Suppositories are solid dosage forms meant to be inserted into body cavities like the rectum, urethra, and vagina to release drugs locally or systemically. This document classifies suppositories based on their site of insertion and discusses their ideal properties, common bases used, and methods of preparation. The main types are rectal, vaginal, urethral, nasal, and ear suppositories. Common bases include glycerinated gelatin, polyethylene glycols, and cocoa butter, which must meet requirements like melting point and toxicity. Preparation involves mixing the drug with the base and molding or allowing it to solidify.
In this presentation viewers will able to learn about liquids for external use such as liniments and lotions, liquids for oral cavity such as mouthwash, throat paints and gargles.
Semisolid Dosage Form: Ointment, creams & Gel.
Learn more with me Asst. Prof. Mr. Manohar D. Kengar, Nootan College of Pharmacy, Kavathemahankal.
Suppository Dosage Form: Type of Suppository, Preparation method, Evaluation
https://youtu.be/NUgFoLuT3cs
In this presentation viewers will able to learn about liquids for external use such as liniments and lotions, liquids for oral cavity such as mouthwash, throat paints and gargles.
Semisolid Dosage Form: Ointment, creams & Gel.
Learn more with me Asst. Prof. Mr. Manohar D. Kengar, Nootan College of Pharmacy, Kavathemahankal.
Suppository Dosage Form: Type of Suppository, Preparation method, Evaluation
https://youtu.be/NUgFoLuT3cs
Alternative to gelatin capsule,mainly focused on non animal origin,explained and market product included in this,most of vegetarian people wont eat animal so we come to new non animal origin region like plants those are HPMC capsule,Pullulan capsule,PVA capsule,Alginatecapsule...
Production of microbial polysaccharides by different microorganism.
Production of Xanthan gun.
Different microorganism like Xanthomonas compestries, Pseudomonas, Alcaligenes etc.
Uses and industrial application of xanthan, Pullulan, Dextran, Xylinan, Curdlan etc.
Excipients..different types of excipients and its applications in pharmacetical industry for manufacturing of dosage forms.
few examples of commercially available excipients in the market for the manufacturing purpose of intended dosage forms.
Telehealth Psychology Building Trust with Clients.pptxThe Harvest Clinic
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Telehealth psychology is a digital approach that offers psychological services and mental health care to clients remotely, using technologies like video conferencing, phone calls, text messaging, and mobile apps for communication.
CHAPTER 1 SEMESTER V - ROLE OF PEADIATRIC NURSE.pdfSachin Sharma
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Pediatric nurses play a vital role in the health and well-being of children. Their responsibilities are wide-ranging, and their objectives can be categorized into several key areas:
1. Direct Patient Care:
Objective: Provide comprehensive and compassionate care to infants, children, and adolescents in various healthcare settings (hospitals, clinics, etc.).
This includes tasks like:
Monitoring vital signs and physical condition.
Administering medications and treatments.
Performing procedures as directed by doctors.
Assisting with daily living activities (bathing, feeding).
Providing emotional support and pain management.
2. Health Promotion and Education:
Objective: Promote healthy behaviors and educate children, families, and communities about preventive healthcare.
This includes tasks like:
Administering vaccinations.
Providing education on nutrition, hygiene, and development.
Offering breastfeeding and childbirth support.
Counseling families on safety and injury prevention.
3. Collaboration and Advocacy:
Objective: Collaborate effectively with doctors, social workers, therapists, and other healthcare professionals to ensure coordinated care for children.
Objective: Advocate for the rights and best interests of their patients, especially when children cannot speak for themselves.
This includes tasks like:
Communicating effectively with healthcare teams.
Identifying and addressing potential risks to child welfare.
Educating families about their child's condition and treatment options.
4. Professional Development and Research:
Objective: Stay up-to-date on the latest advancements in pediatric healthcare through continuing education and research.
Objective: Contribute to improving the quality of care for children by participating in research initiatives.
This includes tasks like:
Attending workshops and conferences on pediatric nursing.
Participating in clinical trials related to child health.
Implementing evidence-based practices into their daily routines.
By fulfilling these objectives, pediatric nurses play a crucial role in ensuring the optimal health and well-being of children throughout all stages of their development.
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
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R3 Stem Cells and Kidney Repair: A New Horizon in Nephrology" explores groundbreaking advancements in the use of R3 stem cells for kidney disease treatment. This insightful piece delves into the potential of these cells to regenerate damaged kidney tissue, offering new hope for patients and reshaping the future of nephrology.
