Richard Kim, MD, and Karon Martyn, MSN, ANP-BC, AOCNP, prepared useful Practice Aids pertaining to mCRC for this CME/MOC/CE activity titled "A Team Approach to Tackling the Complexities in Later Lines of Therapy for Metastatic Colorectal Cancer." For the full presentation, monograph, complete CME/MOC/CE information, and to apply for credit, please visit us at http://bit.ly/2IpIBz4. CME/MOC/CE credit will be available until May 29, 2019.
Richard Kim, MD, and Karon Martyn, MSN, ANP-BC, AOCNP, prepared useful Practice Aids pertaining to mCRC for this CME/MOC/CE activity titled "A Team Approach to Tackling the Complexities in Later Lines of Therapy for Metastatic Colorectal Cancer." For the full presentation, monograph, complete CME/MOC/CE information, and to apply for credit, please visit us at http://bit.ly/2IpIBz4. CME/MOC/CE credit will be available until May 29, 2019.
Colorectal cancer (CRC) has potential to spread within the peritoneal cavity, and this transcoelomic
dissemination is termed “peritoneal metastases” (PM).The aim of this article was to summarise the current
evidence regarding CRC patients at high risk of PM. Colorectal cancer is the second most common cause of cancer
death in the UK. Prompt investigation of suspicious symptoms is important, but there is increasing evidence that
screening for the disease can produce significant reductions in mortality.High quality surgery is of paramount
importance in achieving good outcomes, particularly in rectal cancer, but adjuvant radiotherapy and chemotherapy
have important parts to play. The treatment of advanced disease is still essentially palliative, although surgery for
limited hepatic metastases may be curative in a small proportion of patients.
Venous thromboembolism (VTE) may be the earliest sign of cancer.
Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked VTE .
We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography(CT) of the abdomen and pelvis in patients who had a first unprovoked VTE .
Nowadays the problem of surgical treatment of Colorectal
Cancer (CRC) is becoming very important due to the high speed of increasing morbidity and mortality, which is registered almost in all economically developed countries in the world [1,2]. In 2012, more than one million new cases of CRC were detected on our planet and about half a million people died from this disease [1]. On the territory of Russia, a primary diagnosis of colorectal cancer is annually established in 6000 people, with the highest incidence rates in the North-West region (St. Petersburg and Leningrad region), where in the general structure of oncopathology, colorectal cancer is in the second
A recent study looked at 2000 senior patients who had Stage 1 lung cancer. NPR reports researchers found that after five years, 9 out of 10 of these patients who had surgery for the disease were still alive.
http://ow.ly/BxWH306nH9I
Prevention and early detection of Prostate Cancer: a global view Vitaly Smelov, International Agency for Research on Cancer (IARC), World Health Organisation (WHO)
ISMB Translational Medicine SIG 2016: Reproducible Genomic Interpretation Too...Katie Fisch, Ph.D.
TransMed 2016 SIG presentation for ISMB 2016 in Orlando, Florida (https://www.iscb.org/ismb2016program/ismb2016-sigs#transmed) profiling a precision medicine case study and open source notebooks developed for translational medicine (Jupyter-Genomics https://github.com/ucsd-ccbb/jupyter-genomics).
Protocol for the Treatment Prostate Cancer - Dr Serge JurasunasSheldon Stein
Dr. Serge Jurasunas shares his Prostate Cancer Protocol in this paper, explaining the nature and treatment of Prostate Cancer from a Naturopathic Oncology Perspective. Professor Jurasunas is located in Lisbon Portugal and has lectured worldwide throughout his 50 years as a clinician.
He explains what can be done about the #1 cause of death in males even before lung cancer and what can be done, from the new perspective of Naturopathic Oncology.He offers an example, explains diagnostic procedures with Molecular markers and addresses detox, supplements and treatment.
Further information may be found in his new book, Health and Disease Begin in the Colon" and in his Blog: Naturopathiconcology.blogspot.com .
