LESS current treatment of cartilage defectsClara Jacobson
http://www.frankmccormickmd.com/ Dr. Frank McCorimck is an orthopedic surgeon serving the greater Miami and Fort Lauderdale area. A navy vet and Harvard-trained, Dr. McCormick specializes in sports medicine, arthroscopic surgery, biologic joint preservation, and cartilage failure treatments.
Various Potential Uses of Resveratrol in different diseases such as Cancer, Alzhiemers, Coronary Artery Disease, Ischemic Stroke, Atherosclerosis, Hypertension, Oxidative Stress, Type 2 Diabetes, Impaired Glucose Tolerance, Non Alcoholic fatty liver disease, Neurological Disorders
Future Strategies for Treatment of Brain TumoursAsad Qureshi
It includes a brief description of the methods that are currently employed and the methods that hold promise for the complete cure of brain cancer in the future
LESS current treatment of cartilage defectsClara Jacobson
http://www.frankmccormickmd.com/ Dr. Frank McCorimck is an orthopedic surgeon serving the greater Miami and Fort Lauderdale area. A navy vet and Harvard-trained, Dr. McCormick specializes in sports medicine, arthroscopic surgery, biologic joint preservation, and cartilage failure treatments.
Various Potential Uses of Resveratrol in different diseases such as Cancer, Alzhiemers, Coronary Artery Disease, Ischemic Stroke, Atherosclerosis, Hypertension, Oxidative Stress, Type 2 Diabetes, Impaired Glucose Tolerance, Non Alcoholic fatty liver disease, Neurological Disorders
Future Strategies for Treatment of Brain TumoursAsad Qureshi
It includes a brief description of the methods that are currently employed and the methods that hold promise for the complete cure of brain cancer in the future
Human Genome Engineering, Recent discoveries, Types of Designer babies, Methods used for Designer Babies, CRISPR, ETHICAL CONSIDERATION OF HUMAN GENOME ENGINEERING
Stem Cell Therapy 9 Things You Need to Know by Dr. David Greene of R3 Stem Ce...R3 Stem Cell
In this powerful presentation, Dr. David Greene R3 Stem Cell shares his revolutionary stem cell therapy and how it can help you. With no surgery or medication required, R3 exosome therapy is an innovative regenerative medicine therapy that uses a patient’s cells to treat various conditions, such as heart disease, diabetes, and cancer.
Everything you need to know about stem cells.pptxpallaviparmar9
Adult stem cells (also known as Somatic stem cells) are undifferentiated cells found throughout your body.
In some adult tissues, such as bone marrow, muscle, and brain, discrete populations of adult stem cells generate replacements for other cells that are lost through normal wear and tear, injury, or disease.
Gene therapy is emerging branch of healthcare, we can see that with the possible development it has potential to treat multiple genetic as well as other conditions and disease
hope young scholar can find this presentation useful and i am open to any suggestions
There are a lot of orthopedic conditions and injuries that presently have limited treatment options available.
Here regenerative technologies comes up as a ray of hope among surgeons for the treatment by functionally repairing the tissues and organs using growth factors, stem cells and products developed by genetic engineering with the advancement in the stem cells research field .
The purpose of this presentation is to first provide idea about the orthopedic conditions along with the therapeutic potential of stem cells to treat these diseases.
Multiple sclerosis is generally referred to as an autoimmune disease or disorder in which the nerve cells of brain and spinal cord are attacked by patients own immune system.
The patient's bodys immune system perceives myelin sheet as an intruder and attack it resulting in damage due to which this sheet no longer carry the messages properly causing the message transmission process to be slowed, distorted or stopped altogether.
At present there is no cure available for multiple sclerosis, however, using certain drugs such as interferon’s, exercise and physiotherapy it is possible to manage the attacks and symptoms.
Researchers hope that stem cell therapies may provide new approaches that can both prevent damage and enable us to repair it.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
STEM CELL THERAPY HAS A PROMISE IN Duchenne Muscular Dystrophy, Dr.Sharda jain
1. STEM CELL THERAPY
HAS A PROMISE IN
Duchenne Muscular Dystrophy
Dr. Prabhu Mishra
Dr. Sharda Jain
Dr. Yogesh Agarwala
Dr. Rajesh Dhall
• Dr. Rashmi Jain
• Dr. Indu Tyagi
• Ms. Himani Agnihotri
Public contact
initiative
www.globalstemgenn.com
3. What is Duchenne Muscular
Dystrophy (DMD)?
Duchenne Muscular Dystrophy (DMD) is
an inherited disorder that involves
rapidly-worsening muscle weakness.
• It occurs in approximately 1 out of
every 3,6000 male infants.
• Female infants could be carriers too.
www.globalstemgenn.com
5. What is Duchenne Muscular
Dystrophy (DMD)?
• As this is an inherited
disorder, risks include a
family history of DMD.
