14.50 The Impact of the Clean Air Zone on Air Quality in Birmingham.pdf

•

0 likes•45 views

The document analyzes the impact of Birmingham's Clean Air Zone (CAZ) on air quality in the city. It shows that nitrogen dioxide (NO2) levels decreased by over 30% after the CAZ was implemented at several roadside monitoring sites, providing evidence that the CAZ successfully improved air quality in Birmingham.

Science

The Impact of the
Clean Air Zone on
Air Quality in
Birmingham

-50%
-40%
-30%
-20%
-10%
0%
10%
20%
Pre Covid Post Covid, Pre CAZ Post CAZ
De-Weathered NO2 Concentrations
St Chad's A4540 Roadside Lower Severn Street Colmore Row Ladywood

Recently uploaded

Structures and textures of metamorphic rocks

kumarmathi863

What is greenhouse gasses and how many gasses are there to affect the Earth.

moosaasad1975

role of pramana in research.pptx in science

sonaliswain16

4. An Overview of Sugarcane White Leaf Disease in Vietnam.pdf

ssuserbfdca9

Lateral Ventricles.pdf very easy good diagrams comprehensive

silvermistyshot

Comparative structure of adrenal gland in vertebrates

sachin783648

Nutraceutical market, scope and growth: Herbal drug technology

Lokesh Patil

As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.

Citrus Greening Disease and its Management

subedisuryaofficial

Circulatory system_ Laplace law. Ohms law.reynaults law,baro-chemo-receptors-...

muralinath2

RNA INTERFERENCE: UNRAVELING GENETIC SILENCING

AADYARAJPANDEY1

Introduction: RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression. It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences. dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants. This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes. What are small ncRNAs? micro RNA (miRNA) short interfering RNA (siRNA) Properties of small non-coding RNA: Involved in silencing mRNA transcripts. Called “small” because they are usually only about 21-24 nucleotides long. Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered). Silence an mRNA by base pairing with some sequence on the mRNA. Discovery of siRNA? The first small RNA: In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the development of the worm C. elegans. Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14. Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions. Types of RNAi ( non coding RNA) MiRNA Length (23-25 nt) Trans acting Binds with target MRNA in mismatch Translation inhibition Si RNA Length 21 nt. Cis acting Bind with target Mrna in perfect complementary sequence Piwi-RNA Length ; 25 to 36 nt. Expressed in Germ Cells Regulates trnasposomes activity MECHANISM OF RNAI: First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces. Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands. The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it. THE RISC COMPLEX: RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA Unwinding of double stranded Si RNA by ATP independent Helicase Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA. DICER: endonuclease (RNase Family III) Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC) One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute ARGONAUTE PROTEIN : 1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA 2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity. MiRNA: The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .

(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...

Scintica Instrumentation

Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes. In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.

Nucleic Acid-its structural and functional complexity.

Nistarini College, Purulia (W.B) India

SCHIZOPHRENIA Disorder/ Brain Disorder.pdf

SELF-EXPLANATORY

Seminar of U.V. Spectroscopy by SAMIR PANDA

SAMIR PANDA

GBSN - Microbiology (Lab 4) Culture Media

Areesha Ahmad

general properties of oerganologametal.ppt

IqrimaNabilatulhusni

Richard's entangled aventures in wonderland

Richard Gill

Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.

THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.

Sérgio Sacani

The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.

Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...

Sérgio Sacani

Since volcanic activity was first discovered on Io from Voyager images in 1979, changes on Io’s surface have been monitored from both spacecraft and ground-based telescopes. Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images show that a plume deposit from a powerful eruption at Pillan Patera has covered part of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive optics at visible wavelengths.

Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx

muralinath2

Recently uploaded (20)

Structures and textures of metamorphic rocks

What is greenhouse gasses and how many gasses are there to affect the Earth.

role of pramana in research.pptx in science

4. An Overview of Sugarcane White Leaf Disease in Vietnam.pdf

Lateral Ventricles.pdf very easy good diagrams comprehensive

Comparative structure of adrenal gland in vertebrates

Nutraceutical market, scope and growth: Herbal drug technology

Citrus Greening Disease and its Management

Circulatory system_ Laplace law. Ohms law.reynaults law,baro-chemo-receptors-...

RNA INTERFERENCE: UNRAVELING GENETIC SILENCING

(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...

Nucleic Acid-its structural and functional complexity.

SCHIZOPHRENIA Disorder/ Brain Disorder.pdf

Seminar of U.V. Spectroscopy by SAMIR PANDA

GBSN - Microbiology (Lab 4) Culture Media

general properties of oerganologametal.ppt

Richard's entangled aventures in wonderland

THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.

Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...

Body fluids_tonicity_dehydration_hypovolemia_hypervolemia.pptx