Summarize the first and the second checkpoints during T cell develop.pdf
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Summarize the first and the second checkpoints during T cell development in the thymus. Solution Lymphocytes develp from pluripotent stem cells in bone marrow. Differentiation of these cells requires rearrangement of gene segments to produce functional receptors for its further maturation. There are two checkpoints to decide the distinct lineage of T cells. FIRST CHECKPOINT: 1. Rearrangement of T-cell receptor , and genes. 2. Rearrangement of and genes produces a heterodimeric receptor. 3. Rearrangement of gene produces pre T-cell receptor These cells can enter two distinct lineage i.e or T-cell lineage If none of above rearrangement is successful, then cell dies through apoptosis. SECOND CHEKPOINT 1. T-cell lineage undergoes rearrangement at chain locus leading to expression of CD4 and CD8 receptors. 2. antigen receptor ,CD4/CD8 coreceptor of these cells bind to thymic major histocompatibility complex (MHC) molecules. 3. The type of receptor -MHC interaction produces CD4+CD8-+ lineage or CD4-CD8++ lineage. 4. Both cell lineages have distinct properties and molecular mechanism for receptor specific antigen interaction. If none of above rearrangement is successful, then cell dies through apoptosis..
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2) Positive and negative selection act on this primary repertoire to produce mature, naive T cells that are self-tolerant but responsive to foreign antigens.
3) Mature T cells exit the thymus into secondary lymphoid tissues like lymph nodes and the spleen.
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T –CELLS AND T-REGULATORY CELLxxxxxxxxxxxxxxxxxxxxS.pptx
T –CELLS AND T-REGULATORY CELLxxxxxxxxxxxxxxxxxxxxS.pptx
T cell development, maturation, activation and differentiation
T cell development, maturation, activation and differentiation
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Legal and ethical issues arise in telemedicine regarding beneficence and increasing access to care. While telemedicine can improve quality by increasing accessibility, it may only benefit those with resources. There are also concerns about data control remaining with health organizations and potential ambiguities in practitioner responsibilities between loyalty to patients or their employers as remote care could focus solely on health problems rather than holistic needs.
Using the Graphical User Interface (GUI)Create a user nam.pdf
Use the data points (28, 3.1) and (10, 2.2) to find an equation of the line through these points. Be
sure to use the equation editor to show all steps (slope, point-slope form and slope intercept
form). Video 35 has several practice problems if you are unsure of the steps. Reminder: It is not
OK to leave a decimal in the numerator or denominator of your fraction!
Solution
(28, 3.1) and ( 10, 2.2)
slope = (2.2- 3.1)/( 10 -28)
= 0.05
slope intercept form equation : y = mx +c
y = 0.05x +c Use ( 10, 2.2) to find c:
2.2 = 0.5 +c ---> c = 1.5
y = 0.05x + 1.5
Point slope form : y - 2.2 = 0.05(x -10).
The adjusting entry to record the salaries earned due to employees f.pdf
The adjusting entry to record the salaries earned due to employees for services provided but
unpaid at the end of the accounting period affects the accounts in which of the following ways?
A. Debit Accrued Salaries and credit Salaries Payable.
B. Debit Salaries Expense and credit Cash.
C. Debit Cash and credit Salaries Expense.
D. Debit Salaries Expense and credit Salaries Payable.
E. Debit Salaries Payable and credit Salaries Expense.
Solution
Answer is DGeneral JournalDebitCreditSalaries ExpenseXXXSalaries PayableXXX.
TF A document type definition (DTD) can be referenced by many Exten.pdf
T/F A document type definition (DTD) can be referenced by many Extensible Markup Language
(XML) documents of the same type.
T/F In a document type definition (DTD) file, a plus (+) symbol beside an element indicates that
it is an optional child element within its parent.
T/F Having a web-based database interface eliminates the design and implementation issues of a
database system.
Solution
1) TRUE An external dtd can be referenced by any number of XML files using the syntax >
SYSTEM \"<>.dtd\">
2) FALSE (+) Symbol indicates that the element has to occur atleast once or more than once. So
it is not an optional child element. (*) indicates the occuence of zero or more times.