Colorectal cancer (CRC) has potential to spread within the peritoneal cavity, and this transcoelomic
dissemination is termed “peritoneal metastases” (PM).The aim of this article was to summarise the current
evidence regarding CRC patients at high risk of PM. Colorectal cancer is the second most common cause of cancer
death in the UK. Prompt investigation of suspicious symptoms is important, but there is increasing evidence that
screening for the disease can produce significant reductions in mortality.High quality surgery is of paramount
importance in achieving good outcomes, particularly in rectal cancer, but adjuvant radiotherapy and chemotherapy
have important parts to play. The treatment of advanced disease is still essentially palliative, although surgery for
limited hepatic metastases may be curative in a small proportion of patients.
Venous thromboembolism (VTE) may be the earliest sign of cancer.
Currently, there is a great diversity in practices regarding screening for occult cancer in a person who has an unprovoked VTE .
We sought to assess the efficacy of a screening strategy for occult cancer that included comprehensive computed tomography(CT) of the abdomen and pelvis in patients who had a first unprovoked VTE .
Nowadays the problem of surgical treatment of Colorectal
Cancer (CRC) is becoming very important due to the high speed of increasing morbidity and mortality, which is registered almost in all economically developed countries in the world [1,2]. In 2012, more than one million new cases of CRC were detected on our planet and about half a million people died from this disease [1]. On the territory of Russia, a primary diagnosis of colorectal cancer is annually established in 6000 people, with the highest incidence rates in the North-West region (St. Petersburg and Leningrad region), where in the general structure of oncopathology, colorectal cancer is in the second
A recent study looked at 2000 senior patients who had Stage 1 lung cancer. NPR reports researchers found that after five years, 9 out of 10 of these patients who had surgery for the disease were still alive.
http://ow.ly/BxWH306nH9I
Prevention and early detection of Prostate Cancer: a global view Vitaly Smelov, International Agency for Research on Cancer (IARC), World Health Organisation (WHO)
ISMB Translational Medicine SIG 2016: Reproducible Genomic Interpretation Too...Katie Fisch, Ph.D.
TransMed 2016 SIG presentation for ISMB 2016 in Orlando, Florida (https://www.iscb.org/ismb2016program/ismb2016-sigs#transmed) profiling a precision medicine case study and open source notebooks developed for translational medicine (Jupyter-Genomics https://github.com/ucsd-ccbb/jupyter-genomics).
Protocol for the Treatment Prostate Cancer - Dr Serge JurasunasSheldon Stein
Dr. Serge Jurasunas shares his Prostate Cancer Protocol in this paper, explaining the nature and treatment of Prostate Cancer from a Naturopathic Oncology Perspective. Professor Jurasunas is located in Lisbon Portugal and has lectured worldwide throughout his 50 years as a clinician.
He explains what can be done about the #1 cause of death in males even before lung cancer and what can be done, from the new perspective of Naturopathic Oncology.He offers an example, explains diagnostic procedures with Molecular markers and addresses detox, supplements and treatment.
Further information may be found in his new book, Health and Disease Begin in the Colon" and in his Blog: Naturopathiconcology.blogspot.com .
Feature story from the Garvan Institute of Medical Research's April 2013 issue of Breakthrough newsletter. More at https://www.garvan.org.au/news-events/newsletters
How to have quality of life in Advanced ovarian malignancyRajesh Gajbhiye
Presentation given by Dr Rakhi Gajbhiye, Mauli Hospital Nagpur at MGIMS sewagram for an International conference on Womens Health Fatal Disorders Survival with Quality in collaboration with FOGSI.
This was the function to commemorate 100 th birth centenary of Dr Sushila
Mesothelioma is a form of cancer caused by exposure to asbestos.To get more information about mesothelioma symptoms, diagnosis, treatment options, mesothelioma news and resources for dealing with the cancer mesothelioma or call us at 1.866.855.1229 .