• It is characterized by
rapid progression of
muscle degeneration,
which eventually leads to
loss of movement and
even death.
8. What are the symptoms?
• The symptoms for DMD include
mental retardation , muscle
weakness, difficulty with motor
skill, and frequent falls.
• These symptoms occur before
the victim turns 6, and may
gradually continue to worsen.
• By the time the patient reaches
age 10, he may need braces to
aid walking, or may not be able
to walk at all.
• Most do not cross 25 years.
10. Treatment aims to control the symptoms
in order to improve the quality of the
victim’s life.
Activity is encouraged, as remaining
inactive could worsen DMD.
Physical therapy may be helpful to
maintain muscle strength and function.
Conventional Treatment –
only supportive treatment
www.globalstemgenn.com
11. Conventional Treatment –
only supportive treatment
• Orthopedic appliances (such as
braces and wheelchairs) may
improve mobility.
• Gene therapy may also become
available in the future.
www.globalstemgenn.com
12. Treating DMD with Stem Cell
Therapy - Review of literature
• The development of Regenerative
Medicine with the availability of
cellular transplantation in the form
of Stem Cells has given us the first
major breakthrough in the
management of Muscular
Dystrophy.
www.globalstemgenn.com
13. World Research with
Stem Cell Treatment
Numerous clinical trials are
going on all over the world to
explore the potential of stem
cells in Duchenne Muscular
Dystrophy.
www.globalstemgenn.com
14. Treating DMD with Stem Cell
Therapy - Review of literature
• Conclusion of all literature shows that
the treatment of Muscular Dystrophy
with adult autologous stem cells
combined with an aggressive
rehabilitation program is a safe and
effective form of therapy in slowing
down / halting the progression of the
disease and in producing functional
and neurological improvements in
patients of DMD.
www.globalstemgenn.com
15. Indian Experience of Stem Cell
Therapy in DMD
• Now enough practice based
evidence is available in India to
show that Stem Cell therapy is
a completely safe therapy and
has shown a reasonable
effectiveness to improve the
quality of life.
• Ethically this is in complete accordance with
the World Medical Associations.
16. Stem cell therapy improves the
quality of life.
However the response
Varies from patient
to patient
www.globalstemgenn.com
WORLD RESEARCH ON Duchenne Muscular
Dystrophy
WITH STEM CELL THERAPY
17. World Medical Association
Declaration of Helsinki
• It states that “ In the treatment of a
patient, where proven
interventions do not exist or have
been ineffective, the physician,
may use an unproven intervention
if the physicians judgment if offers
hope of saving life, re-establishing
health or alleviating suffering.
www.globalstemgenn.com
20. Our USP
• World class clinicians and experts from
Regenerative medicine.
• State of the art, in-house stem cell lab to maximize the
yield of good quality Stem Cells
• Accurate treatment protocols for “relevant disorders”
• Proven results and experience in handling complex case
• We use Autologous stem cells for Stem Cell Therapy
(Bone Marrow, Fat, Blood)
www.globalstemgenn.com
21. We offer
Global stemgenn makes suitable
stem cell therapy available to
the ailing patient only after
thorough scientific
deliberations and meticulous
counseling of patient & family
with experts.
www.globalstemgenn.com
22. • Autologous cells for homologous use
• Same setting surgery
• Minimal manipulation of cells
• Don’t promote therapeutic results
You should know
FDA– guidelines…
23. • This is a patient-funded clinical trial
• Stem Cell Therapy is NOT COVERED
BY INSURANCE
• Public undertakings DO ALLOW
in GUJARAT
• The cost of the therapy ranges & mainly
depends on the complexity of the case
Fees and Insurance
cover
www.globalstemgenn.com
24. Global stemgenn offer you stem cell
therapy using latest technology.
These stem cells could be of various types viz.
Hematopoietic (CD 34+), Mesenchymal stem
cells (MSCs) that are processed and isolated
using Good Manufacturing Practice (GMP)
and Good Lab Practice (GLP) in accordance
with AABB standards.
Our Lab USP
www.globalstemgenn.com
25. Our experience of
Stem cell therapy at Global Stemgenn
- It is completely safe,
Non –Toxic and totally devoid of side
effects with good probability of homing
and engraftment with the parent cell,
tissue or organ.
Patient - Safety
www.globalstemgenn.com
28. ADDRESS
11 Gagan Vihar, Near Karkari Morh
Flyover, Delhi - 51
CONTACT US
9599044357(Help line),
9811011690(Watsapp)
011-22414049,22058865
WEBSITE :
www.globalstemgenn.com
www. Stemgenn.com
www.lifecarecentre.in
E-MAIL ID
Contact@globalstemgenn.com
A UNIT
OF ISO 14001:2004 (EMS)
…..Caring hearts, healing
hands
ISO 9001:2008
ISO 9001:2008