3) TRUE This is called managed hosting. This can be availed in Cloud DBMS (CDBMS) where
the clould provider creates, manages and maintains the complete database implementation.
PLEASE HELP!!Loren Seguara and Dale Johnson both work for Southern.pdf
PLEASE HELP!!
Loren Seguara and Dale Johnson both work for Southern Semiconductor Corporation (SSC), a
major producer of computer components. Loren works as a clerical assistant in the Accounting
Department, and Dale works as a packager in the Shipping Department. During their lunch break
one day, they began talking about the company. Dale complained that he had always worked
hard trying not to waste packing materials and efficiently and cost-effectively performing his job.
In spite of his efforts and those of his co-workers in the department, the firm’s stock price had
declined nearly $2.00 per share over the past nine months. Loren indicated that he shared Dale’s
frustration, particularly because the firm’s profits had been rising. Neither could understand why
the firm’s stock price was falling as profits rose. Loren indicated that he had seen documents
describing the firm’s profit-sharing plan under which all managers were partially compensated
on the basis of the firm’s profits. He suggested that maybe it was profit that was important to
management, because it directly affected their pay. Dale said, “That doesn’t make sense, because
the stockholders own the firm. Shouldn’t management do what’s best for stockholders?
Something’s wrong!” Loren responded, “Well, maybe that explains why the company hasn’t
concerned itself with the stock price. Look, the only profits that stockholders receive are in the
form of cash dividends, and this firm has never paid dividends during its 20-year history. We as
stockholders therefore don’t directly benefit from profits. The only way we benefit is for the
stock price to rise.” Dale chimed in, “That probably explains why the firm is being sued by state
and federal environmental officials for dumping pollutants in the adjacent stream. Why spend
money for pollution control? It increases costs, lowers profits, and therefore lowers
management’s earnings!” Loren and Dale realized that the lunch break had ended and they must
quickly return to work. Before leaving, they decided to meet the next day to continue their
discussion.
Please answer the following questions:
1) What should the management of Southern Semiconductor Corporation pursue as its overriding
goal? Why?
2) Does the firm appear to have an “agency problem?” Explain.
3) Evaluate the firm’s approach to pollution control. Does it seem to be ethical? a. Why might
incurring the expense to control pollution be in the best interests of the firm’s owners despite its
negative effect on profits?
4) Does the firm appear to have an effective “corporate governance structure?” Explain any
shortcomings.
5) On the basis of the information provided, what specific recommendations would you offer the
firm?
Appreciate your help in advance!
Solution
1)
The Management of the southern semiconductor should pursue the rise in the wealth of
shareholder. They should think of long term benefit that affects the stock price and not the short
term profit. Currently it looks that the.
Please answer the following at the bottom of the case. ThanksTo ne.pdf
Please answer the following at the bottom of the case. Thanks
To negotiate whether an employee should be retained or not, the CHRO can design the following
line of judgement: Who: Attributes of the person being evaluated, whether they fit in with the
core values of the organization or not. What: Skills of the person, i.e., specialized skills that can
make a difference to the organization’s revenues should be considered.
Where; The geographical region in which they work and whether they are required there or not
need to be evaluated. Why: Major cause for retention should be value-addition or potential for
continued value addition to the organization.
How: Instead of using standard Key Performance Indicators (KPI), customized packages for
valuable employees based on their unique contributions to the organization are a good place to
start. “KPIs are intrinsically linked to a firm\'s strategic goals and are used to help managers
assess whether they\'re on target as they work towards those goals (John, 2017)”. Since Netflix
aims only at retaining A employees, managers at all levels should dedicate time to developing
more A employees to keep adding value to the company.
As we see, the types of power the CHRO has for instance, with the positional power she can
direct the company as per her own methods due to her designation. this power is very crucial as
there are no HR policies in place, there must be a central figure who functions as the model
figure to direct the HR functions of the company which usually work as per the model HR
policies. Then the information power is where the employees coming in can expect to learn and
look up to her as she has an in-depth understanding of the processes and clear about the path she
wishes to take Netflix towards (Patty, 2014).