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
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As we watch Dr. Greene's continued efforts and research in Arizona, it's clear that stem cell therapy holds a promising key to unlocking new doors in the treatment of kidney disease. With each study and trial, we step closer to a world where kidney disease is no longer a life sentence but a treatable condition, thanks to pioneers like Dr. David Greene.
Deep Leg Vein Thrombosis (DVT): Meaning, Causes, Symptoms, Treatment, and Mor...The Lifesciences Magazine
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Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
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Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.Â
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctorsâ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
 Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratoryÂ
 to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
Explore our infographic on 'Essential Metrics for Palliative Care Management' which highlights key performance indicators crucial for enhancing the quality and efficiency of palliative care services.
This visual guide breaks down important metrics across four categories: Patient-Centered Metrics, Care Efficiency Metrics, Quality of Life Metrics, and Staff Metrics. Each section is designed to help healthcare professionals monitor and improve care delivery for patients facing serious illnesses. Understand how to implement these metrics in your palliative care practices for better outcomes and higher satisfaction levels.
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
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This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
3. IntroductionIntroduction
īSuppositories are the solid dosage forms meant
to be inserted into the body cavities other than
the mouth like rectum, urethra and vagina where
they melt or soften to release the drugs and exert
local or systemic effects.
3
4. Classification Of SuppositoriesClassification Of Suppositories
īRectal suppositories
īVaginal suppositories ( PESSARIES )
īUrethral suppositories ( BOUGIES )
īNasal suppositories
īEar suppositories or ear cones(Aurinaries)
4
5. VAGINAL SUPPOSITORYVAGINAL SUPPOSITORY
īThey are also called as PESSARIES.
īSHAPE : globular, oviform or cone-shaped.
Weigh about 3-5gm
īUsed occasionally.
īIntended for local effects like contraceptives,
Antifungal, antiseptics drugs in feminine hygiene
5
6. URETHRAL SUPPOSITORYURETHRAL SUPPOSITORY
īAlso called as BOUGIES .
īSHAPE â slender, pencil-shaped.
īWeight: For females they weight about 2g and are
60-75mm long and 5mm in diameter. For males
they weight about 4g and are 100-150mm long and
5mm in diameter
īIntended for anti-bacterial or as a local anesthetic
preparative for urethral examination and also
erectile dysfunction.
īOccasionally used.
6
7. RECTAL SUPPOSITORYRECTAL SUPPOSITORY
ī Shape: Cone or torpedo shape.
ī Weight: For children's weigh about 1gm and diameter of
3-6mm. For Adults weigh about 2gm and diameter of 3-6mm.
ī Intended for local action to relieve constipation, irritation,
itching and inflammatory associated to hemorrhoids
7
8. NASAL SUPPOSITORYNASAL SUPPOSITORY
Shape: They are thin cylindrical in shape
Weigh: Around 1gm
Base used: Glycero-gelatin base
Used occasionally.
Intended for Anti-inflammatory and anti-allergic
drugs
8
9. EAR CONE (Aurinaries)EAR CONE (Aurinaries)
Shape: They are long cylindrical in shape
Weigh: Around 1gm
Base used: Glycero-gelatin base
Used occasionally.
Eg: Waxylone
9
10. Classification Of Suppositories ViaClassification Of Suppositories Via
Position Of ActionPosition Of Action
LOCAL EFFECT :
īIn case of pain, itching and hemorrhoid.
īLocally active drugs include astringents,
antiseptics, local anesthetics,
vasoconstrictors, anti-inflammatory,
soothing and protective agents and some
laxatives.
SYSTEMIC EFFECT :
īAnti-asthmatics, anti rheumatics, anti-pyretic
and analgesics
10
11. ADVANTAGESADVANTAGES
īEASILY ADMINSTERED to children, old
persons, to unconscious or sometimes to
mentally unstable persons who cannot
swallow the drug.
īConvenient mode of administration for drugs
which irritate the GIT, causing vomiting and
destroyed in acidic pH of stomach and
enzymes of GIT.
īFASTER ONSET OF ACTION as
compared to oral administration because
absorption of drug through rectal mucosa
directly reaches blood
11
12. DISADVANTAGESDISADVANTAGES
īThey are not acceptable by the patients.
īThe manufacturing process is difficult.
īThe drugs which cause irritation to the
mucous membrane cannot be administered
as suppositories.
īMost of the suppositories should be stored
at low temperature10-20°c in a
refrigerator , other wise the base gets
liquified.
īLeakage of the suppositories occurs upon
insertion into the body cavity at elevated
temperature.
