Substance abuse, also known as drug abuse, is a patterned use of a drug in which the user consumes the substance in amounts or with methods which are harmful to themselves or others, and is a form of the substance-related disorder.
Drug addiction is a chronic disease characterized by drug seeking and use that is compulsive, or difficult to control, despite harmful consequences.
Brain changes that occur over time with drug use challenge an addicted person’s self-control and interfere with their ability to resist intense urges to take drugs. This is why drug addiction is also a relapsing disease.
Relapse is the return to drug use after an attempt to stop. Relapse indicates the need for more or different treatment.
Most drugs affect the brain's reward circuit by flooding it with the chemical messenger dopamine. This overstimulation of the reward circuit causes the intensely pleasurable "high" that leads people to take a drug again and again.
Drug addiction is a chronic disease characterized by drug seeking and use that is compulsive, or difficult to control, despite harmful consequences.
Brain changes that occur over time with drug use challenge an addicted person’s self-control and interfere with their ability to resist intense urges to take drugs. This is why drug addiction is also a relapsing disease.
Relapse is the return to drug use after an attempt to stop. Relapse indicates the need for more or different treatment.
Most drugs affect the brain's reward circuit by flooding it with the chemical messenger dopamine. This overstimulation of the reward circuit causes the intensely pleasurable "high" that leads people to take a drug again and again.
suicide - a public health problem
history, global scenario, Indian scenario, etiology, risk factors. protective factors, suicide in adolescents, treatment, prevention, recommendations
Alcoholism, also known as alcohol use disorder (AUD), is a broad term for any drinking of alcohol that results in mental or physical health problems. The disorder was previously divided into two types: alcohol abuse and alcohol dependence.
Substance Abuse
outlines
Definition
Factsheet
Risk factors
ICD classification
Sign and Symptom
The harmful effect of substance abuse on health and behaviour
Prevention and Rehabilitation for substance abusers
References
suicide - a public health problem
history, global scenario, Indian scenario, etiology, risk factors. protective factors, suicide in adolescents, treatment, prevention, recommendations
Alcoholism, also known as alcohol use disorder (AUD), is a broad term for any drinking of alcohol that results in mental or physical health problems. The disorder was previously divided into two types: alcohol abuse and alcohol dependence.
Substance Abuse
outlines
Definition
Factsheet
Risk factors
ICD classification
Sign and Symptom
The harmful effect of substance abuse on health and behaviour
Prevention and Rehabilitation for substance abusers
References
Psychological management of maxillofacial prosthetic patient/ Labial orthodon...Indian dental academy
Indian Dental Academy: will be one of the most relevant and exciting training center with best faculty and flexible training programs for dental professionals who wish to advance in their dental practice,Offers certified courses in Dental implants,Orthodontics,Endodontics,Cosmetic Dentistry, Prosthetic Dentistry, Periodontics and General Dentistry.
Drug addiction is a serious problem that the government has to give full attention because it leads to so many social problems and could greatly affect the health of an individual hooked into it.
Psychological management of maxillofacial prosthetic patient/cosmetic dentist...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Mental health is about enhancing competencies of individuals and communities and enabling them to achieve their self-determined goals. Mental health should be a concern for all of us, rather than only for those who suffer from a mental disorder. Mental health problems affect society as a whole, and not just a small, isolated segment. They are therefore a major challenge to global development. This presentation focuses on the importance of mental health, the common substance abuse and their influence on mental health.
Similar to Substance abuse power presentation (20)
Antepartum haemorrhage (APH) is defined as bleeding from or in to the genital tract, occurring from 24+0 weeks of pregnancy and prior to the birth of the baby. The most important causes of APH are placenta praevia and placental abruption, although these are not the most common.
Types 1 and 2 are classified as minor placental praevia as these typically result in minor antepartum haemorrhaging. Types 3 and 4 are referred to as major placental praevia due to the risk of heavy haemorrhaging in the case of a rupture due to the location of placental attachment.
