
二.真实使馆公证(即留学回国人员证明,不成功不收费)
三.真实教育部学历学位认证（教育部存档！教育部留服网站永久可查）
四.办理各国各大学文凭(一对一专业服务,可全程监控跟踪进度)
如果您处于以下几种情况：
◇在校期间，因各种原因未能顺利毕业……拿不到官方毕业证【q/微741003700】
◇面对父母的压力，希望尽快拿到；
◇不清楚认证流程以及材料该如何准备；
◇回国时间很长，忘记办理；
◇回国马上就要找工作，办给用人单位看；
◇企事业单位必须要求办理的
◇需要报考公务员、购买免税车、落转户口
◇申请留学生创业基金
留信网认证的作用:
1:该专业认证可证明留学生真实身份
2:同时对留学生所学专业登记给予评定
3:国家专业人才认证中心颁发入库证书
4:这个认证书并且可以归档倒地方
5:凡事获得留信网入网的信息将会逐步更新到个人身份内，将在公安局网内查询个人身份证信息后，同步读取人才网入库信息
6:个人职称评审加20分
7:个人信誉贷款加10分
8:在国家人才网主办的国家网络招聘大会中纳入资料，供国家高端企业选择人才
11.1 Role of physical biological in deterioration of grains.pdf
Storagedeteriorationisanyformoflossinquantityandqualityofbio-materials.
Themajorcausesofdeteriorationinstorage
•Physical
•Biological
•Mechanical
•Chemical
Storageonlypreservesquality.Itneverimprovesquality.
Itisadvisabletostartstoragewithqualityfoodproduct.Productwithinitialpoorqualityquicklydepreciates
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.Gadgets for management of stored product pests_Dr.UPR.pdf
Insectsplayamajorroleinthedeteriorationoffoodgrainscausingbothquantitativeandqualitativelosses
Wellprovedthatnogranariescanbefilledwithgrainswithoutinsectsastheharvestedproducecontainegg(or)larvae(or)pupae(or)adultinsectinthembecauseoffieldcarryoverinfestationwhichcannotbeavoidedindevelopingcountrieslikeIndia
Simpletechnologiesfortimelydetectionofinsectsinthestoredproduceandtherebyplantimelycontrolmeasures
Travis Hills of MN is Making Clean Water Accessible to All Through High Flux ...
By harnessing the power of High Flux Vacuum Membrane Distillation, Travis Hills from MN envisions a future where clean and safe drinking water is accessible to all, regardless of geographical location or economic status.
Authoring a personal GPT for your research and practice: How we created the Q...
Thematic analysis in qualitative research is a time-consuming and systematic task, typically done using teams. Team members must ground their activities on common understandings of the major concepts underlying the thematic analysis, and define criteria for its development. However, conceptual misunderstandings, equivocations, and lack of adherence to criteria are challenges to the quality and speed of this process. Given the distributed and uncertain nature of this process, we wondered if the tasks in thematic analysis could be supported by readily available artificial intelligence chatbots. Our early efforts point to potential benefits: not just saving time in the coding process but better adherence to criteria and grounding, by increasing triangulation between humans and artificial intelligence. This tutorial will provide a description and demonstration of the process we followed, as two academic researchers, to develop a custom ChatGPT to assist with qualitative coding in the thematic data analysis process of immersive learning accounts in a survey of the academic literature: QUAL-E Immersive Learning Thematic Analysis Helper. In the hands-on time, participants will try out QUAL-E and develop their ideas for their own qualitative coding ChatGPT. Participants that have the paid ChatGPT Plus subscription can create a draft of their assistants. The organizers will provide course materials and slide deck that participants will be able to utilize to continue development of their custom GPT. The paid subscription to ChatGPT Plus is not required to participate in this workshop, just for trying out personal GPTs during it.
Compexometric titration/Chelatorphy titration/chelating titration
Classification
Metal ion ion indicators
Masking and demasking reagents
Estimation of Magnisium sulphate
Calcium gluconate
Complexometric Titration/ chelatometry titration/chelating titration, introduction, Types-
1.Direct Titration
2.Back Titration
3.Replacement Titration
4.Indirect Titration
Masking agent, Demasking agents
formation of complex
comparition between masking and demasking agents,
Indicators/Metal ion indicators/ Metallochromic indicators/pM indicators,
Visual Technique,PM indicators (metallochromic), Indicators of pH, Redox Indicators
Instrumental Techniques-Photometry
Potentiometry
Miscellaneous methods.
Complex titration with EDTA.
Sexuality - Issues, Attitude and Behaviour - Applied Social Psychology - Psyc...
