Pessaries are solid pharmaceutical preparations inserted into the vagina. They can be used to deliver medication through the vaginal mucosa or to treat medical conditions like pelvic organ prolapse. Pessaries contain active ingredients dispersed in a base that dissolves at body temperature. Common active ingredients in pessaries include ichthammol, crystal violet, lactic acid, and antifungals. Pessaries are manufactured by blending the active ingredients into a glycerogelatin base and molding into shapes for insertion into the vagina.

1. PESSARIES
BY
SRI SHARIKA KUMAR.A

2. PESSARIES
1. WHAT IS A PESSARY ?
According to British Pharmacopoiea(BP)-
Pessaries are solid,single-dose preparations. They
have various shapes ,usually ovoid ,with a volume
and consistency suitable for insertion into vagina.

3.  PESSARIES for Treatment of pelvic organ prolapse

5.  Ring shaped Vaginal pessary

6. ACTIVE SUBSTANCES IN PESSARIES
 They contain one or more active substances
dispersed or dissolved in a suitable bases that may be
soluble or dispersible in water or may melt at body
temperature.
 EXCIPIENTS Such as diluents, adsorbents , surface
active agents, lubricants, antimicrobial preservatives
and colouring matter, authorized by the competent
authority, may be added , if necessary .

7.  “PESSARY” is used in two different ways;
 First sense, a pessary is a supportive device which is
inserted into the vagina to treat a variety of medical
conditions .
A Pessary can also be a pharmaceutical preparation
which is used to deliver drugs rapidly through the
mucus membranes of vagina .

13. RETROVERTED UTERUS

19. PHARMACEUTICAL PESSARY
 A Pharmaceutical pessary is made by blending drugs
with a substance which dissolves at body temperature .
The drugs will slowly leach through the porous
membrane of the vagina .some medications must be
specifically delivered vaginally to be most effective.

21. Medications in pessaries
 The pessaries are also available as tablets and capsules
and are known as vaginal tablets and capsules
respectively .
 The pessaries of ichthammol , crystal violet , lactic
acid are manufactured by using glycerogelatin base .
 Sometimes instructions are given on the label to
moisten pessaries with water before insertion into
vagina to reduce the stinging caused by osmotic
withdrawal of the water from tissues during solution
in the vagina .

22. Medications in pessaries
 The pessaries are also available as tablets and capsules
and are known as vaginal tablets and capsules
respectively .
 The pessaries of ichthammol , crystal violet , lactic
acid are manufactured by using glycerogelatin base .
 Sometimes instructions are given on the label to
moisten pessaries with water before insertion into
vagina to reduce the stinging caused by osmotic
withdrawal of the water from tissues during solution
in the vagina .

23.  Di-iodohydroxyquinoline and nystatin , pessaries
should always be labelled with this advice .pessaries
should be stored in a cool place
 Formula:
 Lactic acid 5g
 Glycero-gelatin base 100g
 Method
 Lubricate the mould with liquid paraffin or arachis oil
. Invert and cool .
Method of pessary preparation

24. Heat the glycerin in a china dish at 100 c and keep it
hot on a water bath .
Add the gelatin to the water . Stir gently to wet the
material thoroughly . Add the hot glycerin , stir again
and heat the china dish on boiling water bath for 15
minutes or until a clear solution is made .
Glycerogelatin base is prepared . Adjust its weight to
100g by evaporating the water .
Remove 5g of the base with a metal spoon or spatula .
Add 5.0g of lactic acid .stir well and pour into a chilled
mould . Mould should be opened as long as possible
because lactic acid lowers the setting point of the
glycero-gelatin mass.

25. Wrap the individual pessary in a metal foil or waxed
paper , as lactic acid pessaries are very hygroscopic .
Pack in a well – closed jar.