12
13. IDEAL PROPERTIES OFIDEAL PROPERTIES OF
SUPPOSITORY BASESSUPPOSITORY BASES
īIt should melt at body temperature or
dissolve or disperse in body fluids.
īIt should release any medicament easily.
īIt should keep its shape when being
handled.
īIt should be non-toxic and non-irritant to
the mucous membrane.
īIt should be stable on storage and also
stable if heated above its M.P.
13
14. IDEAL PROPERTIESIDEAL PROPERTIES
OF SUPPOSITORYOF SUPPOSITORY
BASESBASESīIt should be easily molded and should not
adhere to the mold.
īIt should possess good wetting and
emulsifying properties.
īIt should be able to incorporate a high
percentage of water.
īIt should be chemically and physically
stable
14
16. 1. Hydrophilic bases: these are the one which have the ability to
absorb additional water in the preparation.
They are of two types
i. water-dispersible bases:
ī properties: These are mixtures of non-ionic surfactants which
are chemically related to polyethylene glycols.
ī These are used alone or in combination with other types of
bases
ī Cellulose derivatives like methylcellulose sodium carboxy
methylcellulose also come under this class.
Eg; polyoxyethylene sorbitan fatty acid (tween) 16
SUPPOSITORY BASESSUPPOSITORY BASES
17. ii)Water soluble bases:ii)Water soluble bases:
A. Glycerinated gelatin or Glycero-gelatin:
ī This occurs as a gel .It is a mixture of gelatin,
glycerol and water.
ī According to B.P the composition of the base
is gelatin-14%w/w ,glycerol-70%w/w
ī To get a stiff mass, the quantity of gelatin
should be increased to32%w/w and that of
glycerol reduced to 40%w/w.
17
A. Glycerinated gelatin
B. Polyethylene glycol (PEG) polymers.
18. 18
A- Glycerinated GelatinA- Glycerinated Gelatin
īļ Glycerinated Gelatin is a useful suppository
base, particularly for vaginal suppositories,
where the prolonged localized action is usually
desired.
īļ Glycerinated gelatin suppositories are
translucent, resilient, gelatinous solids that tend
to dissolve or disperse slowly in mucous
secretions to provide prolonged release of active
ingredients.
īļ It is suitable for use with a wide range of
medicaments including alkaloids, boric acid, and
zinc oxide.
19. 19
īļSuppositories made with glycerinated gelatin must
be kept in well-closed containers in a cool place
since they will absorb and dissolve in atmospheric
moisture.
īļSuppositories may have a dehydrating effect and
be irritating to the tissues upon insertion. The
water present in the formula of suppositories
minimizes this action and the suppositories may
be moistened with water prior to insertion to
reduce the tendency of the base to draw water
from mucous.
20. 20
īļIn addition, those suppositories intended for
extended shelf-life should have a
preservative added, such as methylparaben
or propylparaben, or a suitable combination
of the two.
īļTo facilitate administration, glycerinated
gelatin suppositories should be dipped in
water just before use.
21. 21
Preparation of glycerinated gelatin rectalPreparation of glycerinated gelatin rectal
suppositoriessuppositories
īMix or dissolve the medicaments in water to make
a total of 10 g.
īAdd 70 g of glycerin and mix.
īAdd 20 g of granular gelatin, mix carefully to
avoid incorporation of air.
īHeat on a steam bath until the gelatin is dissolved.
īPour the melted mixture into molds and allow to
congeal.
22. 22
Preparation of glycerinated gelatinPreparation of glycerinated gelatin
urethral suppositoriesurethral suppositories
īThe gelatin constitutes about 60% of the
weight of the formula, the glycerin about
20%, and the medicated aqueous portion
about 20%.
23. 23
B-B- Polyethylene Glycol PolymersPolyethylene Glycol Polymers
īą Polyethylene Glycol Polymers have received
much attention as suppository bases in recent
years because they possess many desirable
properties.
īą They are chemically stable, nonirritating,
miscible with water and mucous secretions, and
can be formulated, either by molding or
compression, in a wide range of hardness and
melting point.
24. 24
īąLike glycerinated gelatin, they do not melt at
body temperature, but dissolve to provide a more
prolonged release than theobroma oil.
īąCertain polyethylene glycol polymers may be
used singly as suppository bases but, more
commonly, formulas call for compounds of two or
more molecular weights mixed in various
proportions as needed to yield a finished product
of satisfactory hardness and dissolution time.
25. 25
īąPEGs having average molecular weights of 200,
400 and 600 are clear, colorless liquids.
īąThose having molecular weights of greater than
1000 are wax-like, white solids with hardness
increasing with an increase in the molecular
weight.