The Reward power adds to coercive power as Sharon has the power to retain a well performing
employee as what is been envisaged by the company and with her power to take disciplinary
action against anyone who isn\'t performing to the expectations, Sharon can strike the right
balance of maintaining the best of talent. Sharon\'s people centric approach with her social power
helps her exercise the above powers in the negotiation very smoothly as she can identify and
select the best employees through negotiation and the incoming employee doesn\'t feel out of
place.
Aiding to all these powers is her charismatic power which makes the employees listen to her,
follow her advice or fear her for what she is rather than just her designation and hugely helps
during negotiations as her exercising of any power doesn\'t come across as being impersonal or
arrogant but a necessary action.
If an agreement is not reached, the CHRO should look outside for eligible candidates. BATNA
stands for Best Alternative to a Negotiated Agreement. “BATNA, Best Alternative to a
Negotiated Agreement term was introduced by Roger Fischer and William Ury in 1981. They
proposed that, when negotiating a business agreement, we s.
Mitchell sets sail for the Chemiosmotic New World, despite dire w.pdf
\"Mitchell sets sail for the Chemiosmotic New World, despite dire warnings that he will be
consumed: What does this cartoon convey about the nature of scientific discovery? Source:
Courtesy of Abraham Tulp.
Solution
Brave new world
1. From shakespeares the storm miranda speak wonder how multitude goodly living being are
here how beauty of humanity is o soldier new globe that has such human in it.
2. They\'re generating life and hatching human from bottles and situation them to like the
employment surroundings of their social category..
Learn the genetics vocabulary (see HW4)] For each of the following ge.pdf
Learn the genetics vocabulary (see HW4)] For each of the following genotypes, identify (a) it is
homologous or heterozygous; and the possible gametes for that genotype (gametes are haploid)
For each of the following state whether the letter symbol shown represents a genotype (diploid)
of a gamete E - this represents a gamete because it is a single dominate allele; it was E_e - that
would represent a heterozygous with a pair of alleles. Using the letter \"T\" and \"I\" to represent
the alleles for gene for tongue-rolling show the heterozygous and homozygous possible.
Solution
Question 1
Possible gametes
a
Homozygous
One gamete w
b
Heterozygous
Two gamete t& T
c
Heterozygous
Two gamete A & a
d
Heterozygous
Two gamete D & d
Question 2
a
Genotype (heterozygous ) Kk
b
genotype Homozygous AA
c
allele
Question 3
Homozygous
Dominant
TT
Taster
Heterozygous
Dominant
Tt
Taster
Homozygous
Recessive
tt
Non-Taster
4
Homozygous---------- Dominant—GENEOTYPE---PURPLE --- PP
Homozygous ----Recessive GENEOTYPE---white --- pp
PURPLE --- PP x white --- pp
P
P
p
Pp PURPLE
Pp PURPLE
p
Pp PURPLE
Pp PURPLE
All offspring are purple in color
Question 1
Possible gametes
a
Homozygous
One gamete w
b
Heterozygous
Two gamete t& T
c
Heterozygous
Two gamete A & a
d
Heterozygous
Two gamete D & d.
If nominal GDP is 28000 and the money supply is 7000, what is velocit.pdf
If nominal GDP is 28000 and the money supply is 7000, what is velocity? 11.5 .68 4 18
Solution
- 4 is correct
According to quantity theory of money, M*V = P*Y
P*Y= 28000
M= 7000
V= 28000/7000= 4
- money supply in the economy increases.
Central bank buys bonds from the bank in exchange for money, This increases money supply.
- 830 million is correct
Assets include cash in vault, reserves, loans and bonds.
Since sale of loan is balanced by cash received in exchange
Total assets= 50+180+600= 830 million.
Investments in trade securities are always short term investments. T.pdf
Investments in trade securities are always short term investments. True or False
Solution
Answer : True
Trade securties are basically equity and debt instruments or plans . They are traded in current
period and produce profit. Management invest in these securities inorder to get money in short
term period..
Information Securityfind an article online discussing defense-in-d.pdf
Information Security
find an article online discussing defense-in-depth. List your source and provide a paragraph
summary of what the article stated.