Disorders of the placenta including: FGR, pre-eclampsia, placental abruption and abnormal (velamentous) cord insertion are associated with over 50% of stillbirths and are frequently cited as the primary cause of death [1–3]. Abnormal placental structure and function significantly increases the risk of stillbirth.
Placenta accreta, placenta increta, and placenta percreta. Abnormal placental implantation (accreta, incretak, and percreta) is described using a general clinical term, respectively, morbidly adherent placenta (MAP) [2] or “abnormal invasive placenta” (AIP).
A miscarriage, or spontaneous abortion, is an event that results in the loss of a fetus before 20 weeks of pregnancy. It typically happens during the first trimester, or first three months, of the pregnancy. Miscarriages can happen for a variety of medical reasons, many of which aren't within a person's control.
Chromotherapy Chromotherapy, sometimes called color therapy, colorology or cr...jagan _jaggi
Chromotherapy
Chromotherapy, sometimes called color therapy, colorology, or chromotherapy, is an alternative medicine method, which is considered pseudoscience.
Color therapy (or chromotherapy) is an alternative remedy that uses color and light to treat physical or mental health by balancing the body's energy centers, also known as chakras. This concept dates back to ancient Egyptians who used sun-activated solarium rooms constructed with colored glass for therapeutic purposes.
Behavior therapy or behavioral psychotherapy is a broad term referring to cl...jagan _jaggi
Behavioral therapy is an umbrella term for types of therapy that treat mental health disorders. This form of therapy seeks to identify and help change potentially self-destructive or unhealthy behaviors. It functions on the idea that all behaviors are learned and those unhealthy behaviors can be changed.
Behavior therapy
Behavior therapy or behavioral psychotherapy is a broad term referring to clinical psychotherapy that uses techniques derived from behaviorism and/or cognitive psychology.
light therapy is meant to compensate for the lack of exposure to sunlight th...jagan _jaggi
Light therapy
Description
DescriptionLight therapy—or phototherapy, classically referred to as heliotherapy—consists either of A. exposure to daylight or some equivalent form of light as a treatment for seasonal affective disorder or B. exposure of the skin to specific wavelengths of light using polychromatic polarized light to treat a skin condition.
Center for Mental Health Services, also known as community mental health teams in the United Kingdom, support or treat people with mental disorders in a domiciliary setting, instead of a psychiatric hospital.
The Government of India has launched the National Mental Health Programme (NMHP) in 1982, keeping in view the heavy burden of mental illness in the community, and the absolute inadequacy of mental health care infrastructure in the country to deal with it
Inotropic agents, or inotropes, are medicines that change the force of your h...jagan _jaggi
An inotrope is an agent that alters the force or energy of muscular contractions. Negatively inotropic agents weaken the force of muscular contractions. Positively inotropic agents increase the strength of muscular contraction.
A neurological examination is the assessment of sensory neuron and motor responses, especially reflexes, to determine whether the nervous system is impaired. This typically includes a physical examination and a review of the patient's medical history, but not deeper investigation such as neuroimaging.
Transposition of the great arteries is a serious but rare heart defect present at birth (congenital), in which the two main arteries leaving the heart are reversed (transposed). The condition is also called dextro-transposition of the great arteries.
If you've had a heart attack, you may have already had certain procedures to help you survive your heart attack and diagnose your condition. For example, many heart attack patients have undergone thrombolysis, a procedure that involves injecting a clot-dissolving agent to restore blood flow in a coronary artery.
Defibrillation -cardioversion Cardioversion is a medical procedure by which a...jagan _jaggi
Defibrillation is a technique used in emergency medicine to terminate ventricular fibrillation or pulseless ventricular tachycardia. It uses an electrical shock to reset the electrical state of the heart so that it may beat to a rhythm controlled by its own natural pacemaker cells.
Cardioversion is a medical procedure by which an abnormally fast heart rate (tachycardia) or other cardiac arrhythmia is converted to a normal rhythm using electricity or drugs.