īą Since the water miscible suppositories dissolve
in body fluids and need not be formulated to melt
at body temperature, they can be formulated with
much higher melting points.
26. 26
īąThis property permits a slower release of
medicaments from the base, safe storage at room
temperature without need for refrigeration, and
ease and slow insertion.
īąTo prevent irritation of the mucous membranes
after insertion of PEGs suppositories, they should
contain at least 20% of water or dipped in water
just prior to use.
27. 27
Examples of various PEGs used inExamples of various PEGs used in
suppository basessuppository bases
14501450
80008000
300300
80008000
30%30%
70%70%
60%60%
40%40%
300300
60006000
10001000
33503350
10001000
33503350
48%48%
52%52%
95%95%
5%5%
75%75%
25%25%
28. 2.2. Oleaginous Bases (Fatty) 0rOleaginous Bases (Fatty) 0r Lipophilic BasesLipophilic Bases
1. Coca butter:
ī Properties: It is a natural triglyceride
ī It can exist in more than one crystalline
form i.e., it exhibits polymorphism
ī It consists of mixture of oleic acid ,
palmitic acid , stearic acid .
28
29. 29
If the base is fatty, it has the followingIf the base is fatty, it has the following
additional requirements:additional requirements:
īAcid value is below 0.2.
īSaponification value ranges from 200 to
245.
īIodine value is less than 7.
īThe interval between melting point and
solidification point is small.
30. 30
A- Theobroma OilA- Theobroma Oil oror cocoa buttercocoa butter
īļ Theobroma Oil or cocoa butter is used as a
suppository base because, in large measure, it fulfills
the requirements of an ideal base.
īļ Cocoa butter is primarily a tri-glyceride, it is
yellowish- white, solid, brittle fat, which smells and
tastes like chocolate.
īļ At ordinary room temperatures of 15° to 25°C it is a
hard, amorphous solid, but at 30° to 35°C i.e., at
body temperature, it melts to a bland, nonirritating
oil.
31. 31
īļ Thus in warm climates, theobroma oil
suppositories should be refrigerated.
īļ Cocoa butter has iodine value between 34 and
38.
īļ Its acid value not higher than 4.
32. 32
Disadvantages of theobroma oilDisadvantages of theobroma oil
īą Shrinks only slightly on solidification; a mould
lubricant is therefore required.
īą Exists in four polymorphic forms with different
melting points (18.9, 23.0, 28.0, and 34.5ÂēC).
Theobroma should only be heated for a short time
and at temperatures below 36 ÂēC in order to
minimize the formation of the unstable low melting
point forms.
33. 33
īąThe change (reduction) in melting point caused by
addition of certain drugs such as volatile oils, phenol
or chloral hydrate to cocoa butter suppositories. The
solution is to raise the melting point back to the
desired range by addition of 3% to 5% of beeswax or
spermaceti.
īąTheobroma oil has a low absorptive capacity for
water, but this can be increased by adding surfactants
such as cholesterol 2%, emulsifying wax up to 10%,
polysorbates 5 to 10%, or wool fat 5 to 10%.
However, the addition of surfactants may lead to a
drug- base interaction or affect the release of drug
from suppository.
34. 34
īąTheobroma oil is prone to oxidation (due to
high iodine value); this can be partly
overcome by storage in a cool, dark place.
īąTheobroma oil may vary in consistency, odor,
and color depending on its source like other
natural products.
īąThe low melting point of theobroma oil may
pose storage problems in hot climates.
35. 35
3. Miscellaneous Bases3. Miscellaneous Bases
īChemical or physical Mixtures of oleaginous and
water soluble or water miscible materials.
īEmulsions, generally of w/o type (i.e. mixing of
cocoa butter with emulsifying agents).
īPolyoxyl 40 stearate is a mixture of the mono-
stearate and di-stearate esters of mixed poly-
oxyethylene diols and the free glycols.
īSoap may be used as a base (i.e. Glycerin
suppositories, USP, with soap as the base).
36. 2.Anti-oxidants2.Anti-oxidants
īThey protect the drug and the base from
getting degraded due to oxidation.
īExamples :
i. Ethyl or propyl gallate
ii. Ascorbic acid and its esters
iii.Hydroquinone
iv.Tocopherols
36
37. 3.Emulsifying agents:3.Emulsifying agents:
ī§ They increase the water-absorbing capacity
of fatty bases. This makes it possible to
include aqueous solutions in the formulation.
