Ventilation is important to reduce the spread of COVID-19 in indoor spaces. Increasing outdoor air ventilation rates and avoiding air recirculation can help remove virus-containing particles from occupied areas. For mechanically ventilated buildings, recommendations include extending ventilation system operation times, lowering CO2 setpoints, and keeping systems running at lower rates overnight and on weekends. For naturally ventilated buildings, opening windows more often is suggested. Room air cleaners with HEPA filters can also help locally if placed near occupants.
Indoor Air Quality Monitoring and Assessment for Companies to Understand the current indoor air quality problems in the industry.
This will help us to:
Taking necessary action to reduce poor indoor air quality
Planning for the future to reduce indoor air pollution
Indoor Air Quality Monitoring and Assessment for Companies to Understand the current indoor air quality problems in the industry.
This will help us to:
Taking necessary action to reduce poor indoor air quality
Planning for the future to reduce indoor air pollution
Indoor air quality (IAQ) is a term which refers to the air quality within and around buildings and structures, especially as it relates to the health and comfort of building occupants.
An understanding on requirements to produce Hazardous Pharmaceutical Products. The concept of containment facility and practices are described in easy to understand fashion.
Indoor air quality (IAQ) is a term which refers to the air quality within and around buildings and structures, especially as it relates to the health and comfort of building occupants.
An understanding on requirements to produce Hazardous Pharmaceutical Products. The concept of containment facility and practices are described in easy to understand fashion.
Covid Compliant HVAC Systems for Multi-Site Operatorsdannymillertwt
New CDC and ASHRAE guidelines establish enhanced ventilation standards for business to mitigate the spread of Coronaviruses. This is a simple overview of those recommendations and what operators who rely on rooftop packaged HVAC units can do to comply.
USP 797/800 Cleanroom Compliance by Terra UniversalTerra Universal
Understand the scope and compliance costs of the most recent CGMP standards and USP
guidelines for cleanroom design and operation! Webinar topics covered by our industry-expert speakers include DQSA compliance, designing for USP 800 hazardous drug compounding, and cleanroom cost estimating. Industry experts Will summarize the revised regulations and what theymean for pharmacy cleanrooms. Registrants Will receive Terra Universal's white paper "Designing your compounding Cleanroom for USP/cGMP Compliance."
Speakers
Dr. Chris Munoz, PharmD and Principle Consultant at ITL Consulting
and teaches pharmacy compounding at the University of Southern California (USC)
School of Pharmacy, and serves on the California Pharmacists Association's Policy Committee and Board of Directors. Following Chris's earlier work in compounding pharmacies and for pharmaceutical companies, he began a consulting firm specializing in the business of, and regulatory affairs for, pharmacy compounding.
Dr. Jesse Martinez, PharmD, FASCP and Vice Dean of the College of Pharmacy,
Western University of Heath Sciences
Dr. Jesse Martinez has 37 years Of experience in compounding, sterile and non-sterile pharmacy operations and administration, and research. He has served on local, state and national pharmacy associations and currently teaches fourth-year pharmacy students in advanced Classes that include pharmacist-in-charge training. Jesse consults for the pharmacy industry and is a recognized expert in USP 795, 797 and 300 compliance.
For More Information Please visit
http://www.terrauniversal.com/public/webinar-information-and-downloads.php
http://www.terrauniversal.com/cleanrooms/modular-clean-rooms-x.php
TRAINING MODULE FOR IMPLEMENTATION OF GOOD MANUFACTURING PRACTICES FOR STERILE PRODUCT MANUFACTURING.
This training module is prepared based on (Annex 6. TRS 961, 2011) & readers are highly recommended to see this document in conjunction with Annex 6. TRS 961, 2011.
GMP Requirements for Sterile Products manufacturingsurafel kebede
This training module is prepared based on (Annex 6. TRS 961, 2011) & trainees are highly recommended to read this document together with Annex 6. TRS 961, 2011.
GMP Requirements for Sterile Products manufacturingsurafel kebede
This training module is prepared based on (Annex 6. TRS 961, 2011) & trainees are highly recommended to read this document together with Annex 6. TRS 961, 2011.