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Immersive Learning That Works: Research Grounding and Paths Forward
We will metaverse into the essence of immersive learning, into its three dimensions and conceptual models. This approach encompasses elements from teaching methodologies to social involvement, through organizational concerns and technologies. Challenging the perception of learning as knowledge transfer, we introduce a 'Uses, Practices & Strategies' model operationalized by the 'Immersive Learning Brain' and ‘Immersion Cube’ frameworks. This approach offers a comprehensive guide through the intricacies of immersive educational experiences and spotlighting research frontiers, along the immersion dimensions of system, narrative, and agency. Our discourse extends to stakeholders beyond the academic sphere, addressing the interests of technologists, instructional designers, and policymakers. We span various contexts, from formal education to organizational transformation to the new horizon of an AI-pervasive society. This keynote aims to unite the iLRN community in a collaborative journey towards a future where immersive learning research and practice coalesce, paving the way for innovative educational research and practice landscapes.
Describing and Interpreting an Immersive Learning Case with the Immersion Cub...
Current descriptions of immersive learning cases are often difficult or impossible to compare. This is due to a myriad of different options on what details to include, which aspects are relevant, and on the descriptive approaches employed. Also, these aspects often combine very specific details with more general guidelines or indicate intents and rationales without clarifying their implementation. In this paper we provide a method to describe immersive learning cases that is structured to enable comparisons, yet flexible enough to allow researchers and practitioners to decide which aspects to include. This method leverages a taxonomy that classifies educational aspects at three levels (uses, practices, and strategies) and then utilizes two frameworks, the Immersive Learning Brain and the Immersion Cube, to enable a structured description and interpretation of immersive learning cases. The method is then demonstrated on a published immersive learning case on training for wind turbine maintenance using virtual reality. Applying the method results in a structured artifact, the Immersive Learning Case Sheet, that tags the case with its proximal uses, practices, and strategies, and refines the free text case description to ensure that matching details are included. This contribution is thus a case description method in support of future comparative research of immersive learning cases. We then discuss how the resulting description and interpretation can be leveraged to change immersion learning cases, by enriching them (considering low-effort changes or additions) or innovating (exploring more challenging avenues of transformation). The method holds significant promise to support better-grounded research in immersive learning.
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdf
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
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T cell work
- 1. 7/8/14 IMS BHU (PhD work) ICGEB JHMI/URMC NY BLOOD CENTER Platelets are Immunological Cells that influence the T Cells Kalyan Srivastava, PhD
- 2. Falciparum malaria is a major cause of lethality
- 3. Cerebral Malaria (CM) Overview CM is a severe complication of P. falciparum infection Endemic in sub-Saharan Africa, Indian subcontinent and South America More than a million people die from falciparum infection each year Majority death is among children less than five More than 20% of malaria death is due to the CM impaired consciousness, convulsions and neurological abnormalities, ataxia and coma Diagnosis done by retinopathy Increased serum ET-1, ICAM-1, TNFalpha in pateint Platelets Play Cruicial Role in Malaria InfectionSevere malaria is associated with thrombocytopeniaReduced platelet count often first sign before clinical symptoms Platelets have been implicated to have central role in cerebral malaria Other in part platelet derived molecules such as TGFbeta, PAF, P- Sel has been reported to high in malaria infection CXCR3, CCR5 and CCR1in cerrebral malaria
- 4. 7/8/14 PF4 or CXCL4 PF4 are platelet specific chemokine produced from Platelet and T Cell to some extent Implicated in HIT First ever discovered CXC chemokine Implicated in viral infection and stroke Found in alpha granule of platelets One known receptor is CXCR3
- 5. 7/8/14
- 6. Platelets are activated by iRBC via CD36 on platelets
- 7. • Activated platelet result into the pathogenesis of ECM
- 8. PF4 Drives the Development of ECM
- 9. PF4 Promotes Immune Stimulation and T Cell Trafficking in ECM
- 10. • Monocytes and platelets both play critical roles in atherogenesis. • In later work have shown that PF4, activates monocytes and results in progression of diseases such as Cerebral Malaria (CM). • PF4 mediated KLF4 expression and activation leads to the Mono/Mac activation
- 11. Summary
- 13. Platelets have machinery for antigen presentation
- 14. Platelets process the antigen to present it to T Cell
- 15. 7/8/14
- 16. Platelets exposed to antigen are protective in CM
- 17. 7/8/14
- 18. 7/8/14
- 19. 7/8/14
- 20. 7/8/14
- 21. 7/8/14
- 22. 7/8/14
- 23. 7/8/14
- 24. • CM is a consequence of blood brain barrier break down • Plts play imp role • PF4 plays imp role • IFNbeta is protective in MS • Plts participate in Ag presentation • Plts participate in acute phase response • Plts participate in transplant rejection • … all of it via T Cell response.
- 25. IFNbeta suppresses ECM associated inflammation
- 26. IFNbeta reduces Tcell trafficking studied using flow
- 27. IFNbeta is protective in CM
- 29. 7/8/14
- 30. PF4 Stimulates KLF4 Activity
- 31. Monocytes are Important in the Development of ECM
- 32. PF4 Mediates KLF4 Expression in ECM
- 33. 7/8/14 IL-6 was measured by ELISA