Protocol for the Treatment of Prostate CancerSheldon Stein
Professor of Naturopathic Oncology, Serge Jurasunas explains the nature of prostate cancer and outlines the unique protocols he utilizes at his Lisbon clinic. Additional information is available on his website: www.sergejurasunas.com
The Role of Fruit Flies in Cancer ResearchBrianFrenzel
The common fruit fly (Drosophila melanogaster) has played an important role in medical research for over 100 years. The fly has contributed to many discoveries in genetics, development, cancer, and neurobiology, and has been the basis for six Nobel Prizes in Physiology and Medicine, including the 2017 award for studies on the molecular mechanisms that control circadian rhythms. New research findings demonstrate the effectiveness of fruit fly models in designing personalized cancer treatments and enhancing the safety and efficacy of existing cancer therapies.
The fruit fly provides a flexible and efficient animal model characterized by genetic sequences similar to the human genome. However, the Drosophila’s genetic makeup is significantly smaller and simpler than the human genome. The fruit fly has only four pairs of chromosomes, whereas humans have 23 pairs. However, over 60 percent of the fruit fly’s genes are analogous to those found in humans and 75% of known human disease genes have an identifiable match (or orthologue) in Drosophila. Many of those shared genes are associated with medical conditions such as cancer. Drosophila’s genes can be easily manipulated for research purposes, facilitating study of the transmission of cancer genes.
For example, London-based Vivan Therapeutics relies on fruit flies to select drug therapies for cancer patients. Scientists copy the genetic sequence found in patient tumor cells and recreate it in fruit flies. The fruit flies reproduce, generating thousands of flies carrying the patient’s exact cancer mutations. These are then administered drug combinations to determine the best one for the particular patient. Vivan’s personalized approach is particularly relevant to patients with rare cancers that lack established protocols for effective treatment.
In 2021, a research team at the University of California investigated another application of fruit flies in cancer treatment. The team discovered that tumors in fruit flies release interleukin-6 (ILL-6), an inflammatory chemical that compromises the blood-brain barrier, leading to death. The study focused on blocking IL-6’s action in the body to preserve the blood-brain barrier and reduce mortality. The team successfully extended the lifespan of fruit flies with cancer by blocking IL-6. These results could lead to new therapies for IL-6 mediated cancers such as cachexia, potentially improving survival rates and the quality of life for cancer patients.
In addition to their role in cancer treatment design, fruit flies are also useful in investigating ways to reduce the side effects of cancer therapy. Many have attempted to find ways to ameliorate the adverse effects of cancer therapy, but investigators have struggled with to find ways to selectively inhibit drugs’ harmful actions without compromising their therapeutic ones.
A company that has met with success in this effort is Tosk, Inc., a biotechnology company that uses fruit flies as a low-cost animal model
Running head YOU ARE WHAT YOU EAT1YOU ARE WHAT YOU EAT2.docxtoltonkendal
Running head: YOU ARE WHAT YOU EAT 1
YOU ARE WHAT YOU EAT 2
You Are What You Eat
Awesome Doctor
West Coast University
Abstract
Scientist have found evidence that life with cancer can be extended and certain cancers can be prevented by changing dietary habits. People who are influenced by western society and maintain a western diet are in great danger if nothing is done to limit the intake of meat and consumption of process meats. New dietary guidelines are released every 5 years by the U.S. Department of Agriculture and the department of Health and Human Services. Both organizations are responsible for reviewing clinical evidence and reports from research, and creating new dietary guidelines for consumers to follow. Critics of the new guidelines argue that the USDA has censored the recommendations to eat less red meat in such a way that only the food corporations funding the research receive benefits. Cancer is caused by multiple factors but mainly from exposure to carcinogens and mutations in DNA. Carcinogens either promote cancer growth or initiate cancer growth. Certain risk factors have been associated with the development of cancers. Air pollution, tobacco use, excessive alcohol consumption, occupational hazards, exposure to radiation, and certain aspects of diet are all risk factors liked to be carcinogenic. The carcinogenic links in diet have been attracting a lot of attention in the scientific community. Scientist working with the national cancer institute, under the national institute of health, have been working together to verify the relationship between consuming meat and processed foods, and the development or progression of cancer. The national cancer institute’s division of cancer prevention, conducted a two-year study that divided 200 people into 2 groups that were diagnosed with colorectal cancer within 3 to 6 months of the study. The control group maintained their normal diet that included eating meat and processed foods while the experimental group eliminated meat and processed foods and maintained a strict vegetarian diet for the life of the experiment. The experiments objective was to test the correlation between meat consumption and the effects of colorectal cancer. The funding assisted with the research needed to find subjects for the study and to transport them to and from facilities rented out to perform colonoscopy or CT scan procedures. Graphs were made to measure the rates of reoccurrence or metastasis. 72 of the 200 participants died during the 24-month long experiment. The participants from the control group suffered a loss of 42%, while the experimental group only lost 30% of its participants before the trial was over. Those who maintained a vegetarian diet displayed an additional 25% chance of not developing metastasis and 26% decrease in polyp reoccurrence. Participants in the study who maintained a vegetarian diet developed end stage cancer or metastasis at slower rates. The informatio ...