Cathlab procedures, it's contains what are the procedure doing in the cathla...jagan _jaggi
Cath lab is an examination room in a hospital or clinic with diagnostic imaging equipment used to visualize the arteries of the heart and the chambers of the heart and treat any stenosis or abnormality found.
Arterial blood gas test Diagnostic testjagan _jaggi
Arterial blood gas test
Diagnostic test
Description , An arterial-blood gas test measures the amounts of arterial gases, such as oxygen and carbon dioxide. An ABG test requires that a small volume of blood be drawn from the radial artery with a syringe and a thin needle, but sometimes the femoral artery in the groin or another site is used.
Obstetric instruments power point presentaion jagan _jaggi
Image result for obstetric instrumentswww.slideshare.net
Our gynaecology instruments include: Forceps & Clamps - For uterine and caesarian birthing, hysterectomy and other obstetrics and gynae surgery. Cervical Dilators - For stretching the cervical wall and dilating the cervical muscles. Vaginal Speculums - Used in procedures such as the pap smear.
Florence nightingale was an English social reformer and statistician, and the...jagan _jaggi
Florence Nightingale, OM, RRC, DStJ (/ˈnaɪtɪnɡeɪl/; 12 May 1820 – 13 August 1910) was an English social reformer and statistician, and the founder of modern nursing. Nightingale came to prominence while serving as a manager and trainer of nurses during the Crimean War, in which she organized to care for wounded soldiers.
To strengthen your pelvic floor muscles, sit comfortably and squeeze the muscles 10-15 times in a row. Don't hold your breath or tighten your stomach, buttock or thigh muscles at the same time. When you get used to doing pelvic floor exercises, you can try holding each squeeze for a few seconds.
Breastfeeding techniques The World Health Organization and UNICEF have recomm...jagan _jaggi
Breastfeeding, also known as nursing, is the feeding of babies and young children with milk from a woman's breast. Health professionals recommend that breastfeeding begin within the first hour of a baby's life and continue as often and as much as the baby wants
The World Health Organization and UNICEF have recommended for a decade that mothers breastfeed for at least two years. But most US women who nurse stop before their baby is six months old – and many never start at all.
mental retardation power point presentationjagan _jaggi
Intellectual disability (ID), once called mental retardation, is characterized by below-average intelligence or mental ability and a lack of skills necessary for day-to-day living. People with intellectual disabilities can and do learn new skills, but they learn them more slowly.
The DSM-IV definition utilizes four degrees of severity that reflect the level of intellectual impairment: IQ levels between 50–55 to approximately 70 characterize mild mental retardation, 35—40 to 50–55 characterize moderate mental retardation, 20–25 to 35–40 characterize severe mental retardation,
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
3. Psychoactive SubstancePsychoactive Substance
Psychoactive (psychotropic)Psychoactive (psychotropic) substancesubstance isis
any substance which after absorptionany substance which after absorption
has influence on mental processes bothhas influence on mental processes both
cognitive and affectivecognitive and affective..
4. Substance abuseSubstance abuse
Substance abuse can be defined as usingSubstance abuse can be defined as using
a drug in a way that is inconsistent witha drug in a way that is inconsistent with
medical or social norms and despitemedical or social norms and despite
negative consequences.negative consequences.
6. IntoxicationIntoxication
Intoxication is use of a substance thatIntoxication is use of a substance that
results in maladaptive behavior.results in maladaptive behavior.
7. Withdrawal syndromeWithdrawal syndrome
Withdrawal syndromeWithdrawal syndrome refers to therefers to the
negative psychological and physicalnegative psychological and physical
reactions that occur when use of areactions that occur when use of a
substance ceases or dramaticallysubstance ceases or dramatically
decreases.decreases.
8. BlackoutBlackout
It is an episode during which the personIt is an episode during which the person
continues to function but has no consciouscontinues to function but has no conscious
awareness of his or her behavior at theawareness of his or her behavior at the
time nor any later memory of the behavior.time nor any later memory of the behavior.