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Diabetes is a rapidly and serious health problem in Pakistan. This chronic condition is associated with serious long-term complications, including higher risk of heart disease and stroke. Aggressive treatment of hypertension and hyperlipideamia can result in a substantial reduction in cardiovascular events in patients with diabetes 1. Consequently pharmacist-led diabetes cardiovascular risk (DCVR) clinics have been established in both primary and secondary care sites in NHS Lothian during the past five years. An audit of the pharmaceutical care delivery at the clinics was conducted in order to evaluate practice and to standardize the pharmacists’ documentation of outcomes. Pharmaceutical care issues (PCI) and patient details were collected both prospectively and retrospectively from three DCVR clinics. The PCI`s were categorized according to a triangularised system consisting of multiple categories. These were ‘checks’, ‘changes’ (‘change in drug therapy process’ and ‘change in drug therapy’), ‘drug therapy problems’ and ‘quality assurance descriptors’ (‘timer perspective’ and ‘degree of change’). A verified medication assessment tool (MAT) for patients with chronic cardiovascular disease was applied to the patients from one of the clinics. The tool was used to quantify PCI`s and pharmacist actions that were centered on implementing or enforcing clinical guideline standards. A database was developed to be used as an assessment tool and to standardize the documentation of achievement of outcomes. Feedback on the audit of the pharmaceutical care delivery and the database was received from the DCVR clinic pharmacist at a focus group meeting.
Micro RNA genes and their likely influence in rice (Oryza sativa L.) dynamic ...Open Access Research Paper
Micro RNAs (miRNAs) are small non-coding RNAs molecules having approximately 18-25 nucleotides, they are present in both plants and animals genomes. MiRNAs have diverse spatial expression patterns and regulate various developmental metabolisms, stress responses and other physiological processes. The dynamic gene expression playing major roles in phenotypic differences in organisms are believed to be controlled by miRNAs. Mutations in regions of regulatory factors, such as miRNA genes or transcription factors (TF) necessitated by dynamic environmental factors or pathogen infections, have tremendous effects on structure and expression of genes. The resultant novel gene products presents potential explanations for constant evolving desirable traits that have long been bred using conventional means, biotechnology or genetic engineering. Rice grain quality, yield, disease tolerance, climate-resilience and palatability properties are not exceptional to miRN Asmutations effects. There are new insights courtesy of high-throughput sequencing and improved proteomic techniques that organisms’ complexity and adaptations are highly contributed by miRNAs containing regulatory networks. This article aims to expound on how rice miRNAs could be driving evolution of traits and highlight the latest miRNA research progress. Moreover, the review accentuates miRNAs grey areas to be addressed and gives recommendations for further studies.
Willie Nelson Net Worth: A Journey Through Music, Movies, and Business Venturesgreendigital
Willie Nelson is a name that resonates within the world of music and entertainment. Known for his unique voice, and masterful guitar skills. and an extraordinary career spanning several decades. Nelson has become a legend in the country music scene. But, his influence extends far beyond the realm of music. with ventures in acting, writing, activism, and business. This comprehensive article delves into Willie Nelson net worth. exploring the various facets of his career that have contributed to his large fortune.
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Introduction
Willie Nelson net worth is a testament to his enduring influence and success in many fields. Born on April 29, 1933, in Abbott, Texas. Nelson's journey from a humble beginning to becoming one of the most iconic figures in American music is nothing short of inspirational. His net worth, which estimated to be around $25 million as of 2024. reflects a career that is as diverse as it is prolific.
Early Life and Musical Beginnings
Humble Origins
Willie Hugh Nelson was born during the Great Depression. a time of significant economic hardship in the United States. Raised by his grandparents. Nelson found solace and inspiration in music from an early age. His grandmother taught him to play the guitar. setting the stage for what would become an illustrious career.
First Steps in Music
Nelson's initial foray into the music industry was fraught with challenges. He moved to Nashville, Tennessee, to pursue his dreams, but success did not come . Working as a songwriter, Nelson penned hits for other artists. which helped him gain a foothold in the competitive music scene. His songwriting skills contributed to his early earnings. laying the foundation for his net worth.
Rise to Stardom
Breakthrough Albums
The 1970s marked a turning point in Willie Nelson's career. His albums "Shotgun Willie" (1973), "Red Headed Stranger" (1975). and "Stardust" (1978) received critical acclaim and commercial success. These albums not only solidified his position in the country music genre. but also introduced his music to a broader audience. The success of these albums played a crucial role in boosting Willie Nelson net worth.