Solution
Abstract
The exponential growth of the Internet interconnections has led to a significant growth of cyber
attack incidents often with disastrous and grievous consequences. Malware is the primary choice
of weapon to carry out malicious intents in the cyberspace, either by exploitation into existing
vulnerabilities or utilization of unique characteristics of emerging technologies. The
development of more innovative and effective malware defense mechanisms has been regarded
as an urgent requirement in the cybersecurity community. To assist in achieving this goal, we
first present an overview of the most exploited vulnerabilities in existing hardware, software, and
network layers. This is followed by critiques of existing state-of-the-art mitigation techniques as
why they do or don\'t work. We then discuss new attack patterns in emerging technologies such
as social media, cloud computing, smartphone technology, and critical infrastructure. Finally, we
describe our speculative observations on future research directions.
A multi-layered approach to cyber security utilising machine learning and advanced analytics is
essential to defend against sophisticated multi-stage attacks including:
Insider Threats | Advanced Human Attacks | Supply Chain Infection | Ransomware |
Compromised User Accounts | Data Loss
Prepare for a cyber security incident or attack and how to adequately manage the aftermath with
an organised approach to Incident Response – coordinating resources, people, information,
technology and complying with regulations.
INSIDER THREATS
Insider threat can originate from employees, contractors, third party services or anyone with
access rights to your network, corporate data or business premises.
The challenge is to identify attacks and understand how they develop in real-time by analysing
and correlating the subtle signs of compromise that an insider makes when they infiltrate the
network.
Traditional security measures are no longer sufficient to combat insider threat. A more
sophisticated, intelligence-based approach is required. Cyberseer uses machine-learning
technology to form a behavioural baseline for every user to determine normal activity and spot
new, previously unidentified threat behaviours. The move to a more proactive approach towards
security will enable companies to take action to thwart developing situations escalating into
exfiltrated information or damaging incidents.
ADVANCED HUMAN ATTACKS
Advanced threats use a set of stealthy and continuous processes to target an organisation, which
is often orchestrated for business or political motives by individuals (or groups). The “advanced”
process signifies sophisticated techniques using malware to exploit vulnerabilities in
organisations systems. They are considered persistent because an external command and control
system .
implement the following funtions. myg1 and myg2 are seperate. x and .pdf
implement the following funtions. myg1 and myg2 are seperate. x and y represent the two points
in the graph and w is the distance. after implementing ask the user to choose which funtion they
would like to use.
* insert [myg1 | myg2] x y w
* delete [myg1 | myg2] x y
* printgraph [myg1 | myg2]
* printdegree [myg1 | myg2] // if directed, print both in- and out-degree
* printcomplement [myg1 | myg2]
* eliminatelinks [myg1 | myg2] minW maxW
* differentlinks [myg1 | myg2] [myg1 | myg2]
* commonlinks [myg1 | myg2] [myg1 | myg2]
* dfs_print [myg1 | myg2] x
* bfs_print [myg1 | myg2] x
* isconnected [myg1 | myg2]
* numofconncomp [myg1 | myg2] * quit
here is the program so far. I just need to program and put in those function. I need to make it so
the user can pick what they want to do but I can program that myself. it\'s just programming the
above functions. I put clarifications of them at the bottom.
--------------------------------------------------------------------
graph.c program
#include
#include
typedef enum {FALSE, TRUE} bool;
#define MAXV 100
typedef struct edgenode{
int y;
int weight;
struct edgenode *next;
} edgenodeT;
typedef struct{
edgenodeT *edges[MAXV+1];
int degree[MAXV+1];
int nvertices;
int nedges;
bool directed;
} graphT;
void initialize_graph(graphT *g, bool directed);
void read_graph(graphT *g, char *filename);
void insert_edge(graphT *g, int x, int y, int w);
void print_graph(graphT *g, char *name);
void free_graph(graphT *g);
graphT *copy_graph(graphT *g);
main()
// Assume that MAXV is 6
{
graphT *myg1 = NULL, *myg2 = NULL;
if(argc < 2){
fprintf(stderr, \"Usage: %s graph_filename\", argv[0]);
exit(-1);
}
myg1 = (graphT *) malloc(sizeof(graphT));
if (myg1==NULL) {
fprintf(stderr, \"Cannot allocate memory for the graph\");
exit(-1);
}
initialize_graph(myg1, FALSE);
read_graph(myg1, argv[1]);
print_graph(myg1, \"myg1\");
myg2 = copy_graph(myg1);
print_graph(myg2, \"myg2\");
// NOW in a loop get commands and
// call related functions to perform them...