9. ToleranceTolerance
Tolerance is defined as the need forTolerance is defined as the need for
increasingly larger or more frequent dosesincreasingly larger or more frequent doses
of a substance in order to obtain theof a substance in order to obtain the
desired effects originally produced by adesired effects originally produced by a
lower dose.lower dose.
10. DependenceDependence
DependenceDependence A compulsive or chronicA compulsive or chronic
requirement. The need is so strong as torequirement. The need is so strong as to
generate distress (either physical orgenerate distress (either physical or
psychological) if left unfulfilled.psychological) if left unfulfilled.
13. Biological FactorsBiological Factors
1.Genetics1.Genetics
Children of alcoholics are three timesChildren of alcoholics are three times
more likely than other children to becomemore likely than other children to become
alcoholicsalcoholics
Biological offspring of alcoholic parentsBiological offspring of alcoholic parents
have a significantly greater incidence ofhave a significantly greater incidence of
alcoholism than offspring of nonalcoholicalcoholism than offspring of nonalcoholic
parents.parents.
14. Monozygotic twins have a higher rate forMonozygotic twins have a higher rate for
concordance of alcoholism than dizygoticconcordance of alcoholism than dizygotic
15. 2. Biochemical factors2. Biochemical factors
Norepinephrine and dopamine have beenNorepinephrine and dopamine have been
implicated in opioid, cocaine and ethanolimplicated in opioid, cocaine and ethanol
dependence.dependence.
Abnormalities in alcohol dehydrogenase inAbnormalities in alcohol dehydrogenase in
alcohol dependencealcohol dependence
16. Psychological factorsPsychological factors
LonelinessLoneliness
Unmet needsUnmet needs
Low self esteemLow self esteem
Desire to escape from realityDesire to escape from reality
Sense of adventureSense of adventure
Pleasure seekingPleasure seeking
Sense of inferioritySense of inferiority
Poor impulse controlPoor impulse control
17. Social factorsSocial factors
Religious reasonsReligious reasons
Peer pressurePeer pressure
UrbanizationUrbanization
Extended period of educationExtended period of education
UnemploymentUnemployment
OvercrowdingOvercrowding
Poor social supportPoor social support
Effect of tv and other mass mediaEffect of tv and other mass media
18. Occupation: barmen, executives,Occupation: barmen, executives,
salesmen, actors, entertainers, armysalesmen, actors, entertainers, army
personnel, medical personnel.personnel, medical personnel.
20. Social and EnvironmentalSocial and Environmental
FactorsFactors
laws,laws,
cost, and availabilitycost, and availability
21. Substance-Related DisordersSubstance-Related Disorders
2 Groups:2 Groups:
Substance Use DisordersSubstance Use Disorders
• Abuse or dependenceAbuse or dependence
Substance-Induced DisordersSubstance-Induced Disorders
Intoxication, withdrawal, delirium, dementia,Intoxication, withdrawal, delirium, dementia,
amnesia, psychosis, mood disorder, anxietyamnesia, psychosis, mood disorder, anxiety
disorder, sexual dysfunction, and sleepdisorder, sexual dysfunction, and sleep
disordersdisorders
22. ComorbidityComorbidity
Up to 50% of addicts have comorbidUp to 50% of addicts have comorbid
psychiatric disorderpsychiatric disorder
Antisocial PDAntisocial PD
DepressionDepression
SuicideSuicide
23. Options for where to treatOptions for where to treat
Hospitalization-Hospitalization-
-Due to drug OD, risk of severe withdrawal, medical-Due to drug OD, risk of severe withdrawal, medical
comorbidities, requires restricted access to drugs,comorbidities, requires restricted access to drugs,