Iconic Songs
Willie Nelson net worth is also attributed to his extensive catalog of hit songs. Tracks like "Blue Eyes Crying in the Rain," "On the Road Again," and "Always on My Mind" have become timeless classics. These songs have not only earned Nelson large royalties but have also ensured his continued relevance in the music industry.
Acting and Film Career
Hollywood Ventures
In addition to his music career, Willie Nelson has also made a mark in Hollywood. His distinctive personality and on-screen presence have landed him roles in several films and television shows. Notable appearances include roles in "The Electric Horseman" (1979), "Honeysuckle Rose" (1980), and "Barbarosa" (1982). These acting gigs have added a significant amount to Willie Nelson net worth.
Television Appearances
Nelson's char
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Please visit our website: https://kuddlelife.org
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Characterization and the Kinetics of drying at the drying oven and with micro...Open Access Research Paper
The objective of this work is to contribute to valorization de Nephelium lappaceum by the characterization of kinetics of drying of seeds of Nephelium lappaceum. The seeds were dehydrated until a constant mass respectively in a drying oven and a microwawe oven. The temperatures and the powers of drying are respectively: 50, 60 and 70°C and 140, 280 and 420 W. The results show that the curves of drying of seeds of Nephelium lappaceum do not present a phase of constant kinetics. The coefficients of diffusion vary between 2.09.10-8 to 2.98. 10-8m-2/s in the interval of 50°C at 70°C and between 4.83×10-07 at 9.04×10-07 m-8/s for the powers going of 140 W with 420 W the relation between Arrhenius and a value of energy of activation of 16.49 kJ. mol-1 expressed the effect of the temperature on effective diffusivity.
3. Why ventilation is important: a bit of aerosol science……
Potential airborne transmission…
• Breathed/coughed/sneezed droplets are released, possibly containing virus, by
building occupants. Particle size distribution of coughed droplets is typically ~0.5 to
15µm
• ‘Large’ droplets are said in current guidance to ‘settle out close to their source’.
• Ok, so taking a 10µm droplet as an example: Particle settling velocity (vf) in still air
(e.g. indoors) is 3 mm s-1. So, if released at 2m height, it will be deposited to the
floor in ~11 minutes (so quite a long time)
• But…..
• A 10µm pure water droplet will typically evaporate in ~0.2s (and exhaled droplets
are largely water) leaving any residue present airborne – which could be a virus.
• The size of a coronavirus particle is approx. 80-160 nanometres.
• A particle of this size will remain suspended in the air for a much longer time – in
fact almost indefinitely! (100nm particle vf = ~0.0003 mm s-1)
• Therefore, increasing ventilation rates to remove as many exhaled particles as
possible from occupied spaces is a good idea!
4. What about external pollutant ingress with increased ventilation?
Reducing the ingress of outdoor air pollutants is, of course, very
important – but you have to ‘balance the potential problems’!
• Marylebone Road, London - monitoring station with high air pollution:
Number of days with ‘moderate’ (or greater) levels of air pollution:
• PM2.5 particles: 2019 (7); 2018 (2); 2017 (7); 2016 (10)
• Nitrogen dioxide: 2019 (0); 2018 (20); 2017 (18); 2016 (31)
• So, there are a lot of days per year when air pollutant levels (even in
Central London) are lower than the ‘moderate’ level.
• Under ‘normal’ circumstances there is a benefit in reducing
ventilation rates when outdoor pollution levels are higher – and doing
this dynamically is always best if possible.
• However, while the pandemic lasts, there seems to be a clear benefit
in simply keeping building ventilation rates higher than normal.
5. REHVA: Practical recommendations for building services operation
General principle: Increase the air supply and exhaust ventilation in buildings!
In buildings with mechanical ventilation systems:
• Extended ventilation system operation times are recommended
• Demand-controlled ventilation systems: change CO2 setpoint to a lower value
(possibly a default 400 ppm setting?).
• Keep the ventilation on 24/7, with lowered ventilation rates when people are
absent (overnight and weekends).
• In vacated buildings, maintain the ventilation to operate continuously, but at a
reduced rate (i.e. basic normal ‘non-virus’ building maintenance).
• In springtime/summer with small heating and cooling needs, there will be limited
energy penalties, while helping to remove virus particles from buildings.
• The general advice is to supply as much outside air as is reasonably possible.