free_graph(myg1);
}
initialize_graph (graphT*g, bool directed)
{
int i;
g->nvertices= 0;
g->nedges= 0;
g->directed = directed;
for (i=1; i<=MAXV; i++)
g->edges[i] = NULL;
for(i=1; i<=MAXV; i++)
g->degree[i] = 0;
}
read_graph(graphT *g)
{
int i;
int n, m, dir;
int x, y, w;
FILE *fp
if((fp=fopen(filename,\"r\"))==NULL){
fprintf(stderr, \"Cannot open the graph file\");
exit(-1);
}
scanf(”%d %d %d”, &n, &m, &dir);
g->nvertices= n;
g->nedges= 0;
g->directed= dir;
for (i=1; i<=m; i++) {
scanf(”%d %d %d”, &x, &y, &w);
insert _edge(g, x, y, w);
if(dir==FALSE)
insert _edge(g, y, x, w);
}
fclose(fp);
}
insert_edge(graphT *g, int x, int y, int w)
{
edgenodeT *pe;
pe= malloc(sizeof(edgenodeT)); // check if NULL
pe->weight = w;
pe->y = y;
pe->next = g->edges[x];
g->edges[x] = pe;
g->degree[x]++;
g->nedges++;
}
print_graph (graphT *g, char *name)
{
edgenodeT *pe;
int i;
if(!g) return;
printf(\"Graph Name: %s\ \", name);
for(i=1; i<=g->nvertices; i++){
printf(\"Node %d: \", i);
pe = g->edges[i];
wh.
If two peers share a link in the overlay (they are neighbors in the .pdf
If two peers share a link in the overlay (they are neighbors in the overlay network represented as
a graph), can they necessarily exchange information with low latency? In at most 3 sentences,
explain why or why not.
Solution
Yes two peers can exchange information with low latency using PEER EXCHANGE ROUTINE
OPTIMIZING PROTOCOL(PROP).
I need to fill-in TODOs in .cpp file and in .h file Could some.pdf
I need to fill-in //TODO\'s in .cpp file and in .h file
Could someone help me at least with few of them to give me an idea how deal with it.
***SinglyLinkedList.cpp
#include
#include
#include \"SinglyLinkedList.h\"
void test_constructor() {
SinglyLinkedList lst = {100, 200, 300, 400, 500};
assert(*lst.at(0) == 100);
assert(*lst.at(1) == 200);
assert(*lst.at(2) == 300);
assert(*lst.at(3) == 400);
assert(*lst.at(4) == 500);
assert(lst.size() == 5);
}
void test_remove() {
SinglyLinkedList lst = {100, 200, 300, 400, 500};
lst.remove(2);
assert(*lst.at(0) == 100);
assert(*lst.at(1) == 200);
assert(*lst.at(2) == 400);
assert(*lst.at(3) == 500);
assert(lst.size() == 4);
}
void test_insert() {
// TODO
}
void test_push_back() {
// TODO
}
void test_push_front() {
// TODO
}
void test_append() {
// TODO
}
void test_sum() {
// TODO
}
int main() {
test_constructor();
test_remove();
test_insert();
test_push_back();
test_push_front();
test_append();
test_sum();
}
***SinglyLinkedList.h
#include
#include
template
class SinglyLinkedList {
// Nested class representing the nodes in the list.
class SinglyLinkedListNode {
public:
// The value stored in this node.
T value;
// The next node in the sequence.
SinglyLinkedListNode *next;
SinglyLinkedListNode(T value) :
value(value), next(nullptr) {}
SinglyLinkedListNode(T value, SinglyLinkedListNode *next) :
value(value), next(next) {}
// Return the size (length) of the linked list.
std::size_t size();
};
SinglyLinkedListNode *head;
SinglyLinkedListNode *tail;
public:
// Constructs a new SinglyLinkedList from an initializer_list of type T[].
// This is mostly for convenience, especially when testing.