psychiatric illness with suicidal ideationpsychiatric illness with suicidal ideation
Residential treatment unitResidential treatment unit
-No intensive medical/psychiatric monitoring needs-No intensive medical/psychiatric monitoring needs
-Require a restricted environment-Require a restricted environment
-Partial hospitalization-Partial hospitalization
Outpatient Program -No risk of med/psych morbidity andOutpatient Program -No risk of med/psych morbidity and
highly motivated patienthighly motivated patient
24. TreatmentTreatment
Behavioral InterventionsBehavioral Interventions
Motivation to changeMotivation to change
Group TherapyGroup Therapy
Individual TherapyIndividual Therapy
Self-Help Recovery Groups (AA)Self-Help Recovery Groups (AA)
Therapeutic CommunitiesTherapeutic Communities
Aversion TherapiesAversion Therapies
Family Involvement/TherapyFamily Involvement/Therapy
Relapse PreventionRelapse Prevention
25. TreatmentTreatment
Pharmacologic InterventionPharmacologic Intervention
Treat Co-Occurring Psychiatric DisordersTreat Co-Occurring Psychiatric Disorders
50% will have another psychiatric disorder50% will have another psychiatric disorder
Treat Associated Medical ConditionsTreat Associated Medical Conditions
cardiovascular, cancer, endocrine, hepatic,cardiovascular, cancer, endocrine, hepatic,
hematologic, infectious, neurologic,hematologic, infectious, neurologic,
nutritional, GI, pulmonary, renal,nutritional, GI, pulmonary, renal,
musculoskeletalmusculoskeletal
27. AlcoholismAlcoholism
Alcoholism refers to the use of alcoholicAlcoholism refers to the use of alcoholic
beverages to the point of causing damagebeverages to the point of causing damage
to the individual, society or both.to the individual, society or both.
32. 1. Acute Intoxication1. Acute Intoxication
Blood Alcohol Level -Blood Alcohol Level -
0.08g/dl0.08g/dl
Progress from moodProgress from mood
lability, impairedlability, impaired
judgment, and poorjudgment, and poor
coordination tocoordination to
increasing level ofincreasing level of
neurologic impairmentneurologic impairment
(severe dysarthria,(severe dysarthria,
amnesia, ataxia)amnesia, ataxia)
Can be fatal (loss ofCan be fatal (loss of
airway protectiveairway protective
reflexes, pulmonaryreflexes, pulmonary
aspiration, profound CNSaspiration, profound CNS
depression)depression)
33. 2. Alcohol Withdrawal syndrome2. Alcohol Withdrawal syndrome
EarlyEarly
anxiety, irritability, tremor, insomnia, nausea,anxiety, irritability, tremor, insomnia, nausea,
tachycardia, HTN, hyperthermia, hyperactive reflexestachycardia, HTN, hyperthermia, hyperactive reflexes
SeizuresSeizures
generally seen 24-48 hoursgenerally seen 24-48 hours
most often Grand malmost often Grand mal
Withdrawal Delirium TremensWithdrawal Delirium Tremens
generally between 48-72 hoursgenerally between 48-72 hours
altered mental status, hallucinations, markedaltered mental status, hallucinations, marked
autonomic instabilityautonomic instability
life-threateninglife-threatening
34. Alcohol Withdrawal (cont.)Alcohol Withdrawal (cont.)
BenzodiazepinesBenzodiazepines
GABA agonist - cross-tolerant with alcoholGABA agonist - cross-tolerant with alcohol
reduce risk of SZ; provide comfort/sedationreduce risk of SZ; provide comfort/sedation
AnticonvulsantsAnticonvulsants
reduce risk of SZreduce risk of SZ
Carbamazepine or Valproic acidCarbamazepine or Valproic acid
Thiamine supplementationThiamine supplementation
Risk thiamine deficiency (Wernicke/Korsakoff)Risk thiamine deficiency (Wernicke/Korsakoff)
35. 3.Alcohol induced amnestic3.Alcohol induced amnestic
disorderdisorder
Thiamine deficiency is most frequentThiamine deficiency is most frequent
cause of amnestic disorder.cause of amnestic disorder.
