This document discusses farming systems in sub-Saharan Africa and priorities for science and policy. It presents a framework for classifying farming systems based on agroecology, commodities, and socioeconomic factors. Examples of highland perennial and Albertine Rift systems are provided. Strategic priorities are identified for different systems, such as soil fertility management, market-driven intensification, and reducing transaction costs. The farming systems framework could help target innovations, assess productivity impacts, and organize investments and research by country and region. Sample data layers on resources, drivers, and trends are also listed.