ī§ Examples : polysorbates (tween 60)
ī§ Wool alcohol ,wool fat
4. Hardening agents:
ī These are included in those formulations
where the melting point of the base is
decreased by the drug.
37
38. 38
īThese agents bring the melting point to normal.
īExamples : macrogols with high molecular
weight.
5.Preservatives : They should be included in
suppositories which contain water soluble bases
to prevent microbial growth.
īExamples :methyl paraben , propyl paraben
6.Thickening Agents: They increase the
viscosity of molten base and prevent
sedimentation of suspended insoluble solids.
īExamples: Aluminium monostearate ,collodial
silica ,magnesium stearate.
39. 7.Plasticizers :7.Plasticizers :
īThey impart plasticity to the fatty base
and makes it less brittle.
īExamples :
i. Castor oil
ii.Glycerine or propylene glycol
iii.Glycol
iv.Tween 80
v.Tween 85
39
40. METHODS OF PREPARATIONMETHODS OF PREPARATION
Four methods
Suppositories can be extemporaneously
prepared by one of four methods.
1. Molding by hand or Hand Rolling
2. Compression
3. Fusion Molding or Pour molding
4. Compression in a tabletting machine
40
41. 41
It is the oldest and simplest method of suppository
preparation and may be used when only a few
suppositories are to be prepared in a cocoa butter
base.
īIt has the advantage of avoiding the necessity of
heating the cocoa butter.
īA plastic-like mass is prepared by triturating
grated cocoa butter and active ingredients in a
mortar.
1. Hand Rolling or MOLDING BY HANDor MOLDING BY HAND
42. 42
īThe mass is formed into a ball in the palm of the
hands, then rolled into a uniform cylinder with a
large spatula or small flat board on a pill tile.
īThe cylinder is then cut into the appropriate
number of pieces which are rolled on one end to
produce a conical shape.
īEffective hand rolling requires considerable
practice and skill. The suppository "pipe" or
cylinder tends to crack or hollow in the center,
especially when the mass is insufficiently kneaded
and softened.
MOLDING BY HANDMOLDING BY HAND
43. MOLDING BY HANDMOLDING BY HAND
īHand molding is useful when we are
preparing a small number of suppositories
43
STEP 1
drug
fine powder
48. 48
2. Compression Molding2. Compression Molding
īCompression molding is a method of preparing
suppositories from a mixed mass of grated
suppository base and medicaments which is forced
into a special compression mold using suppository
making machines.
īThe suppository base and the other ingredients are
combined by thorough mixing.
īThe friction of the process causing the base to
soften into a past-like consistency.
49. 49
īOn a small scale, a mortar and pestle may be used
(preheated mortar facilitate softening of the base).
īOn large scale, mechanically operated kneading
mixers and a warmed mixing vessel may be
applied.
īIn the compression machine, the suppository mass
is placed into a cylinder which is then closed.
īPressure is applied from one end to release the
mass from the other end into the suppository mold
or die.
Compression MoldingâĻ..Compression MoldingâĻ..
50. 50
īWhen the die is filled with the mass, a
movable end plate at the back of the die is
removed and when additional pressure is
applied to the mass in the cylinder, the
formed suppositories are ejected.
īThe end plate is returned, and the process is
repeated until all of the suppository mass
has been used.
Compression MoldingâĻ..Compression MoldingâĻ..
51. 51
īThe method requires that the capacity of
the molds first be determined by
compressing a small amount of the base
into the dies and weighing the finished
suppositories.
īWhen active ingredients are added, it is
necessary to omit a portion of the
suppository base, based on the density
factors of the active ingredients.
Compression MoldingâĻ..Compression MoldingâĻ..
56. 56
3. Fusion Molding3. Fusion Molding
īFusion Molding involves:
1- Melting the suppository base
2- Dispersing or dissolving the drug in the melted
base.
3- The mixture is removed from the heat and
poured into a suppository mold.
4- Allowing the melt to congeal
5- Removing the formed suppositories from the
mold.
īThe fusion method can be used with all types of
suppositories and must be used with most of them.
57. 57
Suppository moldsSuppository molds
īSmall scale molds are
capable of producing
6 or 12 suppositories
in a single operation.
īIndustrial molds
produce hundreds of
suppositories from a
single molding.
58. 58
Lubrication of the moldLubrication of the mold
īDepending on the formulation, suppository molds
may require lubrication before the melt is poured
to facilitate the clean and easy removal of the
molded suppository.
īLubrication is seldom necessary when the
suppository base is contracting sufficiently on
cooling.
īLubrication is usually necessary when
glycerinated gelatin suppositories are prepared.