Wernicke’s encephalopathy:Wernicke’s encephalopathy:
Cerebral ataxiaCerebral ataxia
66thth
cranial nerve palsycranial nerve palsy
Periperal neropathyPeriperal neropathy
36. Korsakoff’s psychosisKorsakoff’s psychosis
Gross memory disturbanceGross memory disturbance
DisorientationDisorientation
ConfusionConfusion
Confabulation: the unconscious filling ofConfabulation: the unconscious filling of
memory gaps by imagined or untruememory gaps by imagined or untrue
experience due to memory lossexperience due to memory loss
Poor attention spanPoor attention span
Impaired insightImpaired insight
38. Alcohol treatmentAlcohol treatment
Outpatient CD treatment:Outpatient CD treatment:
support, education, skills training, psychiatricsupport, education, skills training, psychiatric
and psychological treatment, AAand psychological treatment, AA
Medications:Medications:
DisulfiramDisulfiram
NaltrexoneNaltrexone
AcamprosateAcamprosate
39. Medications-alcohol deterrentMedications-alcohol deterrent
therapytherapy
Disulfiram (antabuse) 250mg-500mg po dailyDisulfiram (antabuse) 250mg-500mg po daily
Inhibits aldehyde dehydrogenase andInhibits aldehyde dehydrogenase and
dopamine beta hydroxylasedopamine beta hydroxylase
Aversive reaction when alcohol ingested-Aversive reaction when alcohol ingested-
vasodilatation, flushing, hypotenstion/ HTN,vasodilatation, flushing, hypotenstion/ HTN,
coma / deathcoma / death
Psychiatric side effects - psychosis,Psychiatric side effects - psychosis,
depression, confusion, anxietydepression, confusion, anxiety
Dermatologic rashes and itchingDermatologic rashes and itching
Watch out for forms of alcohol - sauces,Watch out for forms of alcohol - sauces,
mouth wash, cough meds, alcohol basedmouth wash, cough meds, alcohol based
hand sanitizers, etchand sanitizers, etc
40. MedicationsMedications
Naltrexone 50mg po dailyNaltrexone 50mg po daily
Opioid antagonist thought to block mu receptorsOpioid antagonist thought to block mu receptors
reducing intoxication euphoria and cravingsreducing intoxication euphoria and cravings
Hepatotoxicity at high doseHepatotoxicity at high dose
Acamprosate(Campral) 666mg po tidAcamprosate(Campral) 666mg po tid
Unknown MOA but thought to stabilize neuronUnknown MOA but thought to stabilize neuron
excitation and inhibition - may interact with GABA andexcitation and inhibition - may interact with GABA and
Glutamate receptor - cleared renally (check kidneyGlutamate receptor - cleared renally (check kidney
function)function)
42. Benzodiazepine( BZD)/Benzodiazepine( BZD)/
BarbituratesBarbiturates
IntoxicationIntoxication
Similar to alcohol but less cognitive/motorSimilar to alcohol but less cognitive/motor
impairmentimpairment
Variable rate of absorption (lipophilia) andVariable rate of absorption (lipophilia) and
onset of action and duration in CNSonset of action and duration in CNS
The more lipophilic and shorter the duration ofThe more lipophilic and shorter the duration of
action, the more "addicting" .action, the more "addicting" .
43. BenzodiazepineBenzodiazepine
WithdrawaWithdrawall
Anxiety, irritability, insomnia, fatigue, HA,Anxiety, irritability, insomnia, fatigue, HA,
tremor, sweating, poor concentrationtremor, sweating, poor concentration
Common detox mistake is tapering too fast;Common detox mistake is tapering too fast;
symptoms worse at end of tapersymptoms worse at end of taper
Convert short elimination BZD to longerConvert short elimination BZD to longer
elimination half life drug and then slowly taperelimination half life drug and then slowly taper
Outpatient taper- decrease dose every 1-2Outpatient taper- decrease dose every 1-2
weeks and not more than 5 mg Diazepamweeks and not more than 5 mg Diazepam
dose equivalentdose equivalent
46. OPIOIDSOPIOIDS
The commonly abused opioids(narcotics)The commonly abused opioids(narcotics)
are heroin(brown sugar).are heroin(brown sugar).