• If the number of employees attending is reduced, do not concentrate the
remaining employees in smaller areas but maintain physical distancing.
• Exhaust ventilation systems of toilet areas should always be kept on 24/7.
6. REHVA: Practical recommendations for building services operation
In buildings with natural ventilation systems:
• Window opening is usually the only way to boost air exchange (ventilation)
rates – so use more window opening (‘airing’ or purge ventilation).
• It is recommended to actively use openable windows much more than normal
- even when this may cause some thermal discomfort. (So tell staff to ‘bring in
a jumper’ – which should certainly be ok over the summer period!).
• Try to stay away from (or not use) any poorly-ventilated spaces (i.e. spaces
not near to, or without, opening windows).
• Any localised humidification and air-conditioning (heating/cooling) systems
have no practical effects as far as potential virus levels are concerned.
7. REHVA: Practical recommendations for building services operation
Safe use of mechanical ventilation heat recovery systems
• Under certain conditions virus particles in extracted air can re-enter a
building.
• Some heat recovery devices may carry-over viruses attached to particles
from the exhaust air side to the supply air side via leaks.
• Regenerative air-to-air heat exchangers (i.e. rotors, also called enthalpy
wheels) may have air leakage paths if poorly designed and/or maintained.
Possible virus recirculation should not be an issue with HVAC systems equipped
with twin-coil units or heat recovery devices that give 100% air separation
between return and supply.
If in doubt – check. There is currently still plenty of time before the heating
season starts!
8. REHVA: Practical recommendations for building services operation
Mechanical ventilation with air recirculation: Basic principle - don’t use
this feature at the moment!
Virus particles can re-enter a building when centralised air handling units are
equipped with recirculation systems/sectors.
Close any air recirculation dampers (via the Building Management System or
manually).
This may lead to problems with cooling or heating capacity – but avoiding
contamination is currently more important.
Ensure that such actions taken do not lead to any HVAC equipment overheating
- giving an increased risk of fire.
Some air handling units and recirculation sections have return air filters. Unless
these are HEPA filters (generally unlikely in HVAC systems) do not recirculate air
– and even then it is worth checking that there are no air leakage paths around
the filtration units!
9. REHVA: Practical recommendations for building services operation
• Duct cleaning has no practical effect on virus levels – it is much more
important to increase the fresh air supply and avoid any air recirculation.
• More frequent changing of outdoor air filters at ventilation system inlets is not
necessary.
• Free-standing room air cleaners can be useful:
• Those that remove particles from the air can provide a similar effect to
increased ventilation.
• To be effective against the virus, such cleaners must have at least HEPA
filter efficiency. Devices that use electrostatic filtration principles (not
room ionisers!) also work quite well.
• There can be a limited area of beneficial effect from these devices
(depending on room size, ventilation rate, airflow patterns) – so locate
devices near to occupants if possible.
10. BRE: tests carried out on some room air filtration systems
BRE has recently carried out testing of various room air cleaners in controlled
environmental chambers with introduced pollutants (gases, particles and
vapours).
Those with HEPA filters can be very effective at removing airborne particles
down to ~20 nanometres.
BRE also has HVAC testing and consultancy capabilities available if required.
11. Summary of suggested ventilation measures during COVID-19
• If possible, increase the ventilation rate of occupied spaces with outdoor air.
• Extend periods of mechanical ventilation system operation.
• Possibly change (lower) any demand-controlled ventilation set-point for CO2.
• Do not switch ventilation off overnight/weekend. Keep systems running at
lower rate.
• Open windows in naturally-ventilated buildings
• Keep toilet ventilation operating 24/7.
• Switch air handling units with recirculation to 100% outdoor air if possible (i.e.
don’t recirculate air).
• Inspect any heat recovery equipment to be sure of no air leakages paths.
• No need to:
• Change heating, cooling and possible humidification set-points.
• Plan additional duct cleaning for this period.
• Replace central outdoor air inlet filters (follow normal maintenance
schedule).
• Room air cleaners (with HEPA filtration) can be very useful locally –
especially in naturally-ventilated buildings as the heating season approaches
and windows will increasingly need to be closed.
12. Thank you for your attention!
BRE Contact for further information:
Stuart Upton
BRE
E-mail: stuart.upton@bregroup.com
Telephone: +44 (0) 1923 664479
Website: www.bre.co.uk