SinglyLinkedList(std::initializer_list items) : head(nullptr), tail(nullptr) {
if (items.size() == 0) {
return;
}
// initializer_lists were designed to be used iteratively,
// so thats what we do.
// Can you think of how to write this recursively?
auto it = items.begin();
while (it != items.end()) {
this->push_back(*it++);
}
}
// Return a pointer to the value at the given index.
// If the index is larger than the size of the list,
// return a nullptr.
//
// ASIDE: We will cover exceptions later.
T* at(std::size_t i);
// Pushes a new node onto the back of the list.
void push_back(T value);
// Pushes a new node onto the front of the list.
void push_front(T value);
// Return the size (length) of the linked list.
std::size_t size();
// Remove the specified node from the list.
void remove(std::size_t i);
// Insert the value at the index.
void insert(std::size_t i, T value);
// Append the given list to this one.
void append(SinglyLinkedList list);
};
template
T* SinglyLinkedList::at(std::size_t i) {
// TODO
}
template
void SinglyLinkedList::push_back(T value) {
// TODO
// Make sure that this is a O(1) operation!
}
template
void SinglyLinkedList::push_front(T value) {
// TODO
// Make sure that this is a O(1) operation!
}
template
void SinglyLinkedList::remove(std::size_t i) {
// TODO
// Don\'t forget to not only unlink the node, b.
how important is Negative Emotionality to an accounting career plea.pdf
Negative emotionality can be important for an accounting career as emotions like embarrassment, anxiety, and frustration can lead one to study rigorously, seek feedback on performance, and find personal satisfaction in their work. Experiencing negative emotions within academic accounting can enhance job performance and motivation to investigate and find evidence, which are motivated by the negative nature of accounting functions and jobs. Therefore, negative emotionality is considered important to have for an accounting career.
How do I know whether miscellaneous expense goes on top or bottom of.pdf
How do I know whether miscellaneous expense goes on top or bottom of the description in the
general journal?
Solution
Expenses are always debited and in the journal entry accounts are debited first and then credited.
Therefore miscellaneous expense will be debited and hence recorded first.
Thus miscellaneous expense will be recorded on the top..
Given a 1024 by 1024 RAM block, answer the following questions a) If.pdf
Given a 1024 by 1024 RAM block, answer the following questions a) If we used that to make
an 2-bit wide memory i) How many 2-bit locations would there be? ii) How many address bits
would we need to address those locations? iii) How many of those address bits would go to the
decoder? The MUX? b) If we used that to make a 16-bit wide memory [3] i) How many 16-bit
locations would there be? ii) How many address bits would we need to address those locations?
iii) How many of those address bits would go to the decoder? The MUX?
Solution
2)
a) Given Ram = 1024 bytes = 8192 bits
i) If 2 bits = 1 location
then 1024 bytes = 8192 bits = 8192 / 2 locations = 4096 locations
ii) 1 location = 1 binary representation
Therefore, 2n represents the locations .
4096 locations <= 2n where n is no of bits required
4096 locations <= 212 => 12 bits of address bits required
iii)
Out of 12 address bits ; 11 bits goes to the MUX
b)
i) If 16 bits = 1 location
then 1024 bytes = 8192 bits = 8192 / 16 locations = 512 locations
ii) 1 location = 1 binary representation
Therefore, 2n represents the locations .
512 locations <= 2n where n is no of bits required
512 locations <= 29 => 9 bits of address bits required
iii) out of 9 address bits ; 8 bits are given to decoder.
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of any area. Consequently, a wide range of professionals, including earth system scientists, land
and water managers, and urban planners, are interested in obtaining data on land use and cover
changes, conversion trends, and other related patterns. The spatial dimensions of land use and
cover support policymakers and scientists in making well-informed decisions, as alterations in
these patterns indicate shifts in economic and social conditions. Monitoring such changes with the
help of Advanced technologies like Remote Sensing and Geographic Information Systems is
crucial for coordinated efforts across different administrative levels. Advanced technologies like
Remote Sensing and Geographic Information Systems
9
Changes in vegetation cover refer to variations in the distribution, composition, and overall
structure of plant communities across different temporal and spatial scales. These changes can
occur natural.
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