Various Potential Uses of Resveratrol in different diseases such as Cancer, Alzhiemers, Coronary Artery Disease, Ischemic Stroke, Atherosclerosis, Hypertension, Oxidative Stress, Type 2 Diabetes, Impaired Glucose Tolerance, Non Alcoholic fatty liver disease, Neurological Disorders

1. The Therapeutic Potential of Resveratrol -
A Review of Clinical Trials
PRESENTED BY GUIDANCE BY
DANISH SAYYAD Dr. A.P. PINGLE
Quality Assurance Techniques Dept. Pharmaceutical Chemistry
FIRST YEAR M.PHARM
Roll no - 09
NDMVP SAMAJ’S COLLEGE OF PHARMACY, NASHIK.
1

2. • Sources include the skin of grapes, blueberries,
raspberries, mulberries, and peanuts.
• It is a Stilbenoid (C6-C2-C6)
• It is a Phytoalexin
• It is a Solution to French Paradox
• It is a Neutraceutical

3. • Chemo preventive and Chemotherapeutic
• Effects all 3 stages of carcinogenesis i.e.
Initiation, Promotion and Progression
• Induce Apoptosis pathway
• Affects Nuclear factor κB (NF-κB)
• Inhibits IGF-1R (hypertrophy) and activate P53
(Tumor Protein)
• Inhibits phosphatidyl-inositol-3-
kinase(PI3K)/Protein kinase B (Akt)/mTOR
pathway

5. • Inhibits cyclooxygenases (COX) – anti
inflammatory
• Inhibits Vascular cell adhesion molecules
(VCAM) that affects activity of smooth muscles
cells which are responsible for the development
of atherosclerosis and hypertension
• Inhibits Platelet aggregation and prevent blood
clot formation
• Anti Aging - Activation of longevity gene
(Sirtuins)
Pharmacokinetics – More effective topically rather
orally (quickly metabolized and excreted)

7. References
1. Adi Y. Berman, Rachel A. Motechin, Maia Y. Wiesenfeld and
Marina K. Holz, “The therapeutic potential of resveratrol: a
review of clinical Trials”, Nature precision oncology, nature
publications, 1-9 (2017)
2. Chung, S. et al. Regulation of SIRT1 in cellular functions:
role of polyphenols. Arch. Biochem. Biophys. 501, 79–90
(2010).
3. Magyar, K. et al. Cardioprotection by resveratrol: a human
clinical trial in patients with stable coronary artery disease.
Clin. Hemorheol. Microcirc. 50, 179–187(2012).
4. Paller, C. J. et al. A phase I study of muscadine grape skin
extract in men with biochemically recurrent prostate cancer:
safety, tolerability, and dose determination. Prostate 75,
1518–1525 (2015).

8. 5. Pasinetti, G. M., Wang, J., Ho, L., Zhao, W. & Dubner, L.
Roles of resveratrol and other grape-derived polyphenols in
Alzheimer’s disease prevention and treatment. Biochim.
Biophys. Acta 1852, 1202–1208 (2015).
6. Chen, J., Bai, Q., Zhao, Z., Sui, H. & Xie, X. Resveratrol
improves delayed r-tPA treatment outcome by reducing
MMPs. Acta Neurol. Scand. 134, 54–60 (2016).
7. Alayev, A., Berger, S. M., Kramer, M. Y., Schwartz, N. S. &
Holz, M. K. The combination of rapamycin and resveratrol
blocks autophagy and induces apoptosis in breast cancer cells.
J. Cell. Biochem. 116, 450–457 (2015).
8. David A. Sinclair. A conserved NAD binding pocket that
regulates protein-protein interactions during aging. Science,
24 Mar 2017: Vol. 355, Issue 6331, pp. 1312-1317.