Synthetic preparation like pethidine,Synthetic preparation like pethidine,
fortwin.fortwin.
47. OPIOIDSOPIOIDS
Bind to the Opioid receptor in the CNS to modulate painBind to the Opioid receptor in the CNS to modulate pain
Intoxication-Intoxication- pinpoint pupils, sedation, constipation,pinpoint pupils, sedation, constipation,
bradycardia, hypotension and decreased respiratory ratebradycardia, hypotension and decreased respiratory rate
Withdrawal-Withdrawal-
Not life threatening unless severe medical illness butNot life threatening unless severe medical illness but
extremely uncomfortable.extremely uncomfortable.
dilated pupils lacrimation, goosebumps, diarrhea,dilated pupils lacrimation, goosebumps, diarrhea,
myalgias, arthralgias, dysphoria or agitationmyalgias, arthralgias, dysphoria or agitation
53. Stimulants (Amphetamines, Cocaine,Stimulants (Amphetamines, Cocaine,
Others)Others)
Stimulants are drugs that stimulate orStimulants are drugs that stimulate or
excite the central nervous system.excite the central nervous system.
55. STIMULANTSSTIMULANTS
(cont.)(cont.)
Chronic intoxicationChronic intoxication
affective blunting, fatigue, sadness, socialaffective blunting, fatigue, sadness, social
withdrawal, hypotension, bradycardia, musclewithdrawal, hypotension, bradycardia, muscle
weaknessweakness
WithdrawalWithdrawal
Not severe but have exhaustion with sleepNot severe but have exhaustion with sleep
(crash)(crash)
Treat with rest and supportTreat with rest and support
56. CocaineCocaine
Route: nasal, IV or smokedRoute: nasal, IV or smoked
Has vasoconstrictive effects that may outlastHas vasoconstrictive effects that may outlast
use and increase risk for CVA and MIuse and increase risk for CVA and MI
Neuroadaptation:Neuroadaptation: cocaine mainly preventscocaine mainly prevents
reuptake of DAreuptake of DA
57. Treatment - Stimulant UseTreatment - Stimulant Use
Disorder (cocaine)Disorder (cocaine)
Treatment including support, education,Treatment including support, education,
PsychotherapyPsychotherapy
PharmacotherapyPharmacotherapy
Amyl nitrite is an antidoteAmyl nitrite is an antidote
AntidepressentAntidepressent
58. AmphetaminesAmphetamines
Similar intoxication syndrome to cocaine butSimilar intoxication syndrome to cocaine but
usually longerusually longer
Route - oral, IV, nasally, smokedRoute - oral, IV, nasally, smoked
No vasoconstrictive effectNo vasoconstrictive effect
NeuroadaptationNeuroadaptation
inhibit reuptake of DA, NE, SE - greatest effect on DAinhibit reuptake of DA, NE, SE - greatest effect on DA
59. Chronic use results in neurotoxicityChronic use results in neurotoxicity
possibly from glutamate and axonalpossibly from glutamate and axonal
degenerationdegeneration
Can see permanent amphetamineCan see permanent amphetamine
psychosis with continued usepsychosis with continued use
Treatment similar as for cocaine but noTreatment similar as for cocaine but no
known substances to reduce cravingsknown substances to reduce cravings
60. Treatment – Stimulant UseTreatment – Stimulant Use
Disorder (amphetamine)Disorder (amphetamine)
Treatment: including support, educationTreatment: including support, education
No specific medications have been foundNo specific medications have been found
helpful in treatmenthelpful in treatment
62. TobaccoTobacco
Most important preventable cause of death /Most important preventable cause of death /
diseasedisease
45% of smokers die of tobacco induced disorder45% of smokers die of tobacco induced disorder
Second hand smoke causes death / morbiditySecond hand smoke causes death / morbidity
Psychiatric pts at risk for Nicotine dependence-Psychiatric pts at risk for Nicotine dependence-