This is a breakdown of the film download presentation I created last year. It discusses the industry as well as the effect of search and recommendation systems on online media.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Stroma Cells May Inhibit the Growth of Pancreatic Cancer Tumors
1. Cancer
Cells
May
Fight
Pancreatic
Cancer
in
Earlier
Stages
A
new
study
presented
by
Dr.
Paul
E.
Oberstein
and
Dr.
Kenneth
P.
Olive
in
the
journal
Cancer
Cell
came
to
a
surprising
conclusion
regarding
one
of
the
most
common
types
of
pancreatic
cancer
known
as
Pancreatic
Ductal
Adenocarcinoma
(PDAC).
PDAC
makes
up
90%
of
pancreatic
cancer
cases
and
has
a
very
poor
outlook.
The
average
survival
rate
is
just
6
months
after
a
patient
has
been
diagnosed.
PDAC
tumors
are
made
up
of
both
tumor
and
stromal
cells.
Stroma
is
the
connective
tissue
in
organs,
and
includes
both
fibroblast
(tissue
that
provides
structure
to
cells)
and
cellular
material
such
as
collagen.
Stromal
cells
are
of
particular
interest
to
researchers
as
many
think
they
play
a
strong
role
in
the
development
of
cancer.
In
a
previous
study,
Dr.
Olive
reduced
the
content
of
stromal
cells
in
mice
with
pancreatic
cancer
by
blocking
a
molecular
pathway
used
by
these
cells
and
then
treated
the
mice
with
chemotherapy.
The
mice
treated
with
the
combination
of
blocked
stromal
cells
and
chemotherapy
survived
longer
than
those
treated
with
either
of
these
options
alone,
or
those
that
received
no
treatment
at
all.
But,
when
this
was
tested
in
humans
the
opposite
occurred.
Comparing
the
two,
studies
Dr.
Oberstein
and
Dr.
Olive
surmised
that
the
difference
could
be
due
to
the
fact
that
human
patients
were
given
chemotherapy
for
a
longer
period
of
time.
Perhaps
the
combination
of
reduced
stromal
cells
and
chemotherapy
had
one
effect
in
a
shorter
treatment
cycle
and
a
different
effect
in
a
longer
one.
To
test
this
they
repeated
the
study
with
mice
that
were
in
an
earlier
stage
of
the
disease
and
treated
them
with
chemotherapy
longer.
Now
the
chemotherapy
reduced
survival
similar
to
the
results
of
the
human
clinical
trial.
Working
with
collaborators
Ben
Stanger
at
the
University
of
Pennsylvania
and
Andrew
Rhim
from
the
University
of
Michigan,
Drs.
Olive
and
Oberstein
demonstrated
that
there
are
certain
cell
types
in
a
tumor
that
might
actually
inhibit
cancer
growth.
These
findings
were
not
expected
and
disproved
a
common
theory
about
pancreatic
cancer
tumors.
Ongoing
work
will
study
how
these
stromal
cells
may
actually
inhibit
tumor
growth.
For
more
information
on
cancer
research
and
treatment
at
Columbia
University
Medical
Center
visit
the
Division
of
Hematology/Oncology
web
page.
The
full
article
Stromal
Elements
Act
to
Restrain,
Rather
Than
Support,
Pancreatic
Ductal
Adenocarcinoma
is
available
on
Cancer
Cell.