75%-90 % of Schizophrenia pts smoke75%-90 % of Schizophrenia pts smoke
63. Tobacco (Tobacco (cont.)cont.)
No intoxication diagnosisNo intoxication diagnosis
initial use associated with dizziness, nauseainitial use associated with dizziness, nausea
NeuroadaptationNeuroadaptation
nicotine acetylcholine receptors on DA neurons innicotine acetylcholine receptors on DA neurons in
ventral tegmental area release DAventral tegmental area release DA
ToleranceTolerance
rapidrapid
WithdrawalWithdrawal
irritability, anxiety, decreased concentration,irritability, anxiety, decreased concentration,
insomnia, increased appetiteinsomnia, increased appetite
79. MDMAMDMA
Designer club drugDesigner club drug
3-6 hour duration3-6 hour duration
Tolerance develops quickly and unpleasant sideTolerance develops quickly and unpleasant side
effects with continued use (teeth grinding) soeffects with continued use (teeth grinding) so
dependence less likelydependence less likely
83. Cannabis (Marijuana/ ganja)Cannabis (Marijuana/ ganja)
Cannabis sativa is the hemp plantCannabis sativa is the hemp plant
Cannabis is most often smoked inCannabis is most often smoked in
cigarettes but it can be eaten(bang).cigarettes but it can be eaten(bang).
lipid soluble;lipid soluble;
long half life of 50 hourslong half life of 50 hours
84. CANNABISCANNABIS
IntoxicationIntoxication--
Appetite and thirst increaseAppetite and thirst increase
Colors/ sounds/ tastes are clearerColors/ sounds/ tastes are clearer
Increased confidence and euphoriaIncreased confidence and euphoria
RelaxationRelaxation
Increased libidoIncreased libido
Transient depression, anxiety, paranoiaTransient depression, anxiety, paranoia
Tachycardia, dry mouth,Tachycardia, dry mouth,
Slowed reaction time/ motor speedSlowed reaction time/ motor speed
Impaired cognitionImpaired cognition
PsychosisPsychosis
85. CANNABIS (cont.)CANNABIS (cont.)
NeuroadaptationNeuroadaptation
Neuromodulator effect; decrease uptake of GABANeuromodulator effect; decrease uptake of GABA
and DAand DA
WithdrawaWithdrawal - insomnia, irritability, anxiety, poorl - insomnia, irritability, anxiety, poor
appetite, depression, physical discomfortappetite, depression, physical discomfort
86. CANNABIS (cont.)CANNABIS (cont.)
TreatmentTreatment
-Detox and rehab-Detox and rehab
-Behavioral model-Behavioral model
-No pharmacological treatment but-No pharmacological treatment but
maymay treat other psychiatric symptomstreat other psychiatric symptoms
88. PHENACYCLIDINE ( PCP)PHENACYCLIDINE ( PCP)
"Angel Dust""Angel Dust"
Dissociative anestheticDissociative anesthetic
IntoxicationIntoxication::
severe dissociative reactionssevere dissociative reactions – paranoid delusions,– paranoid delusions,
hallucinations, can become very agitated/ violent withhallucinations, can become very agitated/ violent with
decreased awareness of pain.decreased awareness of pain.
Cerebellar symptomsCerebellar symptoms - ataxia- ataxia
With severe over doseWith severe over dose - mute, catatonic, muscle rigidity,- mute, catatonic, muscle rigidity,
HTN, hyperthermia, coma and deathHTN, hyperthermia, coma and death
89. PCP cont.PCP cont.
TreatmentTreatment
antipsychotic drugs or BZD if requiredantipsychotic drugs or BZD if required
Low stimulation environmentLow stimulation environment
NeuroadaptationNeuroadaptation
opiate receptor effectsopiate receptor effects
No tolerance or withdrawalNo tolerance or withdrawal